FI71126C - Foerfarande foer framstaellning av n-(1-alkyl- eller allyl -2-pyrrolidinylmetyl)-2-metoxi-4-amino- -5-alkylsulfonylbensamider - Google Patents

Foerfarande foer framstaellning av n-(1-alkyl- eller allyl -2-pyrrolidinylmetyl)-2-metoxi-4-amino- -5-alkylsulfonylbensamider Download PDF

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Publication number
FI71126C
FI71126C FI790182A FI790182A FI71126C FI 71126 C FI71126 C FI 71126C FI 790182 A FI790182 A FI 790182A FI 790182 A FI790182 A FI 790182A FI 71126 C FI71126 C FI 71126C
Authority
FI
Finland
Prior art keywords
methoxy
amino
acid
formula
ethyl
Prior art date
Application number
FI790182A
Other languages
English (en)
Finnish (fi)
Other versions
FI790182A (fi
FI71126B (fi
Inventor
Michel Thominet
Jacques Acher
Jean-Claude Monier
Original Assignee
Ile De France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ile De France filed Critical Ile De France
Publication of FI790182A publication Critical patent/FI790182A/fi
Priority to FI861130A priority Critical patent/FI73412C/fi
Application granted granted Critical
Publication of FI71126B publication Critical patent/FI71126B/fi
Publication of FI71126C publication Critical patent/FI71126C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
FI790182A 1978-01-20 1979-01-19 Foerfarande foer framstaellning av n-(1-alkyl- eller allyl -2-pyrrolidinylmetyl)-2-metoxi-4-amino- -5-alkylsulfonylbensamider FI71126C (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI861130A FI73412C (fi) 1978-01-20 1986-03-18 2-metoxi-4-amino-5-alkyltio- (eller alkylsulfonyl)benzoesyraderivat.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7801632 1978-01-04
FR7801632A FR2415099A1 (fr) 1978-01-20 1978-01-20 Nouveaux derives de 4-amino-5-alkylsulfonyl ortho-anisamides, leurs procedes de preparation et leur application comme psychotropes

Publications (3)

Publication Number Publication Date
FI790182A FI790182A (fi) 1979-07-21
FI71126B FI71126B (fi) 1986-08-14
FI71126C true FI71126C (fi) 1986-11-24

Family

ID=9203689

Family Applications (1)

Application Number Title Priority Date Filing Date
FI790182A FI71126C (fi) 1978-01-20 1979-01-19 Foerfarande foer framstaellning av n-(1-alkyl- eller allyl -2-pyrrolidinylmetyl)-2-metoxi-4-amino- -5-alkylsulfonylbensamider

Country Status (42)

Country Link
US (2) US4294828A (pt)
JP (1) JPS6049192B2 (pt)
AR (2) AR221354A1 (pt)
AT (1) AT377977B (pt)
AU (1) AU528561B2 (pt)
BE (1) BE872585A (pt)
BG (2) BG31497A3 (pt)
CA (1) CA1101430A (pt)
CH (1) CH637927A5 (pt)
CS (1) CS226181B2 (pt)
CY (1) CY1201A (pt)
DD (1) DD141520A5 (pt)
DE (1) DE2901181C2 (pt)
DK (1) DK158346C (pt)
EG (1) EG14045A (pt)
ES (2) ES476755A1 (pt)
FI (1) FI71126C (pt)
FR (1) FR2415099A1 (pt)
GB (2) GB2012765B (pt)
GR (1) GR64431B (pt)
HK (1) HK12184A (pt)
HU (1) HU179793B (pt)
IE (1) IE47798B1 (pt)
IL (1) IL56411A (pt)
IN (1) IN150226B (pt)
IT (1) IT1164655B (pt)
LU (1) LU80786A1 (pt)
MC (1) MC1232A1 (pt)
MX (2) MX5793E (pt)
NL (1) NL191707C (pt)
NO (1) NO151320C (pt)
NZ (1) NZ189378A (pt)
OA (1) OA06156A (pt)
PH (2) PH15725A (pt)
PL (2) PL116532B1 (pt)
PT (1) PT69068A (pt)
RO (2) RO80311A (pt)
SE (2) SE448874B (pt)
SU (1) SU820659A3 (pt)
YU (2) YU42172B (pt)
ZA (1) ZA79219B (pt)
ZM (1) ZM579A1 (pt)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
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FR2440946A2 (fr) * 1978-01-20 1980-06-06 Ile De France Nouveaux benzamides heterocycliques substitues, leurs procedes de preparation et leur application comme modificateurs du comportement
ZA818221B (en) * 1980-12-12 1982-10-27 Beecham Group Plc Pharmaceutical compounds
FR2550447B1 (fr) * 1983-08-10 1986-01-17 Ile De France Application du n-(ally-2-pyrrolidinylmethyl) 2-methoxy 4-amino 5-methylsulfamoyl benzamide comme antiagregant plaquettaire
FR2574795B1 (fr) * 1984-12-18 1987-11-20 Ile De France Nouveau procede industriel de synthese du n-((1'-allyl 2'-pyrrolidinyl) methyl) 2-methoxy 4,5-azimido benzamide
FR2584401B1 (fr) * 1985-07-04 1987-11-20 Ile De France Nouveau benzamide, son procede de preparation et son application dans le domaine therapeutique
US5260319A (en) * 1989-12-26 1993-11-09 Hoechst-Roussel Pharmaceuticals Incorporated Thienobenzoxepins and naphthothiophenes
US5227388A (en) * 1989-12-26 1993-07-13 Hoechst-Roussel Pharmaceuticals Incorporated Thienobenzoxepins and naphthothiophenes
FR2678266A1 (fr) * 1991-06-28 1992-12-31 Delagrange Laboratoires Nouveaux derives de 2-hydroxy 4-amino 5-ethylsulfonyl benzamide utiles comme anxiolytiques.
FR2699533A1 (fr) * 1992-12-21 1994-06-24 Mouhtaram Mohamed Dérivés de N-((1,4-dialkyl-6-arylpipérazine-2-yl)méthyl)benzamides. (Isomères cis et trans) Propriétés pharmacologiques et applications.
FR2753376B1 (fr) * 1996-09-18 1998-10-16 Synthelabo Compositions pharmaceutiques comprenant de l'amisulpride et leurs applications therapeutiques
FR2762213B1 (fr) * 1997-04-18 1999-05-14 Synthelabo Composition pharmaceutique a retention gastrique
US6169094B1 (en) 1998-07-14 2001-01-02 Sanofi-Synthelabo Compositions of (S) (-)-amisulpride
CA2450073C (en) 2001-07-25 2017-08-29 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
RU2005135454A (ru) * 2003-05-16 2006-06-27 Пфайзер Продактс Инк. (Us) Терапевтические комбинации атипичных нейролептиков с модуляторами гамк и/или противосудорожными препаратами
FR2857263B1 (fr) * 2003-07-09 2005-09-09 Sanofi Synthelabo Nouvelle composition pharmaceutique solide comprenant de l'amisulpride
WO2005107808A2 (en) * 2004-05-11 2005-11-17 Pfizer Products Inc. Combination of atypical antipsychotics and 5-ht1b receptor antagonists
GT200600161A (es) * 2005-04-22 2007-03-14 Nuevas combinaciones terapeuticas para el tratamiento o la prevencion de los trastornos psicoticos
CN102379684B (zh) 2005-04-28 2014-11-19 普罗透斯数字保健公司 药物信息系统
JP2010503710A (ja) 2006-09-18 2010-02-04 ラプトール ファーマシューティカル インコーポレイテッド 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
US7825156B2 (en) * 2007-02-02 2010-11-02 Copharms Method of treating bipolar depression with a benzamide derivative
EP2321011A1 (en) * 2008-06-25 2011-05-18 Pfizer Inc. Diaryl compounds and uses thereof
US20100105755A1 (en) * 2008-09-12 2010-04-29 Auspex Pharmaceuticals, Inc. Substituted benzamide modulators of dopamine receptor
PT3395372T (pt) 2009-02-20 2022-05-05 Enhanx Biopharm Inc Sistema de entrega de medicamentos à base de glutationa
WO2010129819A2 (en) 2009-05-06 2010-11-11 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
CN101898991B (zh) * 2009-05-31 2013-09-25 江苏天士力帝益药业有限公司 一种(s)(-)-氨磺必利d-(-)-酒石酸盐的合成方法
CN101628886B (zh) * 2009-08-25 2012-12-12 北京紫萌同达科技有限公司 一种2-甲氧基-4-氨基-5-乙砜基苯甲酸的合成方法
GB201004020D0 (en) * 2010-03-11 2010-04-21 Acacia Pharma Ltd New therapeutic use
AU2016216578B2 (en) * 2010-03-11 2017-11-23 Acacia Pharma Limited The use of amisulpride as an anti-emetic
AU2014202535B2 (en) * 2010-03-11 2016-05-26 Acacia Pharma Limited The use of amisulpride as an anti-emetic
US20130096319A1 (en) 2010-06-17 2013-04-18 Lupin Limited Process for preparation of amisulpride
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN103319384A (zh) * 2013-06-18 2013-09-25 苏州诚和医药化学有限公司 制备2-甲氧基-4-氨基-5-乙砜基苯甲酸的方法
CN103304453A (zh) * 2013-06-18 2013-09-18 苏州诚和医药化学有限公司 两步法合成2-甲氧基-4-氨基-5-乙砜基苯甲酸
CN103450058B (zh) * 2013-09-18 2015-10-14 广安凯特医药化工有限公司 一种氨磺必利酸的制备方法
CN104725292B (zh) * 2015-03-23 2017-07-25 湖北荆江源制药股份有限公司 一种(s)(‑)‑氨磺必利的制备方法
GB201618425D0 (en) * 2016-11-01 2016-12-14 Acacia Pharma Ltd method
ES2908949T3 (es) 2016-11-28 2022-05-04 Lb Pharmaceuticals Inc Agentes psicotrópicos y sus usos
US11377421B2 (en) 2016-11-28 2022-07-05 Lb Pharmaceuticals Inc. Psychotropic agents and uses thereof
CN106995397B (zh) * 2016-12-12 2020-01-14 河北医科大学 R-氨磺必利药用盐、制备方法、晶型及其用途
GB201702250D0 (en) 2017-02-10 2017-03-29 Acacia Pharma Ltd Method
JP7268026B2 (ja) 2017-12-05 2023-05-02 サノビオン ファーマシューティカルズ インク 非ラセミ混合物およびその使用
EP3720435B1 (en) 2017-12-05 2024-03-06 Sunovion Pharmaceuticals Inc. Crystal forms and production methods thereof
CN110790693A (zh) * 2018-08-02 2020-02-14 北京万全德众医药生物技术有限公司 一种(s)(-)-氨磺必利的制备方法
KR20220018004A (ko) 2019-06-04 2022-02-14 선오비온 파마슈티컬스 인코포레이티드 조절 방출 제형 및 이의 용도

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3342826A (en) * 1964-01-13 1967-09-19 Ile De France Heterocyclic aminoalkyl benzamides
FR2313935A1 (fr) * 1975-06-10 1977-01-07 Ile De France Nouveaux benzamides substitues, leurs derives et leur procede de preparation
US3862139A (en) * 1972-06-23 1975-01-21 Delmar Chem Heterocyclic benzamide compounds
FR2244760B1 (pt) * 1973-09-25 1980-06-27 Ile De France
FR2299862B1 (fr) * 1975-02-07 1978-07-21 Ile De France Nouveau
FR2294698A1 (fr) * 1974-12-18 1976-07-16 Synthelabo Nouveaux derives des methoxy-2 benzamides substitues, leurs sels, leur preparation et les medicaments qui en renferment
IE42210B1 (en) * 1974-12-18 1980-06-18 Synthelabo 2-methoxy-benzamide derivatives

Also Published As

Publication number Publication date
SE7900380L (sv) 1979-07-21
CA1101430A (en) 1981-05-19
SE460968B (sv) 1989-12-11
NO790180L (no) 1979-07-23
GB2012765B (en) 1982-09-08
DK158346C (da) 1990-10-08
ES477782A1 (es) 1979-09-16
SE8603773D0 (sv) 1986-09-09
MC1232A1 (fr) 1979-10-26
MX5793E (es) 1984-07-19
BG31497A3 (en) 1982-01-15
RO80311A (ro) 1982-12-06
US4401822A (en) 1983-08-30
PH22287A (en) 1988-07-22
SE448874B (sv) 1987-03-23
PL212899A1 (pt) 1980-01-14
HU179793B (en) 1982-12-28
PL116532B1 (en) 1981-06-30
DD141520A5 (de) 1980-05-07
EG14045A (en) 1983-09-30
HK12184A (en) 1984-02-24
AR220574A1 (es) 1980-11-14
PL118151B1 (en) 1981-09-30
DE2901181C2 (de) 1984-07-19
YU25483A (en) 1983-10-31
YU5079A (en) 1983-06-30
GB2083458A (en) 1982-03-24
ATA39879A (de) 1983-12-15
CS226181B2 (en) 1984-03-19
RO76393A (ro) 1981-03-30
FI790182A (fi) 1979-07-21
IL56411A (en) 1982-09-30
ES476755A1 (es) 1979-06-01
GR64431B (en) 1980-03-21
NZ189378A (en) 1983-03-15
IE790092L (en) 1979-07-20
IT1164655B (it) 1987-04-15
NL191707B (nl) 1995-12-01
FI71126B (fi) 1986-08-14
IE47798B1 (en) 1984-06-27
DK20979A (da) 1979-07-21
OA06156A (fr) 1981-06-30
LU80786A1 (fr) 1979-09-07
DK158346B (da) 1990-05-07
YU41278B (en) 1986-12-31
PH15725A (en) 1983-03-18
DE2901181A1 (de) 1979-07-26
US4294828A (en) 1981-10-13
IL56411A0 (en) 1979-03-12
NO151320C (no) 1985-04-17
CY1201A (en) 1983-12-31
BE872585A (fr) 1979-06-07
GB2083458B (en) 1983-03-09
NO151320B (no) 1984-12-10
PT69068A (fr) 1979-02-01
IN150226B (pt) 1982-08-21
CH637927A5 (fr) 1983-08-31
AR221354A1 (es) 1981-01-30
SE8603773L (sv) 1986-09-09
NL191707C (nl) 1996-04-02
AT377977B (de) 1985-05-28
AU528561B2 (en) 1983-05-05
ZA79219B (en) 1980-01-30
IT7947706A0 (it) 1979-01-18
MX7623E (es) 1990-03-27
SU820659A3 (ru) 1981-04-07
YU42172B (en) 1988-06-30
JPS6049192B2 (ja) 1985-10-31
NL7900457A (nl) 1979-07-24
GB2012765A (en) 1979-08-01
FR2415099B1 (pt) 1981-02-20
FR2415099A1 (fr) 1979-08-17
AU4337379A (en) 1979-07-26
ZM579A1 (en) 1979-12-21
JPS54145658A (en) 1979-11-14
BG31496A3 (en) 1982-01-15

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