JPS5217455A - Production of novel derivatives of aminobenzo cycloheptene and salts thereof and pharmaceutical composition - Google Patents

Production of novel derivatives of aminobenzo cycloheptene and salts thereof and pharmaceutical composition

Info

Publication number
JPS5217455A
JPS5217455A JP51089272A JP8927276A JPS5217455A JP S5217455 A JPS5217455 A JP S5217455A JP 51089272 A JP51089272 A JP 51089272A JP 8927276 A JP8927276 A JP 8927276A JP S5217455 A JPS5217455 A JP S5217455A
Authority
JP
Japan
Prior art keywords
aminobenzo
cycloheptene
salts
production
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP51089272A
Other languages
English (en)
Inventor
Nedoretsuku Riyushian
Pierute Andore
Deyumon Kuroodo
Ereenu Kannanjiese Marii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of JPS5217455A publication Critical patent/JPS5217455A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C07D295/116—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/12—One of the condensed rings being a six-membered aromatic ring the other ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP51089272A 1975-07-28 1976-07-28 Production of novel derivatives of aminobenzo cycloheptene and salts thereof and pharmaceutical composition Pending JPS5217455A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7523499A FR2319332A1 (fr) 1975-07-28 1975-07-28 Nouveaux derives de l'aminobenzocycloheptene et leurs sels, procede de preparation et application a titre de medicaments desdits produits

Publications (1)

Publication Number Publication Date
JPS5217455A true JPS5217455A (en) 1977-02-09

Family

ID=9158434

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51089272A Pending JPS5217455A (en) 1975-07-28 1976-07-28 Production of novel derivatives of aminobenzo cycloheptene and salts thereof and pharmaceutical composition

Country Status (23)

Country Link
US (1) US4091115A (ja)
JP (1) JPS5217455A (ja)
AT (1) AT346303B (ja)
AU (1) AU503674B2 (ja)
BE (1) BE844555A (ja)
CA (1) CA1088070A (ja)
CH (1) CH616647A5 (ja)
DD (1) DD126800A5 (ja)
DE (1) DE2633889C2 (ja)
DK (1) DK143105C (ja)
ES (2) ES450166A1 (ja)
FI (1) FI63014C (ja)
FR (1) FR2319332A1 (ja)
GB (1) GB1503119A (ja)
HU (1) HU175289B (ja)
IE (1) IE44014B1 (ja)
IL (1) IL50116A (ja)
LU (1) LU75470A1 (ja)
NL (1) NL7608398A (ja)
PT (1) PT65413B (ja)
SE (1) SE7607944L (ja)
SU (1) SU682121A3 (ja)
ZA (1) ZA764546B (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003291819A (ja) * 2002-03-29 2003-10-15 Sanyo Electric Co Ltd 台 車
JP2014141514A (ja) * 2007-06-15 2014-08-07 Univ Of Florida Research Foundation Inc 治療化合物
JP2016172750A (ja) * 2009-05-05 2016-09-29 ユニバーシティ オブ フロリダ リサーチ ファウンデーション，インコーポレイテッド 治療化合物

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2365339A1 (fr) * 1976-09-23 1978-04-21 Roussel Uclaf Nouveaux derives de l'aminobenzocycloheptene, ainsi que leurs sels, procede de preparation et application a titre de medicaments de ces nouveaux produits
DK390477A (da) * 1977-05-23 1978-11-24 Sandoz Ag Fremgangsmaade til fremstilling af cycloheptenderivater
FR2409256A1 (fr) * 1977-11-18 1979-06-15 Roussel Uclaf Nouveaux derives de la 5h-benzocycloepten-7-amine et leurs sels, procede de preparation et application a titre de medicament
FR2633617B1 (fr) * 1988-07-04 1991-02-08 Adir Nouveaux derives du benzocycloheptene, leur procede de preparation et les compositions pharmaceutiques les renfermant
JPH051033A (ja) * 1991-06-18 1993-01-08 Tanabe Seiyaku Co Ltd ベンゾシクロヘプテン誘導体及びその製法
JP2007508314A (ja) * 2003-10-08 2007-04-05 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ ピロバレロン類縁体及びそれらの治療的使用
BRPI0911622B8 (pt) 2008-04-28 2021-05-25 Janssen Pharmaceutica Nv derivados de benzoxepina e benzociclo-heptano, seu processo de preparação, seu uso e composição farmacêutica que os compreende

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1202791B (de) * 1960-09-19 1965-10-14 Smith Kline French Lab Verfahren zur Herstellung substituierter Cyclopropylamine
US3253037A (en) * 1962-06-19 1966-05-24 Ciba Geigy Corp N-2-alkynyl-amino-benzocylo-alkanes
US3836534A (en) * 1969-05-01 1974-09-17 Colgate Palmolive Co 5-piperazino-6-hydroxy-5h-benzo-cycloheptenes
US3751420A (en) * 1971-04-01 1973-08-07 Squibb & Sons Inc Monoolmonoene amines

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003291819A (ja) * 2002-03-29 2003-10-15 Sanyo Electric Co Ltd 台 車
JP2014141514A (ja) * 2007-06-15 2014-08-07 Univ Of Florida Research Foundation Inc 治療化合物
JP2016172750A (ja) * 2009-05-05 2016-09-29 ユニバーシティ オブ フロリダ リサーチ ファウンデーション，インコーポレイテッド 治療化合物
US10017458B2 (en) 2009-05-05 2018-07-10 University Of Florida Research Foundation, Incorporated Therapeutic tetrahydronaphthalene compounds

Also Published As

Publication number Publication date
ES461268A1 (es) 1978-08-16
IE44014L (en) 1977-01-28
SU682121A3 (ru) 1979-08-25
IE44014B1 (en) 1981-07-29
ZA764546B (en) 1977-09-28
PT65413B (fr) 1978-06-09
DE2633889A1 (de) 1977-02-17
NL7608398A (nl) 1977-02-01
AU1629576A (en) 1978-02-02
US4091115A (en) 1978-05-23
FI762107A (ja) 1977-01-29
LU75470A1 (ja) 1977-04-06
FR2319332B1 (ja) 1978-11-17
IL50116A0 (en) 1976-09-30
ATA555776A (de) 1978-03-15
FI63014B (fi) 1982-12-31
FI63014C (fi) 1983-04-11
PT65413A (fr) 1976-08-01
DD126800A5 (ja) 1977-08-10
AU503674B2 (en) 1979-09-13
DE2633889C2 (de) 1982-12-23
FR2319332A1 (fr) 1977-02-25
CA1088070A (fr) 1980-10-21
IL50116A (en) 1979-10-31
CH616647A5 (ja) 1980-04-15
BE844555A (fr) 1977-01-27
SE7607944L (sv) 1977-01-29
DK338376A (da) 1977-01-29
GB1503119A (en) 1978-03-08
ES450166A1 (es) 1977-11-16
HU175289B (hu) 1980-06-28
DK143105B (da) 1981-03-30
AT346303B (de) 1978-11-10
DK143105C (da) 1981-11-09

Similar Documents

Publication Publication Date Title
JPS5257176A (en) Production of novel imidazolidine and pharmaceutical composition
IL50836A0 (en) Novel cyclopolypeptides their production and pharmaceutical compositions containing them
JPS523057A (en) Production of imydill benzeneedicarboxylic acid and tricarboxylic acid derivatives and cuarable composition containing same as curing agent
JPS5328178A (en) Production of novel pyperidylindole derivatives * salt thereof and pharmaceutical composition
JPS51146449A (en) Preparation of novel cromanci compound and pharmaceutical composition
JPS51143664A (en) Production of 55aroyll11 loweralkylpyloll22acetic acid derivatives
JPS5268198A (en) Production of novel condensed ririmidine derivatives and pharmaceutical composition containing same
JPS5217455A (en) Production of novel derivatives of aminobenzo cycloheptene and salts thereof and pharmaceutical composition
JPS5350131A (en) Production of novel amidoxime derivatives and pharmaceutical composition
JPS5273835A (en) Production of propionic acid derivatives and pharmaceutical composition
JPS527999A (en) Production of evrnamenine derivatives and pharmaceutical composition
IL51426A0 (en) Novel derivatives of tetrahydroechinocandin b their production and pharmaceutical compositions containing them
IL50904A (en) -aminoketone derivatives process of preparing them and pharmaceutical compositions containing them
JPS51131888A (en) Production of novel 99 alkylaminooerythromycine and pharmaceutical composition containing same
ZA751359B (en) Derivative of gentamine and its salts process of preparation and pharmaceutical compositions
JPS5212150A (en) Production of novel naphthalene derivatives and pharmaceutical composition
JPS5236664A (en) Production of novel 55 thiazolemethaneamine derivatives and salts and pharmaceutical composition
JPS51143663A (en) Production of novel prostaglandine like compound and pharmaceutical composition containing same
JPS525799A (en) Production of indroquinolidine derivative and pharmaceutical composition containing same
JPS5217462A (en) Production of alphaamethyll55 benzoylthiophenee22acetic acid * novel salt thereof and pharmaceutical composition
JPS52113956A (en) Production of novel lactone derivatives of cyclopentanol and pharmaceutical composition
JPS5285126A (en) Novel phenetylamine derivatives* salts thereof and pharmaceutical composition
JPS5253856A (en) Production of prostaglandine like compound and pharmaceutical composition
JPS5217456A (en) Production of novel derivatives of 77aminoo6*77dihydro *5h* benzocycloheptene and salts thereof and pharmaceutical composition
JPS51131877A (en) Production of novel thiazole derivatives and herbicidal composition