FI63014C - Foer framstaellning av nya farmakologiskt aktiva aminobensocykloheptenderivat och deras salter avsedda 5-hydroxi- och 5-oxo-6,7,8,9-tetrahydroaminobensocykloheptenderivat och deras salter - Google Patents

Foer framstaellning av nya farmakologiskt aktiva aminobensocykloheptenderivat och deras salter avsedda 5-hydroxi- och 5-oxo-6,7,8,9-tetrahydroaminobensocykloheptenderivat och deras salter Download PDF

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Publication number
FI63014C
FI63014C FI762107A FI762107A FI63014C FI 63014 C FI63014 C FI 63014C FI 762107 A FI762107 A FI 762107A FI 762107 A FI762107 A FI 762107A FI 63014 C FI63014 C FI 63014C
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FI
Finland
Prior art keywords
mixture
compound
benzocycloheptene
added
tetrahydro
Prior art date
Application number
FI762107A
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English (en)
Finnish (fi)
Other versions
FI63014B (fi
FI762107A (fr
Inventor
Lucien Nedelec
Andre Pierdet
Claude Dumont
Marie-Helene Kannengiesser
Original Assignee
Roussel Uclaf
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Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of FI762107A publication Critical patent/FI762107A/fi
Publication of FI63014B publication Critical patent/FI63014B/fi
Application granted granted Critical
Publication of FI63014C publication Critical patent/FI63014C/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C07D295/116—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/12—One of the condensed rings being a six-membered aromatic ring the other ring being at least seven-membered
FI762107A 1975-07-28 1976-07-23 Foer framstaellning av nya farmakologiskt aktiva aminobensocykloheptenderivat och deras salter avsedda 5-hydroxi- och 5-oxo-6,7,8,9-tetrahydroaminobensocykloheptenderivat och deras salter FI63014C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7523499 1975-07-28
FR7523499A FR2319332A1 (fr) 1975-07-28 1975-07-28 Nouveaux derives de l'aminobenzocycloheptene et leurs sels, procede de preparation et application a titre de medicaments desdits produits

Publications (3)

Publication Number Publication Date
FI762107A FI762107A (fr) 1977-01-29
FI63014B FI63014B (fi) 1982-12-31
FI63014C true FI63014C (fi) 1983-04-11

Family

ID=9158434

Family Applications (1)

Application Number Title Priority Date Filing Date
FI762107A FI63014C (fi) 1975-07-28 1976-07-23 Foer framstaellning av nya farmakologiskt aktiva aminobensocykloheptenderivat och deras salter avsedda 5-hydroxi- och 5-oxo-6,7,8,9-tetrahydroaminobensocykloheptenderivat och deras salter

Country Status (23)

Country Link
US (1) US4091115A (fr)
JP (1) JPS5217455A (fr)
AT (1) AT346303B (fr)
AU (1) AU503674B2 (fr)
BE (1) BE844555A (fr)
CA (1) CA1088070A (fr)
CH (1) CH616647A5 (fr)
DD (1) DD126800A5 (fr)
DE (1) DE2633889C2 (fr)
DK (1) DK143105C (fr)
ES (2) ES450166A1 (fr)
FI (1) FI63014C (fr)
FR (1) FR2319332A1 (fr)
GB (1) GB1503119A (fr)
HU (1) HU175289B (fr)
IE (1) IE44014B1 (fr)
IL (1) IL50116A (fr)
LU (1) LU75470A1 (fr)
NL (1) NL7608398A (fr)
PT (1) PT65413B (fr)
SE (1) SE7607944L (fr)
SU (1) SU682121A3 (fr)
ZA (1) ZA764546B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2365339A1 (fr) * 1976-09-23 1978-04-21 Roussel Uclaf Nouveaux derives de l'aminobenzocycloheptene, ainsi que leurs sels, procede de preparation et application a titre de medicaments de ces nouveaux produits
DK390477A (da) * 1977-05-23 1978-11-24 Sandoz Ag Fremgangsmaade til fremstilling af cycloheptenderivater
FR2409256A1 (fr) * 1977-11-18 1979-06-15 Roussel Uclaf Nouveaux derives de la 5h-benzocycloepten-7-amine et leurs sels, procede de preparation et application a titre de medicament
FR2633617B1 (fr) * 1988-07-04 1991-02-08 Adir Nouveaux derives du benzocycloheptene, leur procede de preparation et les compositions pharmaceutiques les renfermant
JPH051033A (ja) * 1991-06-18 1993-01-08 Tanabe Seiyaku Co Ltd ベンゾシクロヘプテン誘導体及びその製法
JP2003291819A (ja) * 2002-03-29 2003-10-15 Sanyo Electric Co Ltd 台 車
CA2542077A1 (fr) * 2003-10-08 2005-04-21 President And Fellows Of Harvard College Analogues de pyrovalerone et utilisations therapeutiques
JP5513378B2 (ja) * 2007-06-15 2014-06-04 ユニバーシティ オブ フロリダ リサーチ ファウンデーション，インコーポレイテッド 治療化合物
US8278466B2 (en) * 2008-04-28 2012-10-02 Janssen Pharmaceutica Nv Benzocycloheptane and benzoxepine derivatives
EP2427183A4 (fr) * 2009-05-05 2014-01-08 Univ Florida Composés thérapeutiques

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1202791B (de) * 1960-09-19 1965-10-14 Smith Kline French Lab Verfahren zur Herstellung substituierter Cyclopropylamine
US3253037A (en) * 1962-06-19 1966-05-24 Ciba Geigy Corp N-2-alkynyl-amino-benzocylo-alkanes
US3836534A (en) * 1969-05-01 1974-09-17 Colgate Palmolive Co 5-piperazino-6-hydroxy-5h-benzo-cycloheptenes
US3751420A (en) * 1971-04-01 1973-08-07 Squibb & Sons Inc Monoolmonoene amines

Also Published As

Publication number Publication date
ES450166A1 (es) 1977-11-16
JPS5217455A (en) 1977-02-09
PT65413B (fr) 1978-06-09
AU503674B2 (en) 1979-09-13
DE2633889C2 (de) 1982-12-23
DE2633889A1 (de) 1977-02-17
IE44014L (en) 1977-01-28
FI63014B (fi) 1982-12-31
AT346303B (de) 1978-11-10
IL50116A (en) 1979-10-31
PT65413A (fr) 1976-08-01
CA1088070A (fr) 1980-10-21
DK143105C (da) 1981-11-09
AU1629576A (en) 1978-02-02
NL7608398A (nl) 1977-02-01
DK143105B (da) 1981-03-30
CH616647A5 (fr) 1980-04-15
FR2319332A1 (fr) 1977-02-25
ZA764546B (en) 1977-09-28
SU682121A3 (ru) 1979-08-25
GB1503119A (en) 1978-03-08
SE7607944L (sv) 1977-01-29
DD126800A5 (fr) 1977-08-10
US4091115A (en) 1978-05-23
LU75470A1 (fr) 1977-04-06
FR2319332B1 (fr) 1978-11-17
ATA555776A (de) 1978-03-15
FI762107A (fr) 1977-01-29
ES461268A1 (es) 1978-08-16
IL50116A0 (en) 1976-09-30
HU175289B (hu) 1980-06-28
BE844555A (fr) 1977-01-27
IE44014B1 (en) 1981-07-29
DK338376A (da) 1977-01-29

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Owner name: ROUSSEL, UCLAF