FI81357B - Foerfarande foer framstaellning av griseolinsyraderivat. - Google Patents

Foerfarande foer framstaellning av griseolinsyraderivat. Download PDF

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Publication number
FI81357B
FI81357B FI844225A FI844225A FI81357B FI 81357 B FI81357 B FI 81357B FI 844225 A FI844225 A FI 844225A FI 844225 A FI844225 A FI 844225A FI 81357 B FI81357 B FI 81357B
Authority
FI
Finland
Prior art keywords
acid
singlet
compound
group
doublet
Prior art date
Application number
FI844225A
Other languages
English (en)
Finnish (fi)
Other versions
FI844225A0 (fi
FI844225L (fi
FI81357C (sv
Inventor
Masakatsu Kaneko
Yoshinobu Murofushi
Misako Kimura
Mitsuo Yamazaki
Nobuyoshi Iwata
Fumio Nakagawa
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of FI844225A0 publication Critical patent/FI844225A0/fi
Publication of FI844225L publication Critical patent/FI844225L/fi
Publication of FI81357B publication Critical patent/FI81357B/fi
Application granted granted Critical
Publication of FI81357C publication Critical patent/FI81357C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Insulating Materials (AREA)
  • Fats And Perfumes (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)

Claims (2)

1. Förfarande för framställning av derivat av griseolinsyra som kan användas som läkemedel raed formeln (I): 5 H . o HOOC ^===^ 'N ill HOOC-/ s \ ® OR12 OR12 15 där: 12 R är väte eller en acylgrupp A avser en grupp med följande formel: 20 R5 fr s 30 där: 5 9 10 11 R är väte eller en grupp med formeln -OR , -NR R eller SR , där R^ är väte eller en C^-C^-alkylgrupp och R^ och R^ är väte, C.-C -alkyl, C.-C -hydroxialkyl, C -C,-aminoalkyl, fenyl, naftyl, l o ib 1 ° io 11 35 bensyl, amino eller C -C,-alkoxi eller R och R kan tillsammans 1 o med kväveatomen tili vilken de är anslutna vara en piperidino- eller en morfolinogrupp; II 41 81357 1 och farmaceutiskt acceptabla salter och estrar av dessa, utom sjMlva 7'(R)~ griseolinsyra och dess salter, kännetecknat därav, att 5 a) man bringar en förening med formeln (XXIII) άι> r13ooc r13ooc—<; 0 ^ or12 15 där: Qftl2 Z är en halogenatom; (ΧΧΠΙΙ är en acylgrupp 13 R Mr en karboxiskyddande grupp; 20. kontakt med ett nukleofilt ämne, valbart i nMrvaro av ett syrabindande Mmne, för att fä en förening med formeln (XXIV) d’hoc-^? OR12
30 V2 com! dMr: R^,R^ och Mr definierade som ovan, och 35 42 81 357 12 1 b) valbart avlägsnar den karboxiskyddande gruppen R genom hydrolyse-ring vid basiska förhallanden for att fa en fbrening med formeln (XXV) oJ {m H00SC>--r
10 HOOC—OH OH
1 Patentkrav
2. Förfarande enligt patentkrav 1, kännetecknad dMrav, att nMmnda reaktioner och reagenser som används i dessa Mr salunda valda J5 och utförs i sadan ordning att man far en forening enligt formeln (I) som Mr N -metylgriseolinsyra. 20 25 30 35
FI844225A 1983-10-28 1984-10-26 Förfarande för framställning av griseolinsyraderivat FI81357C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP20236283 1983-10-28
JP58202362A JPS6094992A (ja) 1983-10-28 1983-10-28 グリゼオ−ル酸誘導体

Publications (4)

Publication Number Publication Date
FI844225A0 FI844225A0 (fi) 1984-10-26
FI844225L FI844225L (fi) 1985-04-29
FI81357B true FI81357B (fi) 1990-06-29
FI81357C FI81357C (sv) 1990-10-10

Family

ID=16456245

Family Applications (1)

Application Number Title Priority Date Filing Date
FI844225A FI81357C (sv) 1983-10-28 1984-10-26 Förfarande för framställning av griseolinsyraderivat

Country Status (12)

Country Link
US (1) US4634706A (sv)
EP (1) EP0143557B1 (sv)
JP (1) JPS6094992A (sv)
KR (1) KR930000165B1 (sv)
AT (1) ATE39357T1 (sv)
CA (1) CA1267408A (sv)
DE (1) DE3475714D1 (sv)
DK (1) DK166323C (sv)
ES (4) ES537154A0 (sv)
FI (1) FI81357C (sv)
NO (1) NO164904C (sv)
SU (4) SU1600632A3 (sv)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4783532A (en) * 1983-10-28 1988-11-08 Sankyo Company Limited Process for preparing griseolic acid derivatives
IT1196261B (it) * 1984-09-20 1988-11-16 Pierrel Spa Derivati nucleosidici e purinici 8-sostituiti
DK167878B1 (da) * 1985-04-19 1993-12-27 Sankyo Co Griseolsyrederivater
EP0319050B1 (en) 1985-04-19 1995-04-12 Sankyo Company Limited Griseolic acid derivatives, their preparation and their use
JPH0631307B2 (ja) * 1985-04-27 1994-04-27 三共株式会社 グリゼオ−ル酸誘導体の製法
US5214048A (en) * 1987-05-19 1993-05-25 Nippon Kayaku Kabushiki Kaisha Oxetanocins
JPH0774229B2 (ja) * 1987-12-02 1995-08-09 三共株式会社 グリゼオール酸モノエステル誘導体
US5091431A (en) * 1988-02-08 1992-02-25 Schering Corporation Phosphodiesterase inhibitors
JPH0689020B2 (ja) * 1988-06-30 1994-11-09 三共株式会社 グリゼオール酸のモノエステル誘導体
US4971972A (en) * 1989-03-23 1990-11-20 Schering Corporation Phosphodiesterase inhibitors having an optionally substituted purine derivative portion and a benzo- or cyclopenta-furan portion
JP3645580B2 (ja) * 1993-10-22 2005-05-11 株式会社フジモト・ブラザーズ グルコースエステル誘導体を含有する脳代謝改善剤
US6291516B1 (en) 1999-01-13 2001-09-18 Curis, Inc. Regulators of the hedgehog pathway, compositions and uses related thereto
EP1312363A1 (en) * 2001-09-28 2003-05-21 Pfizer Products Inc. Methods of treatment and kits comprising a growth hormone secretagogue
US7342884B2 (en) * 2002-03-13 2008-03-11 Harmonic, Inc. Method and apparatus for one directional communications in bidirectional communications channel
WO2011081915A2 (en) * 2009-12-15 2011-07-07 Cebix Inc. Methods for treating erectile dysfunction in patients with insulin-dependent diabetes
US20230294012A1 (en) * 2021-02-19 2023-09-21 Anhui Jinhe Industrial Co., Ltd. Production apparatus and production method of sucrose-6-ester

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3862189A (en) * 1973-08-14 1975-01-21 Warner Lambert Co Aralkyl-substituted purines and pyrimidines as antianginal bronchodilator agents
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4138562A (en) * 1977-02-09 1979-02-06 The Regents Of The University Of Minnesota Adenosine deaminase resistant antiviral purine nucleosides and method of preparation
JPS5668695A (en) * 1979-11-10 1981-06-09 Sankyo Co Ltd Enzyme inhibitor griseolic acid and its preparation
DE3028273A1 (de) * 1980-07-25 1982-02-25 Fa. Dr. Willmar Schwabe, 7500 Karlsruhe Durch purinbasen substituierte 1.4;3.6-dianhydro-hexit-nitrate
JPS60246396A (ja) * 1984-05-22 1985-12-06 Sankyo Co Ltd 酵素阻害物質ジヒドロデスオキシグリゼオ−ル酸及びその塩類

Also Published As

Publication number Publication date
ES547292A0 (es) 1986-02-16
NO844291L (no) 1985-04-29
ES547291A0 (es) 1986-11-16
EP0143557A3 (en) 1985-07-03
ES8604737A1 (es) 1985-12-01
NO164904B (no) 1990-08-20
DK513384D0 (da) 1984-10-26
FI844225A0 (fi) 1984-10-26
DK513384A (da) 1985-04-29
FI844225L (fi) 1985-04-29
SU1468421A3 (ru) 1989-03-23
SU1468422A3 (ru) 1989-03-23
SU1600632A3 (ru) 1990-10-15
FI81357C (sv) 1990-10-10
KR930000165B1 (ko) 1993-01-11
NO164904C (no) 1990-11-28
US4634706A (en) 1987-01-06
DE3475714D1 (en) 1989-01-26
JPS6094992A (ja) 1985-05-28
DK166323C (da) 1993-08-30
SU1604158A3 (ru) 1990-10-30
CA1267408A (en) 1990-04-03
KR850003415A (ko) 1985-06-17
ATE39357T1 (de) 1989-01-15
ES8700673A1 (es) 1986-10-16
ES8701193A1 (es) 1986-11-16
ES537154A0 (es) 1985-12-01
EP0143557A2 (en) 1985-06-05
DK166323B (da) 1993-04-05
ES8604981A1 (es) 1986-02-16
ES547347A0 (es) 1986-10-16
JPH0432837B2 (sv) 1992-06-01
EP0143557B1 (en) 1988-12-21

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Owner name: SANKYO COMPANY LIMITED