FI65433C - Foerfarande foer framstaellning av en kristallin form av natriumsaltet av 7-aminotiazolylacetamidocefalosporansyrans oximderivat - Google Patents

Foerfarande foer framstaellning av en kristallin form av natriumsaltet av 7-aminotiazolylacetamidocefalosporansyrans oximderivat Download PDF

Info

Publication number
FI65433C
FI65433C FI782494A FI782494A FI65433C FI 65433 C FI65433 C FI 65433C FI 782494 A FI782494 A FI 782494A FI 782494 A FI782494 A FI 782494A FI 65433 C FI65433 C FI 65433C
Authority
FI
Finland
Prior art keywords
acid
solvate
sodium salt
ethanol
sodium
Prior art date
Application number
FI782494A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI782494A (fi
FI65433B (fi
Inventor
Gaston Amiard
Jean Jolly
Dieter Bormann
Walter Duerckheimer
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9194564&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI65433(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of FI782494A publication Critical patent/FI782494A/fi
Application granted granted Critical
Publication of FI65433B publication Critical patent/FI65433B/fi
Publication of FI65433C publication Critical patent/FI65433C/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI782494A 1977-08-17 1978-08-16 Foerfarande foer framstaellning av en kristallin form av natriumsaltet av 7-aminotiazolylacetamidocefalosporansyrans oximderivat FI65433C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7725142A FR2400519A1 (fr) 1977-08-17 1977-08-17 Forme cristalline du sel de sodium d'un derive oximine de l'acide 7-amino-thiazolyl acetamido cephalosporanique, son procede de preparation et son application comme medicament
FR7725142 1977-08-17

Publications (3)

Publication Number Publication Date
FI782494A FI782494A (fi) 1979-02-18
FI65433B FI65433B (fi) 1984-01-31
FI65433C true FI65433C (fi) 1984-05-10

Family

ID=9194564

Family Applications (1)

Application Number Title Priority Date Filing Date
FI782494A FI65433C (fi) 1977-08-17 1978-08-16 Foerfarande foer framstaellning av en kristallin form av natriumsaltet av 7-aminotiazolylacetamidocefalosporansyrans oximderivat

Country Status (34)

Country Link
US (1) US4224371A (pt)
EP (1) EP0001024B1 (pt)
JP (1) JPS5441890A (pt)
AT (2) AT366049B (pt)
AU (1) AU520898B2 (pt)
BG (2) BG33887A3 (pt)
CA (1) CA1121343A (pt)
CS (2) CS207646B2 (pt)
DD (1) DD137588A5 (pt)
DE (1) DE2860358D1 (pt)
DK (2) DK152213C (pt)
EG (1) EG13520A (pt)
ES (1) ES472381A1 (pt)
FI (1) FI65433C (pt)
FR (1) FR2400519A1 (pt)
GE (2) GEP19960476B (pt)
GR (1) GR73661B (pt)
HR (1) HRP931395B1 (pt)
HU (1) HU181497B (pt)
IE (1) IE47230B1 (pt)
IL (1) IL55186A (pt)
IT (1) IT1107961B (pt)
MD (2) MD247C2 (pt)
MX (2) MX5448E (pt)
NO (1) NO156168C (pt)
NZ (1) NZ188163A (pt)
OA (1) OA06016A (pt)
PL (1) PL126619B1 (pt)
PT (1) PT68431A (pt)
RO (1) RO79999A (pt)
SI (1) SI7811917A8 (pt)
SU (2) SU799666A3 (pt)
YU (1) YU42166B (pt)
ZA (1) ZA784187B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60120886A (ja) * 1983-12-02 1985-06-28 Takeda Chem Ind Ltd セフェムカルボン酸のナトリウム塩の結晶
JPS60142987A (ja) * 1983-12-29 1985-07-29 Mochida Pharmaceut Co Ltd セフアロスポリン誘導体
DE150507T1 (de) * 1983-12-29 1987-02-26 Mochida Pharmaceutical Co., Ltd., Tokio/Tokyo Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate.
US4840945A (en) * 1985-04-01 1989-06-20 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
US4937330A (en) * 1985-08-12 1990-06-26 The Upjohn Company Conversion of cephalosporin hydrohalide salt to alkali metal salt
US4880798A (en) * 1986-11-25 1989-11-14 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
JPS63132893A (ja) * 1986-11-25 1988-06-04 Mochida Pharmaceut Co Ltd 新規セフアロスポリン誘導体、その製法およびそれらを有効成分とする抗菌剤
RU2021274C1 (ru) 1991-05-17 1994-10-15 Польска Акадэмия Наук Институт Хэмии Органичнэй Способ получения аминотиазолильных производных цефалоспорина
US5318781A (en) * 1993-04-06 1994-06-07 Hoffmann-La Roche Inc. Absorption enhancement of antibiotics
US5574154A (en) * 1994-09-29 1996-11-12 Alnejma Bulk Pharmaceutical Co. A.B.P.C. Process for the preparation of cephalosporanic compounds
GB9423459D0 (en) * 1994-11-21 1995-01-11 Biochemie Gmbh Silylation process
AT402928B (de) * 1994-12-23 1997-09-25 Biochemie Gmbh Neues verfahren zur herstellung von cefotaxim
AU690482B2 (en) * 1996-03-18 1998-04-23 Ranbaxy Laboratories Limited Process for producing cephalosporin antibiotics
GB9717629D0 (en) * 1997-08-21 1997-10-22 Johnson Matthey Plc Removal of residual organic solvents
WO2001092254A1 (fr) * 2000-05-30 2001-12-06 Fujisawa Pharmaceutical Co., Ltd. Procede permettant de remplacer des solvants contenus dans des cristaux de type clathrates
WO2004063203A1 (en) * 2003-01-10 2004-07-29 Orchid Chemicals & Pharmaceuticals Ltd Process for the preparation of cefotaxime sodium
CN100361995C (zh) * 2004-10-27 2008-01-16 山东瑞阳制药有限公司 注射级无菌头孢噻肟钠的一步法制备工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3970651A (en) * 1974-01-07 1976-07-20 Bristol-Myers Company Crystalline cephalosporin derivative
US3985747A (en) * 1974-05-24 1976-10-12 Bristol-Myers Company Crystalline sesquihydrate of 7-[D-α-amino-α-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
US4006138A (en) * 1975-04-11 1977-02-01 Eli Lilly And Company Crystalline form of sodium O-formylcefamandole
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
SE440655B (sv) * 1976-01-23 1985-08-12 Roussel Uclaf Sett att framstella nya oximderivat av 7-amino-tiazolyl-acetamido-cefalosporansyra

Also Published As

Publication number Publication date
JPS5441890A (en) 1979-04-03
US4224371A (en) 1980-09-23
PL126619B1 (en) 1983-08-31
NO156168B (no) 1987-04-27
HRP931395B1 (en) 1996-04-30
DD137588A5 (de) 1979-09-12
EP0001024B1 (fr) 1981-01-21
GEP19960475B (en) 1996-07-22
IT7850648A0 (it) 1978-08-08
DE2860358D1 (en) 1981-03-12
DK163514C (da) 1992-07-27
SI7811917A8 (en) 1997-12-31
IE781669L (en) 1979-02-17
NO782782L (no) 1979-02-20
DK159786A (da) 1986-04-09
MD225C2 (ro) 1995-12-31
DK152213B (da) 1988-02-08
MD247B1 (ro) 1995-07-31
EP0001024A1 (fr) 1979-03-07
PT68431A (fr) 1978-09-01
NZ188163A (en) 1981-10-19
ZA784187B (en) 1979-09-26
ATA52280A (de) 1981-07-15
CS207647B2 (en) 1981-08-31
FI782494A (fi) 1979-02-18
AU3896578A (en) 1980-02-21
BG33888A3 (en) 1983-05-16
CS207646B2 (en) 1981-08-31
JPS6145626B2 (pt) 1986-10-08
ATA563578A (de) 1981-07-15
MX5448E (es) 1983-08-09
PL209080A1 (pl) 1979-06-04
SU852175A3 (ru) 1981-07-30
YU191778A (en) 1983-02-28
YU42166B (en) 1988-06-30
IT1107961B (it) 1985-12-02
DK152213C (da) 1988-07-11
DK361078A (da) 1979-02-18
NO156168C (no) 1987-08-19
AU520898B2 (en) 1982-03-04
CA1121343A (fr) 1982-04-06
AT366050B (de) 1982-03-10
FR2400519A1 (fr) 1979-03-16
GEP19960476B (en) 1996-07-22
MD225B1 (ro) 1995-06-30
DK163514B (da) 1992-03-09
ES472381A1 (es) 1979-03-16
BG33887A3 (en) 1983-05-16
MD247C2 (ro) 1995-12-31
DK159786D0 (da) 1986-04-09
EG13520A (en) 1982-03-31
MX155976A (es) 1988-06-06
FR2400519B1 (pt) 1980-05-16
HU181497B (en) 1983-07-28
IE47230B1 (en) 1984-01-25
AT366049B (de) 1982-03-10
IL55186A0 (en) 1978-09-29
GR73661B (pt) 1984-03-28
FI65433B (fi) 1984-01-31
IL55186A (en) 1981-07-31
RO79999A (ro) 1982-10-11
OA06016A (fr) 1981-06-30
SU799666A3 (ru) 1981-01-23

Similar Documents

Publication Publication Date Title
FI65433C (fi) Foerfarande foer framstaellning av en kristallin form av natriumsaltet av 7-aminotiazolylacetamidocefalosporansyrans oximderivat
RU2118959C1 (ru) ГИДРОХЛОРИД 7β-[(Z)-2-(2-АМИНО-4-ТИАЗОЛИЛ)-2-ГИДРОКСИИМИНОАЦЕТАМИДО]-3-(1,2,3-ТРИАЗОЛ-4-ИЛ)-ТИОМЕТИЛТИО-3-ЦЕФЕМ-4-КАРБОНОВОЙ КИСЛОТЫ, ЕГО КРИСТАЛЛОГИДРАТ И СПОСОБ ИХ ПОЛУЧЕНИЯ
JPS62174018A (ja) 細菌性感染症治療剤
US4483855A (en) Cephalosporin derivative and antibiotic compositions
US20060276463A1 (en) Pure levofloxacin hemihydrate and processes for preparation thereof
US4146710A (en) Solid cephalosporin salt
SE444683B (sv) Syn-isomerer av 3-substituerade 7-amino-tiazolyl-acetamido-cefalosporansyraforeningar och farmaceutiska kompositioner till anvendning mot gram-positiva och gram-negativa bakterier
JPS6337116B2 (pt)
NZ566790A (en) Crystalline sodium salt of cephalosporin antibiotic
JPH0741484A (ja) セフェム化合物及び抗菌剤
CN1145067A (zh) 唑酮的抗螺旋杆菌酯和氨基甲酸酯衍生物
NO158219B (no) Fremgangsmaate for fremstilling av et krystallinsk hemi-syresalt av et cefalosporinderivat.
JP2575590B2 (ja) トリアゾリルチオメチルチオセファロスポリン塩酸塩およびその水和物結晶ならびにそれらの製法
US4959469A (en) Crystalline cephalosporin compounds
IE44319B1 (en) A crystalline sodium salt of cephacetrile
JP7556554B2 (ja) コンテゾリドアセフォサミルの医薬結晶及びその製造方法並びにその使用
KR890000787B1 (ko) 세팔로스포린 유도체 성분의 주사용 또는 외용제의 제조방법
US5068322A (en) Crystalline cephalosporin compounds
DE2404664A1 (de) Neue cephalosporanderivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen
CN104004003B (zh) 头孢克肟衍生物及其制备方法和用途
EP3502124A9 (en) Crystal of sulfate of polymyxin b1, b2, or mixture thereof, and manufacturing method of same
KR100226273B1 (ko) 신규 세팔로스포린계 수용성 유도체 및 그의 제조방법
KR870001017B1 (ko) 7-아미노-1-시클로프로필-6,8-디플루오로-1,4-디히드로-4-옥소퀴놀린-3-카르복실산의 제조 방법
WO2008056221A2 (en) Crystalline sulfate salt of cephalosporin antibiotic
JPS6125028B2 (pt)

Legal Events

Date Code Title Description
MA Patent expired
MA Patent expired

Owner name: ROUSSEL UCLAF SOCIETE ANONYME