FI87210C - Foerfarande foer framstaellning av terapeutiskt anvaendbara bensimidazolderivat - Google Patents
Foerfarande foer framstaellning av terapeutiskt anvaendbara bensimidazolderivat Download PDFInfo
- Publication number
- FI87210C FI87210C FI863661A FI863661A FI87210C FI 87210 C FI87210 C FI 87210C FI 863661 A FI863661 A FI 863661A FI 863661 A FI863661 A FI 863661A FI 87210 C FI87210 C FI 87210C
- Authority
- FI
- Finland
- Prior art keywords
- radical
- methyl
- compound
- formula
- prepared
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 10
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title claims 2
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 title claims 2
- -1 cyano, methylthio, methylsulfinyl Chemical group 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 6
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical compound [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- QSLPNSWXUQHVLP-UHFFFAOYSA-N $l^{1}-sulfanylmethane Chemical compound [S]C QSLPNSWXUQHVLP-UHFFFAOYSA-N 0.000 claims 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 229910052801 chlorine Chemical group 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- BCIIMDOZSUCSEN-UHFFFAOYSA-N piperidin-4-amine Chemical compound NC1CCNCC1 BCIIMDOZSUCSEN-UHFFFAOYSA-N 0.000 claims 1
- 125000006513 pyridinyl methyl group Chemical group 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8513453 | 1985-09-11 | ||
| FR8513453A FR2587029B1 (fr) | 1985-09-11 | 1985-09-11 | Derives de benzimidazole, leur preparation et leur application en therapeutique |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI863661A0 FI863661A0 (fi) | 1986-09-10 |
| FI863661L FI863661L (fi) | 1987-03-12 |
| FI87210B FI87210B (fi) | 1992-08-31 |
| FI87210C true FI87210C (fi) | 1992-12-10 |
Family
ID=9322797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI863661A FI87210C (fi) | 1985-09-11 | 1986-09-10 | Foerfarande foer framstaellning av terapeutiskt anvaendbara bensimidazolderivat |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US4820710A (en:Method) |
| EP (1) | EP0217700B1 (en:Method) |
| JP (1) | JPS6261979A (en:Method) |
| KR (1) | KR930001411B1 (en:Method) |
| AR (1) | AR243187A1 (en:Method) |
| AT (1) | ATE103603T1 (en:Method) |
| AU (1) | AU582894B2 (en:Method) |
| CA (1) | CA1272486A (en:Method) |
| CS (1) | CS357991A3 (en:Method) |
| DE (2) | DE3689748T2 (en:Method) |
| DK (1) | DK170594B1 (en:Method) |
| ES (1) | ES2001782A6 (en:Method) |
| FI (1) | FI87210C (en:Method) |
| FR (1) | FR2587029B1 (en:Method) |
| GR (1) | GR862318B (en:Method) |
| HU (1) | HU196597B (en:Method) |
| IE (1) | IE61607B1 (en:Method) |
| IL (1) | IL79992A (en:Method) |
| LU (1) | LU90085I2 (en:Method) |
| NL (1) | NL970029I2 (en:Method) |
| NO (2) | NO167026C (en:Method) |
| NZ (1) | NZ217537A (en:Method) |
| PT (1) | PT83355B (en:Method) |
| ZA (1) | ZA866901B (en:Method) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2618435B1 (fr) * | 1987-07-23 | 1989-10-27 | Synthelabo | Derives de benzimidazole, leur preparation et leur application en therapeutique |
| FR2637595B1 (fr) * | 1988-10-11 | 1990-11-30 | Synthelabo | Derives de benzimidazole, leur preparation et leur application en therapeutique |
| JPH02294758A (ja) * | 1989-05-09 | 1990-12-05 | Nec Corp | 計算機使用時間管理方式 |
| FR2658823B1 (fr) * | 1990-02-27 | 1992-04-30 | Adir | Nouveaux derives d'aminomethylpiperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent . |
| FR2666582B1 (fr) * | 1990-09-07 | 1994-09-02 | Synthelabo | Derives de benzimidazole, leur preparation et leur application en therapeutique. |
| FR2693194B1 (fr) * | 1992-07-03 | 1994-09-23 | Synthelabo | Dérivés d'alcanecarboxamide, leur préparation et leur application thérapeutique. |
| FR2745500B1 (fr) * | 1996-03-04 | 1998-04-03 | Synthelabo | Formulations pharmaceutiques a liberation prolongee contenant de la mizolastine |
| JPH10101564A (ja) * | 1996-09-27 | 1998-04-21 | Mitsubishi Chem Corp | 鼻炎予防及び／又は治療剤 |
| US6369235B1 (en) | 1997-02-25 | 2002-04-09 | The United States Of America As Represented By The Department Of Health And Human Services | Substituted benzimidazoles, and methods of use thereof, for the inhibition of HIV reverse transcription and for the treatment of HIV infection |
| FR2762214B1 (fr) * | 1997-04-17 | 2000-10-06 | Synthelabo | Utilisation de la mizolastine pour la preparation d'un medicament destine au traitement de l'inflammation |
| EP0958820A1 (en) * | 1998-05-19 | 1999-11-24 | Sanofi-Synthelabo | Use of an imidazol derivative for the manufacture of a medicament for treating auto-immunodiseases |
| ES2208098B1 (es) * | 2002-10-02 | 2005-10-16 | Ragactives, S.L. | Procedimiento e intermedios para la obtencion de derivados de 1-(1h-bencimidazol-2-il)-4-(2-aminopirimidin) piperidina. |
| BRPI0414918A (pt) * | 2003-09-30 | 2006-11-07 | Janssen Pharmaceutica Nv | compostos de benzoimidazola |
| ES2245227B1 (es) * | 2004-04-06 | 2007-03-01 | Ragactives, S.L. | Formas cristalinas de mizolastina, procedimientos para su obtencion y composiciones farmaceuticas que las contienen. |
| NZ597108A (en) * | 2009-06-25 | 2014-04-30 | Alkermes Pharma Ireland Ltd | Prodrugs of nh-acidic compounds |
| RS56352B2 (sr) | 2009-06-25 | 2023-02-28 | Alkermes Pharma Ireland Ltd | Heterociklična jedinjenja za lečenje neuroloških i psiholoških poremećaja |
| CN102140076A (zh) * | 2010-02-03 | 2011-08-03 | 辽宁本源制药有限公司 | 咪唑斯汀中间体的制备 |
| NZ722096A (en) | 2011-12-15 | 2016-11-25 | Alkermes Pharma Ireland Ltd | Prodrugs of secondary amine compounds |
| WO2019173230A1 (en) | 2018-03-05 | 2019-09-12 | Alkermes Pharma Ireland Limited | Aripiprazole dosing strategy |
| JP7227398B2 (ja) * | 2019-04-11 | 2023-02-21 | 帝人ファーマ株式会社 | ベンズイミダゾール誘導体及びその使用 |
| WO2023107705A1 (en) | 2021-12-10 | 2023-06-15 | Incyte Corporation | Bicyclic amines as cdk12 inhibitors |
| CN116655596A (zh) * | 2022-02-17 | 2023-08-29 | 济南同路医药科技发展有限公司 | 一种大粒径咪唑斯汀原料药制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4281005A (en) * | 1979-03-05 | 1981-07-28 | Merck & Co., Inc. | Novel 2-pyridylimidazole compounds |
| US4556660A (en) * | 1982-07-12 | 1985-12-03 | Janssen Pharmaceutica N.V. | N-(Bicyclic heterocyclyl)-4-piperidinamines |
| EP0144101B1 (en) * | 1983-11-30 | 1991-02-06 | Janssen Pharmaceutica N.V. | Bicyclic heterocyclyl containing n-(bicyclic heterocyclyl)-4-piperidinamines |
| US4588722A (en) * | 1984-01-09 | 1986-05-13 | Janssen Pharmaceutica N.V. | N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives |
| PH23995A (en) * | 1984-01-09 | 1990-02-09 | Janssen Pharmaceutica Nv | 4((bicycle heterocyclyl)-methyl and hetero)piperidines |
-
1985
- 1985-09-11 FR FR8513453A patent/FR2587029B1/fr not_active Expired
-
1986
- 1986-09-02 DE DE3689748T patent/DE3689748T2/de not_active Expired - Lifetime
- 1986-09-02 AT AT86401928T patent/ATE103603T1/de active
- 1986-09-02 DE DE1997175081 patent/DE19775081I2/de active Active
- 1986-09-02 EP EP86401928A patent/EP0217700B1/fr not_active Expired - Lifetime
- 1986-09-09 IL IL79992A patent/IL79992A/xx not_active IP Right Cessation
- 1986-09-10 FI FI863661A patent/FI87210C/fi not_active IP Right Cessation
- 1986-09-10 GR GR862318A patent/GR862318B/el unknown
- 1986-09-10 KR KR1019860007594A patent/KR930001411B1/ko not_active Expired - Lifetime
- 1986-09-10 DK DK431586A patent/DK170594B1/da not_active IP Right Cessation
- 1986-09-10 IE IE241686A patent/IE61607B1/en not_active IP Right Cessation
- 1986-09-10 ZA ZA866901A patent/ZA866901B/xx unknown
- 1986-09-10 HU HU863907A patent/HU196597B/hu unknown
- 1986-09-10 NZ NZ217537A patent/NZ217537A/xx unknown
- 1986-09-10 NO NO863608A patent/NO167026C/no not_active IP Right Cessation
- 1986-09-10 ES ES8601773A patent/ES2001782A6/es not_active Expired
- 1986-09-10 CA CA000517916A patent/CA1272486A/en not_active Expired - Lifetime
- 1986-09-10 JP JP61214978A patent/JPS6261979A/ja active Granted
- 1986-09-10 PT PT83355A patent/PT83355B/pt unknown
- 1986-09-10 AR AR86305197A patent/AR243187A1/es active
- 1986-09-10 US US06/906,279 patent/US4820710A/en not_active Expired - Lifetime
- 1986-09-10 AU AU62552/86A patent/AU582894B2/en not_active Expired
-
1988
- 1988-12-12 US US07/283,468 patent/US4912219A/en not_active Expired - Lifetime
-
1991
- 1991-11-25 CS CS913579A patent/CS357991A3/cs unknown
-
1997
- 1997-07-25 NL NL970029C patent/NL970029I2/nl unknown
- 1997-07-30 LU LU90085C patent/LU90085I2/fr unknown
-
2001
- 2001-10-15 NO NO2001017C patent/NO2001017I1/no unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ND | Supplementary protection certificate (spc) granted | ||
| SPCG | Supplementary protection certificate granted |
Spc suppl protection certif: L93 Extension date: 20101121 |
|
| FG | Patent granted |
Owner name: SANOFI-SYNTHELABO |
|
| PC | Transfer of assignment of patent |
Owner name: SANOFI-AVENTIS |
|
| MA | Patent expired |