FI120718B - Förfarande för framställning av vätskefyllda mjuka gelatinkapslar - Google Patents

Förfarande för framställning av vätskefyllda mjuka gelatinkapslar Download PDF

Info

Publication number
FI120718B
FI120718B FI944452A FI944452A FI120718B FI 120718 B FI120718 B FI 120718B FI 944452 A FI944452 A FI 944452A FI 944452 A FI944452 A FI 944452A FI 120718 B FI120718 B FI 120718B
Authority
FI
Finland
Prior art keywords
capsule
capsule shell
propylene glycol
gelatin
component
Prior art date
Application number
FI944452A
Other languages
English (en)
Finnish (fi)
Other versions
FI944452A0 (sv
FI944452A (sv
Inventor
Werner Brox
Armin Meinzer
Horst Zande
Original Assignee
Novartis Ag
Scherer Gmbh R P
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6498793&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI120718(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag, Scherer Gmbh R P filed Critical Novartis Ag
Publication of FI944452A0 publication Critical patent/FI944452A0/sv
Publication of FI944452A publication Critical patent/FI944452A/sv
Application granted granted Critical
Publication of FI120718B publication Critical patent/FI120718B/sv

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Cosmetics (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)

Claims (15)

1. Förfarande för framställning av en vätske-fylld mjuk gelatinkapsel som innehäller en farmakolo-giskt aktiv substans i ett bärarmedium och uppvisar 5 ett kapselskal och ett kapselinnehäll, kanne-tecknat av att kapselskalet innehäller gelatin och en migrerande komponent 1,2-propylenglykol som ocksä finns i kapselinnehället och som är ett lös-ningsmedel för den aktiva substansen, varvid kapselin-10 nehället är i form av en mikroemulsionsförkoncentrat, gelatinet är i form av band och vid vilket förfarande kapselskalet bildas genom att avkyla gelatinband och avkylningen genomförs genom att använda ett flytande kylmedel. 15
2. Förfarande enligt patentkrav 1, vid vilket förfarande kapselskalet innehäller gelatin, mjuknings-medel och, om det är önskvärt eller nödvändigt, andra hjälpmedel, varvid lösningsmedlet ätminstone delvis är 1,2-propylenglykol, men inte huvudsakligen polyety-20 lenglykol, kännetecknat av att kapselskalet innehäller 1,2-propylenglykol.
·*·,· 3. Förfarande enligt patentkrav 1 eller 2, • 1 kännetecknat av att kapselskalet innehäller ,·] minst 5 vikt-% migrerande komponent. 25
4. Förfarande enligt nägot av patentkraven 1- ***; 3, kännetecknat av att kapselskalet inne- ··· ·*” häller 2-40 vikt-% migrerande komponent. *·1
: 5. Förfarande enligt nägot av patentkraven 1- 4, kännetecknat av att kapselinnehället in-ϊ,ϊ ϊ 30 nehäller etanol som hjälplösningsmedel.
!***: 6. Förfarande enligt nägot av patentkraven 1- , 5, kännetecknat av att kapselskalet, efter * *j torkningen, innehäller upp till32 vikt-% migrerande ' * komponent. :]*|i 35
7. Förfarande enligt patentkrav 6, k ä n - ·*·*. netecknat av att det torkade kapselskalet in- * · nehäller 10 - 32 vikt-% migrerande komponent.
8. Förfarande enligt nägot av patentkraven 1-7, kännetecknat av att kapselskalet ocksä innehäller glycerol.
9. Förfarande enligt nägot av patentkraven 1- 5 8, kännetecknat av att förfarande den mjuka gelatinkapsel ocksä innehäller en farmakologiskt aktiv substans vars löslighet i vatten är mindre än 1% (vikt/volym).
10. Förfarande enligt patentkrav 9, k ä n -10 netecknat av att den farmakologiskt aktiva substansen är cyklosporin.
11. Förfarande enligt patentkrav 10 kännetecknat av att den farmakologiskt aktiva substansen har valts bland cyklosporin A, cyklosporin G, 15 [3'-desoxy-3'-oxo-MeBmt]1[Vai]2-ciklosporin.
12. Förfarande enligt patentkrav 9, kännetecknat av att förfarande den farmakologiskt aktiva substansen är makrolid.
13. Förfarande enligt patentkrav 12, k ä n -20 netecknat av att förfarande den farmakologiskt aktiva substansen har valts bland rapamycin, 40-0-(2- , , hydroxi)-etyl-rapamycin, FK506, askomycin eller 33- • · · epi-kloro-33-FR 520. • · i ί·ί
: 14. Förfarande enligt patentkrav 8, k ä n - 25 netecknat av att förfarande viktförhällandet ♦ ..*·* mellan migrerande komponent och glycerol är 1:1 ·;· 1:0,2.
·*:*; 15. Förfarande enligt patentkrav 1, k ä n - netecknat av att vatten används som kylmedel. ... 30 • · · • * · ·· e · • · • t· t • φ • · · • ·· « · ··· • · • * ··· 1 · • i · • e •
FI944452A 1993-09-28 1994-09-26 Förfarande för framställning av vätskefyllda mjuka gelatinkapslar FI120718B (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4332931 1993-09-28
DE4332931 1993-09-28

Publications (3)

Publication Number Publication Date
FI944452A0 FI944452A0 (sv) 1994-09-26
FI944452A FI944452A (sv) 1995-03-29
FI120718B true FI120718B (sv) 2010-02-15

Family

ID=6498793

Family Applications (1)

Application Number Title Priority Date Filing Date
FI944452A FI120718B (sv) 1993-09-28 1994-09-26 Förfarande för framställning av vätskefyllda mjuka gelatinkapslar

Country Status (31)

Country Link
US (4) US5985321A (sv)
EP (3) EP1033128B2 (sv)
JP (1) JP3071642B2 (sv)
KR (1) KR100200174B1 (sv)
CN (2) CN1182842C (sv)
AT (2) ATE398448T1 (sv)
AU (1) AU690571B2 (sv)
CA (3) CA2302963C (sv)
CZ (1) CZ290314B6 (sv)
DE (2) DE69435104D1 (sv)
DK (2) DK1033128T4 (sv)
ES (2) ES2152281T3 (sv)
FI (1) FI120718B (sv)
FR (1) FR2710532B1 (sv)
GB (1) GB2282586B (sv)
GR (1) GR3035179T3 (sv)
HK (1) HK1078478A1 (sv)
HU (2) HU221681B1 (sv)
IL (1) IL111067A (sv)
IT (1) IT1274931B (sv)
NO (1) NO312334B1 (sv)
NZ (1) NZ264536A (sv)
PE (1) PE31295A1 (sv)
PL (1) PL178884B1 (sv)
PT (2) PT649651E (sv)
RU (1) RU2140783C1 (sv)
SG (1) SG46531A1 (sv)
SI (2) SI0649651T1 (sv)
SK (2) SK285204B6 (sv)
TW (1) TW438609B (sv)
ZA (1) ZA947567B (sv)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0623018B1 (de) * 1992-01-17 1995-12-27 ALFATEC-PHARMA GmbH Verfahren zur herstellung von weichgelatinekapseln nach einem tropfverfahren
US6204243B1 (en) 1993-09-01 2001-03-20 Novatis Ag Pharmaceutical preparations for the targeted treatment of crohn's disease and ulcerative colitis
DE69435104D1 (de) 1993-09-28 2008-07-31 Scherer Gmbh R P Herstellung von Weichgelatinekapseln
PE52896A1 (es) * 1994-10-26 1996-12-12 Novartis Ag Composicion farmaceutica
US7205279B2 (en) * 1995-10-25 2007-04-17 Novartis Ag Pharmaceutical compositions
GB2308545B (en) * 1994-10-26 1999-06-02 Novartis Ag Pharmaceutical microemulsion preconcentrates
US5603951A (en) * 1994-11-09 1997-02-18 Hanmi Pharm. Ind. Co., Ltd. Cyclosporin-containing soft capsule compositions
NZ280689A (en) * 1995-12-15 1997-08-22 Bernard Charles Sherma Sherman Pharmaceutical composition comprising a cyclosporipharmaceutical composition comprising a cyclosporin; a tocol, tocopherol or tocotrienol; and propylen; a tocol, tocopherol or tocotrienol; and propylene carbonate or polyethylene glycol ne carbonate or polyethylene glycol
US5858401A (en) 1996-01-22 1999-01-12 Sidmak Laboratories, Inc. Pharmaceutical composition for cyclosporines
JPH1071186A (ja) * 1996-08-29 1998-03-17 Shionogi & Co Ltd カプセルのバンドシール形成方法
GB2355195B (en) 1997-01-30 2001-09-12 Novartis Ag Oil-free pharmaceutical compositions containing cyclosporin A
PT982035E (pt) * 1998-08-18 2004-08-31 Panacea Biotec Ltd Composicao de ciclosporina compreendendo um veiculo hidrofilo
HU226498B1 (en) * 1998-11-17 2009-03-02 Hoffmann La Roche Process for the manufacture of liquid filled capsules
DK1154759T3 (da) 1998-12-30 2008-12-08 Dexcel Ltd Dispergerbart koncentrat til indgift af cyclosporin
US20030104048A1 (en) * 1999-02-26 2003-06-05 Lipocine, Inc. Pharmaceutical dosage forms for highly hydrophilic materials
EP1200090B1 (en) * 1999-08-03 2013-09-11 ICOS Corporation Pharmaceutical formulation comprising a beta-carboline and its use for treating sexual dysfunction
JP4601100B2 (ja) * 1999-11-08 2010-12-22 三生医薬株式会社 マスティックの油液を内包した軟カプセル
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
CA2422580C (en) * 2000-09-18 2011-05-17 Rpg Life Sciences Limited Selfemulsifiable formulation having enhanced bioabsorption and immunosuppression activities
ATE275391T1 (de) * 2000-10-12 2004-09-15 Boehringer Ingelheim Pharma Neue tiotropium-haltige inhalationspulver
KR100847679B1 (ko) * 2000-10-31 2008-07-23 베링거 인겔하임 파마슈티칼즈, 인코포레이티드 피라논 프로테아제 억제제의 경구 투여 자가-유화 제형
JP4214350B2 (ja) * 2001-01-15 2009-01-28 日本電気株式会社 携帯電話のｓｉｍカード取り付け構造
US20030138483A1 (en) * 2001-05-25 2003-07-24 Sergio Petriconi Soft elastic capsules and compositions thereof
US20030070679A1 (en) * 2001-06-01 2003-04-17 Boehringer Ingelheim Pharma Kg Capsules containing inhalable tiotropium
US20040013732A1 (en) * 2001-09-25 2004-01-22 Michael Farber Starch-based delivery system for creatine
CA2461730C (en) * 2001-10-19 2012-05-15 Isotechnika Inc. Novel cyclosporin analog microemulsion preconcentrates
US6752953B2 (en) * 2001-12-03 2004-06-22 Yung Shin Pharmaceutical Co., Ltd. Method for manufacturing hard non-gelatin pharmaceutical capsules
KR20030062894A (ko) * 2002-01-21 2003-07-28 주식회사 보창 소프트젤라틴캡슐제조기의 성형드럼 냉각장치
US7067150B2 (en) 2002-04-16 2006-06-27 Scepter Holdings, Inc. Delivery systems for functional ingredients
AU2003256844A1 (en) * 2002-07-29 2004-02-16 Alza Corporation Methods and dosage forms for controlled delivery of paliperidone
US7763280B2 (en) * 2002-11-28 2010-07-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing powder formulation for inhalation
KR100525234B1 (ko) * 2003-02-19 2005-10-28 한국유나이티드제약 주식회사 사이클로스포린 함유 연질캅셀제 및 그 제조방법
US7134978B2 (en) * 2003-07-28 2006-11-14 Sagittarius Life Science Corporation Seamless BB paintball
US7247010B2 (en) * 2003-10-01 2007-07-24 Technophar Equipment & Service Limited Servo control for capsule making machine
FR2861992B1 (fr) * 2003-11-10 2007-07-20 Sanofi Synthelabo Composition pharmaceutique destinee a l'administration orale d'un derive de pyrazole-3-carboxamide.
CA2546004C (en) * 2003-11-12 2010-09-14 National Paintball Supply, Inc. Projectile, projectile core, and method of making
US20050175686A1 (en) * 2004-02-11 2005-08-11 Ramachandran Radhakrishnan Drug delivery system using a solubilized gelatin shell composition and unit dose drug delivery using a special shape soft gelatin capsule
JP2005255677A (ja) * 2004-02-12 2005-09-22 Nof Corp シクロスポリン製剤
US20080160086A1 (en) * 2004-02-19 2008-07-03 Scepter Holdings, Inc. Delivery Systems For Calcium
US20060153824A1 (en) * 2005-01-13 2006-07-13 Everett Laboratories, Inc. Methods and kits for co-administration of nutritional supplements
MX2007011250A (es) 2005-03-21 2007-11-14 Ivax Pharmaceuticals Sro Inhibidor de la cristalizacion y su uso en capsulas de gelatina.
US20060275361A1 (en) * 2005-06-03 2006-12-07 Cadbury Adams Usa Llc. Rapidly dissolving gelatin compositions and products made therefrom
CN102579467A (zh) 2005-11-14 2012-07-18 阿里亚德医药股份有限公司 雷帕霉素衍生物在治疗癌症中的用途
CN1919194A (zh) * 2006-08-17 2007-02-28 刘瑜玲 西罗莫司的液体组合物
CA2677036A1 (en) * 2007-03-06 2008-09-12 Bioriginal Food & Science Corp. Soft gelatin capsule shells containing oil soluble flavoring and methods of making the same
US20090110724A1 (en) * 2007-10-31 2009-04-30 Everett Laboratories, Inc. Compositions and methods for treatment of pain
PE20130307A1 (es) 2008-09-16 2013-03-22 Boehringer Ingelheim Int Formas cristalinas de un derivado de 2-tiazolil-4-quinolinil-oxi, un potente inhibidor de hcv
DK2365802T3 (da) 2008-11-11 2017-11-13 Univ Texas Mikrokapsler af rapamycin og anvendelse til behandling af cancer
GEP20146016B (en) 2009-07-07 2014-01-27 Boehringer Ingelheim Int Pharmaceutical composition containing hepatitis c viral protease inhibitor
US9283211B1 (en) 2009-11-11 2016-03-15 Rapamycin Holdings, Llc Oral rapamycin preparation and use for stomatitis
US8530497B2 (en) 2010-03-11 2013-09-10 Boehringer Ingelheim International Gmbh Crystalline salts of a potent HCV inhibitor
GB201006012D0 (en) * 2010-04-09 2010-05-26 Ayanda As Composition
EP2595610A4 (en) * 2010-07-19 2015-10-28 Procaps S A IMPROVED DEVICE AND METHOD FOR PRODUCING SOFT GEL CAPSULES
AP2013006733A0 (en) 2010-09-30 2013-02-28 Boehringer Ingelheim Int Solid state forms of a potent HCV inhibitor
US20120107395A1 (en) * 2010-11-01 2012-05-03 Viva Pharmaceutical Inc. Probiotic Soft Gel Compositions
US8621764B2 (en) 2011-03-16 2014-01-07 John PUCKETT Gelatin capsule formulation and drying system
AU2012240313A1 (en) 2011-04-04 2013-05-02 Gilead Sciences, Inc. Solid state forms of HIV inhibitor
CN103732255B (zh) * 2011-09-02 2016-04-06 富士胶片株式会社 软胶囊制剂、软胶囊制剂用组合物及软胶囊制剂的制造方法
US20130261134A1 (en) 2012-03-30 2013-10-03 Boehringer Ingelheim International Gmbh Mesylate salt forms of a potent hcv inhibitor
WO2014055618A1 (en) 2012-10-03 2014-04-10 Gilead Sciences, Inc. Solid state forms of hiv inhibitor: hemi-succinate of (2s)-2-tert-butoxy-2-(4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl)acetic acid)
DK2968281T3 (da) 2013-03-13 2020-11-02 Univ Texas Mtor-hæmmere til forebyggelse af vækst af tarmpolyp
CN103315975B (zh) * 2013-06-05 2015-09-02 天津科技大学 一种明胶-CaCO3矿物质胶囊壳及其制备方法
LT3024463T (lt) * 2013-07-25 2020-07-10 Neuren Pharmaceuticals Limited Neuroapsauginiai bicikliniai junginiai ir jų panaudojimo būdai autizmo spektro sutrikimų ir neuroliginių vystymosi sutrikimų gydymui
US9700544B2 (en) 2013-12-31 2017-07-11 Neal K Vail Oral rapamycin nanoparticle preparations
CA2933908C (en) 2013-12-31 2024-01-30 Rapamycin Holdings, Llc Oral rapamycin nanoparticle preparations and use
AU2016308568A1 (en) * 2015-08-19 2018-02-22 Vivus Llc Pharmaceutical formulations
CN112240659A (zh) * 2020-10-17 2021-01-19 温州桑盾信息科技有限公司 一种胶囊机安全防护用自动降温机构

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4198391A (en) * 1973-07-20 1980-04-15 R. P. Scherer Ltd. Pharmaceutical compositions
US3870547A (en) 1974-01-24 1975-03-11 Owens Corning Fiberglass Corp Starch coated fibers for embedding in resin matrix forming materials and composites so formed
AT366576B (de) * 1974-02-22 1982-04-26 Wellcome Found Verfahren zur herstellung von pharmazeutischen praeparaten
GB1508770A (en) 1974-04-01 1978-04-26 Scherer Ltd R Pharmaceutical compositions
US4067960A (en) * 1975-06-20 1978-01-10 R. P. Scherer Limited Pharmaceutical compositions containing cardiac glycoside
FI65914C (fi) * 1978-03-07 1984-08-10 Sandoz Ag Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
JPS5933018B2 (ja) * 1980-03-17 1984-08-13 森下仁丹株式会社 高融点物質のマイクロカプセル製造方法とその製造装置
DE3237814A1 (de) * 1982-10-12 1984-04-12 Warner-Lambert Co., 07950 Morris Plains, N.J. Wasserfreie emulsionen und verwendung derselben
DE3307353C2 (de) * 1983-03-02 1985-01-31 R.P. Scherer GmbH, 6930 Eberbach Polyethylenglykolhaltige Weichgelatinekapsel und Verfahren zu ihrer Herstellung
GB8305693D0 (en) * 1983-03-02 1983-04-07 Scherer Ltd R P Pharmaceutical compositions
DE3406497A1 (de) 1984-02-23 1985-09-05 Mueller Bernhard Willi Werner Hochdisperse pharmazeutische mehrkomponentensysteme und verfahren zu ihrer herstellung
US4609403A (en) * 1984-03-12 1986-09-02 Warner-Lambert Company Foam soft gelatin capsules and their method of manufacture
US4713246A (en) 1984-03-19 1987-12-15 Bristol-Myers Company Etoposide oral dosage form
DE3579384D1 (de) * 1984-07-24 1990-10-04 Scherer Gmbh R P Oxytetracyclin-hc1-weichgelatinekapseln und verfahren zu ihrer herstellung.
DE3445237C1 (de) * 1984-12-12 1986-06-05 R.P. Scherer GmbH, 6930 Eberbach Weichgelatinekapseln und Verfahren zu ihrer Herstellung
DE3529694A1 (de) 1985-08-20 1987-02-26 Scherer Gmbh R P Gelatinekapseln und verfahren zu ihrer herstellung
JPS62207460A (ja) 1986-03-07 1987-09-11 株式会社三協 ゼラチンカプセルの製造装置におけるゼラチンシ−ト成型装置
DE3676491D1 (de) 1986-04-05 1991-02-07 Scherer Gmbh R P Gelatinekapseln mit gesteuerter wirkstofffreisetzung und verfahren zur herstellung derselben.
DE3629386A1 (de) * 1986-08-29 1988-03-03 Scherer Gmbh R P Gelatinekapseln und verfahren zu ihrer herstellung
US4927638A (en) * 1986-10-08 1990-05-22 Bristol-Myers Company Etoposide solutions
US5154930A (en) * 1987-03-05 1992-10-13 The Liposome Company, Inc. Pharmacological agent-lipid solution preparation
JPS63309264A (ja) 1987-06-10 1988-12-16 Kamata Seisakusho:Kk ソフトカプセル製造機
US4817367A (en) * 1987-08-10 1989-04-04 Sankyo Co., Ltd. Apparatus for manufacturing gelatin capsule and method therefor
GB8721455D0 (en) 1987-09-11 1987-10-21 Lilly Industries Ltd Capsules
HU205010B (en) * 1987-09-15 1992-03-30 Sandoz Ag Process for producing pharmaceutical compositions comprising compounds soluble up to 1 per cent and having medical activity
AU609242B2 (en) * 1988-01-29 1991-04-26 Novartis Ag Cyclosporin compositions
US5376381A (en) * 1988-02-25 1994-12-27 The Liposome Company, Inc. Integrity protected gelatin
US5342625A (en) * 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
GB2222770B (en) * 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
US4935293A (en) 1988-10-25 1990-06-19 Unifi, Inc. Continuous multi-filament polyester substrate readily adherable to a vinyl sheet
US4935243A (en) * 1988-12-19 1990-06-19 Pharmacaps, Inc. Chewable, edible soft gelatin capsule
DE69013923T2 (de) * 1989-08-17 1995-03-16 Cortecs Ltd., Isleworth Arzneiformulierungen.
US5532002A (en) * 1989-08-17 1996-07-02 Cortecs Limited Gelatin pharmaceutical formulations
US5178877A (en) * 1991-01-04 1993-01-12 Abbott Laboratories Encapsulated renin inhibitor composition
GB9113872D0 (en) * 1991-06-27 1991-08-14 Sandoz Ag Improvements in or relating to organic compounds
US6262022B1 (en) * 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
US5224294A (en) * 1991-07-25 1993-07-06 E. I. Du Pont De Nemours And Company Hydroponic growth system
US5200191A (en) * 1991-09-11 1993-04-06 Banner Gelatin Products Corp. Softgel manufacturing process
US5206219A (en) * 1991-11-25 1993-04-27 Applied Analytical Industries, Inc. Oral compositions of proteinaceous medicaments
DE4201178C2 (de) * 1992-01-17 1995-12-07 Alfatec Pharma Gmbh Verfahren zur Herstellung von Weichgelatinekapseln nach einem Tropfverfahren
EP0573978B1 (en) * 1992-06-12 1999-04-21 Kao Corporation Bath additive composition comprising surfactant-containing seamless capsules and method for producing the capsules.
US5626872A (en) * 1992-06-16 1997-05-06 Roemmers S.A.I.C.F. Pharmaceutical soft capsules containing lysine clonixinate and a process for their preparation
CZ278863B6 (en) 1992-09-07 1994-07-13 Galena Medicinal preparations with n-methylated cyclic undecapeptides
US5376293A (en) * 1992-09-14 1994-12-27 State Of South Dakota As Represented By The Department Of Transportation Deicer
GB9221220D0 (en) * 1992-10-09 1992-11-25 Sandoz Ag Organic componds
JPH06157916A (ja) 1992-11-30 1994-06-07 Warner Lambert Kk カプセル硬皮膜組成物
US5376688A (en) * 1992-12-18 1994-12-27 R. P. Scherer Corporation Enhanced solubility pharmaceutical solutions
US5431916A (en) * 1993-04-29 1995-07-11 The Procter & Gamble Company Pharmaceutical compositions and process of manufacture thereof
CH686761A5 (de) 1993-05-27 1996-06-28 Sandoz Ag Galenische Formulierungen.
CN1077800C (zh) 1993-07-01 2002-01-16 韩美药品工业株式会社 环孢菌素软胶囊组合物
US5505961A (en) * 1993-08-05 1996-04-09 R. P. Scherer Corporation Gelatin capsules containing a highly concentrated acetaminophen solution
US6204243B1 (en) * 1993-09-01 2001-03-20 Novatis Ag Pharmaceutical preparations for the targeted treatment of crohn's disease and ulcerative colitis
IL110752A (en) * 1993-09-13 2000-07-26 Abbott Lab Liquid semi-solid or solid pharmaceutical composition for an HIV protease inhibitor
DE69435104D1 (de) * 1993-09-28 2008-07-31 Scherer Gmbh R P Herstellung von Weichgelatinekapseln
KR0146671B1 (ko) * 1994-02-25 1998-08-17 김충환 사이클로스포린-함유 분말 조성물
US5641512A (en) * 1995-03-29 1997-06-24 The Procter & Gamble Company Soft gelatin capsule compositions
US5614217A (en) * 1995-06-07 1997-03-25 R.P. Scherer Corporation Capsule shell formulation to produce brittle capsules
NZ280689A (en) * 1995-12-15 1997-08-22 Bernard Charles Sherma Sherman Pharmaceutical composition comprising a cyclosporipharmaceutical composition comprising a cyclosporin; a tocol, tocopherol or tocotrienol; and propylen; a tocol, tocopherol or tocotrienol; and propylene carbonate or polyethylene glycol ne carbonate or polyethylene glycol
US5958876A (en) 1996-06-19 1999-09-28 Novartis Ag Cyclosporin-containing pharmaceutical compositions
US6239124B1 (en) * 1996-07-30 2001-05-29 Novartis Ag Pharmaceutical compositions for the treatment of transplant rejection or autoimmune or inflammatory conditions comprising cyclosporin A and 40-0-(2-hydroxyethyl)-rapamycin
US5798333A (en) * 1996-09-17 1998-08-25 Sherman; Bernard C. Water-soluble concentrates containing cyclosporins
FR2755368B1 (fr) * 1996-11-04 1999-03-19 Oreal Composition rincable pour le soin de la peau

Also Published As

Publication number Publication date
HUT70417A (en) 1995-10-30
PE31295A1 (es) 1995-10-16
KR100200174B1 (ko) 1999-06-15
AU7423794A (en) 1995-04-13
RU94034106A (ru) 1996-11-10
GB2282586A (en) 1995-04-12
ITRM940613A0 (it) 1994-09-26
ES2152281T3 (es) 2001-02-01
DK1033128T3 (da) 2008-10-20
CA2332631A1 (en) 1995-03-29
CA2302963C (en) 2001-10-23
PT1033128E (pt) 2008-08-08
SI0649651T1 (en) 2001-02-28
JPH07149625A (ja) 1995-06-13
NO943563D0 (no) 1994-09-26
US6589536B1 (en) 2003-07-08
FR2710532B1 (fr) 1997-06-20
IT1274931B (it) 1997-07-29
EP1033128B2 (en) 2011-11-23
NO943563L (no) 1995-03-29
CN1108930A (zh) 1995-09-27
SK285204B6 (sk) 2006-08-03
EP0649651B1 (en) 2000-12-13
HU228201B1 (en) 2013-01-28
PL178884B1 (pl) 2000-06-30
ES2308955T5 (es) 2012-04-03
SI1033128T2 (sl) 2012-02-29
PL305188A1 (en) 1995-04-03
CA2132933C (en) 2000-07-18
GB2282586B (en) 1998-04-22
SK284268B6 (sk) 2004-12-01
DE69426408D1 (de) 2001-01-18
ATE198041T1 (de) 2000-12-15
CA2132933A1 (en) 1995-03-29
FI944452A0 (sv) 1994-09-26
EP1033128B1 (en) 2008-06-18
FR2710532A1 (fr) 1995-04-07
DK1033128T4 (da) 2012-03-19
GB9419353D0 (en) 1994-11-09
TW438609B (en) 2001-06-07
US6555132B1 (en) 2003-04-29
HU9402772D0 (en) 1994-12-28
CA2302963A1 (en) 1995-03-29
CN100473377C (zh) 2009-04-01
NZ264536A (en) 1996-09-25
KR950007820A (ko) 1995-04-15
EP1029538A3 (en) 2003-10-15
SI1033128T1 (sl) 2009-02-28
RU2140783C1 (ru) 1999-11-10
CN1636554A (zh) 2005-07-13
NO312334B1 (no) 2002-04-29
ATE398448T1 (de) 2008-07-15
ES2308955T3 (es) 2008-12-16
IL111067A0 (en) 1994-12-29
HU0105382D0 (en) 2002-02-28
SK115794A3 (en) 1995-05-10
HU221681B1 (hu) 2002-12-28
IL111067A (en) 1999-12-31
DK0649651T3 (da) 2001-02-26
DE69435104D1 (de) 2008-07-31
FI944452A (sv) 1995-03-29
GR3035179T3 (en) 2001-04-30
CZ290314B6 (cs) 2002-07-17
DE69426408T2 (de) 2001-07-12
US7078054B2 (en) 2006-07-18
AU690571B2 (en) 1998-04-30
EP1033128A3 (en) 2001-02-28
EP1033128A2 (en) 2000-09-06
EP0649651A1 (en) 1995-04-26
CZ236094A3 (en) 1995-04-12
ITRM940613A1 (it) 1996-03-26
HK1078478A1 (en) 2006-03-17
SG46531A1 (en) 1998-02-20
JP3071642B2 (ja) 2000-07-31
US20030206930A1 (en) 2003-11-06
ZA947567B (en) 1996-06-28
CN1182842C (zh) 2005-01-05
EP1029538A2 (en) 2000-08-23
PT649651E (pt) 2001-03-30
US5985321A (en) 1999-11-16
CA2332631C (en) 2002-11-19

Similar Documents

Publication Publication Date Title
FI120718B (sv) Förfarande för framställning av vätskefyllda mjuka gelatinkapslar
KR100518135B1 (ko) 매크롤라이드를 안정화하는 방법
US5589455A (en) Cyclosporin-containing soft capsule compositions
US5958876A (en) Cyclosporin-containing pharmaceutical compositions
CZ283516B6 (cs) Léčivé přípravky, zejména pro vnitřní aplikaci, ve formě samomikroemulgujících terapeutických systémů
CN1127350C (zh) 含有环孢菌素的软胶囊制剂
AU741923B2 (en) Pharmaceutical compositions
NO324852B1 (no) Mykgelatinkapsler og deres fremstilling
NO324355B1 (no) Vaeskefylt mykgelatinkapsel
WO2004073693A1 (en) Soft capsule containing cyclosporine and it's manufacturing process

Legal Events

Date Code Title Description
GB Transfer or assigment of application

Owner name: R.P. SCHERER GMBH

FG Patent granted

Ref document number: 120718

Country of ref document: FI

MA Patent expired