FI87565B - Analogifoerfarande foer framstaellning av antibakteriellt aktiva 6-fluor-7-diazabicykloalkyl-1,4-dihydro-4-oxo-3-kinolinkarboxylsyraderivat - Google Patents

Analogifoerfarande foer framstaellning av antibakteriellt aktiva 6-fluor-7-diazabicykloalkyl-1,4-dihydro-4-oxo-3-kinolinkarboxylsyraderivat Download PDF

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Publication number
FI87565B
FI87565B FI863756A FI863756A FI87565B FI 87565 B FI87565 B FI 87565B FI 863756 A FI863756 A FI 863756A FI 863756 A FI863756 A FI 863756A FI 87565 B FI87565 B FI 87565B
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FI
Finland
Prior art keywords
compounds
dihydro
diazabicyclo
formula
oxo
Prior art date
Application number
FI863756A
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English (en)
Finnish (fi)
Other versions
FI863756A0 (fi
FI863756A (fi
FI87565C (sv
Inventor
Martin Raymond Jefson
Paul Robert Mcguirk
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Pfizer
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Publication of FI863756A0 publication Critical patent/FI863756A0/fi
Publication of FI863756A publication Critical patent/FI863756A/fi
Application granted granted Critical
Publication of FI87565B publication Critical patent/FI87565B/fi
Publication of FI87565C publication Critical patent/FI87565C/sv

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Materials For Photolithography (AREA)

Claims (2)

1. Analogiförfarande för framställning av antibak-teriellt aktiva 6-fluor-7-diazabicykloalkyl-l,4-dihydro-5 4-oxo-3-kinolinkarboxylsyraderivat med formeln I 0 Il (I)
10 R2^ \ m ^ k eller farmaceutiskt godtagbara syraadditionssalter därav, varvid
15 R^ är väte, en farmaceutiskt godtagbar katjon el ler (C^-Cg)-alkyl; och R2 är 8-metyl-3,8-diazabicyklo[3.2.l]oct-3-yl, (IS,4S)-2,5-diazabicyklo[2.2.1]hept-2-yl eller (1S,4S)- 5-metyl-2,5-diazabicyklo[2.2.1]hept-2-yl; k ä n n e -20 tecknat därav, att man omsätter en förening med formeln II 0 F c°2r1 :.0 25 |T f (ID k 30 väri R1 betecknar samraa som ovan och Hai är halogen, med en förening med formeln r2h 2 35 väri R betecknar samma som ovan, och eventuellt överför 15 87565 en erhällen förening med formeln I tili ett syraaddi-tionssalt.
2. Förfarande enligt patentkravet 1, k ä n n e -t e c k n a t därav, att man framställer 1-cyklopropyl-5 6-fluor-1,4-dihydro-7-(8-metyl-3,8-diazabicyklo[3.2.11- oct-3-yl)-4-oxo-3-kinolinkarboxylsyra.
FI863756A 1985-09-18 1986-09-17 Analogiförfarande för framställning av antibakteriellt aktiva 6-fluor- 7-diazabicykloalkyl-1,4-dihydro-4-oxo-3-kinolinkarboxylsyraderivat FI87565C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77747185A 1985-09-18 1985-09-18
US77747185 1985-09-18

Publications (4)

Publication Number Publication Date
FI863756A0 FI863756A0 (fi) 1986-09-17
FI863756A FI863756A (fi) 1987-03-19
FI87565B true FI87565B (fi) 1992-10-15
FI87565C FI87565C (sv) 1993-01-25

Family

ID=25110350

Family Applications (1)

Application Number Title Priority Date Filing Date
FI863756A FI87565C (sv) 1985-09-18 1986-09-17 Analogiförfarande för framställning av antibakteriellt aktiva 6-fluor- 7-diazabicykloalkyl-1,4-dihydro-4-oxo-3-kinolinkarboxylsyraderivat

Country Status (42)

Country Link
US (3) US4775668A (sv)
EP (1) EP0215650B1 (sv)
JP (1) JPH0798819B2 (sv)
KR (1) KR870000961B1 (sv)
CN (1) CN1014789B (sv)
AT (1) ATE72245T1 (sv)
AU (1) AU576302B2 (sv)
BG (2) BG49275A3 (sv)
CA (1) CA1340734C (sv)
CY (1) CY1774A (sv)
CZ (1) CZ277825B6 (sv)
DD (1) DD259190A5 (sv)
DE (2) DE19675019I2 (sv)
DK (1) DK171276B1 (sv)
EG (1) EG18184A (sv)
ES (1) ES2001428A6 (sv)
FI (1) FI87565C (sv)
GR (1) GR862363B (sv)
HK (1) HK132795A (sv)
HU (1) HU200462B (sv)
IE (1) IE58966B1 (sv)
IL (1) IL80033A (sv)
IN (1) IN166416B (sv)
LU (1) LU90356I2 (sv)
MA (1) MA20770A1 (sv)
MW (1) MW5886A1 (sv)
MX (1) MX173358B (sv)
MY (1) MY102518A (sv)
NO (1) NO170335C (sv)
NZ (1) NZ217614A (sv)
OA (1) OA08410A (sv)
PH (2) PH24048A (sv)
PL (1) PL149987B1 (sv)
PT (1) PT83388B (sv)
SG (1) SG28094G (sv)
SK (1) SK667886A3 (sv)
SU (1) SU1482531A3 (sv)
UA (1) UA6340A1 (sv)
YU (1) YU45024B (sv)
ZA (1) ZA867063B (sv)
ZM (1) ZM8586A1 (sv)
ZW (1) ZW19386A1 (sv)

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Also Published As

Publication number Publication date
EP0215650A2 (en) 1987-03-25
IL80033A0 (en) 1986-12-31
AU576302B2 (en) 1988-08-18
NZ217614A (en) 1989-11-28
HUT43070A (en) 1987-09-28
EG18184A (en) 1992-12-30
NO863718L (no) 1987-03-19
FI863756A0 (fi) 1986-09-17
YU161786A (en) 1987-10-31
NO170335C (no) 1992-10-07
FI863756A (fi) 1987-03-19
AU6276886A (en) 1987-03-19
IE862479L (en) 1987-03-18
FI87565C (sv) 1993-01-25
PT83388B (pt) 1989-05-12
PL261410A1 (en) 1987-11-16
PL149987B1 (en) 1990-04-30
CZ277825B6 (en) 1993-06-16
ZW19386A1 (en) 1986-12-10
DK445886D0 (da) 1986-09-17
SU1482531A3 (ru) 1989-05-23
MW5886A1 (en) 1987-12-09
SK278605B6 (en) 1997-11-05
CZ667886A3 (en) 1993-02-17
EP0215650A3 (en) 1987-12-02
BG61091B2 (bg) 1996-10-31
JPH0798819B2 (ja) 1995-10-25
NO170335B (no) 1992-06-29
SG28094G (en) 1994-10-28
DK171276B1 (da) 1996-08-19
NO863718D0 (no) 1986-09-17
MX173358B (es) 1994-02-23
MA20770A1 (fr) 1987-04-01
KR870003106A (ko) 1987-04-15
OA08410A (fr) 1988-06-30
LU90356I2 (fr) 1999-04-26
CN1014789B (zh) 1991-11-20
PT83388A (en) 1986-10-01
DE3683711D1 (de) 1992-03-12
IE58966B1 (en) 1993-12-01
MX3751A (es) 1993-09-01
US4775668A (en) 1988-10-04
JPS62103083A (ja) 1987-05-13
EP0215650B1 (en) 1992-01-29
HK132795A (en) 1995-09-01
DE19675019I2 (de) 2004-01-29
YU45024B (en) 1991-06-30
US5091383A (en) 1992-02-25
US4861779A (en) 1989-08-29
ATE72245T1 (de) 1992-02-15
ZA867063B (en) 1988-04-27
IN166416B (sv) 1990-05-05
ZM8586A1 (en) 1987-03-27
PH24048A (en) 1990-03-05
SK667886A3 (en) 1997-11-05
ES2001428A6 (es) 1988-05-16
MY102518A (en) 1992-07-31
DD259190A5 (de) 1988-08-17
KR870000961B1 (ko) 1987-05-14
CN86106385A (zh) 1987-06-03
IL80033A (en) 1992-05-25
GR862363B (en) 1987-01-19
DK445886A (da) 1987-05-27
HU200462B (en) 1990-06-28
BG49275A3 (en) 1991-09-16
PH25338A (en) 1991-04-30
UA6340A1 (uk) 1994-12-29
CY1774A (en) 1995-10-20
CA1340734C (en) 1999-09-14

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