FI69834C - Foerfarande foer framstaellning av terapeutiskt anvaendbara etr- eller tioetermerkaptoacylproliner - Google Patents

Foerfarande foer framstaellning av terapeutiskt anvaendbara etr- eller tioetermerkaptoacylproliner Download PDF

Info

Publication number
FI69834C
FI69834C FI792498A FI792498A FI69834C FI 69834 C FI69834 C FI 69834C FI 792498 A FI792498 A FI 792498A FI 792498 A FI792498 A FI 792498A FI 69834 C FI69834 C FI 69834C
Authority
FI
Finland
Prior art keywords
proline
solution
cis
methyl
oxopropyl
Prior art date
Application number
FI792498A
Other languages
English (en)
Finnish (fi)
Other versions
FI792498A (fi
FI69834B (fi
Inventor
Miguel Angel Ondetti
John Krapcho
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of FI792498A publication Critical patent/FI792498A/fi
Application granted granted Critical
Publication of FI69834B publication Critical patent/FI69834B/fi
Publication of FI69834C publication Critical patent/FI69834C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
FI792498A 1978-08-11 1979-08-10 Foerfarande foer framstaellning av terapeutiskt anvaendbara etr- eller tioetermerkaptoacylproliner FI69834C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US93288378A 1978-08-11 1978-08-11
US93288378 1978-08-11
KR790002731 1979-08-10
KR1019790002731A KR830002450B1 (ko) 1978-08-11 1979-08-10 치환 프로린의 메르캅토아실 유도체의 제조방법

Publications (3)

Publication Number Publication Date
FI792498A FI792498A (fi) 1980-02-12
FI69834B FI69834B (fi) 1985-12-31
FI69834C true FI69834C (fi) 1986-05-26

Family

ID=26626596

Family Applications (1)

Application Number Title Priority Date Filing Date
FI792498A FI69834C (fi) 1978-08-11 1979-08-10 Foerfarande foer framstaellning av terapeutiskt anvaendbara etr- eller tioetermerkaptoacylproliner

Country Status (30)

Country Link
JP (2) JPS5527199A (fr)
KR (1) KR830002450B1 (fr)
AR (1) AR229081A1 (fr)
AT (1) AT379589B (fr)
AU (1) AU530690B2 (fr)
BE (1) BE878191A (fr)
CA (1) CA1144930A (fr)
CH (1) CH642064A5 (fr)
CS (1) CS228118B2 (fr)
DD (1) DD145749A5 (fr)
DE (1) DE2932021C2 (fr)
DK (1) DK154553C (fr)
ES (1) ES483311A1 (fr)
FI (1) FI69834C (fr)
FR (1) FR2435469A1 (fr)
GB (1) GB2028327B (fr)
GR (1) GR72420B (fr)
IE (1) IE48802B1 (fr)
IN (1) IN152712B (fr)
IT (1) IT1117782B (fr)
LU (2) LU81593A1 (fr)
NL (2) NL193374C (fr)
NZ (1) NZ191036A (fr)
PH (1) PH15030A (fr)
PT (1) PT70049A (fr)
RO (1) RO78870B (fr)
SE (1) SE447477B (fr)
SU (1) SU1066460A3 (fr)
YU (1) YU41876B (fr)
ZA (1) ZA793633B (fr)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4483861A (en) * 1978-10-31 1984-11-20 Santen Pharmaceutical Co., Ltd. Antihypertensive sulfur-containing compounds
CA1132985A (fr) * 1978-12-22 1982-10-05 John Krapcho Derives cetal et thiocetal de la mercaptoacyl proline
US4347371A (en) * 1978-12-30 1982-08-31 Santen Pharmaceutical Co., Ltd. Disulfide compounds
US4234489A (en) * 1979-06-25 1980-11-18 E. R. Squibb & Sons, Inc. Pyroglutamic acid derivatives and analogs
US4288368A (en) * 1979-07-30 1981-09-08 E. R. Squibb & Sons, Inc. Dithioacylproline derivatives
US4291040A (en) * 1979-10-22 1981-09-22 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 4-disubstituted prolines and 4-substituted dehydroprolines
US4692458A (en) * 1980-03-05 1987-09-08 University Of Miami Anti-hypertensive agents
AU542211B2 (en) * 1980-03-07 1985-02-14 Gruppo Lepetit S.P.A. Mercaptocycloalkyl carbonyl prolines
GB2070586A (en) * 1980-03-21 1981-09-09 Squibb & Sons Inc Derivatives of Proline or Pipecolic Acid
US4284624A (en) 1980-05-02 1981-08-18 E. R. Squibb & Sons, Inc. Mixed disulfides
US4578474A (en) * 1980-06-23 1986-03-25 E. R. Squibb & Sons, Inc. Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids
US4390695A (en) * 1980-06-23 1983-06-28 E. R. Squibb & Sons, Inc. Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids
US4316905A (en) * 1980-07-01 1982-02-23 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of various 4-substituted prolines
US4332726A (en) * 1980-08-25 1982-06-01 E. R. Squibb & Sons, Inc. Purification of mercaptoacyl amino acids
US4307110A (en) * 1980-09-12 1981-12-22 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 3-substituted proline derivatives
US4311705A (en) * 1980-10-06 1982-01-19 E. R. Squibb & Sons, Inc. Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines
US4312809A (en) 1980-10-31 1982-01-26 E. R. Squibb & Sons, Inc. Lactam derivatives of mercaptoacylamino acids
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
US4337201A (en) * 1980-12-04 1982-06-29 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted prolines
US4384123A (en) * 1980-12-04 1983-05-17 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted prolines
US4416831A (en) 1981-04-27 1983-11-22 E. R. Squibb & Sons, Inc. Amino and substituted amino phosphinylalkanoyl compounds
US4374131A (en) 1981-04-27 1983-02-15 E. R. Squibb & Sons, Inc. Amino and substituted amino phosphinyl-alkanoyl compounds
US4416833A (en) 1981-05-04 1983-11-22 E. R. Squibb & Sons, Inc. Substituted carbonyl phosphinyl-alkanoyl compounds
US4381297A (en) 1981-05-04 1983-04-26 E. R. Squibb & Sons, Inc. Substituted carbonyl phosphinyl-alkanoyl compounds
US4497953A (en) * 1981-06-01 1985-02-05 E. R. Squibb & Sons, Inc. Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids
US4377701A (en) * 1981-09-21 1983-03-22 E. R. Squibb & Sons, Inc. 4-Methylene-1-[[(alranoyl or arylcarbonyl)mercapto]acyl]proline and pipecolic acid
US4555506A (en) * 1981-12-24 1985-11-26 E. R. Squibb & Sons, Inc. Phosphorus containing compounds and use as hypotensives
US4452791A (en) * 1982-03-15 1984-06-05 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4560680A (en) * 1982-03-15 1985-12-24 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4616005A (en) * 1982-06-23 1986-10-07 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
US4452790A (en) * 1982-06-23 1984-06-05 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
US4703043A (en) * 1982-06-23 1987-10-27 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensive
US4567166A (en) * 1982-07-14 1986-01-28 E. R. Squibb & Sons, Inc. Amino and substituted amino phosphinylalkanoyl compounds useful for treating hypertension
EP0187037A3 (fr) * 1984-12-21 1988-03-23 Takeda Chemical Industries, Ltd. Dérivés de pipéridine, leur production et emploi
AU632596B2 (en) * 1989-08-21 1993-01-07 E.R. Squibb & Sons, Inc. Phosphonate substituted amino or imino acids useful as antihypertensives
JPH05344844A (ja) * 1992-06-12 1993-12-27 Suzumo Kiko Kk 焼おむすびせんべいの製造方法
EP0640594A1 (fr) 1993-08-23 1995-03-01 Fujirebio Inc. Dérivé de hydantoine comme inhibiteur de métalloprotease
US5435286A (en) * 1994-05-02 1995-07-25 Cummins Engine Company, Inc. Ball link assembly for vehicle engine drive trains
US7659305B2 (en) 2002-10-31 2010-02-09 Pfizer Inc. Therapeutic proline derivatives
GB0225379D0 (en) * 2002-10-31 2002-12-11 Pfizer Ltd Therapeutic proline derivatives
WO2006038119A1 (fr) * 2004-10-08 2006-04-13 Warner-Lambert Company Llc Synthese stereoselective d'alcoxy-prolines n-protegees
GB0715626D0 (en) * 2007-08-10 2007-09-19 Generics Uk Ltd Crystalline form of zofenopril calcium
CN101981004B (zh) * 2008-02-27 2014-09-17 基因里克斯(英国)有限公司 晶体形式
US8853421B2 (en) 2008-02-27 2014-10-07 Generics [Uk] Limited Crystalline forms of zofenopril calcium
SI23949A (sl) 2011-12-19 2013-06-28 Silverstone Pharma Nove kristalne soli zofenoprila, postopek za njihovo dobivanje in njihova uporaba v terapiji

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2340092A2 (fr) * 1976-02-09 1977-09-02 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
AU509899B2 (en) * 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4116962A (en) * 1976-12-03 1978-09-26 E. R. Squibb & Sons, Inc. Pyrrolidine and piperidine-2-carboxylic acid derivatives
US4113715A (en) * 1977-01-17 1978-09-12 E. R. Squibb & Sons, Inc. Amino acid derivatives
US4108886A (en) * 1977-03-11 1978-08-22 E. R. Squibb & Sons, Inc. Thiopropanoylamino acid derivatives
PH15381A (en) * 1978-02-21 1982-12-17 Squibb & Sons Inc Halogen substituted mercaptoacylamino acids
US4154934A (en) * 1978-08-11 1979-05-15 E. R. Squibb & Sons, Inc. Mercaptoacylamino derivatives of heterocyclic carboxylic acids

Also Published As

Publication number Publication date
AR229081A1 (es) 1983-06-15
FR2435469A1 (fr) 1980-04-04
CS228118B2 (en) 1984-05-14
IT1117782B (it) 1986-02-24
NL193374B (nl) 1999-04-01
DK154553C (da) 1989-04-17
CH642064A5 (de) 1984-03-30
ZA793633B (en) 1980-07-30
JPH0134987B2 (fr) 1989-07-21
AU530690B2 (en) 1983-07-28
JPH01287069A (ja) 1989-11-17
JPS5527199A (en) 1980-02-27
AT379589B (de) 1986-01-27
DE2932021A1 (de) 1980-02-21
FR2435469B1 (fr) 1983-02-11
IN152712B (fr) 1984-03-17
ES483311A1 (es) 1980-04-16
YU192379A (en) 1983-02-28
GB2028327A (en) 1980-03-05
FI792498A (fi) 1980-02-12
LU90403I2 (fr) 2000-07-07
SU1066460A3 (ru) 1984-01-07
PT70049A (en) 1979-09-01
IE48802B1 (en) 1985-05-15
PH15030A (en) 1982-05-13
NL193374C (nl) 1999-08-03
ATA541679A (de) 1985-06-15
LU81593A1 (fr) 1979-12-07
KR830002450B1 (ko) 1983-10-26
DK154553B (da) 1988-11-28
NL990024I1 (nl) 1999-11-01
RO78870A (fr) 1982-07-06
KR830001269A (ko) 1983-04-29
RO78870B (ro) 1985-01-30
SE447477B (sv) 1986-11-17
DK335879A (da) 1980-02-12
DE2932021C2 (de) 1994-05-19
YU41876B (en) 1988-02-29
IE791544L (en) 1980-02-11
BE878191A (fr) 1980-02-11
GR72420B (fr) 1983-11-03
FI69834B (fi) 1985-12-31
IT7949954A0 (it) 1979-08-03
CA1144930A (fr) 1983-04-19
DD145749A5 (de) 1981-01-07
NL7906120A (nl) 1980-02-13
NZ191036A (en) 1984-05-31
SE7906722L (sv) 1980-02-12
NL990024I2 (nl) 1999-11-01
AU4919079A (en) 1980-02-14
GB2028327B (en) 1982-11-24

Similar Documents

Publication Publication Date Title
FI69834C (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara etr- eller tioetermerkaptoacylproliner
US4316906A (en) Mercaptoacyl derivatives of substituted prolines
US4310461A (en) Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids
JP3273515B2 (ja) 抗血栓剤としてのペプチドアルデヒド類
US4154960A (en) Amino acid derivatives
US4578474A (en) Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids
EP0927161B1 (fr) Inhibiteurs de metalloproteases a cycle amino substitue
US4390695A (en) Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids
US4692458A (en) Anti-hypertensive agents
JPS604815B2 (ja) プロリン誘導体
JPS6059226B2 (ja) プロリン誘導体および関連化合物
CS197285B2 (en) Process for preparing carboxyalkylacylaminoacids
NO781392L (no) Merkaptoalkylsylfonyl-prolin-derivater og beslektede forbindelser
HU183652B (en) Process for preparing bicyclic compounds
KR0151783B1 (ko) 신규의 프롤린 유도체
US4296033A (en) 4-Azido-1-mercaptoacyl proline
US5883121A (en) Epoxysuccinamide derivative or salt thereof, and medicine comprising the same
CA2258354A1 (fr) Nouveaux derives d'epoxysuccinamide et sels associes
CA1124726A (fr) Derives du pyrrolidinecarboxaldehyde, du piperidinecarboxaldehyde et de leurs intermediaires
US4307110A (en) Mercaptoacyl derivatives of 3-substituted proline derivatives
US4284779A (en) Amino acid derivatives
EP0042639B1 (fr) Dérivés azido, imide, amide et amino de mercaptoacylprolines et d'acides pipécoliques doués d' activité hypotensive
DK156054B (da) Analogifremgangsmaade til fremstilling af n-(3-acylthio-2-methylpropanoyl)-prolinforbindelser eller salte heraf
US4308388A (en) 4-Azido-1-mercaptoacyl pipecolic acid
US4497953A (en) Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids

Legal Events

Date Code Title Description
FD Application lapsed
SPCG Supplementary protection certificate granted

Spc suppl protection certif: L99

Extension date: 20040810

ND Supplementary protection certificate (spc) granted
MA Patent expired

Owner name: MENARINI INTERNATIONAL OPERATIONS