MD225C2 - Method of hydrated crystalline form of natrium salt 3-acetoxymethyl-7o2-(2-amino-4-triazolyl)-2-methoxyiminoacetamidou cef-3-em-4-carbonic acid, sin isomer preparation - Google Patents
Method of hydrated crystalline form of natrium salt 3-acetoxymethyl-7o2-(2-amino-4-triazolyl)-2-methoxyiminoacetamidou cef-3-em-4-carbonic acid, sin isomer preparationInfo
- Publication number
- MD225C2 MD225C2 MD94-0267A MD940267A MD225C2 MD 225 C2 MD225 C2 MD 225C2 MD 940267 A MD940267 A MD 940267A MD 225 C2 MD225 C2 MD 225C2
- Authority
- MD
- Moldova
- Prior art keywords
- natrium
- salt
- cef
- acetoxymethyl
- triazolyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to the method of preparation of cefalosporine class antibiotics, namely of new hydrated crystalline form of natrium salt 3-acetoxymethyl-7ő2-(2-amino-4-triazolyl)-2-methoxyiminoacetamidoú cef-3-em-4-carbonic acid, sin-isomer of formula IThe purpose of the invention is preparation of cefalosporine antibiotic in the new crystalline form having increased stability and weak hydrophility.The method forsees interaction of 3-acetoxymethyl-7ő2-(2-amino-4-triazolyl)-2-methoxyiminoacetamidoú cef-3-em-4-carbonic acid, sin-isomer or its hydrate, ethanolic solvate, formic acid solvate or mixture of hydrate and ethanolic or formic acid solvate in the method medium with natrium salt of organic acid, selected from group containing from acetonate of natrium, ethylgexanoate of natrium and diethylacetate of natrium crystalline methanolic solvate of natrium salt of formula I that is formed, it is separated and in the case of necessity is converted in crystalline salt of natrium non containing methanol or directly crystalline methanolic solvate of natrium salt.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7725142A FR2400519A1 (en) | 1977-08-17 | 1977-08-17 | CRYSTALLINE FORM OF SODIUM SALT OF AN OXIMIN DERIVATIVE OF 7-AMINO-THIAZOLYL ACETAMIDO CEPHALOSPORANIC, ITS PREPARATION PROCESS AND ITS APPLICATION AS A MEDICINAL PRODUCT |
| SU782645701A SU799666A3 (en) | 1977-08-17 | 1978-08-09 | Method of preparing hydrated crystalline form of sodium salt of 3-acetoxymethyl-7-/2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido/ceph-3-em-4-carboxyl acid, sin-isomer |
| SU802891755A SU852175A3 (en) | 1977-08-17 | 1980-03-12 | Method of preparing hydrated crystalline form of sodium salt of 3-acetoxymethyl-7-/2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido/-ceph-3-em-4-carboxilic acid, sin-isomer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD225B1 MD225B1 (en) | 1995-06-30 |
| MD225C2 true MD225C2 (en) | 1995-12-31 |
Family
ID=9194564
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0275A MD247C2 (en) | 1977-08-17 | 1994-09-08 | Method of preparation of hydrated crystalline form of natrium salt of 3-acetaoxymethyl-7-(2-(2-amino-4 thiazolyl)-2-methoxyiminoacetamylou-cef-3em-4-carbonic acid, sin-isomer |
| MD94-0267A MD225C2 (en) | 1977-08-17 | 1994-09-08 | Method of hydrated crystalline form of natrium salt 3-acetoxymethyl-7o2-(2-amino-4-triazolyl)-2-methoxyiminoacetamidou cef-3-em-4-carbonic acid, sin isomer preparation |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0275A MD247C2 (en) | 1977-08-17 | 1994-09-08 | Method of preparation of hydrated crystalline form of natrium salt of 3-acetaoxymethyl-7-(2-(2-amino-4 thiazolyl)-2-methoxyiminoacetamylou-cef-3em-4-carbonic acid, sin-isomer |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US4224371A (en) |
| EP (1) | EP0001024B1 (en) |
| JP (1) | JPS5441890A (en) |
| AT (2) | AT366049B (en) |
| AU (1) | AU520898B2 (en) |
| BG (2) | BG33887A3 (en) |
| CA (1) | CA1121343A (en) |
| CS (2) | CS207646B2 (en) |
| DD (1) | DD137588A5 (en) |
| DE (1) | DE2860358D1 (en) |
| DK (2) | DK152213C (en) |
| EG (1) | EG13520A (en) |
| ES (1) | ES472381A1 (en) |
| FI (1) | FI65433C (en) |
| FR (1) | FR2400519A1 (en) |
| GE (2) | GEP19960475B (en) |
| GR (1) | GR73661B (en) |
| HR (1) | HRP931395B1 (en) |
| HU (1) | HU181497B (en) |
| IE (1) | IE47230B1 (en) |
| IL (1) | IL55186A (en) |
| IT (1) | IT1107961B (en) |
| MD (2) | MD247C2 (en) |
| MX (2) | MX155976A (en) |
| NO (1) | NO156168C (en) |
| NZ (1) | NZ188163A (en) |
| OA (1) | OA06016A (en) |
| PL (1) | PL126619B1 (en) |
| PT (1) | PT68431A (en) |
| RO (1) | RO79999A (en) |
| SI (1) | SI7811917A8 (en) |
| SU (2) | SU799666A3 (en) |
| YU (1) | YU42166B (en) |
| ZA (1) | ZA784187B (en) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60120886A (en) * | 1983-12-02 | 1985-06-28 | Takeda Chem Ind Ltd | Crystal of cephemcarboxylic acid sodium salt |
| DE3485860T2 (en) * | 1983-12-29 | 1993-01-14 | Mochida Pharm Co Ltd | CEPHALOSPORINE COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS. |
| JPS60142987A (en) * | 1983-12-29 | 1985-07-29 | Mochida Pharmaceut Co Ltd | Cephalosporin derivative |
| US4840945A (en) * | 1985-04-01 | 1989-06-20 | Mochida Pharmaceutical Co., Ltd. | Cephalosporin derivatives |
| WO1987001117A2 (en) * | 1985-08-12 | 1987-02-26 | The Upjohn Company | Conversion of cephalosporin hydrohalide salt to alkali metal salt |
| JPS63132893A (en) * | 1986-11-25 | 1988-06-04 | Mochida Pharmaceut Co Ltd | Novel cephalosporin derivative, production thereof and antibacterial agent containing said derivative as active ingredient |
| US4880798A (en) * | 1986-11-25 | 1989-11-14 | Mochida Pharmaceutical Co., Ltd. | Cephalosporin derivatives |
| RU2021274C1 (en) | 1991-05-17 | 1994-10-15 | Польска Акадэмия Наук Институт Хэмии Органичнэй | Process for preparing aminothiazolyl cephalosporin derivatives |
| US5318781A (en) * | 1993-04-06 | 1994-06-07 | Hoffmann-La Roche Inc. | Absorption enhancement of antibiotics |
| US5574154A (en) * | 1994-09-29 | 1996-11-12 | Alnejma Bulk Pharmaceutical Co. A.B.P.C. | Process for the preparation of cephalosporanic compounds |
| GB9423459D0 (en) * | 1994-11-21 | 1995-01-11 | Biochemie Gmbh | Silylation process |
| AT402928B (en) * | 1994-12-23 | 1997-09-25 | Biochemie Gmbh | NEW METHOD FOR PRODUCING CEFOTAXIM |
| AU690482B2 (en) * | 1996-03-18 | 1998-04-23 | Ranbaxy Laboratories Limited | Process for producing cephalosporin antibiotics |
| GB9717629D0 (en) * | 1997-08-21 | 1997-10-22 | Johnson Matthey Plc | Removal of residual organic solvents |
| WO2001092254A1 (en) * | 2000-05-30 | 2001-12-06 | Fujisawa Pharmaceutical Co., Ltd. | Method for replacing organic solvents contained in clathrate crystals |
| WO2004063203A1 (en) * | 2003-01-10 | 2004-07-29 | Orchid Chemicals & Pharmaceuticals Ltd | Process for the preparation of cefotaxime sodium |
| CN100361995C (en) * | 2004-10-27 | 2008-01-16 | 山东瑞阳制药有限公司 | One-step preparation process of aseptic cefotaxime sodium for injection |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3970651A (en) * | 1974-01-07 | 1976-07-20 | Bristol-Myers Company | Crystalline cephalosporin derivative |
| US3985747A (en) * | 1974-05-24 | 1976-10-12 | Bristol-Myers Company | Crystalline sesquihydrate of 7-[D-α-amino-α-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid |
| DK154939C (en) * | 1974-12-19 | 1989-06-12 | Takeda Chemical Industries Ltd | METHOD OF ANALOGUE FOR THE PREPARATION OF THIAZOLYLACETAMIDO-CEPHEM COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE SALTS OR ESTERS THEREOF |
| US4006138A (en) * | 1975-04-11 | 1977-02-01 | Eli Lilly And Company | Crystalline form of sodium O-formylcefamandole |
| SE440655B (en) * | 1976-01-23 | 1985-08-12 | Roussel Uclaf | SET TO MAKE NEW OXIME DERIVATIVES OF 7-AMINO-THIAZOLYL-ACETAMIDO-CEPHALOSPORANIC ACID |
| DE2760123C2 (en) * | 1976-01-23 | 1986-04-30 | Roussel-Uclaf, Paris | 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporanic acids, their preparation and pharmaceutical compositions containing them |
-
1977
- 1977-08-17 FR FR7725142A patent/FR2400519A1/en active Granted
-
1978
- 1978-07-20 IL IL55186A patent/IL55186A/en active IP Right Grant
- 1978-07-22 OA OA56566A patent/OA06016A/en unknown
- 1978-07-24 ZA ZA00784187A patent/ZA784187B/en unknown
- 1978-08-02 DD DD78207090A patent/DD137588A5/en unknown
- 1978-08-03 DE DE7878400072T patent/DE2860358D1/en not_active Expired
- 1978-08-03 EP EP78400072A patent/EP0001024B1/en not_active Expired
- 1978-08-03 AT AT0563578A patent/AT366049B/en not_active IP Right Cessation
- 1978-08-04 ES ES472381A patent/ES472381A1/en not_active Expired
- 1978-08-08 CS CS785183A patent/CS207646B2/en unknown
- 1978-08-08 IT IT50648/78A patent/IT1107961B/en active Protection Beyond IP Right Term
- 1978-08-09 SU SU782645701A patent/SU799666A3/en active
- 1978-08-10 YU YU1917/78A patent/YU42166B/en unknown
- 1978-08-10 US US05/932,437 patent/US4224371A/en not_active Expired - Lifetime
- 1978-08-10 SI SI7811917A patent/SI7811917A8/en unknown
- 1978-08-11 MX MX7926A patent/MX155976A/en unknown
- 1978-08-11 MX MX787309U patent/MX5448E/en unknown
- 1978-08-11 GR GR56985A patent/GR73661B/el unknown
- 1978-08-15 BG BG7840671A patent/BG33887A3/en unknown
- 1978-08-15 BG BG7942035A patent/BG33888A3/en unknown
- 1978-08-16 FI FI782494A patent/FI65433C/en not_active IP Right Cessation
- 1978-08-16 RO RO78101982A patent/RO79999A/en unknown
- 1978-08-16 PT PT68431A patent/PT68431A/en unknown
- 1978-08-16 DK DK361078A patent/DK152213C/en not_active IP Right Cessation
- 1978-08-16 NO NO782782A patent/NO156168C/en unknown
- 1978-08-16 HU HU78RO993A patent/HU181497B/en unknown
- 1978-08-16 AU AU38965/78A patent/AU520898B2/en not_active Expired
- 1978-08-16 NZ NZ188163A patent/NZ188163A/en unknown
- 1978-08-16 PL PL1978209080A patent/PL126619B1/en unknown
- 1978-08-16 CA CA000309454A patent/CA1121343A/en not_active Expired
- 1978-08-16 EG EG510/78A patent/EG13520A/en active
- 1978-08-17 IE IE1669/78A patent/IE47230B1/en not_active IP Right Cessation
- 1978-08-17 JP JP9958078A patent/JPS5441890A/en active Granted
-
1979
- 1979-06-27 CS CS794439A patent/CS207647B2/en unknown
-
1980
- 1980-01-31 AT AT0052280A patent/AT366050B/en not_active IP Right Cessation
- 1980-03-12 SU SU802891755A patent/SU852175A3/en active
-
1986
- 1986-04-09 DK DK159786A patent/DK163514C/en not_active IP Right Cessation
-
1993
- 1993-07-31 GE GEAP19931371A patent/GEP19960475B/en unknown
- 1993-07-31 GE GEAP19931355A patent/GEP19960476B/en unknown
- 1993-11-11 HR HRP-1917/78A patent/HRP931395B1/en not_active IP Right Cessation
-
1994
- 1994-09-08 MD MD94-0275A patent/MD247C2/en unknown
- 1994-09-08 MD MD94-0267A patent/MD225C2/en unknown
Non-Patent Citations (1)
| Title |
|---|
| Cerere nr. 2439518/23-04, SU, Int. Cl C 07 D 50/60, 1976 * |
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