PH24073A - Substituted 2-(2-aminobenzylthio)benzimidazole derivatives the corresponding sulfoxides and sulfones,a process for their preparation,pharmaceutical composition containing them and their use as inhibitors of gastric acid secretion - Google Patents

Substituted 2-(2-aminobenzylthio)benzimidazole derivatives the corresponding sulfoxides and sulfones,a process for their preparation,pharmaceutical composition containing them and their use as inhibitors of gastric acid secretion

Info

Publication number
PH24073A
PH24073A PH34172A PH34172A PH24073A PH 24073 A PH24073 A PH 24073A PH 34172 A PH34172 A PH 34172A PH 34172 A PH34172 A PH 34172A PH 24073 A PH24073 A PH 24073A
Authority
PH
Philippines
Prior art keywords
aminobenzylthio
sulfones
inhibitors
substituted
preparation
Prior art date
Application number
PH34172A
Inventor
Hans-Jochen Lang
Gerhard Rackur
Manfred Rosner
Andreas Herling
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19853530342 external-priority patent/DE3530342A1/en
Priority claimed from DE19863610609 external-priority patent/DE3610609A1/en
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of PH24073A publication Critical patent/PH24073A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
PH34172A 1985-08-24 1986-08-22 Substituted 2-(2-aminobenzylthio)benzimidazole derivatives the corresponding sulfoxides and sulfones,a process for their preparation,pharmaceutical composition containing them and their use as inhibitors of gastric acid secretion PH24073A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19853530342 DE3530342A1 (en) 1985-08-24 1985-08-24 Substituted toluidines, processes for their preparation, pharmaceutical preparations containing them and their use as gastric acid secretion inhibitors
DE19863610609 DE3610609A1 (en) 1986-03-29 1986-03-29 Substituted toluidines, processes for their preparation, pharmaceutical preparations containing them and their use as gastric secretion inhibitors

Publications (1)

Publication Number Publication Date
PH24073A true PH24073A (en) 1990-03-05

Family

ID=25835350

Family Applications (1)

Application Number Title Priority Date Filing Date
PH34172A PH24073A (en) 1985-08-24 1986-08-22 Substituted 2-(2-aminobenzylthio)benzimidazole derivatives the corresponding sulfoxides and sulfones,a process for their preparation,pharmaceutical composition containing them and their use as inhibitors of gastric acid secretion

Country Status (17)

Country Link
EP (1) EP0213474B1 (en)
JP (1) JPH0791276B2 (en)
KR (1) KR940005020B1 (en)
AR (1) AR243167A1 (en)
AT (1) ATE85328T1 (en)
DE (1) DE3687675D1 (en)
DK (1) DK401586A (en)
ES (1) ES2001389A6 (en)
FI (1) FI89910C (en)
GR (1) GR862180B (en)
HU (1) HU199126B (en)
IE (1) IE59587B1 (en)
IL (1) IL79813A0 (en)
NO (1) NO169169C (en)
NZ (1) NZ217322A (en)
PH (1) PH24073A (en)
PT (1) PT83240B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0239129B1 (en) 1986-03-28 1991-09-25 Otsuka Pharmaceutical Co., Ltd. Hydroquinoline compounds, compositions containing same and processes for preparing same
EP0251536A1 (en) * 1986-06-24 1988-01-07 FISONS plc Benzimidazoles, their production, formulation and use as gastric acid secretion inhibitors
IT1222412B (en) * 1987-07-31 1990-09-05 Chiesi Farma Spa THYOMETHYL AND SULFINYL METHYL DERIVED WITH ANTI-SECRET ACID GASTRIC ACTION, THEIR PREPARATION PROCEDURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
EP0318085A3 (en) * 1987-11-25 1990-03-14 Merck Frosst Canada Inc. Heterazole dialkanoic acids
CA1322005C (en) * 1987-11-25 1993-09-07 Robert N. Young Benzoheterazoles
JP2564162B2 (en) * 1988-02-12 1996-12-18 日本ケミファ株式会社 Quaternary salts of benzimidazole derivatives
ES2047451B1 (en) * 1992-07-10 1994-10-01 Sint Quimica Sa PROCEDURE FOR THE PREPARATION OF A STABLE ORAL PHARMACEUTICAL COMPOSITION.
KR20040028815A (en) * 2004-01-07 2004-04-03 화인고무(주) Synthetic Leather that injection and heat adhension is available without using cement
CN115433167B (en) * 2022-11-10 2023-03-24 中国药科大学 Benzo-heterocyclic compound with Snail inhibitory activity, preparation method thereof, pharmaceutical composition and medical application

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE332167C (en) 1918-08-09 1921-01-26 Chem Fab Vorm Goldenberg Glycerine substitute
BE788805A (en) 1971-09-22 1973-01-02 Lafon Victor NEW ANTALGIC DERIVATIVES FROM THE SULFUR ARYLAMINE SERIES
SE416649B (en) 1974-05-16 1981-01-26 Haessle Ab PROCEDURE FOR THE PREPARATION OF SUBSTANCES WHICH PREVENT Gastric acid secretion
SE7804231L (en) 1978-04-14 1979-10-15 Haessle Ab Gastric acid secretion
US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
ZA825106B (en) * 1981-08-13 1983-04-27 Haessle Ab Novel pharmaceutical compositions
US4472409A (en) 1981-11-05 1984-09-18 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects
DE3333314A1 (en) 1983-09-15 1985-03-28 Hoechst Ag, 6230 Frankfurt SUBSTITUTED PYRIDO (1,2-C) IMIDAZO (1,2-A) BENZIMIDAZOLES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AND PHARMACEUTICAL PREPARATIONS BASED ON THESE COMPOUNDS
GB8417271D0 (en) * 1984-07-06 1984-08-08 Fisons Plc Biologically active nitrogen heterocycles
DE3585252D1 (en) * 1984-07-06 1992-03-05 Fisons Plc BENZIMIDAZOLES, AND METHOD FOR THE PRODUCTION THEREOF, THE FORMULATION AND USE THEREOF AS ANCIENT ANTI-ACIDIC COMPETITION.
AU4640985A (en) * 1984-08-31 1986-03-06 Nippon Chemiphar Co. Ltd. Benzimidazole derivatives
DE3509333A1 (en) 1985-03-15 1986-09-18 Hoechst Ag, 6230 Frankfurt SUBSTITUTED BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND THEIR USE AS AN INGESTIC ACID INHIBITOR
AU5768886A (en) * 1985-05-24 1986-11-27 G.D. Searle & Co. 2-((1-h-benzimidazol-2-ylsulfinyl)methyl)benzenamines
WO1987001114A2 (en) * 1985-08-21 1987-02-26 Byk Gulden Lomberg Chemische Fabrik Gmbh New amines, process for their manufacture, their use and medicines containing them

Also Published As

Publication number Publication date
NO169169C (en) 1992-05-20
JPH0791276B2 (en) 1995-10-04
FI863382A (en) 1987-02-25
ES2001389A6 (en) 1988-05-16
DK401586A (en) 1987-02-25
NZ217322A (en) 1990-02-26
IL79813A0 (en) 1986-11-30
FI863382A0 (en) 1986-08-21
NO863389D0 (en) 1986-08-22
FI89910C (en) 1993-12-10
HUT44242A (en) 1988-02-29
HU199126B (en) 1990-01-29
EP0213474B1 (en) 1993-02-03
FI89910B (en) 1993-08-31
IE59587B1 (en) 1994-03-09
AU6174586A (en) 1987-02-26
PT83240B (en) 1989-03-30
PT83240A (en) 1986-09-01
AR243167A1 (en) 1993-07-30
NO169169B (en) 1992-02-10
DK401586D0 (en) 1986-08-22
AU595231B2 (en) 1990-03-29
KR870002087A (en) 1987-03-30
ATE85328T1 (en) 1993-02-15
NO863389L (en) 1987-02-25
GR862180B (en) 1986-12-23
EP0213474A3 (en) 1987-05-20
KR940005020B1 (en) 1994-06-09
EP0213474A2 (en) 1987-03-11
DE3687675D1 (en) 1993-03-18
JPS6251671A (en) 1987-03-06

Similar Documents

Publication Publication Date Title
AU590390B2 (en) Substituted thienoimidazole derivatives, a process for their preparation, pharmaceutical compositions containing them, and their use as inhibitors of gastric acid secretion
DE2960293D1 (en) Substituted pyridylsulfinylbenzimidazoles having gastric acid secretion properties, pharmaceutical preparations containing same, and intermediates for their preparation
PT82342A (en) Process for the preparation of hialuronic acid derivatives
AU5231186A (en) Amino-salicylic acid derivatives salts thereof process for their preparation and pharmaceutical compositions containing them
AU7829087A (en) Process for the preparation of benzoic acid derivatives
PT82121A (en) Process for the preparation of novel aromatic heterocyclic acid derivatives and of pharmaceutical compositions containing the same
ZA855030B (en) Benzimadzoles,benzoxales,benzothiazoles and their production,formulation and use as gastric acid secretion inhibitors
PH24073A (en) Substituted 2-(2-aminobenzylthio)benzimidazole derivatives the corresponding sulfoxides and sulfones,a process for their preparation,pharmaceutical composition containing them and their use as inhibitors of gastric acid secretion
PT83188A (en) Process for the preparation of benzimidazole derivatives and of pharmaceutical compositions containing the same
PT83565A (en) Process for the preparation of acid aryl-heterocyclic-alcoxi-acetic derivatives and of pharmaceutical compositions containing same
IL87122A0 (en) Substituted thienoinidazole derivatives,process for the preparation thereof,pharmaceutical compositions containing them,and the use thereof as inhibitors of gastric acid secretion,as gastroprotectives and as medicaments for intestinal inflammations
AU7465487A (en) Benzimidazole derivatives and their use as gastric acid secretion inhibitors
ZA878658B (en) Substituted thienoimidazole-toluidine derivatives,a process for their preparation,pharmaceutical compositions containing them,and their use as inhibitors of gastric acid secretion
DE3661070D1 (en) 2-(substituted sulfamyl) derivatives of 6-nitrobenzoic acid, process for their preparation and pharmaceutical compositions containing them
JPS57165373A (en) Guanidine derivative, manufacture and medicinal composition containing same for gastric acid secretion inhibition
AU578104B2 (en) Pharmaceutical composition of peroxydiphosphoric acid derivatives
IL87428A0 (en) Substituted thienoimidazole derivatives,processes for their preparation,pharmaceutical formulations containing them and their use as gastric acid secretion inhibitors
ZA861490B (en) New benzoic acid derivatives,pharmaceutical compositions containing these compounds and processes for the preparation of these compounds and compositions
AU595231C (en) Substituted toluidines, a process for their preparation pharmaceutical formulations containing them, and their use as inhibitors of gastric acid secretion
AU2065188A (en) Substituted thienoimidazole derivatives, processes for their preparation, pharmaceutical formulations containing them and their use as gastric acid secretion inhibitors
ZA866369B (en) Substituted toluidines,a process for their preparation,pharmaceutical formulations containing them,and their use as inhibitors of gastric acid secretion
ZA867827B (en) Benzimadazoles,benzoxazoles,benzothiazoles and their production,formulation and use as gastric acid secretion inhibitors
YU43408B (en) Process for preparation of 2-(4-isobuthylphenyl)-prophiohydroxamic acid
ZA871216B (en) Substituted thienoimidazole derivatives,a process for their preparation,pharmaceutical compositions containing them,and their use as inhibitors of gastric acid secretion
ZA888395B (en) Substituted thienoimidazole derivatives,processes for their preparation,pharmaceutical preparations containing them and their use as inhibitors of gastric acid secretion