FI120722B - I en nedfryst, vattenhaltig bärarvätska immobiliserade gasbubblasuspensioner - Google Patents
I en nedfryst, vattenhaltig bärarvätska immobiliserade gasbubblasuspensioner Download PDFInfo
- Publication number
- FI120722B FI120722B FI963202A FI963202A FI120722B FI 120722 B FI120722 B FI 120722B FI 963202 A FI963202 A FI 963202A FI 963202 A FI963202 A FI 963202A FI 120722 B FI120722 B FI 120722B
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- FI
- Finland
- Prior art keywords
- microbubbles
- gas
- suspension
- suspensions
- suspension according
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Acoustics & Sound (AREA)
- Physics & Mathematics (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Degasification And Air Bubble Elimination (AREA)
- Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
- Freezing, Cooling And Drying Of Foods (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Treating Waste Gases (AREA)
- Sampling And Sample Adjustment (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Claims (22)
1. Frusen suspension av gasbubblor, immobiliserade inne i en frusen vattenbaserad transportörvätska vid en 5 temperatur mellan -1 °C och -196 °C, där den nämnda trans-portörvätskan, som innehäller gasbubblorna och de vanliga tillsatserna, är en fysiologiskt acceptabel transportör, kännetecknat därav, att immobiliserade gasbubblorna innehäller gaser eller gasblandningar som har kokpunkter 10 under -18 °C och är mikrobubblor som är sammanbundna av ett smältbart hölje av gasformigt/flytande ytaktivt medel med storlekar under 10 pm, där suspensionen, när den är i flytande form, kan bli injekterade och är nyttig som kon-trastmedel för avbildning vid ultraljudsundersökningar av 15 blod och vävnad av levande varelser.
2. Suspension enligt patentkrav 1, känneteck-n a d av att temperaturen av den frusna transportörvätskan är mellan -10 °C och -76 °C.
3. Suspension enligt patentkrav 1, känneteck- 20 nad av att storleken av de fiesta mikrobubblor är mellan , , 2 pm och 9 pm. • · ·
4. Suspension enligt patentkrav 3, känneteck- *·..* nad av att storleken av de fiesta mikrobubblor är mellan • · ·.*·: 3 pm och 5 pm. ·· « • 25
5. Suspension enligt patentkrav 1 eller 2, kän- : netecknad av att tillsatserna inkluderar, som ytaktiva ··· :*·*; medel, lamellära fosfolipider i form av mono- eller mäng- molekylära membranskikt.
,···, 6. Suspension enligt patentkrav 5, känneteck- • · · 30 nad av att de lamellära fosfolipiderna är i form av uni- • * eller multilamellära liposomer. ‘"'i
7. Suspension enligt patentkrav 5, känneteck- *i·*: nad av att de lamellära fosfolipiderna är mättade fosfo- .···. lipider. • » ··· • · 27
8. Suspension enligt patentkrav 6 eller 7, kin-netecknad av att fosfolipiderna är utvalda bland fos-fatidsyra, fosfatidilkolin, fosfatidiletenolamin, fosfati-dilserin, fosfatidilglycerol, fosfatidilinositol, cardio- 5 lipin och sfingomielin eller deras blandningar.
9. Suspension enligt patentkrav 1 eller 2, kän-netecknad av att tillsatserna inkluderar ämnen utvalda bland dicetylfosfat, colesterol, ergosterol, fytosterol, sitosterol, lanosterol, tocoferol, propylgallat, ascorbyl- 10 palmitat och butylhydroxitoluen.
10. Suspension enligt patentkrav 1 eller 2, kän-netecknad av att tillsatserna inkluderar sorbitol eller icke-joniska ytaktiva medel som sampolymerer av poly-oxietylen/polyoxipropilen.
11. Suspension enligt nägot av föregäende patent krav, kännetecknad av att tillsatserna inkluderar viskositetsökningsmedel och/eller stabilisatorer utvalda bland linjära och tvärbundna poly- och oligosackarider, socker, hydrofilpolymerer och joderade föreningar i en 20 viktproportion med de ytaktiva medlen mellan 1:5 och 100:1. • • * ·
12. Suspension enligt nägot av föregäende patent-krav, kännetecknad av att tillsatserna omfattar vida- • · ·.**: re högst 50 vikt-% olaminerade ytaktiva medel, utvalda ·· ♦ j *#ί 25 bland fettalkoholer, estrar och etrar av fettsyra, och al- koholer med polyalkoholer.
13. Suspension enligt patentkrav 12, kanne- * tecknad av att polyalkoholerna Sr polyalkylen glycoler, polyalkylerade socker och andra kolhydrater, och polyalky-30 lerad glycerol. • ·
14. Suspension enligt patentkrav 1 eller 2, kin-netecknad av att den innehäller 107 - 108 mikrobubb- *·**! lor /ml, 108 - 109 mikrobubblor/ml eller 109 - 1010 mikro- .··*, bubblor/ml. ««· • · 28
15. Suspension enligt patentkrav 1, kfinneteck-nad av att gasen är utvald bland de gaser som innehäller halogen, luft, syre, kväve, koldioxid eller blandningar av dessa.
16. Suspension enligt patentkrav 15, känne- tecknad av att gasen som innehäller halogen är utvald bland gruppen som bestär av SF6, CF4, C2F6, C2F8, C3F6, C3F8, C4F6, C4F8, C4F10, C5F10, C5F12 och blandningar av dessa.
17. Metod för framställning av frusna suspensioner av gasbubblor enligt patentkrav 1 - 16, kännetecknad av följande etapper: a) den flytande suspensionen av de nämnda mikro-bubblorna placeras i en avkylningsanordning, 15 b) mikrobubblorna immobiliseras genom avkylning till en temper a tur mellan -1 °C och -196 °C, företrädesvis en temperatur mellan -10 °C och -76 °C och, c) frysningsförhällandena underhälls för längtids-perioder.
18. Metod enligt patentkrav 17, kännetecknad av att den frusna suspensionen underhälls i en miljö av · • · * *: inertgas eller gasblandning, där ätminstone en gas är den ·· gas som är inkapsulerad i mikrobubblorna. * · ϊ/··
19. Metod enligt patentkrav 17, kännetecknad :***! 25 av att mikrobubblorna innehäller en gas eller gasbland- : ;*j ning, där ätminstone en gas har en kokpunkt under -18 °C. ·*·
20. Metod enligt patentkrav 17, kännetecknad • * av att suspensionen är upptinad och underhällen i rumstem- #... peratur för en period före användning. • · · U, 30
21. Användning av en frusen suspension enligt nä- • · *·** got av patentkraven 1-16 för framställning av en suspen- *i·*: sion för injektion för användning i ultraljudsavbildningen *:··· av organer och vävnader. y.·
22. Användning av en frusen suspension enligt nä- • · ***. 35 got av patentkraven 1-16 för framställing av en suspen sion för injektion för användning i framställning av eko-grafiska kontrastmedel för ultraljudsundersökning.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP94810731 | 1994-12-16 | ||
| EP94810731 | 1994-12-16 | ||
| IB9501124 | 1995-12-14 | ||
| PCT/IB1995/001124 WO1996018420A1 (en) | 1994-12-16 | 1995-12-14 | Method of storage of ultrasonic gas suspensions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI963202A FI963202A (sv) | 1996-08-15 |
| FI963202A0 FI963202A0 (sv) | 1996-08-15 |
| FI120722B true FI120722B (sv) | 2010-02-15 |
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ID=8218355
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI963202A FI120722B (sv) | 1994-12-16 | 1996-08-15 | I en nedfryst, vattenhaltig bärarvätska immobiliserade gasbubblasuspensioner |
Country Status (19)
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| EP (1) | EP0744962B2 (sv) |
| JP (1) | JP3958358B2 (sv) |
| KR (1) | KR100382811B1 (sv) |
| CN (1) | CN1066965C (sv) |
| AT (1) | ATE205404T1 (sv) |
| AU (1) | AU701807B2 (sv) |
| CA (1) | CA2181340C (sv) |
| CZ (1) | CZ291540B6 (sv) |
| DE (1) | DE69522670T3 (sv) |
| DK (1) | DK0744962T4 (sv) |
| ES (1) | ES2162943T5 (sv) |
| FI (1) | FI120722B (sv) |
| IL (1) | IL116328A (sv) |
| NO (1) | NO313031B1 (sv) |
| NZ (1) | NZ295744A (sv) |
| PT (1) | PT744962E (sv) |
| WO (1) | WO1996018420A1 (sv) |
| ZA (1) | ZA9510721B (sv) |
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| US6397098B1 (en) | 1994-09-21 | 2002-05-28 | Medrad, Inc. | Data communication and control for medical imaging systems |
| US5837221A (en) * | 1996-07-29 | 1998-11-17 | Acusphere, Inc. | Polymer-lipid microencapsulated gases for use as imaging agents |
| GB9617811D0 (en) | 1996-08-27 | 1996-10-09 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| US6610764B1 (en) | 1997-05-12 | 2003-08-26 | Metabolix, Inc. | Polyhydroxyalkanoate compositions having controlled degradation rates |
| US6867248B1 (en) | 1997-05-12 | 2005-03-15 | Metabolix, Inc. | Polyhydroxyalkanoate compositions having controlled degradation rates |
| US6828357B1 (en) | 1997-07-31 | 2004-12-07 | Metabolix, Inc. | Polyhydroxyalkanoate compositions having controlled degradation rates |
| GB9717589D0 (en) * | 1997-08-19 | 1997-10-22 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| ZA9811087B (en) | 1997-12-04 | 1999-06-03 | Bracco Research Sa | Automatic liquid injection system and method |
| EP2258742A1 (en) | 1997-12-22 | 2010-12-08 | Metabolix, Inc. | Polyhydroxyalkanoate compositons having controlled degradation rates |
| DE19805012A1 (de) * | 1998-02-07 | 1999-08-12 | Thomas Gieselmann | Kontrastmittel zur Verwendung als Diagnostikum bei bildgebenden Verfahren sowie seine Herstellung |
| DE19840536A1 (de) | 1998-08-28 | 2000-03-09 | Schering Ag | Mit Ultraschallkontrastmittel gefüllte Spritze mit einer magnetischen Bewegungsvorrichtung |
| DE19840532A1 (de) | 1998-08-28 | 2000-03-09 | Schering Ag | Mit Ultraschallkonstrastmittel gefüllte Spritze mit einer mechanischen Bewegungsvorrichtung |
| US6514515B1 (en) | 1999-03-04 | 2003-02-04 | Tepha, Inc. | Bioabsorbable, biocompatible polymers for tissue engineering |
| US6317623B1 (en) | 1999-03-12 | 2001-11-13 | Medrad, Inc. | Apparatus and method for controlling contrast enhanced imaging procedures |
| US6575930B1 (en) | 1999-03-12 | 2003-06-10 | Medrad, Inc. | Agitation devices and dispensing systems incorporating such agitation devices |
| DK1163019T3 (da) | 1999-03-25 | 2008-03-03 | Metabolix Inc | Medicinske indretninger og anvendelser af polyhydroxyalkanoatpolymere |
| WO2001012069A1 (en) | 1999-08-13 | 2001-02-22 | Point Biomedical Corporation | Hollow microspheres with controlled fragility for medical use |
| EP2286843A3 (en) | 2000-06-02 | 2011-08-03 | Bracco Suisse SA | Compounds for targeting endothelial cells |
| US6387077B1 (en) | 2000-10-13 | 2002-05-14 | Mallinckrodt Inc. | Apparatus and method for providing a suspended agent |
| EP1387637B1 (en) | 2001-04-06 | 2007-10-31 | Bracco Research S.A. | Apparatus for measuring local physical parameters in a fluid filled cavity |
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