ES8604981A1 - Un procedimiento para preparar derivados de acido griseolico - Google Patents

Un procedimiento para preparar derivados de acido griseolico

Info

Publication number
ES8604981A1
ES8604981A1 ES547292A ES547292A ES8604981A1 ES 8604981 A1 ES8604981 A1 ES 8604981A1 ES 547292 A ES547292 A ES 547292A ES 547292 A ES547292 A ES 547292A ES 8604981 A1 ES8604981 A1 ES 8604981A1
Authority
ES
Spain
Prior art keywords
alkyl
alkoxy
opt
halogen
substd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES547292A
Other languages
English (en)
Other versions
ES547292A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of ES8604981A1 publication Critical patent/ES8604981A1/es
Publication of ES547292A0 publication Critical patent/ES547292A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Insulating Materials (AREA)
  • Fats And Perfumes (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE ACIDO GRISEOLICO. CONSISTE EN HIDROLIZAR UN COMPUESTO DE FORMULA (II) PARA OBTENER DERIVADOS DE ACIDO GRISEOLICO DE FORMULA (I) DONDE R5 ES H O HALOGENO, UN GRUPO AZIDO O UN GRUPO DE FORMULA -OR9, -NR10R11 O -SR9, DONDE R9 ES H, UN GRUPO ALQUILO CON C 1 A 6, UN GRUPO HETEROCICLICO, UN GRUPO TRI(ALQUIL C 1 A 4)SILILO Y OTROS; R10 Y R11 SON IGUALES O DIFERENTES Y CADA UNO REPRESENTA H, HIDROXI, UN GRUPO ALQUILO DE C 1 A 6, UN GRUPO HIDROXIALQUILO DE C 1 A 6 Y OTROS. LA HIDROLISIS SE EFECTUA BAJO CONDICIONES BASICAS, EN UN SISTEMA ACUOSO, A TEMPERATURA AMBIENTE Y DURANTE 1 A 5 HORAS. SE UTILIZAN POR SU CAPACIDAD DE INHIBIR LA ACTIVIDAD DE LA FOSFODIESTEARASA (PDE) DE ADENOSIN MONOFOSFATO CICLICO (CAMP).
ES547292A 1983-10-28 1985-09-25 Un procedimiento para preparar derivados de acido griseolico Expired ES8604981A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58202362A JPS6094992A (ja) 1983-10-28 1983-10-28 グリゼオ−ル酸誘導体

Publications (2)

Publication Number Publication Date
ES8604981A1 true ES8604981A1 (es) 1986-02-16
ES547292A0 ES547292A0 (es) 1986-02-16

Family

ID=16456245

Family Applications (4)

Application Number Title Priority Date Filing Date
ES537154A Expired ES8604737A1 (es) 1983-10-28 1984-10-26 Un procedimiento para preparar derivados de acido griseolico
ES547292A Expired ES8604981A1 (es) 1983-10-28 1985-09-25 Un procedimiento para preparar derivados de acido griseolico
ES547291A Expired ES8701193A1 (es) 1983-10-28 1985-09-25 Un procedimiento para preparar derivados de acido griseolico
ES547347A Expired ES8700673A1 (es) 1983-10-28 1985-09-26 Un procedimiento para preparar derivados de acido griseolico

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES537154A Expired ES8604737A1 (es) 1983-10-28 1984-10-26 Un procedimiento para preparar derivados de acido griseolico

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES547291A Expired ES8701193A1 (es) 1983-10-28 1985-09-25 Un procedimiento para preparar derivados de acido griseolico
ES547347A Expired ES8700673A1 (es) 1983-10-28 1985-09-26 Un procedimiento para preparar derivados de acido griseolico

Country Status (12)

Country Link
US (1) US4634706A (es)
EP (1) EP0143557B1 (es)
JP (1) JPS6094992A (es)
KR (1) KR930000165B1 (es)
AT (1) ATE39357T1 (es)
CA (1) CA1267408A (es)
DE (1) DE3475714D1 (es)
DK (1) DK166323C (es)
ES (4) ES8604737A1 (es)
FI (1) FI81357C (es)
NO (1) NO164904C (es)
SU (4) SU1600632A3 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4783532A (en) * 1983-10-28 1988-11-08 Sankyo Company Limited Process for preparing griseolic acid derivatives
IT1196261B (it) * 1984-09-20 1988-11-16 Pierrel Spa Derivati nucleosidici e purinici 8-sostituiti
FI94133C (fi) * 1985-04-19 1995-07-25 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten griseoliinihapon johdannaisten valmistamiseksi
ATE48611T1 (de) * 1985-04-19 1989-12-15 Sankyo Co Griseolinsaeurederivate, ihre herstellung und ihre verwendung.
JPH0631307B2 (ja) * 1985-04-27 1994-04-27 三共株式会社 グリゼオ−ル酸誘導体の製法
US5214048A (en) * 1987-05-19 1993-05-25 Nippon Kayaku Kabushiki Kaisha Oxetanocins
JPH0774229B2 (ja) * 1987-12-02 1995-08-09 三共株式会社 グリゼオール酸モノエステル誘導体
US5091431A (en) * 1988-02-08 1992-02-25 Schering Corporation Phosphodiesterase inhibitors
JPH0689020B2 (ja) * 1988-06-30 1994-11-09 三共株式会社 グリゼオール酸のモノエステル誘導体
US4971972A (en) * 1989-03-23 1990-11-20 Schering Corporation Phosphodiesterase inhibitors having an optionally substituted purine derivative portion and a benzo- or cyclopenta-furan portion
JP3645580B2 (ja) * 1993-10-22 2005-05-11 株式会社フジモト・ブラザーズ グルコースエステル誘導体を含有する脳代謝改善剤
US6291516B1 (en) * 1999-01-13 2001-09-18 Curis, Inc. Regulators of the hedgehog pathway, compositions and uses related thereto
EP1312363A1 (en) * 2001-09-28 2003-05-21 Pfizer Products Inc. Methods of treatment and kits comprising a growth hormone secretagogue
US7342884B2 (en) * 2002-03-13 2008-03-11 Harmonic, Inc. Method and apparatus for one directional communications in bidirectional communications channel
US20110190192A1 (en) * 2009-12-15 2011-08-04 Cebix Inc. Methods for treating erectile dysfunction in patients with insulin-dependent diabetes
US20230294012A1 (en) * 2021-02-19 2023-09-21 Anhui Jinhe Industrial Co., Ltd. Production apparatus and production method of sucrose-6-ester

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3862189A (en) * 1973-08-14 1975-01-21 Warner Lambert Co Aralkyl-substituted purines and pyrimidines as antianginal bronchodilator agents
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4138562A (en) * 1977-02-09 1979-02-06 The Regents Of The University Of Minnesota Adenosine deaminase resistant antiviral purine nucleosides and method of preparation
JPS5668695A (en) * 1979-11-10 1981-06-09 Sankyo Co Ltd Enzyme inhibitor griseolic acid and its preparation
DE3028273A1 (de) * 1980-07-25 1982-02-25 Fa. Dr. Willmar Schwabe, 7500 Karlsruhe Durch purinbasen substituierte 1.4;3.6-dianhydro-hexit-nitrate
JPS60246396A (ja) * 1984-05-22 1985-12-06 Sankyo Co Ltd 酵素阻害物質ジヒドロデスオキシグリゼオ−ル酸及びその塩類

Also Published As

Publication number Publication date
FI81357C (fi) 1990-10-10
ES537154A0 (es) 1985-12-01
ES547292A0 (es) 1986-02-16
SU1604158A3 (ru) 1990-10-30
CA1267408A (en) 1990-04-03
ATE39357T1 (de) 1989-01-15
SU1468422A3 (ru) 1989-03-23
NO164904B (no) 1990-08-20
KR850003415A (ko) 1985-06-17
FI844225A0 (fi) 1984-10-26
DK166323C (da) 1993-08-30
ES8604737A1 (es) 1985-12-01
EP0143557A2 (en) 1985-06-05
NO844291L (no) 1985-04-29
DK166323B (da) 1993-04-05
ES8701193A1 (es) 1986-11-16
ES547347A0 (es) 1986-10-16
NO164904C (no) 1990-11-28
DE3475714D1 (en) 1989-01-26
DK513384A (da) 1985-04-29
ES547291A0 (es) 1986-11-16
SU1468421A3 (ru) 1989-03-23
KR930000165B1 (ko) 1993-01-11
ES8700673A1 (es) 1986-10-16
US4634706A (en) 1987-01-06
DK513384D0 (da) 1984-10-26
JPH0432837B2 (es) 1992-06-01
EP0143557A3 (en) 1985-07-03
JPS6094992A (ja) 1985-05-28
FI81357B (fi) 1990-06-29
EP0143557B1 (en) 1988-12-21
SU1600632A3 (ru) 1990-10-15
FI844225L (fi) 1985-04-29

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