FI67709C - Foerfarande foer framstaellning av antibakteriska halvsyntetiska 4"-sulfonylamino-oleandomycin-derivat - Google Patents
Foerfarande foer framstaellning av antibakteriska halvsyntetiska 4"-sulfonylamino-oleandomycin-derivat Download PDFInfo
- Publication number
- FI67709C FI67709C FI781478A FI781478A FI67709C FI 67709 C FI67709 C FI 67709C FI 781478 A FI781478 A FI 781478A FI 781478 A FI781478 A FI 781478A FI 67709 C FI67709 C FI 67709C
- Authority
- FI
- Finland
- Prior art keywords
- oleandomycin
- deoxy
- thienyl
- methyl
- acetyl
- Prior art date
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- 230000000844 anti-bacterial effect Effects 0.000 title claims description 5
- -1 monosubstituted phenyl Chemical group 0.000 claims description 77
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical group ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 75
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical group CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 75
- 150000001875 compounds Chemical class 0.000 claims description 37
- 238000000034 method Methods 0.000 claims description 30
- 239000000203 mixture Substances 0.000 claims description 18
- 125000001544 thienyl group Chemical group 0.000 claims description 15
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
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- 125000002541 furyl group Chemical group 0.000 claims description 6
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- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 3
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- 125000004093 cyano group Chemical group *C#N 0.000 claims description 3
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- 125000001624 naphthyl group Chemical group 0.000 claims description 3
- 125000004076 pyridyl group Chemical group 0.000 claims description 3
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- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims description 2
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- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
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- 239000004305 biphenyl Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 229960002351 oleandomycin Drugs 0.000 description 86
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- RZPAKFUAFGMUPI-KGIGTXTPSA-N oleandomycin Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@]2(OC2)C[C@H](C)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C RZPAKFUAFGMUPI-KGIGTXTPSA-N 0.000 description 34
- RZPAKFUAFGMUPI-UHFFFAOYSA-N Oleandomycin Natural products O1C(C)C(O)C(OC)CC1OC1C(C)C(=O)OC(C)C(C)C(O)C(C)C(=O)C2(OC2)CC(C)C(OC2C(C(CC(C)O2)N(C)C)O)C1C RZPAKFUAFGMUPI-UHFFFAOYSA-N 0.000 description 32
- 235000019367 oleandomycin Nutrition 0.000 description 32
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- 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- VNNLHYZDXIBHKZ-UHFFFAOYSA-N thiophene-2-sulfonyl chloride Chemical compound ClS(=O)(=O)C1=CC=CS1 VNNLHYZDXIBHKZ-UHFFFAOYSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229960005041 troleandomycin Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79585077A | 1977-05-11 | 1977-05-11 | |
| US79585077 | 1977-05-11 | ||
| US88360878 | 1978-03-06 | ||
| US05/883,608 US4136253A (en) | 1977-05-11 | 1978-03-06 | Semi-synthetic 4"-sulfonylamino-oleandomycin derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI781478A7 FI781478A7 (fi) | 1978-11-12 |
| FI67709B FI67709B (fi) | 1985-01-31 |
| FI67709C true FI67709C (fi) | 1985-05-10 |
Family
ID=27121658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI781478A FI67709C (fi) | 1977-05-11 | 1978-05-10 | Foerfarande foer framstaellning av antibakteriska halvsyntetiska 4"-sulfonylamino-oleandomycin-derivat |
Country Status (31)
| Country | Link |
|---|---|
| JP (1) | JPS53149990A (cs) |
| AR (1) | AR219529A1 (cs) |
| AT (1) | AT357263B (cs) |
| AU (1) | AU500587B1 (cs) |
| CA (1) | CA1098123A (cs) |
| CH (1) | CH631461A5 (cs) |
| CS (1) | CS199728B2 (cs) |
| DD (1) | DD135907A5 (cs) |
| DE (1) | DE2820411C2 (cs) |
| DK (1) | DK148845C (cs) |
| EG (1) | EG13371A (cs) |
| ES (1) | ES469648A1 (cs) |
| FI (1) | FI67709C (cs) |
| FR (1) | FR2390453A1 (cs) |
| GB (1) | GB1590162A (cs) |
| GR (1) | GR70056B (cs) |
| HU (1) | HU180279B (cs) |
| IE (1) | IE46839B1 (cs) |
| IL (1) | IL54688A (cs) |
| IT (1) | IT1094816B (cs) |
| LU (1) | LU79638A1 (cs) |
| NL (1) | NL174254C (cs) |
| NO (1) | NO145384C (cs) |
| NZ (1) | NZ187229A (cs) |
| PH (1) | PH15382A (cs) |
| PL (1) | PL111988B1 (cs) |
| PT (1) | PT68019B (cs) |
| RO (1) | RO75819A (cs) |
| SE (1) | SE446340B (cs) |
| SU (1) | SU860707A1 (cs) |
| YU (1) | YU40963B (cs) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4124755A (en) * | 1978-01-03 | 1978-11-07 | Pfizer Inc. | 11-Alkanoyl-4"-deoxy-4"-isonitrilo-oleandomycin derivatives |
| US4133950A (en) * | 1978-01-03 | 1979-01-09 | Pfizer Inc. | 4"-Deoxy-4"-carbamate and dithiocarbamate derivatives of oleandomycin and its esters |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3836519A (en) * | 1973-05-04 | 1974-09-17 | Abbott Lab | Sulfonyl derivatives of erythromycin |
-
1978
- 1978-04-11 SE SE7804080A patent/SE446340B/sv not_active IP Right Cessation
- 1978-04-24 AU AU35379/78A patent/AU500587B1/en not_active Expired
- 1978-04-25 PH PH21053A patent/PH15382A/en unknown
- 1978-05-05 CS CS782903A patent/CS199728B2/cs unknown
- 1978-05-05 YU YU1082/78A patent/YU40963B/xx unknown
- 1978-05-09 GB GB18353/78A patent/GB1590162A/en not_active Expired
- 1978-05-09 CA CA302,902A patent/CA1098123A/en not_active Expired
- 1978-05-09 PT PT68019A patent/PT68019B/pt unknown
- 1978-05-10 HU HU78PI623A patent/HU180279B/hu unknown
- 1978-05-10 DE DE2820411A patent/DE2820411C2/de not_active Expired
- 1978-05-10 NZ NZ187229A patent/NZ187229A/xx unknown
- 1978-05-10 NL NLAANVRAGE7805007,A patent/NL174254C/xx not_active IP Right Cessation
- 1978-05-10 JP JP5540578A patent/JPS53149990A/ja active Granted
- 1978-05-10 CH CH508978A patent/CH631461A5/fr not_active IP Right Cessation
- 1978-05-10 NO NO781656A patent/NO145384C/no unknown
- 1978-05-10 IL IL54688A patent/IL54688A/xx unknown
- 1978-05-10 LU LU79638A patent/LU79638A1/xx unknown
- 1978-05-10 IT IT23229/78A patent/IT1094816B/it active
- 1978-05-10 FR FR7813918A patent/FR2390453A1/fr active Granted
- 1978-05-10 DK DK205878A patent/DK148845C/da not_active IP Right Cessation
- 1978-05-10 FI FI781478A patent/FI67709C/fi not_active IP Right Cessation
- 1978-05-10 AT AT338978A patent/AT357263B/de not_active IP Right Cessation
- 1978-05-10 EG EG301/78A patent/EG13371A/xx active
- 1978-05-10 IE IE953/78A patent/IE46839B1/en unknown
- 1978-05-10 PL PL1978206687A patent/PL111988B1/pl unknown
- 1978-05-10 ES ES469648A patent/ES469648A1/es not_active Expired
- 1978-05-10 GR GR56192A patent/GR70056B/el unknown
- 1978-05-10 RO RO7894029A patent/RO75819A/ro unknown
- 1978-05-10 SU SU782616147A patent/SU860707A1/ru active
- 1978-05-11 DD DD78205329A patent/DD135907A5/xx unknown
- 1978-05-11 AR AR272125A patent/AR219529A1/es active
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: PFIZER INC. |