KR950007820A - 연질 젤라틴 캡슐 제조 방법 - Google Patents
연질 젤라틴 캡슐 제조 방법 Download PDFInfo
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- KR950007820A KR950007820A KR1019940024487A KR19940024487A KR950007820A KR 950007820 A KR950007820 A KR 950007820A KR 1019940024487 A KR1019940024487 A KR 1019940024487A KR 19940024487 A KR19940024487 A KR 19940024487A KR 950007820 A KR950007820 A KR 950007820A
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- South Korea
- Prior art keywords
- capsule
- soft gelatin
- component
- gelatin
- gelatin capsule
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- 239000007903 gelatin capsule Substances 0.000 title claims abstract 27
- 238000004519 manufacturing process Methods 0.000 title claims abstract 5
- 239000002775 capsule Substances 0.000 claims abstract 27
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract 17
- 108010010803 Gelatin Proteins 0.000 claims abstract 13
- 229920000159 gelatin Polymers 0.000 claims abstract 13
- 239000008273 gelatin Substances 0.000 claims abstract 13
- 235000019322 gelatine Nutrition 0.000 claims abstract 13
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract 13
- 239000002904 solvent Substances 0.000 claims abstract 9
- 238000001816 cooling Methods 0.000 claims abstract 8
- 229960004063 propylene glycol Drugs 0.000 claims abstract 8
- 239000007788 liquid Substances 0.000 claims abstract 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 5
- 239000004014 plasticizer Substances 0.000 claims abstract 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 9
- 238000000034 method Methods 0.000 claims 5
- 239000002826 coolant Substances 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 3
- 239000013543 active substance Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical group CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 2
- 229930105110 Cyclosporin A Natural products 0.000 claims 2
- 108010036949 Cyclosporine Proteins 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 229960001265 ciclosporin Drugs 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- MEJYDZQQVZJMPP-ULAWRXDQSA-N (3s,3ar,6r,6ar)-3,6-dimethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan Chemical compound CO[C@H]1CO[C@@H]2[C@H](OC)CO[C@@H]21 MEJYDZQQVZJMPP-ULAWRXDQSA-N 0.000 claims 1
- ZMKGDQSIRSGUDJ-VSROPUKISA-N (3s,6s,9s,12r,15s,18s,21s,24s,30s,33s)-33-[(e,1r,2r)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-30-propyl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,1 Chemical compound CCC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O ZMKGDQSIRSGUDJ-VSROPUKISA-N 0.000 claims 1
- CYSGHNMQYZDMIA-UHFFFAOYSA-N 1,3-Dimethyl-2-imidazolidinon Chemical compound CN1CCN(C)C1=O CYSGHNMQYZDMIA-UHFFFAOYSA-N 0.000 claims 1
- ZMKGDQSIRSGUDJ-UHFFFAOYSA-N NVa2 cyclosporine Natural products CCCC1NC(=O)C(C(O)C(C)CC=CC)N(C)C(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(C(C)C)NC(=O)C(CC(C)C)N(C)C(=O)CN(C)C1=O ZMKGDQSIRSGUDJ-UHFFFAOYSA-N 0.000 claims 1
- 239000012141 concentrate Substances 0.000 claims 1
- 229930182912 cyclosporin Natural products 0.000 claims 1
- 108010019249 cyclosporin G Proteins 0.000 claims 1
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims 1
- 229940075557 diethylene glycol monoethyl ether Drugs 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 238000005538 encapsulation Methods 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 239000003120 macrolide antibiotic agent Substances 0.000 claims 1
- 239000004530 micro-emulsion Substances 0.000 claims 1
- 239000006104 solid solution Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Nanotechnology (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Transplantation (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Cosmetics (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
Abstract
본 발명은 젤라틴, 가소제, 및 바람직하거나 필요하다면 추가로 보조재를 함유하는 캡슐 외피와, 용매를 함유하는 캡슐 충전물을 지닌 연질 젤라틴 캡슐에 관한 것으로서, 이때, 상기 용매를 캡슐 충전물 및 캡슐 외피내에 용매로서 1, 2-프로필렌글리콜과 같은 확산성 용매를 함유한다. 상기 캡슐의 제조 방법은 상기 연질 젤라틴 캡슐을 제조하기 위한 방법중에 젤라틴 밴드가 액체, 바람직하게는 물로 냉각되므로써 개선된 것이다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (26)
- 캡슐 외피가 캡슐 충전물 중에도 또한 존재하는 확산성 성분(글리세롤이외의 다른 화합물)을 함유하는 것을 특징으로 하는 액체 충전된 연질 젤라틴 캡슐.
- 제1항에 있어서, 확산성 성분이 젤라틴과 혼합할 수 있거나, 젤라틴과 고용체를 형성할 수 있는 비휘발성약학적 허용성 용매인 것을 특징으로 하는 연질 젤라틴 캡슐.
- 제1항 또는 제2항에 있어서, 확산성 성분이 테트라히드로푸틸알콜 에테르, 디에딜렌글리콜 모노 에틸 에테르, 1, 3-디메틸-2-이미다졸리디논, 디메틸이소소르바이드, 폴리에틸렌 글리콜 또는 프로필렌 글리콜임을 특징으로 하는 연질 젤라틴 캡슐.
- 제3항에 있어서, 확산성 성분이 1, 2-프로필렌글리콜인 연질 젤라틴 캡슐.
- 제1항에 있어서, 캡슐 외피가 1, 2-프로필렌글리콜을 함유하는 것을 특징으로 하는, 젤라틴, 가소제, 바람직하거나 필요하다면, 추가로 보조제를 함유하는 캡슐 외피와, 1, 2-프로필렌글리콜이 일부분 이상이나, 폴리에틸렌글리콜이 주성분은 아닌 용매를 함유하는 캡슐 충전물을 지닌 연질 젤라틴 캡슐.
- 제1항 내지 제5항중 어느 한 항에 있어서, 캡슐 충전물이 친지성 성분을 함유함을 특징으로 하는 연질 젤라틴 캡슐.
- 제1항 내지 제6항 중 어느 한 항에 있어서, 캡슐 충전물이 계면활성제를 함유함을 특징으로 하는 연질 젤라틴 캡슐.
- 제1항 내지 제7항 중 어느 한 항에 있어서, 캡슐 충전물이 물과 혼합될때 유제를 형성할 수 있는 것임을 특징으로 하는 연질 젤라틴 캡슐.
- 제1항 내지 제8항중 어느 한 항에 있어서, 캡슐 충전물이 친수성 및 확산성 성분으로서 1, 2-프로필렌글리콜을 함유하는 미소유제 예비-농축물의 형태임을 특징으로 하는 연질 젤라틴 캡슐.
- 제1항 내지 제9항 중 어느 한 항에 있어서, 캡슐 외피가 5% 이상의 확산성 성분을 함유함을 특징으로 하는 연질 젤라틴 캡슐.
- 제1항 내지 제10항 중 어느 한 항에 있어서, 캡슐 외피가 5 내지 40%의 확산성 성분을 함유함을 특징으로 하는 연질 젤라틴 캡슐.
- 제1항 내지 제11항 중 어느 한 항에 있어서, 건조된 캡슐 충전물이 에탄올을 함유함을 특징으로 하는 연질젤라틴 캡슐.
- 제1항 내지 제12항 중 어느 한 항에 있어서, 건조된 캡슐 외피가 32% 이하의 확산성 성분을 함유함을 특징으로 하는 연질 젤라틴 캡슐.
- 제1항 내지 제13항 중 어느 한 항에 있어서, 건조된 캡슐 외피가 10내지 32%의 확산성 성분을 함유함을 특징으로 하는 연질 젤라틴 캡슐.
- 제1항 내지 제14항 중 어느 한 항에 있어서, 캡슐 외피가 또한 글리세롤을 함유함을 특징으로 하는 연질젤라틴 캡슐.
- 제1항 내지 제15항 중 어느 한 항에 있어서, 물에 대한 가용성이 1% 미만인 약리학적 활성 물질을 함유하는 연질 젤라틴 캡슐.
- 제16항에 있어서, 약리학적 활성 물질이 시클로스포린 또는 마크롤라이드인 연질 젤라틴 캡슐.
- 제17항에 있어서, 약리학적 활성 물질이 시클로스포린 A 또는 G인 연질 젤라틴 캡슐.
- 액체 혼합물증의 한 성분이 젤라틴내로 확산하는 경향을 갖고 있는, 연질 젤라틴 캡슐을 형성하기 위해 젤라틴중의 액체 혼합물을 캡슐화하는 방법에 있어서, 상기 캡슐화 방법에 사용된 젤라틴 조성물이 또한 상기 확산성 성분을 함유하며, 상기 확산성 성분은 글리세를 이외의 다른 화합물임을 특징으로 하는 방법.
- 제19항에 있어서, 제1항 내지 제18항 중 어느 한 항에서 청구된 임의의 연질 젤라틴 캡슐을 함유하는 방법.
- 젤라틴 및 점착성을 유도하는 성분을 함유하는 캡슐 외피를 지닌 연질 젤라틴 캡슐을 제조하는 방법에 있어서, 상기 캡슐 외피를 형성시키기 위한 젤라틴 밴드의 냉각이 액체 냉각제를 사용하여 실시됨을 특징으로 하는 방법.
- 제21항에 있어서, 젤라틴 밴드를 냉각시키기 위한 냉각 드럼이 액채 냉각제를 함유함을 특징으로 하는, 젤라틴, 가소제, 및 바람직하거나 필요하다면, 추가로 보조제를 함유하는 캡슐 외피와, 용매를 함유하는 캡슐 충전물을 갖고 있으며, 이 용매의 일부분 이상은 1, 2-프로필렌글리콜이고 캡슐 외피도 1, 2-프로필렌글리콜을 함유하는, 연질 젤라틴 캡슐을 제조하는 방법.
- 제22항에 있어서, 냉각제로서 물이 사용됨을 특징으로 하는 방법.
- 제19항 내지 제23항 중 어느 한 항의 방법으로 제조된 캡슐.
- 연질 젤라틴 캡슐 외피를 형성시키기 위해 젤라틴 밴드를 냉각시키는 냉각드럼에 있어서, 이 드럼이 액체 냉각제, 예컨대, 물을 사용하여 드럼 표면을 냉각시키기 위한 수단으로 되어 있는 냉각 드럼.
- 제25항에 있어서, 연질 젤라틴 캡슐을 제조하기 위한 기계와 연결되어 있는 냉각 드럼.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019980043773A KR100202331B1 (en) | 1993-09-28 | 1998-10-17 | Soft gelatin capsule manufacture |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP4332931.4 | 1993-09-28 | ||
| DE4332931 | 1993-09-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR950007820A true KR950007820A (ko) | 1995-04-15 |
| KR100200174B1 KR100200174B1 (ko) | 1999-06-15 |
Family
ID=6498793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019940024487A KR100200174B1 (ko) | 1993-09-28 | 1994-09-28 | 연질 젤라틴 캡슐 제조 방법 |
Country Status (31)
| Country | Link |
|---|---|
| US (4) | US5985321A (ko) |
| EP (3) | EP1033128B2 (ko) |
| JP (1) | JP3071642B2 (ko) |
| KR (1) | KR100200174B1 (ko) |
| CN (2) | CN1182842C (ko) |
| AT (2) | ATE398448T1 (ko) |
| AU (1) | AU690571B2 (ko) |
| CA (3) | CA2302963C (ko) |
| CZ (1) | CZ290314B6 (ko) |
| DE (2) | DE69435104D1 (ko) |
| DK (2) | DK0649651T3 (ko) |
| ES (2) | ES2152281T3 (ko) |
| FI (1) | FI120718B (ko) |
| FR (1) | FR2710532B1 (ko) |
| GB (1) | GB2282586B (ko) |
| GR (1) | GR3035179T3 (ko) |
| HK (1) | HK1078478A1 (ko) |
| HU (2) | HU221681B1 (ko) |
| IL (1) | IL111067A (ko) |
| IT (1) | IT1274931B (ko) |
| NO (1) | NO312334B1 (ko) |
| NZ (1) | NZ264536A (ko) |
| PE (1) | PE31295A1 (ko) |
| PL (1) | PL178884B1 (ko) |
| PT (2) | PT649651E (ko) |
| RU (1) | RU2140783C1 (ko) |
| SG (1) | SG46531A1 (ko) |
| SI (2) | SI0649651T1 (ko) |
| SK (2) | SK284268B6 (ko) |
| TW (1) | TW438609B (ko) |
| ZA (1) | ZA947567B (ko) |
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- 1994-09-24 EP EP00103110A patent/EP1033128B2/en not_active Expired - Lifetime
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- 1994-09-24 DK DK00103110.3T patent/DK1033128T4/da active
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- 1994-09-24 AT AT94115081T patent/ATE198041T1/de active
- 1994-09-24 DE DE69426408T patent/DE69426408T2/de not_active Expired - Lifetime
- 1994-09-24 SI SI9430487T patent/SI1033128T2/sl unknown
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- 1994-09-26 IT ITRM940613A patent/IT1274931B/it active IP Right Grant
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- 1994-09-27 CN CNB941160211A patent/CN1182842C/zh not_active Expired - Lifetime
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- 1994-09-28 KR KR1019940024487A patent/KR100200174B1/ko not_active IP Right Cessation
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1997
- 1997-04-29 US US08/841,734 patent/US5985321A/en not_active Expired - Lifetime
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2000
- 2000-02-07 US US09/499,497 patent/US6589536B1/en not_active Expired - Fee Related
- 2000-10-17 US US09/690,401 patent/US6555132B1/en not_active Expired - Fee Related
- 2000-12-29 GR GR20000402869T patent/GR3035179T3/el unknown
-
2003
- 2003-05-13 US US10/437,098 patent/US7078054B2/en not_active Expired - Fee Related
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2005
- 2005-11-21 HK HK05110510.5A patent/HK1078478A1/xx not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100478350B1 (ko) * | 1996-08-29 | 2005-05-16 | 시오노기세이야쿠가부시키가이샤 | 캡슐의밴드형밀봉부형성방법 |
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