FI62667C - Foerfarande foer framstaellning av antiemetiska 1-(benzazolylalkyl)piperidinderivat - Google Patents
Foerfarande foer framstaellning av antiemetiska 1-(benzazolylalkyl)piperidinderivat Download PDFInfo
- Publication number
- FI62667C FI62667C FI762086A FI762086A FI62667C FI 62667 C FI62667 C FI 62667C FI 762086 A FI762086 A FI 762086A FI 762086 A FI762086 A FI 762086A FI 62667 C FI62667 C FI 62667C
- Authority
- FI
- Finland
- Prior art keywords
- dihydro
- benzimidazol
- parts
- formula
- piperidinyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (2)
1. Förfarande för framställning av antiemetiska 1-(bensazo-lylalkyDpiperidin-derivat med formeln I och farmaceutiskt godtag-bara syraadditionssalter därav, Y II E(CH,) -Ah-ICH.) -l/ N//C'\-M (I) 2
" 2" Y_yV/ 2 r7A=Ar8 1 2 i vilken formel R och R betecknar väte, halogen, lägre alkyl eller trifluormetyl, B är en tvävärd -N<L)-CO- eller -N=CH-radi- kal, som är bunden till besinningen via heteroatomen, varvid L är väte, lägre alkyl, lägre alkylkarbonyl eller lägre alkenyl, R3 är väte eller metyl, m och n betecknar ett heltal 1 eller 2, 7 8 R och R betecknar väte, halogen, lägre alkyl eller trifluormetyl, Y är 0 eller S, M är väte, lägre alkyl eller lägre alkylkarbonyl och den streckade linjen är en eventuell bindning mellan kolato-merna 3 och 4 i piperidinringen, förutsatt att, dä Y är S, har piperidinringen en enkelbindning mellan kolatomerna 3 och 4 och M är väte, kännetecknat därav, att man a) omsätter en förening med formeln /Ά r3 B N-(CH_) -CH-(CH0) -x (II) v f 2 m 2 n 12 3 där R , R , R , B, m och n betecknar samma som ovan och X är en reaktiv estergrupp, som är härledd frän motsvarande alkohol, med en förening med formeln 6 2 6 6 7 41 Υ It / \ /\ ΗΝ f—KL Ν-Μ (III) 7 8 där R , R , Υ och M betecknar samma som ovan, i ett lämpligt organiskt lösningsmedel, eller b) avlägsnar skyddsgruppen P pä i och för sig känt sätt frän en förening med formeln
0 Y Il O tl /\ I f~\ /C\ ^-(CH2)m-CH-(CH2)n-N^ ^~M (IV) 1 2 3 7 8 där R,R,R,R,R,m,n, Y och M betecknar samma sora ovan, eller c) cykliserar en förening med formeln R3 " ΐ n_/\ H,li .,ΝΗ-(ΟΗ,) -CH-(CH,) -N ,)-if N-M (V) 1 2 3 7 8 där R, R , R , R , R , m, nY och M betecknar samma som ovan, medelst ett lämpligt cykliseringsmedel pä i och för sig känt sätt, eller d) cykliserar en förening med formeln
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI813935A FI65249C (fi) | 1975-07-21 | 1981-12-08 | Foerfarande foer framstaellning av terapeutiskt anvaendbara 1-enyl-8-bensimidazol-1-ylpropyl-1,3,8-triazaspiro(4,5)deka n--onderivat |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59779375A | 1975-07-21 | 1975-07-21 | |
| US59779375 | 1975-07-21 | ||
| US05/687,139 US4066772A (en) | 1975-07-21 | 1976-05-17 | 1,3-Dihydro-1-[3-(1-piperidinyl)propyl]-2H-benzimidazol-2-ones and related compounds |
| US68713976 | 1976-05-17 | ||
| KR760001697 | 1976-07-12 | ||
| KR7601697A KR810000334B1 (ko) | 1975-07-21 | 1976-07-12 | 1-(벤즈 아조릴알킬) 피페리딘 유도체의 제조방법 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI762086A FI762086A (sv) | 1977-01-22 |
| FI62667B FI62667B (fi) | 1982-10-29 |
| FI62667C true FI62667C (fi) | 1983-02-10 |
Family
ID=27348142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI762086A FI62667C (fi) | 1975-07-21 | 1976-07-20 | Foerfarande foer framstaellning av antiemetiska 1-(benzazolylalkyl)piperidinderivat |
Country Status (25)
| Country | Link |
|---|---|
| JP (1) | JPS5217475A (sv) |
| AT (1) | AT364358B (sv) |
| AU (1) | AU511027B2 (sv) |
| BG (1) | BG26526A3 (sv) |
| CA (1) | CA1085852A (sv) |
| CH (1) | CH623820A5 (sv) |
| CS (1) | CS202550B2 (sv) |
| DE (1) | DE2632870A1 (sv) |
| DK (1) | DK154950C (sv) |
| ES (3) | ES449740A1 (sv) |
| FI (1) | FI62667C (sv) |
| GB (1) | GB1542514A (sv) |
| HK (1) | HK14180A (sv) |
| IE (1) | IE43496B1 (sv) |
| IT (1) | IT1062614B (sv) |
| KE (1) | KE3215A (sv) |
| LU (1) | LU75354A1 (sv) |
| MY (1) | MY8100017A (sv) |
| NL (1) | NL187442C (sv) |
| NZ (1) | NZ181256A (sv) |
| PH (1) | PH13710A (sv) |
| PT (1) | PT65387B (sv) |
| RO (1) | RO70566A (sv) |
| SE (2) | SE426490B (sv) |
| YU (1) | YU39969B (sv) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4501749A (en) * | 1983-10-31 | 1985-02-26 | Merck & Co., Inc. | Peripherally selective dopamine antagonists in the treatment of ocular hypertension |
| JPS6248684A (ja) * | 1985-08-26 | 1987-03-03 | Sumitomo Chem Co Ltd | 新規なヨ−ドブチロフエノン誘導体およびその製造法 |
| JPS62251313A (ja) * | 1986-04-25 | 1987-11-02 | 信越ポリマー株式会社 | 結束装置 |
| US6355659B1 (en) | 1994-07-29 | 2002-03-12 | Laboratorios Del Dr. Esteve, S.A. | 4-(4-Chlorophenyl)-1236-tetrahydro-1(1H-124-triazol-1-yl)butty)pyrideine and salts thereof; pharmaceutical compositions and method of treating psychoses utilizing same |
| FR2723091B1 (fr) * | 1994-07-29 | 1996-11-08 | Esteve Labor Dr | Tetrahydropyridine-(6,4-hydroxypiperidine) alkylazoles |
| PA8603801A1 (es) * | 2003-05-27 | 2004-12-16 | Janssen Pharmaceutica Nv | Derivados de la quinazolina |
| MXPA06007017A (es) | 2003-12-18 | 2006-08-31 | Janssen Pharmaceutica Nv | Derivados de pirido y pirimidopirimidina como agentes antiproliferativos. |
| NI200700147A (es) | 2004-12-08 | 2019-05-10 | Janssen Pharmaceutica Nv | Derivados de quinazolina inhibidores de cinasas dirigidos a multip |
| WO2008006884A2 (en) | 2006-07-13 | 2008-01-17 | Janssen Pharmaceutica N.V. | Mtki quinazoline derivatives |
| EP1997805A1 (en) * | 2007-06-01 | 2008-12-03 | Commissariat à l'Energie Atomique | Compounds with antiparasitic activity, applications thereof to the treatment of infectious diseases caused by apicomplexans |
| DK2185562T3 (en) | 2007-07-27 | 2016-02-22 | Janssen Pharmaceutica Nv | PYRROLOPYRIMIDINES SUITABLE FOR TREATING PROLIFERATIVE DISEASES |
| EP3564240B1 (en) | 2007-08-31 | 2022-04-06 | Purdue Pharma L.P. | Piperidine intermediates |
| US9090618B2 (en) | 2012-12-27 | 2015-07-28 | Purdue Pharma L.P. | Substituted benzimidazole-type piperidine compounds and uses thereof |
| CN108697700B (zh) * | 2016-02-04 | 2021-08-17 | 辛多美制药有限公司 | 氘代多潘立酮组合物和用于治疗病症的方法 |
| US11364226B2 (en) | 2017-06-30 | 2022-06-21 | Cinrx Pharma, Llc | Deuterated domperidone compositions, methods, and preparation |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE633495A (sv) * | 1962-06-13 | |||
| BE633914A (sv) * | 1962-06-22 | |||
| US3629267A (en) * | 1968-10-28 | 1971-12-21 | Smith Kline French Lab | Benzoheterocyclicalkyl derivatives of 4-(2-keto -1-benzimidazolinyl)-piperidine 4-(2-keto - 1 - benzimidazolinyl) -1 2 3 6 tetrahydropyridine 1 - phenyl - 1 3 8-triazaspiro(4 5)decan - 4 - one and 2 4 9-triazaspiro(5 5)undecan-1 3 5-trione |
| AU4698672A (en) * | 1972-09-22 | 1972-11-09 | Ciba-Geigy Ag | Azacycloaliphatic compounds, process for their manufacture and compositions containing them |
| FR2218100A1 (en) * | 1973-02-20 | 1974-09-13 | Janssen Pharmaceutica Nv | Neuroleptic tricyclic derivs. - of benzimidazolinones and triazaspiro-4,5-decan-4-ones |
| US3989707A (en) * | 1974-06-21 | 1976-11-02 | Janssen Pharmaceutica N.V. | Benzimidazolinone derivatives |
-
1976
- 1976-06-23 NZ NZ181256A patent/NZ181256A/xx unknown
- 1976-06-30 GB GB7627242A patent/GB1542514A/en not_active Expired
- 1976-07-07 CA CA256,450A patent/CA1085852A/en not_active Expired
- 1976-07-07 RO RO7686860A patent/RO70566A/ro unknown
- 1976-07-08 PH PH18663A patent/PH13710A/en unknown
- 1976-07-09 ES ES449740A patent/ES449740A1/es not_active Expired
- 1976-07-09 LU LU75354A patent/LU75354A1/xx unknown
- 1976-07-16 AU AU15964/76A patent/AU511027B2/en not_active Expired
- 1976-07-16 CS CS764688A patent/CS202550B2/cs unknown
- 1976-07-19 IT IT50499/76A patent/IT1062614B/it active
- 1976-07-19 JP JP51085216A patent/JPS5217475A/ja active Granted
- 1976-07-20 AT AT0534776A patent/AT364358B/de not_active IP Right Cessation
- 1976-07-20 CH CH929176A patent/CH623820A5/de not_active IP Right Cessation
- 1976-07-20 FI FI762086A patent/FI62667C/fi not_active IP Right Cessation
- 1976-07-20 SE SE7608265A patent/SE426490B/sv not_active IP Right Cessation
- 1976-07-20 DK DK327576A patent/DK154950C/da not_active IP Right Cessation
- 1976-07-20 PT PT65387A patent/PT65387B/pt unknown
- 1976-07-20 NL NLAANVRAGE7608023,A patent/NL187442C/xx not_active IP Right Cessation
- 1976-07-20 IE IE1602/76A patent/IE43496B1/en not_active IP Right Cessation
- 1976-07-20 BG BG7633791A patent/BG26526A3/xx unknown
- 1976-07-21 YU YU1794/76A patent/YU39969B/xx unknown
- 1976-07-21 DE DE19762632870 patent/DE2632870A1/de active Granted
-
1977
- 1977-08-16 ES ES461630A patent/ES461630A1/es not_active Expired
- 1977-08-16 ES ES461631A patent/ES461631A1/es not_active Expired
-
1980
- 1980-03-20 HK HK141/80A patent/HK14180A/xx unknown
- 1980-12-11 SE SE8008713A patent/SE435621B/sv not_active IP Right Cessation
-
1981
- 1981-12-30 MY MY17/81A patent/MY8100017A/xx unknown
-
1982
- 1982-05-21 KE KE3215A patent/KE3215A/xx unknown
Also Published As
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| KR800000491B1 (ko) | 1-벤즈아조릴알킬-4-치환된 피페리딘의 제조방법 | |
| NO145472B (no) | Analogifremgangsmaate til fremstilling av terapeutisk aktive 1-(benzazolylalkyl)piperidin-derivater | |
| KR810001715B1 (ko) | 5-[4-(디아릴메틸)-1-피페라지닐알킬〕벤즈이미다졸 유도체의 제조방법 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired | ||
| MA | Patent expired |
Owner name: JANSSEN PHARMACEUTICA N.V. |