FI752434A - - Google Patents

Info

Publication number
FI752434A
FI752434A FI752434A FI752434A FI752434A FI 752434 A FI752434 A FI 752434A FI 752434 A FI752434 A FI 752434A FI 752434 A FI752434 A FI 752434A FI 752434 A FI752434 A FI 752434A
Authority
FI
Finland
Application number
FI752434A
Other languages
Finnish (fi)
Other versions
FI62841B (fi
FI62841C (fi
Inventor
William J Gottstein
Murray A Kaplan
Alphonse P Granatek
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of FI752434A publication Critical patent/FI752434A/fi
Priority to FI802984A priority Critical patent/FI63565C/fi
Priority to FI811452A priority patent/FI63943C/fi
Publication of FI62841B publication Critical patent/FI62841B/fi
Application granted granted Critical
Publication of FI62841C publication Critical patent/FI62841C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C265/00—Derivatives of isocyanic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI752434A 1974-09-03 1975-08-29 Foerfarande foer framstaellning av terapeutiskt anvaendbara 7-o-aminometyl- eller metylaminometylfenyl- eller cyklohexa dinyl- eller tienylacetamido)-3-(1-karboximetyl- (eller -et yl eller -propyl-)-tetrazol-5-yltiometyl)-3-cefem-4-karboxy lsror samt deras farmaceutiskt godtagbara salter FI62841C (fi)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FI802984A FI63565C (fi) 1974-09-03 1980-09-22 Saosom mellanprodukt vid framstaellning av 7-acylamido-3-(1-karboxi-laegre-alkyl-tetrazol-5-yltiometyl)-3-cefem-4-karbonsyror och deras salter och laett hydrolyserbara estrar anvaendbara foereningar
FI811452A FI63943C (fi) 1974-09-03 1981-05-12 Vid framstaellning av 7-acylamido-3-(1-karboxi-laegre-alkyl-tetrazol-5-yltiometyl)-3-cefem-4-karboxylsyror och deras salter saosom mellanprodukter anvaendbara foereningar

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US50299174A 1974-09-03 1974-09-03
US50299174 1974-09-03
US59097175 1975-06-27
US05/590,971 US4297489A (en) 1974-09-03 1975-06-27 7-α-Amino-substituted acylamino-3-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acids

Publications (3)

Publication Number Publication Date
FI752434A true FI752434A (da) 1976-03-04
FI62841B FI62841B (fi) 1982-11-30
FI62841C FI62841C (fi) 1983-03-10

Family

ID=27054342

Family Applications (1)

Application Number Title Priority Date Filing Date
FI752434A FI62841C (fi) 1974-09-03 1975-08-29 Foerfarande foer framstaellning av terapeutiskt anvaendbara 7-o-aminometyl- eller metylaminometylfenyl- eller cyklohexa dinyl- eller tienylacetamido)-3-(1-karboximetyl- (eller -et yl eller -propyl-)-tetrazol-5-yltiometyl)-3-cefem-4-karboxy lsror samt deras farmaceutiskt godtagbara salter

Country Status (21)

Country Link
US (1) US4297489A (da)
JP (1) JPS6150956B2 (da)
AR (1) AR222771A1 (da)
BG (1) BG27091A3 (da)
CA (4) CA1135255A (da)
CH (1) CH636882A5 (da)
DD (2) DD123471A5 (da)
DE (2) DE2560655C2 (da)
DK (4) DK145262C (da)
ES (2) ES440707A1 (da)
FI (1) FI62841C (da)
FR (1) FR2283686A1 (da)
HU (1) HU169490B (da)
IE (1) IE43123B1 (da)
IL (1) IL48020A (da)
LU (1) LU73306A1 (da)
NL (1) NL161758C (da)
NO (1) NO152509C (da)
OA (1) OA05096A (da)
SE (3) SE431548B (da)
YU (5) YU213275A (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4286089A (en) * 1974-12-27 1981-08-25 Smithkline Corporation 7-Acyl-3-(substituted tetrazolyl thiomethyl)cephalosporins
US4278670A (en) * 1976-07-12 1981-07-14 Smithkline Corporation 7-Alpha-oxyiminoacylcephalosporins
US4101656A (en) * 1976-07-12 1978-07-18 Smithkline Corporation 7β-Acylamino-3-(alkanesulfonamidoalkyl substituted tetrazolylthiomethyl) cephalosporins, antibacterial compositions containing them and methods of treating bacterial infections with them
DE2724092A1 (de) * 1977-05-27 1978-12-07 Smithkline Corp Cephalosporine, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
FR2387235A1 (fr) * 1978-01-23 1978-11-10 Fujisawa Pharmaceutical Co Procede de preparation de composes d'acide 3,7-disubstitue-3-cephem-4-carboxylique et nouveaux produits ainsi obtenus, ayant une forte activite antibacterienne
US4243803A (en) * 1979-07-05 1981-01-06 Bristol-Myers Company Production of 7-(2-aminomethylphenylacetamido)-3-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid
US4374994A (en) * 1979-07-05 1983-02-22 Bristol-Myers Company Process for preparation of 5-mercaptotetrazolyl-1-acetic acid
EP0029998B1 (en) * 1979-11-30 1985-03-06 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds, processes for their preparation and pharmaceutical compositions containing them
JPS56158791A (en) * 1980-05-10 1981-12-07 Taisho Pharmaceut Co Ltd Cephalosporin compound
IL63767A0 (en) * 1980-09-17 1981-12-31 Lilly Co Eli Cephalosporin compounds
JPS57188594A (en) * 1981-05-15 1982-11-19 Eisai Co Ltd Preparation of 7-(2-amino-2-phenylacetamido)cephem derivative
US4448958A (en) * 1982-10-20 1984-05-15 Bristol-Myers Company Purification of ceforanide
US4749522A (en) * 1985-10-31 1988-06-07 Angio-Medical Corporation Supercritical fluid extraction of animal derived materials
DE3641822A1 (de) * 1986-12-06 1988-06-16 Goedecke Ag Verwendung von dihydrophenylaminosaeurederivaten und diese enthaltende arzneimittel zur immunmodulation und cytostase

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3819623A (en) * 1968-04-12 1974-06-25 Fujisawa Pharmaceutical Co 3,7-disubstituted cephalosporin compounds
DE1953861C2 (de) * 1969-10-25 1982-12-23 Fujisawa Pharmaceutical Co., Ltd., Osaka 7-Tetrazolylacetamido-3-thiomethyl-3-cephem-4- carbonsäuren
US3814755A (en) * 1972-08-30 1974-06-04 Bristol Myers Co 7-(omikron-aminomethylphenylacetamido)-3-(tetrazolo(4,5-b)pyridazin-6-ylthiomethyl)-3-cephem-4-carboxylic acid
GB1478055A (en) 1973-07-27 1977-06-29 Erba Carlo Spa Cephalosporin compounds
US4074929A (en) 1973-08-29 1978-02-21 Amp Incorporated Cable card edge connector
NL7414119A (nl) * 1973-10-31 1975-05-02 Fujisawa Pharmaceutical Co Werkwijze ter bereiding van 1h-tetrazool-5-thiol- derivaten en 1-gesubstitueerde 1h-tetrazool- -5-thiolen.
US4205166A (en) * 1974-02-20 1980-05-27 Fujisawa Pharmaceutical Co., Ltd. 7-Substituted-3-aminoalkyl-, acylaminoalkyl-, or hydroxyalkyl-substituted heterocyclic thiomethyl-3-cephem-4-carboxylic acid derivatives and preparation thereof
US4092476A (en) * 1974-02-21 1978-05-30 Beecham Group Limited Phthalidyl esters of 7-[(α amino, 2 substituted acetamido)-3-(heterocyclic-thio methyl)]cephalosporins
US4068074A (en) * 1974-04-05 1978-01-10 Yamanouchi Pharmaceutical Co., Ltd. Cephalosporin derivatives having at the 3-position of the cephem ring a heterocyclic thiomethyl group with a carboxy or sulfo group and at the 7-position of the cephem ring an α-heterocylic acylaminophenyl-acetamide group
US4160086A (en) * 1974-04-27 1979-07-03 Beecham Group Limited 3-Heterocyclicthio-7-α-carboxy 2-aryl acetamido cephalosporanic acid
JPS612674B2 (da) * 1974-06-20 1986-01-27 Meiji Seika Co
US4182863A (en) * 1974-09-03 1980-01-08 Bristol-Myers Company 7-Amino-3-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid
US4172196A (en) * 1974-09-03 1979-10-23 Bristol-Myers Company Certain 7-α-substituted-α-hydroxyacetamido-3-(1-carboxymethyltetrazol-5-yl-thiomethyl)-3-cephem-4-carboxylic acids
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
US4286089A (en) * 1974-12-27 1981-08-25 Smithkline Corporation 7-Acyl-3-(substituted tetrazolyl thiomethyl)cephalosporins
US4183925A (en) * 1975-03-27 1980-01-15 Pfizer Inc. 7-Aminophenylacetamido-Δ3 -cephem antibacterial agents and method of use
JPS525787A (en) * 1975-06-27 1977-01-17 Bristol Myers Co Antiibacterial agent
US4013648A (en) * 1975-07-23 1977-03-22 Bristol-Myers Company Δ2,3 -0-2-Isocephem-4-carboxylic acid and derivatives as antibacterial agents
US4220644A (en) * 1976-05-03 1980-09-02 Smithkline Corporation 7-Acylamino-3-(substituted tetrazolyl thiomethyl) cephalosporins
US4118563A (en) * 1977-11-25 1978-10-03 Bristol-Myers Company Production of 7-(2-aminomethylphenylacetamido-3-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid

Also Published As

Publication number Publication date
CH636882A5 (de) 1983-06-30
DK367279A (da) 1979-08-31
DK147483B (da) 1984-08-27
IL48020A0 (en) 1975-11-25
CA1123840A (en) 1982-05-18
SE7907672L (sv) 1979-09-14
YU44964B (en) 1991-06-30
YU223281A (en) 1983-12-31
DK423383D0 (da) 1983-09-16
SE453507B (sv) 1988-02-08
US4297489A (en) 1981-10-27
DK145262B (da) 1982-10-18
DE2538804C2 (de) 1986-10-16
OA05096A (fr) 1981-01-31
DK391075A (da) 1976-03-04
NL7510391A (nl) 1976-03-05
DK423383A (da) 1983-09-16
YU44669B (en) 1990-12-31
CA1135256A (en) 1982-11-09
DK148796B (da) 1985-09-30
DK145262C (da) 1983-03-14
YU223081A (en) 1983-12-31
DK162388B (da) 1991-10-21
YU44833B (en) 1991-04-30
HU169490B (da) 1976-12-28
YU213275A (en) 1982-02-28
FI62841B (fi) 1982-11-30
SE435279B (sv) 1984-09-17
SE8305539L (sv) 1983-10-07
DE2560655C2 (da) 1988-07-14
JPS5154580A (da) 1976-05-13
NO152509C (no) 1985-10-09
SE7509702L (sv) 1976-03-04
ES440707A1 (es) 1977-07-01
DD130787A5 (de) 1978-05-03
FR2283686B1 (da) 1983-07-08
DK147483C (da) 1985-03-25
CA1135254A (en) 1982-11-09
IL48020A (en) 1982-02-28
SE8305539D0 (sv) 1983-10-07
DK148796C (da) 1986-03-17
SE431548B (sv) 1984-02-13
DD123471A5 (da) 1976-12-20
CA1135255A (en) 1982-11-09
ES457998A1 (es) 1978-03-01
JPS6150956B2 (da) 1986-11-06
LU73306A1 (da) 1976-08-13
NO152509B (no) 1985-07-01
BG27091A3 (da) 1979-08-15
YU223381A (en) 1983-06-30
NL161758C (nl) 1980-03-17
AR222771A1 (es) 1981-06-30
YU223181A (en) 1983-12-31
FI62841C (fi) 1983-03-10
DK162388C (da) 1992-03-16
DE2538804A1 (de) 1976-07-15
NO752983L (da) 1976-03-04
IE43123L (en) 1976-03-03
IE43123B1 (en) 1980-12-31
DK240582A (da) 1982-05-27
FR2283686A1 (fr) 1976-04-02

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Legal Events

Date Code Title Description
MA Patent expired
MA Patent expired

Owner name: BRISTOL-MYERS CO