FI69300C - Foerfarande foer framstaellning av terapeutiskt anvaendbara ny karbostyrilderivat - Google Patents

Foerfarande foer framstaellning av terapeutiskt anvaendbara ny karbostyrilderivat Download PDF

Info

Publication number
FI69300C
FI69300C FI781811A FI781811A FI69300C FI 69300 C FI69300 C FI 69300C FI 781811 A FI781811 A FI 781811A FI 781811 A FI781811 A FI 781811A FI 69300 C FI69300 C FI 69300C
Authority
FI
Finland
Prior art keywords
group
carbostyril
propoxy
methyl
carbon atoms
Prior art date
Application number
FI781811A
Other languages
English (en)
Finnish (fi)
Other versions
FI69300B (fi
FI781811A (fi
Inventor
Takao Nishi
Hiraki Ueda
Kazuyuki Nakagava
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP6931977A external-priority patent/JPS545981A/ja
Priority claimed from JP7586377A external-priority patent/JPS5412385A/ja
Priority claimed from JP53023012A external-priority patent/JPS6059912B2/ja
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of FI781811A publication Critical patent/FI781811A/fi
Publication of FI69300B publication Critical patent/FI69300B/fi
Application granted granted Critical
Publication of FI69300C publication Critical patent/FI69300C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
FI781811A 1977-06-10 1978-06-07 Foerfarande foer framstaellning av terapeutiskt anvaendbara ny karbostyrilderivat FI69300C (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP6931977 1977-06-10
JP6931977A JPS545981A (en) 1977-06-10 1977-06-10 Carbostyryl derivatives
JP7586377 1977-06-24
JP7586377A JPS5412385A (en) 1977-06-24 1977-06-24 Carbostyril derivative
JP2301278 1978-02-28
JP53023012A JPS6059912B2 (ja) 1978-02-28 1978-02-28 カルボスチリル誘導体

Publications (3)

Publication Number Publication Date
FI781811A FI781811A (fi) 1978-12-11
FI69300B FI69300B (fi) 1985-09-30
FI69300C true FI69300C (fi) 1986-01-10

Family

ID=27284068

Family Applications (1)

Application Number Title Priority Date Filing Date
FI781811A FI69300C (fi) 1977-06-10 1978-06-07 Foerfarande foer framstaellning av terapeutiskt anvaendbara ny karbostyrilderivat

Country Status (21)

Country Link
US (1) US4298739A (ko)
AR (2) AR224345A1 (ko)
AT (1) AT367038B (ko)
AU (1) AU510138B2 (ko)
CA (1) CA1098907A (ko)
CH (1) CH636087A5 (ko)
DE (1) DE2825048A1 (ko)
DK (1) DK149449C (ko)
ES (2) ES470690A1 (ko)
FI (1) FI69300C (ko)
FR (1) FR2393795B1 (ko)
GB (1) GB2002745B (ko)
IE (1) IE46852B1 (ko)
IT (1) IT1108326B (ko)
MX (1) MX5527E (ko)
NL (1) NL178074C (ko)
NO (1) NO148813C (ko)
NZ (1) NZ187452A (ko)
PH (1) PH14670A (ko)
PT (1) PT68157A (ko)
SE (1) SE444562B (ko)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU843739A3 (ru) * 1978-02-17 1981-06-30 Карл Томэ Гмбх (Фирма) Способ получени карбостириловыхили ОКСиНдОлОВыХ пРОизВОдНыХ
JPS56122356A (en) * 1980-02-29 1981-09-25 Otsuka Pharmaceut Co Ltd Carbostyril derivative
AT383594B (de) * 1980-02-29 1987-07-27 Otsuka Pharma Co Ltd Verfahren zum herstellen von neuen carbostyrilderivaten und ihren salzen
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.
US4442111A (en) * 1981-07-25 1984-04-10 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Antithrombotic sulfimino and sulfoximino indolinones-2
US4578381A (en) * 1982-07-05 1986-03-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
CH655110A5 (de) * 1982-09-03 1986-03-27 Otsuka Pharma Co Ltd Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
US4663320A (en) * 1983-02-16 1987-05-05 Syntex (U.S.A.) Inc. (2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinoazolinyl)oxyalkylamides, compositions and the use thereof
US4490371A (en) * 1983-02-16 1984-12-25 Syntex (U.S.A.) Inc. N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides
HU191316B (en) * 1984-02-15 1987-02-27 Syntex Usa Inc.,Us Process for producing (2-oxo-1,2,3,5-tetrahydro-imidazo /2,1-b/ quinazoline)-oxy-lakyl-amides and pharmacutical compositions containing them
US4670434A (en) * 1985-11-14 1987-06-02 Syntex (U.S.A.) Inc. (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors
US5227381A (en) * 1988-05-02 1993-07-13 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative
JP2753622B2 (ja) 1988-05-02 1998-05-20 大塚製薬株式会社 カルボスチリル誘導体
TW201305B (ko) * 1991-04-03 1993-03-01 Otsuka Pharma Co Ltd
WO1993004042A1 (fr) * 1991-08-23 1993-03-04 Otsuka Pharmaceutical Co., Ltd. Derive de carbostyrile et antiagregant plaquettaire
US5958926A (en) * 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
AU2006311577B2 (en) 2005-11-09 2013-02-07 Zalicus Inc. Methods, compositions, and kits for the treatment of medical conditions
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
AU2008261102B2 (en) 2007-06-04 2013-11-28 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
DE102008022221A1 (de) 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2
EP2328910B1 (en) 2008-06-04 2014-08-06 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
EP2196453A1 (en) * 2008-12-10 2010-06-16 Cellvir Novel substituted aryl derivatives, their process of preparation and their therapeutical uses as anti-HIV agents
CN102639512B (zh) 2009-08-21 2015-12-09 大塚制药株式会社 苯并[b][1,4]二氮杂*-2,4-二酮化合物的制备方法
TWI481601B (zh) 2009-08-21 2015-04-21 Otsuka Pharma Co Ltd 含氮化合物及藥學組成物
US8541404B2 (en) 2009-11-09 2013-09-24 Elexopharm Gmbh Inhibitors of the human aldosterone synthase CYP11B2
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
MX357121B (es) 2011-03-01 2018-06-27 Synergy Pharmaceuticals Inc Star Proceso de preparacion de agonistas c de guanilato ciclasa.
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
EP2958577A2 (en) 2013-02-25 2015-12-30 Synergy Pharmaceuticals Inc. Guanylate cyclase receptor agonists for use in colonic cleansing
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
BR112015030326A2 (pt) 2013-06-05 2017-08-29 Synergy Pharmaceuticals Inc Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos
US20160184387A1 (en) 2013-08-09 2016-06-30 Dominique Charmot Compounds and methods for inhibiting phosphate transport
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR207554A1 (es) * 1972-12-02 1976-10-15 Otsuka Pharma Co Ltd Procedimiento para producir derivados de 3-alquil-5-((3,4-dihidro-5-carbostiril)oximetil)-oxazolidinona-(2)
JPS5239035B2 (ko) * 1972-12-14 1977-10-03
JPS5234629B2 (ko) * 1973-02-03 1977-09-05
NL179275C (nl) * 1973-10-24 1986-08-18 Otsuka Pharma Co Ltd Werkwijze voor de bereiding van farmacologisch werkzame glycerol-derivaten en werkwijze voor de bereiding van preparaten die ze bevatten.
US4022784A (en) * 1974-01-31 1977-05-10 Otsuka Pharmaceutical Company Limited 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyril and -3,4-dihydrocarbostyril derivatives
FI59246C (fi) * 1974-06-24 1981-07-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av benscykloamidderivat anvaendbara vid trombos- och emboliterapin
JPS54119478A (en) * 1978-03-06 1979-09-17 Otsuka Pharmaceut Co Ltd Carbostyril derivative

Also Published As

Publication number Publication date
DE2825048A1 (de) 1978-12-14
FI69300B (fi) 1985-09-30
FR2393795A1 (fr) 1979-01-05
AU3686678A (en) 1979-12-13
DK149449B (da) 1986-06-16
PH14670A (en) 1981-10-30
ATA421378A (de) 1981-10-15
US4298739A (en) 1981-11-03
ES470690A1 (es) 1979-10-16
AT367038B (de) 1982-05-25
CH636087A5 (de) 1983-05-13
IT7868355A0 (it) 1978-06-09
DE2825048C2 (ko) 1991-05-08
DK149449C (da) 1986-11-24
IT1108326B (it) 1985-12-09
CA1098907A (en) 1981-04-07
AR225755A1 (es) 1982-04-30
GB2002745A (en) 1979-02-28
NL7806245A (nl) 1978-12-12
SE7806710L (sv) 1978-12-11
NO148813C (no) 1983-12-21
NL178074C (nl) 1986-01-16
FI781811A (fi) 1978-12-11
AR224345A1 (es) 1981-11-30
IE46852B1 (en) 1983-10-05
ES479138A1 (es) 1979-07-01
NZ187452A (en) 1980-05-27
SE444562B (sv) 1986-04-21
GB2002745B (en) 1982-02-17
DK254878A (da) 1979-02-09
IE781104L (en) 1978-12-10
FR2393795B1 (fr) 1986-07-25
MX5527E (es) 1983-09-23
NO148813B (no) 1983-09-12
NO782022L (no) 1978-12-12
AU510138B2 (en) 1980-06-12
PT68157A (en) 1978-07-01

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Owner name: OTSUKA PHARMACEUTICAL CO. LTD.