MD225C2 - Procedeu de obţinere a formei hidratate cristaline a sării de sodiu a acidului 3-acetoximetil-7-12-(2-amino-4-tiazolil)-2-metoxiiminoacetamido-cef-3-em-4-carbonic, sin-izomerului - Google Patents

Procedeu de obţinere a formei hidratate cristaline a sării de sodiu a acidului 3-acetoximetil-7-12-(2-amino-4-tiazolil)-2-metoxiiminoacetamido-cef-3-em-4-carbonic, sin-izomerului

Info

Publication number
MD225C2
MD225C2 MD94-0267A MD940267A MD225C2 MD 225 C2 MD225 C2 MD 225C2 MD 940267 A MD940267 A MD 940267A MD 225 C2 MD225 C2 MD 225C2
Authority
MD
Moldova
Prior art keywords
natrium
salt
cef
acetoxymethyl
triazolyl
Prior art date
Application number
MD94-0267A
Other languages
English (en)
Russian (ru)
Other versions
MD225B1 (ro
Inventor
Gaston Amiard
Dieter Bormann
Walter Duerckheimer
Jean Jolly
Original Assignee
Roussel Uclaf, Societe Anonyme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9194564&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MD225(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Roussel Uclaf, Societe Anonyme filed Critical Roussel Uclaf, Societe Anonyme
Publication of MD225B1 publication Critical patent/MD225B1/ro
Publication of MD225C2 publication Critical patent/MD225C2/ro

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Invenţia se referă la un procedeu de obţinere a antibioticelor din grupa cefalosporinelor, şi anume a unei noi forme hidratate cristaline a sării de sodiu a acidului 3-acetoximetil-7-[2-(2-amino-4-tiazolil)-2-metoxiiminoacetamido]-cef-3-em-4-carbonic, a sin-izomerului cu formula:Sarcina invenţiei constă în obţinerea unui antibiotic cefalosporinic într-o formă nouă cristalină cu o stabilitate sporită şi hidrofilitate joasă.Procedeul prevede interacţiunea acidului 3-acetoximetil-7-[2-(2-amino-4-tiazolil)-2-2-metoxiiminoacetamido]-cef-3-em-4-carbonic, sin-izometului sau hidratului lui, solvatului etanolic, solvatului formiatic sau a amestecului hidratului şi solvaţilor etanolic sau formiatic, în mediu de metanol cu sarea de sodiu a unui acid organic, selectat din grupa, ce constă din acetat de sodiu, etilhexanoat de sodiu şi dietilacetat de sodiu, etilhexanoat de sodiu şi dietilacetat de soiu.Solvatul metanolic cristalin al sării de sodiu cu formula I, ce se formează, se separă şi, în caz de necesitate, se transformă în sare de sodiu cristalină, ce nu conţine metanol, şi se hidratează sau ea sau nemijlocit solvatul metanolic cristalin al sării de sodiu.
MD94-0267A 1977-08-17 1994-09-08 Procedeu de obţinere a formei hidratate cristaline a sării de sodiu a acidului 3-acetoximetil-7-12-(2-amino-4-tiazolil)-2-metoxiiminoacetamido-cef-3-em-4-carbonic, sin-izomerului MD225C2 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR7725142A FR2400519A1 (fr) 1977-08-17 1977-08-17 Forme cristalline du sel de sodium d'un derive oximine de l'acide 7-amino-thiazolyl acetamido cephalosporanique, son procede de preparation et son application comme medicament
SU782645701A SU799666A3 (ru) 1977-08-17 1978-08-09 Способ получени гидратированной крис-ТАлличЕСКОй фОРМы НАТРиЕВОй СОли 3-АцЕТОКСи-МЕТил-7 2-(2-АМиНО-4-ТиАзОлил)-2-МЕТОКСи-иМиНОАцЕТАМидО цЕф-3-EM-4-КАРбОНОВОй КиС-лОТы,СиН-изОМЕРА
SU802891755A SU852175A3 (ru) 1977-08-17 1980-03-12 Способ получени гидратированнойКРиСТАлличЕСКОй фОРМы НАТРиЕВОйСОли 3-АцЕТОКСиМЕТил-7-/2-(2-АМиНО- 4-ТиАзОлил)-2-МЕТОКСииМиНОАцЕТАМидО/- цЕф-3-EM-4-КАРбОНОВОй КиСлОТы, СиН- изОМЕРА

Publications (2)

Publication Number Publication Date
MD225B1 MD225B1 (ro) 1995-06-30
MD225C2 true MD225C2 (ro) 1995-12-31

Family

ID=9194564

Family Applications (2)

Application Number Title Priority Date Filing Date
MD94-0275A MD247C2 (ro) 1977-08-17 1994-09-08 Procedeu de obţinere a formei hidratate cristaline a sării de sodiu a acidului 3-acetoximetil-7-[2-(2-amino-4-tiazolil)-2-metoxiiminoacetamido] -cef-3-em-4-carbonic, a sin-izomerului
MD94-0267A MD225C2 (ro) 1977-08-17 1994-09-08 Procedeu de obţinere a formei hidratate cristaline a sării de sodiu a acidului 3-acetoximetil-7-12-(2-amino-4-tiazolil)-2-metoxiiminoacetamido-cef-3-em-4-carbonic, sin-izomerului

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MD94-0275A MD247C2 (ro) 1977-08-17 1994-09-08 Procedeu de obţinere a formei hidratate cristaline a sării de sodiu a acidului 3-acetoximetil-7-[2-(2-amino-4-tiazolil)-2-metoxiiminoacetamido] -cef-3-em-4-carbonic, a sin-izomerului

Country Status (34)

Country Link
US (1) US4224371A (ro)
EP (1) EP0001024B1 (ro)
JP (1) JPS5441890A (ro)
AT (2) AT366049B (ro)
AU (1) AU520898B2 (ro)
BG (2) BG33887A3 (ro)
CA (1) CA1121343A (ro)
CS (2) CS207646B2 (ro)
DD (1) DD137588A5 (ro)
DE (1) DE2860358D1 (ro)
DK (2) DK152213C (ro)
EG (1) EG13520A (ro)
ES (1) ES472381A1 (ro)
FI (1) FI65433C (ro)
FR (1) FR2400519A1 (ro)
GE (2) GEP19960476B (ro)
GR (1) GR73661B (ro)
HR (1) HRP931395B1 (ro)
HU (1) HU181497B (ro)
IE (1) IE47230B1 (ro)
IL (1) IL55186A (ro)
IT (1) IT1107961B (ro)
MD (2) MD247C2 (ro)
MX (2) MX5448E (ro)
NO (1) NO156168C (ro)
NZ (1) NZ188163A (ro)
OA (1) OA06016A (ro)
PL (1) PL126619B1 (ro)
PT (1) PT68431A (ro)
RO (1) RO79999A (ro)
SI (1) SI7811917A8 (ro)
SU (2) SU799666A3 (ro)
YU (1) YU42166B (ro)
ZA (1) ZA784187B (ro)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60120886A (ja) * 1983-12-02 1985-06-28 Takeda Chem Ind Ltd セフェムカルボン酸のナトリウム塩の結晶
JPS60142987A (ja) * 1983-12-29 1985-07-29 Mochida Pharmaceut Co Ltd セフアロスポリン誘導体
DE150507T1 (de) * 1983-12-29 1987-02-26 Mochida Pharmaceutical Co., Ltd., Tokio/Tokyo Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate.
US4840945A (en) * 1985-04-01 1989-06-20 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
US4937330A (en) * 1985-08-12 1990-06-26 The Upjohn Company Conversion of cephalosporin hydrohalide salt to alkali metal salt
US4880798A (en) * 1986-11-25 1989-11-14 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
JPS63132893A (ja) * 1986-11-25 1988-06-04 Mochida Pharmaceut Co Ltd 新規セフアロスポリン誘導体、その製法およびそれらを有効成分とする抗菌剤
RU2021274C1 (ru) 1991-05-17 1994-10-15 Польска Акадэмия Наук Институт Хэмии Органичнэй Способ получения аминотиазолильных производных цефалоспорина
US5318781A (en) * 1993-04-06 1994-06-07 Hoffmann-La Roche Inc. Absorption enhancement of antibiotics
US5574154A (en) * 1994-09-29 1996-11-12 Alnejma Bulk Pharmaceutical Co. A.B.P.C. Process for the preparation of cephalosporanic compounds
GB9423459D0 (en) * 1994-11-21 1995-01-11 Biochemie Gmbh Silylation process
AT402928B (de) * 1994-12-23 1997-09-25 Biochemie Gmbh Neues verfahren zur herstellung von cefotaxim
AU690482B2 (en) * 1996-03-18 1998-04-23 Ranbaxy Laboratories Limited Process for producing cephalosporin antibiotics
GB9717629D0 (en) * 1997-08-21 1997-10-22 Johnson Matthey Plc Removal of residual organic solvents
WO2001092254A1 (fr) * 2000-05-30 2001-12-06 Fujisawa Pharmaceutical Co., Ltd. Procede permettant de remplacer des solvants contenus dans des cristaux de type clathrates
WO2004063203A1 (en) * 2003-01-10 2004-07-29 Orchid Chemicals & Pharmaceuticals Ltd Process for the preparation of cefotaxime sodium
CN100361995C (zh) * 2004-10-27 2008-01-16 山东瑞阳制药有限公司 注射级无菌头孢噻肟钠的一步法制备工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3970651A (en) * 1974-01-07 1976-07-20 Bristol-Myers Company Crystalline cephalosporin derivative
US3985747A (en) * 1974-05-24 1976-10-12 Bristol-Myers Company Crystalline sesquihydrate of 7-[D-α-amino-α-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
US4006138A (en) * 1975-04-11 1977-02-01 Eli Lilly And Company Crystalline form of sodium O-formylcefamandole
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
SE440655B (sv) * 1976-01-23 1985-08-12 Roussel Uclaf Sett att framstella nya oximderivat av 7-amino-tiazolyl-acetamido-cefalosporansyra

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Cerere nr. 2439518/23-04, SU, Int. Cl C 07 D 50/60, 1976 *

Also Published As

Publication number Publication date
JPS5441890A (en) 1979-04-03
US4224371A (en) 1980-09-23
PL126619B1 (en) 1983-08-31
NO156168B (no) 1987-04-27
HRP931395B1 (en) 1996-04-30
DD137588A5 (de) 1979-09-12
EP0001024B1 (fr) 1981-01-21
FI65433C (fi) 1984-05-10
GEP19960475B (en) 1996-07-22
IT7850648A0 (it) 1978-08-08
DE2860358D1 (en) 1981-03-12
DK163514C (da) 1992-07-27
SI7811917A8 (en) 1997-12-31
IE781669L (en) 1979-02-17
NO782782L (no) 1979-02-20
DK159786A (da) 1986-04-09
DK152213B (da) 1988-02-08
MD247B1 (ro) 1995-07-31
EP0001024A1 (fr) 1979-03-07
PT68431A (fr) 1978-09-01
NZ188163A (en) 1981-10-19
ZA784187B (en) 1979-09-26
ATA52280A (de) 1981-07-15
CS207647B2 (en) 1981-08-31
FI782494A (fi) 1979-02-18
AU3896578A (en) 1980-02-21
BG33888A3 (en) 1983-05-16
CS207646B2 (en) 1981-08-31
JPS6145626B2 (ro) 1986-10-08
ATA563578A (de) 1981-07-15
MX5448E (es) 1983-08-09
PL209080A1 (pl) 1979-06-04
SU852175A3 (ru) 1981-07-30
YU191778A (en) 1983-02-28
YU42166B (en) 1988-06-30
IT1107961B (it) 1985-12-02
DK152213C (da) 1988-07-11
DK361078A (da) 1979-02-18
NO156168C (no) 1987-08-19
AU520898B2 (en) 1982-03-04
CA1121343A (fr) 1982-04-06
AT366050B (de) 1982-03-10
FR2400519A1 (fr) 1979-03-16
GEP19960476B (en) 1996-07-22
MD225B1 (ro) 1995-06-30
DK163514B (da) 1992-03-09
ES472381A1 (es) 1979-03-16
BG33887A3 (en) 1983-05-16
MD247C2 (ro) 1995-12-31
DK159786D0 (da) 1986-04-09
EG13520A (en) 1982-03-31
MX155976A (es) 1988-06-06
FR2400519B1 (ro) 1980-05-16
HU181497B (en) 1983-07-28
IE47230B1 (en) 1984-01-25
AT366049B (de) 1982-03-10
IL55186A0 (en) 1978-09-29
GR73661B (ro) 1984-03-28
FI65433B (fi) 1984-01-31
IL55186A (en) 1981-07-31
RO79999A (ro) 1982-10-11
OA06016A (fr) 1981-06-30
SU799666A3 (ru) 1981-01-23

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