FI89910B - Foerfarande foer framstaellning av terapeutiskt aktiva bensimidazolderivat - Google Patents

Foerfarande foer framstaellning av terapeutiskt aktiva bensimidazolderivat Download PDF

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Publication number
FI89910B
FI89910B FI863382A FI863382A FI89910B FI 89910 B FI89910 B FI 89910B FI 863382 A FI863382 A FI 863382A FI 863382 A FI863382 A FI 863382A FI 89910 B FI89910 B FI 89910B
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FI
Finland
Prior art keywords
formula
compound
compounds
acid
same
Prior art date
Application number
FI863382A
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English (en)
Finnish (fi)
Other versions
FI89910C (sv
FI863382A (fi
FI863382A0 (fi
Inventor
Hans-Jochen Lang
Andreas W Herling
Manfred Roesner
Gerhard Rackur
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19853530342 external-priority patent/DE3530342A1/de
Priority claimed from DE19863610609 external-priority patent/DE3610609A1/de
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI863382A0 publication Critical patent/FI863382A0/fi
Publication of FI863382A publication Critical patent/FI863382A/fi
Application granted granted Critical
Publication of FI89910B publication Critical patent/FI89910B/fi
Publication of FI89910C publication Critical patent/FI89910C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Claims (2)

1. Förfarande för framställning av terapeutiskt aktiva bensimidazolderivat med formeln 5 “ V4 R5 15. vilken A är -S- eller -SO-, R1 är C1.4-alkyl, företrädesvis metyl eller etyl, R3, R4, R5 och R6 är lika eller olika och betyder vä-te, C1.4-alkyl eller metoxi och
20 R13 och R14 är lika eller olika och betyder C1.4-alko- xi, samt för framställning av deras fysiologiskt godtagbara salter, kännetecknat därav, att . . en förening med formeln ' ‘ 25 R13 ^YVe1 (II) :V: 30 ^ i vilken R13 och R14 betyder detsamma som ovan och Q1 är i) en avgäende grupp eller ii) en grupp -SH eller -S~, 35 bringas att reagera med en förening med formeln 16 3 991 0 H Rl V /H 2 5 (iii) r4 I5 10 i vilken R1, R3, R4, R5 och R6, betyder detsamma som. ovan, Q2 i det ovan nämnda fallet i) är -SH- eller -S- och i det ovan nämnda fallet ii) en avgäende grupp, och den enhällna föreningen med formeln I, i vilken A 15 är -S-, eventuellt oxideras tili en motsvarande förening, i vilken A är -SO-, och den enhällna föreningen med formeln I eventuellt förvandlas tili ett fysiologiskt godtagbart sait.
2. Förfarande enligt patentkravet 1, k ä n n e -20 tecknat därav, att 2-(2-etylaminobensylsulfinyl)- 5,6-dimetoxibensimidazol eller dess fysiologiskt godtagba-ra sait framställs. l!
FI863382A 1985-08-24 1986-08-21 Förfarande för framställning av terapeutiskt aktiva bensimidazolderiva t FI89910C (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19853530342 DE3530342A1 (de) 1985-08-24 1985-08-24 Substituierte toluidine, verfahren zu ihrer herstellung, diese enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer
DE3530342 1985-08-24
DE19863610609 DE3610609A1 (de) 1986-03-29 1986-03-29 Substituierte toluidine, verfahren zu ihrer herstellung, diese enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer
DE3610609 1986-03-29

Publications (4)

Publication Number Publication Date
FI863382A0 FI863382A0 (fi) 1986-08-21
FI863382A FI863382A (fi) 1987-02-25
FI89910B true FI89910B (fi) 1993-08-31
FI89910C FI89910C (sv) 1993-12-10

Family

ID=25835350

Family Applications (1)

Application Number Title Priority Date Filing Date
FI863382A FI89910C (sv) 1985-08-24 1986-08-21 Förfarande för framställning av terapeutiskt aktiva bensimidazolderiva t

Country Status (17)

Country Link
EP (1) EP0213474B1 (sv)
JP (1) JPH0791276B2 (sv)
KR (1) KR940005020B1 (sv)
AR (1) AR243167A1 (sv)
AT (1) ATE85328T1 (sv)
DE (1) DE3687675D1 (sv)
DK (1) DK401586A (sv)
ES (1) ES2001389A6 (sv)
FI (1) FI89910C (sv)
GR (1) GR862180B (sv)
HU (1) HU199126B (sv)
IE (1) IE59587B1 (sv)
IL (1) IL79813A0 (sv)
NO (1) NO169169C (sv)
NZ (1) NZ217322A (sv)
PH (1) PH24073A (sv)
PT (1) PT83240B (sv)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2038612T3 (es) 1986-03-28 1993-08-01 Otsuka Pharmaceutical Co., Ltd. Compuestos de hidroquinolina, composiciones que los contienen y procedimientos para prepararlas.
EP0251536A1 (en) * 1986-06-24 1988-01-07 FISONS plc Benzimidazoles, their production, formulation and use as gastric acid secretion inhibitors
IT1222412B (it) * 1987-07-31 1990-09-05 Chiesi Farma Spa Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica,loro procedimento di preparazione e composizioni farmaceutiche che li contengono
CA1322005C (en) * 1987-11-25 1993-09-07 Robert N. Young Benzoheterazoles
EP0318085A3 (en) * 1987-11-25 1990-03-14 Merck Frosst Canada Inc. Heterazole dialkanoic acids
JP2564162B2 (ja) * 1988-02-12 1996-12-18 日本ケミファ株式会社 ベンズイミダゾール誘導体の四級塩
ES2047451B1 (es) * 1992-07-10 1994-10-01 Sint Quimica Sa Procedimiento para la preparacion de una composicion farmaceutica oral estable.
KR20040028815A (ko) * 2004-01-07 2004-04-03 화인고무(주) 접착제를 사용하지 않는 사출 및 열융착을 가능하게하는인조피혁
CN115433167B (zh) * 2022-11-10 2023-03-24 中国药科大学 具有Snail抑制活性的苯并杂环类化合物、其制备方法、药物组合物和医药用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE332167C (de) 1918-08-09 1921-01-26 Chem Fab Vorm Goldenberg Glyzerinersatz
BE788805A (fr) 1971-09-22 1973-01-02 Lafon Victor Nouveaux derives antalgiques de la serie des arylamines soufrees
SE416649B (sv) 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
IL66340A (en) * 1981-08-13 1986-08-31 Haessle Ab Pharmaceutical compositions comprising pyridylmethyl-thiobenzimidazole derivatives,certain such novel derivatives and their preparation
US4472409A (en) 1981-11-05 1984-09-18 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects
DE3333314A1 (de) 1983-09-15 1985-03-28 Hoechst Ag, 6230 Frankfurt Substituierte pyrido(1,2-c)imidazo(1,2-a)benzimidazole, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
GB8417271D0 (en) * 1984-07-06 1984-08-08 Fisons Plc Biologically active nitrogen heterocycles
EP0174717B1 (en) 1984-07-06 1992-01-22 FISONS plc Benzimidazoles, and their production formulation and use as gastric acid secretion inhibitors
AU4640985A (en) 1984-08-31 1986-03-06 Nippon Chemiphar Co. Ltd. Benzimidazole derivatives
DE3509333A1 (de) 1985-03-15 1986-09-18 Hoechst Ag, 6230 Frankfurt Substituierte benzimidazolderivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer
AU5768886A (en) * 1985-05-24 1986-11-27 G.D. Searle & Co. 2-((1-h-benzimidazol-2-ylsulfinyl)methyl)benzenamines
WO1987001114A2 (en) * 1985-08-21 1987-02-26 Byk Gulden Lomberg Chemische Fabrik Gmbh New amines, process for their manufacture, their use and medicines containing them

Also Published As

Publication number Publication date
NO863389L (no) 1987-02-25
NZ217322A (en) 1990-02-26
PT83240B (pt) 1989-03-30
NO863389D0 (no) 1986-08-22
KR870002087A (ko) 1987-03-30
IL79813A0 (en) 1986-11-30
PT83240A (de) 1986-09-01
HU199126B (en) 1990-01-29
DK401586A (da) 1987-02-25
KR940005020B1 (ko) 1994-06-09
PH24073A (en) 1990-03-05
AU595231B2 (en) 1990-03-29
EP0213474B1 (de) 1993-02-03
GR862180B (en) 1986-12-23
FI89910C (sv) 1993-12-10
JPH0791276B2 (ja) 1995-10-04
FI863382A (fi) 1987-02-25
NO169169C (no) 1992-05-20
DE3687675D1 (de) 1993-03-18
IE59587B1 (en) 1994-03-09
ES2001389A6 (es) 1988-05-16
DK401586D0 (da) 1986-08-22
NO169169B (no) 1992-02-10
AR243167A1 (es) 1993-07-30
ATE85328T1 (de) 1993-02-15
JPS6251671A (ja) 1987-03-06
EP0213474A3 (en) 1987-05-20
AU6174586A (en) 1987-02-26
HUT44242A (en) 1988-02-29
FI863382A0 (fi) 1986-08-21
EP0213474A2 (de) 1987-03-11

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Owner name: HOECHST AKTIENGESELLSCHAFT