BG33888A3 - Метод за получаване на кристален хидрат на син изомера на натриевата сол на 3-ацетокси метиловия естер на 7-/2-амино-4-тиайолил/- -2-метоксиамино-ацетамидо-цеф-3-ем-4-карбонова киселина - Google Patents

Метод за получаване на кристален хидрат на син изомера на натриевата сол на 3-ацетокси метиловия естер на 7-/2-амино-4-тиайолил/- -2-метоксиамино-ацетамидо-цеф-3-ем-4-карбонова киселина

Info

Publication number
BG33888A3
BG33888A3 BG042035A BG4203578A BG33888A3 BG 33888 A3 BG33888 A3 BG 33888A3 BG 042035 A BG042035 A BG 042035A BG 4203578 A BG4203578 A BG 4203578A BG 33888 A3 BG33888 A3 BG 33888A3
Authority
BG
Bulgaria
Prior art keywords
bracket
mean
cef
methoxyimino
acetamido
Prior art date
Application number
BG042035A
Other languages
English (en)
Inventor
Gaston Amiard
Dieter Bormann
Walter Duerckheimer
Jean Jolly
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9194564&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG33888(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of BG33888A3 publication Critical patent/BG33888A3/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Метод за получаване на кристален хидрат на син-изомера на натриевата сол на з-ацетоксиметиловия естер на 7-/2-(-2-амино-4-тиазолил)-2-метокиимино-ацетамидо/-цеф-3-ем-4-карбонова киселина с формула.... Патентните претенции са формулирани в 5 точки.
BG042035A 1977-08-17 1978-08-15 Метод за получаване на кристален хидрат на син изомера на натриевата сол на 3-ацетокси метиловия естер на 7-/2-амино-4-тиайолил/- -2-метоксиамино-ацетамидо-цеф-3-ем-4-карбонова киселина BG33888A3 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7725142A FR2400519A1 (fr) 1977-08-17 1977-08-17 Forme cristalline du sel de sodium d'un derive oximine de l'acide 7-amino-thiazolyl acetamido cephalosporanique, son procede de preparation et son application comme medicament

Publications (1)

Publication Number Publication Date
BG33888A3 true BG33888A3 (bg) 1983-05-16

Family

ID=9194564

Family Applications (2)

Application Number Title Priority Date Filing Date
BG040671A BG33887A3 (bg) 1977-08-17 1978-08-15 Метод за получаване на кристален хидрат на син-изомера на натриевата сол на 3-ацетоксиметиловия естер на 7- 2-(2-амино- 4-тиазолил)-2-метоксиимино-ацетамидо-цеф-3-ем-4-карбонова киселина
BG042035A BG33888A3 (bg) 1977-08-17 1978-08-15 Метод за получаване на кристален хидрат на син изомера на натриевата сол на 3-ацетокси метиловия естер на 7-/2-амино-4-тиайолил/- -2-метоксиамино-ацетамидо-цеф-3-ем-4-карбонова киселина

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BG040671A BG33887A3 (bg) 1977-08-17 1978-08-15 Метод за получаване на кристален хидрат на син-изомера на натриевата сол на 3-ацетоксиметиловия естер на 7- 2-(2-амино- 4-тиазолил)-2-метоксиимино-ацетамидо-цеф-3-ем-4-карбонова киселина

Country Status (34)

Country Link
US (1) US4224371A (bg)
EP (1) EP0001024B1 (bg)
JP (1) JPS5441890A (bg)
AT (2) AT366049B (bg)
AU (1) AU520898B2 (bg)
BG (2) BG33887A3 (bg)
CA (1) CA1121343A (bg)
CS (2) CS207646B2 (bg)
DD (1) DD137588A5 (bg)
DE (1) DE2860358D1 (bg)
DK (2) DK152213C (bg)
EG (1) EG13520A (bg)
ES (1) ES472381A1 (bg)
FI (1) FI65433C (bg)
FR (1) FR2400519A1 (bg)
GE (2) GEP19960476B (bg)
GR (1) GR73661B (bg)
HR (1) HRP931395B1 (bg)
HU (1) HU181497B (bg)
IE (1) IE47230B1 (bg)
IL (1) IL55186A (bg)
IT (1) IT1107961B (bg)
MD (2) MD247C2 (bg)
MX (2) MX155976A (bg)
NO (1) NO156168C (bg)
NZ (1) NZ188163A (bg)
OA (1) OA06016A (bg)
PL (1) PL126619B1 (bg)
PT (1) PT68431A (bg)
RO (1) RO79999A (bg)
SI (1) SI7811917A8 (bg)
SU (2) SU799666A3 (bg)
YU (1) YU42166B (bg)
ZA (1) ZA784187B (bg)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60120886A (ja) * 1983-12-02 1985-06-28 Takeda Chem Ind Ltd セフェムカルボン酸のナトリウム塩の結晶
DE3485860T2 (de) * 1983-12-29 1993-01-14 Mochida Pharm Co Ltd Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate.
JPS60142987A (ja) * 1983-12-29 1985-07-29 Mochida Pharmaceut Co Ltd セフアロスポリン誘導体
US4840945A (en) * 1985-04-01 1989-06-20 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
EP0233255B1 (en) * 1985-08-12 1996-05-29 The Upjohn Company Conversion of cephalosporin hydrohalide salt to alkali metal salt
US4880798A (en) * 1986-11-25 1989-11-14 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
JPS63132893A (ja) * 1986-11-25 1988-06-04 Mochida Pharmaceut Co Ltd 新規セフアロスポリン誘導体、その製法およびそれらを有効成分とする抗菌剤
RU2021274C1 (ru) 1991-05-17 1994-10-15 Польска Акадэмия Наук Институт Хэмии Органичнэй Способ получения аминотиазолильных производных цефалоспорина
US5318781A (en) * 1993-04-06 1994-06-07 Hoffmann-La Roche Inc. Absorption enhancement of antibiotics
US5574154A (en) * 1994-09-29 1996-11-12 Alnejma Bulk Pharmaceutical Co. A.B.P.C. Process for the preparation of cephalosporanic compounds
GB9423459D0 (en) * 1994-11-21 1995-01-11 Biochemie Gmbh Silylation process
AT402928B (de) * 1994-12-23 1997-09-25 Biochemie Gmbh Neues verfahren zur herstellung von cefotaxim
AU690482B2 (en) * 1996-03-18 1998-04-23 Ranbaxy Laboratories Limited Process for producing cephalosporin antibiotics
GB9717629D0 (en) * 1997-08-21 1997-10-22 Johnson Matthey Plc Removal of residual organic solvents
WO2001092254A1 (fr) * 2000-05-30 2001-12-06 Fujisawa Pharmaceutical Co., Ltd. Procede permettant de remplacer des solvants contenus dans des cristaux de type clathrates
WO2004063203A1 (en) * 2003-01-10 2004-07-29 Orchid Chemicals & Pharmaceuticals Ltd Process for the preparation of cefotaxime sodium
CN100361995C (zh) * 2004-10-27 2008-01-16 山东瑞阳制药有限公司 注射级无菌头孢噻肟钠的一步法制备工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3970651A (en) * 1974-01-07 1976-07-20 Bristol-Myers Company Crystalline cephalosporin derivative
US3985747A (en) * 1974-05-24 1976-10-12 Bristol-Myers Company Crystalline sesquihydrate of 7-[D-α-amino-α-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
US4006138A (en) * 1975-04-11 1977-02-01 Eli Lilly And Company Crystalline form of sodium O-formylcefamandole
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
SE440655B (sv) * 1976-01-23 1985-08-12 Roussel Uclaf Sett att framstella nya oximderivat av 7-amino-tiazolyl-acetamido-cefalosporansyra

Also Published As

Publication number Publication date
MX5448E (es) 1983-08-09
IL55186A (en) 1981-07-31
DK163514C (da) 1992-07-27
PT68431A (fr) 1978-09-01
EP0001024A1 (fr) 1979-03-07
DD137588A5 (de) 1979-09-12
US4224371A (en) 1980-09-23
IT1107961B (it) 1985-12-02
AT366050B (de) 1982-03-10
MD247B1 (ro) 1995-07-31
AT366049B (de) 1982-03-10
DK152213B (da) 1988-02-08
PL209080A1 (pl) 1979-06-04
AU3896578A (en) 1980-02-21
CS207646B2 (en) 1981-08-31
SU799666A3 (ru) 1981-01-23
YU191778A (en) 1983-02-28
DK159786A (da) 1986-04-09
HRP931395B1 (en) 1996-04-30
BG33887A3 (bg) 1983-05-16
DK159786D0 (da) 1986-04-09
SI7811917A8 (en) 1997-12-31
CS207647B2 (en) 1981-08-31
GR73661B (bg) 1984-03-28
DK163514B (da) 1992-03-09
ATA563578A (de) 1981-07-15
YU42166B (en) 1988-06-30
NO782782L (no) 1979-02-20
MD247C2 (ro) 1995-12-31
RO79999A (ro) 1982-10-11
GEP19960476B (en) 1996-07-22
MD225B1 (ro) 1995-06-30
FR2400519B1 (bg) 1980-05-16
DK152213C (da) 1988-07-11
PL126619B1 (en) 1983-08-31
SU852175A3 (ru) 1981-07-30
AU520898B2 (en) 1982-03-04
JPS5441890A (en) 1979-04-03
ZA784187B (en) 1979-09-26
MD225C2 (ro) 1995-12-31
IL55186A0 (en) 1978-09-29
HU181497B (en) 1983-07-28
FI65433B (fi) 1984-01-31
ES472381A1 (es) 1979-03-16
CA1121343A (fr) 1982-04-06
NZ188163A (en) 1981-10-19
MX155976A (es) 1988-06-06
IE781669L (en) 1979-02-17
IE47230B1 (en) 1984-01-25
EG13520A (en) 1982-03-31
DK361078A (da) 1979-02-18
JPS6145626B2 (bg) 1986-10-08
ATA52280A (de) 1981-07-15
GEP19960475B (en) 1996-07-22
NO156168B (no) 1987-04-27
FI65433C (fi) 1984-05-10
FR2400519A1 (fr) 1979-03-16
EP0001024B1 (fr) 1981-01-21
OA06016A (fr) 1981-06-30
IT7850648A0 (it) 1978-08-08
DE2860358D1 (en) 1981-03-12
FI782494A (fi) 1979-02-18
NO156168C (no) 1987-08-19

Similar Documents

Publication Publication Date Title
BG33888A3 (bg) Метод за получаване на кристален хидрат на син изомера на натриевата сол на 3-ацетокси метиловия естер на 7-/2-амино-4-тиайолил/- -2-метоксиамино-ацетамидо-цеф-3-ем-4-карбонова киселина
CA1224457A (en) Process for the preparation of cephem compounds
PT66353B (fr) Procede de preparation de nouvelles alcoyloximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique
JPS5430194A (en) Cephalosporin derivative and its preparation
ES8503339A1 (es) Procedimiento para la obtencion de tetrahidropiridazinonas
NL7801779A (nl) Werkwijze voor het bereiden van kristallen van natriumcarbonaatmonohydraat.
ES412859A1 (es) Un procedimiento para la preparacion de un derivado de 7- (alfa hidroxi-alfa-fenil) acetamido - 3 - (1 - metil - 1h - tetrazol - 5 - iltiometil) cefalosporina.
LU79313A1 (fr) Procede de preparation de nouvelles oximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique
RO80298A (ro) Procedeu pentru prepararea unor derivati triazolil-alchenici
MA20109A1 (fr) Procede de preparation de composes de cepheme
FR2364922A1 (fr) Sel solide de la cephalosporine et procede pour le preparer
LU79080A1 (fr) Procede de preparation de nouvelles oximes derivees de 1'acide 3-thiadiazolyl thiomethyl 7-amino thiazolyl acetamido cephalosporanique
YU297976A (en) Process for preparing the crystalline from of the cefacetrial sodium salt
BG34904A3 (bg) Метод за получаване на d- сескинатриева сол на окса- бета- лактам
JPS5515454A (en) Novel cephalosporin derivative
IT1078470B (it) Procedimento per la produzione di derivati di acido cefalosporanico
JPS5315395A (en) Cephalosporin derivatives and their preparation
GB1508314A (en) 7-alpha-methoxy-7-beta-(substituted-acetamido)-cephalosporins and methods for their preparation
ES443372A1 (es) Un procedimiento para la preparacion de derivados del acido 3-cefem-4-carboxilico.
JPS52130820A (en) Production of tetrachloronaphthalic acid derivative
JPS5414968A (en) Production of biganite derivative heterocyclic five membered calboxylic acid salt
ES418688A1 (es) Un procedimiento para preparar nuevos derivados de quino- leina.
ES438894A1 (es) Procedimiento de obtencion de los esteres de hidroxibencil- cefalosporinas y sus sales.