FI120394B - Substituoituja bentseenisulfonyyliureoita, ja -tioureoita, menetelmä niiden valmistamiseksi ja niiden käyttö farmaseuttisen valmisteen valmistukseen sekä niitä sisältävät farmaseuttiset valmisteet - Google Patents

Substituoituja bentseenisulfonyyliureoita, ja -tioureoita, menetelmä niiden valmistamiseksi ja niiden käyttö farmaseuttisen valmisteen valmistukseen sekä niitä sisältävät farmaseuttiset valmisteet Download PDF

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Publication number
FI120394B
FI120394B FI960587A FI960587A FI120394B FI 120394 B FI120394 B FI 120394B FI 960587 A FI960587 A FI 960587A FI 960587 A FI960587 A FI 960587A FI 120394 B FI120394 B FI 120394B
Authority
FI
Finland
Prior art keywords
atoms
aminocarbonylmethyl
alkyl
formula
carbon atoms
Prior art date
Application number
FI960587A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI960587A (fi
FI960587A0 (fi
Inventor
Joachim Kaiser
Dieter Mania
Heinrich Englert
Heinz Goegelein
Uwe Gerlach
Peter Crause
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI960587A0 publication Critical patent/FI960587A0/fi
Publication of FI960587A publication Critical patent/FI960587A/fi
Application granted granted Critical
Publication of FI120394B publication Critical patent/FI120394B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/40—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of thiourea or isothiourea groups further bound to other hetero atoms
    • C07C335/42—Sulfonylthioureas; Sulfonylisothioureas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
    • C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/58—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
FI960587A 1995-02-10 1996-02-08 Substituoituja bentseenisulfonyyliureoita, ja -tioureoita, menetelmä niiden valmistamiseksi ja niiden käyttö farmaseuttisen valmisteen valmistukseen sekä niitä sisältävät farmaseuttiset valmisteet FI120394B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19504379A DE19504379A1 (de) 1995-02-10 1995-02-10 Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate sowie sie enthaltende pharmazeutische Präparate
DE19504379 1995-02-10

Publications (3)

Publication Number Publication Date
FI960587A0 FI960587A0 (fi) 1996-02-08
FI960587A FI960587A (fi) 1996-08-11
FI120394B true FI120394B (fi) 2009-10-15

Family

ID=7753608

Family Applications (1)

Application Number Title Priority Date Filing Date
FI960587A FI120394B (fi) 1995-02-10 1996-02-08 Substituoituja bentseenisulfonyyliureoita, ja -tioureoita, menetelmä niiden valmistamiseksi ja niiden käyttö farmaseuttisen valmisteen valmistukseen sekä niitä sisältävät farmaseuttiset valmisteet

Country Status (30)

Country Link
US (1) US5607976A (xx)
EP (1) EP0726250B1 (xx)
JP (1) JP3774773B2 (xx)
KR (1) KR100446565B1 (xx)
CN (1) CN1064041C (xx)
AR (1) AR001082A1 (xx)
AT (1) ATE197291T1 (xx)
AU (1) AU700883B2 (xx)
BR (1) BR9600370A (xx)
CA (1) CA2169219C (xx)
CZ (1) CZ290809B6 (xx)
DE (2) DE19504379A1 (xx)
DK (1) DK0726250T3 (xx)
ES (1) ES2152440T3 (xx)
FI (1) FI120394B (xx)
GR (1) GR3034886T3 (xx)
HR (1) HRP960063B1 (xx)
HU (1) HU224211B1 (xx)
IL (1) IL117078A (xx)
MY (1) MY114693A (xx)
NO (1) NO305750B1 (xx)
NZ (1) NZ280954A (xx)
PL (1) PL181656B1 (xx)
PT (1) PT726250E (xx)
RU (1) RU2155750C2 (xx)
SI (1) SI9600040B (xx)
SK (1) SK281357B6 (xx)
TR (1) TR199600747A2 (xx)
TW (1) TW419457B (xx)
ZA (1) ZA961050B (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19832009A1 (de) 1998-07-16 2000-01-20 Hoechst Marion Roussel De Gmbh 2,5-Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharamazeutische Präparate
DE19858253A1 (de) * 1998-12-17 2000-06-21 Aventis Pharma Gmbh Verwendung von Inhibitoren des KQt1-Kanals zur Herstellung eines Medikaments zur Behandlung von Krankheiten, die durch Helminthen und Ektoparasiten hervorgerufen werden
DE10060809A1 (de) * 2000-12-07 2002-06-20 Aventis Pharma Gmbh Substituierte Anthranilsäuren, ihre Verwendung als Medikament oder Diagnostikum, sowie sie enthaltendes Medikament, sowie ein pharmazeutisches Kombinationspräparat mit einem Natrium/Wasserstoff-Austausch (NHE)-Blocker
DE10129704A1 (de) * 2001-06-22 2003-01-02 Aventis Pharma Gmbh Verwendung von Benzolsulfonyl(thio)harnstoffen in der Behandlung des septischen Schocks
CN1330630C (zh) * 2004-03-10 2007-08-08 中国药科大学 新的磺酰(硫)脲衍生物、其制备方法及含有它们的药物组合物
UA87854C2 (xx) * 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-бензил)-2-фенілбутанаміди як модулятори рецептора андрогену$n-(2-бензил)-2-фенилбутанамиды как модуляторы рецептора андрогена
MX2008013238A (es) * 2006-04-12 2008-10-21 Merck & Co Inc Antagonistas de los canales de calcio de tipo t de piridil amida.
JP5524071B2 (ja) * 2007-10-24 2014-06-18 メルク・シャープ・アンド・ドーム・コーポレーション 複素環フェニルアミドｔ型カルシウムチャネルアンタゴニスト

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE243821C (xx) *
DE1493672C3 (de) * 1964-08-01 1974-05-02 Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt Verfahren zur Herstellung von Benzolsulfonylharnstoffen
DE1518874C3 (de) * 1964-10-07 1975-03-13 Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt Benzolsulfonylharnstoffe und Verfahren zu ihrer Herstellung
DE1443919C3 (de) * 1964-12-28 1973-11-29 Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt Benzolsulfonylharnstoffe, Ver fahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitun gen
US3917690A (en) * 1966-11-29 1975-11-04 Hoechst Ag Benzenesulfonyl ureas and process for their manufacture
DE1568648C3 (de) * 1966-12-19 1975-03-27 Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt Benzolsulfonylharnstoffe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
BE754454A (fr) * 1969-08-06 1971-02-05 Bayer Ag Nouveaux composes hypoglycemiques du type d'arylsulfonylurees et d'arylsulfonylsemicarbazides contenant des groupes carbonamide
DE2413514C3 (de) * 1974-03-21 1982-03-04 Hoechst Ag, 6000 Frankfurt N-Acylaminoathylbenzolsulfonyl-N'-methylharnstoffe, Verfahren zu ihrer Herstellung und deren Verwendung
DE3011153A1 (de) * 1980-03-22 1981-10-15 Hoechst Ag, 6000 Frankfurt Verwendung von n-(4- spitze klammer auf 2-(5-chlor-2-methoxy-benzamido)-aethylspitze klammer zu -benzolsulfonyl)-n'-methyl-harnstoff
US5215985A (en) * 1990-07-20 1993-06-01 E. R. Squibb & Sons, Inc. Method for treating ischemic insult to neurons employing an ATP-sensitive potassium channel blocker
ES2098069T3 (es) * 1993-02-23 1997-04-16 Hoechst Ag Bencenosulfonil-ureas y -tioureas sustituidas, procedimiento para su preparacion y su utilizacion como agentes farmaceuticos.

Also Published As

Publication number Publication date
RU2155750C2 (ru) 2000-09-10
SK17596A3 (en) 1996-10-02
NO960529D0 (no) 1996-02-09
NO305750B1 (no) 1999-07-19
DE59606062D1 (de) 2000-12-07
BR9600370A (pt) 1998-03-03
NZ280954A (en) 1996-10-28
HRP960063B1 (en) 2001-08-31
PL181656B1 (pl) 2001-08-31
EP0726250B1 (de) 2000-11-02
CZ38296A3 (en) 1996-08-14
KR100446565B1 (ko) 2004-12-03
JPH08245553A (ja) 1996-09-24
DK0726250T3 (da) 2001-01-08
SK281357B6 (sk) 2001-02-12
NO960529L (no) 1996-08-12
SI9600040A (en) 1996-10-31
HRP960063A2 (en) 1997-10-31
CZ290809B6 (cs) 2002-10-16
HU9503932D0 (en) 1996-03-28
CN1064041C (zh) 2001-04-04
ES2152440T3 (es) 2001-02-01
KR960031431A (ko) 1996-09-17
PL312531A1 (en) 1996-08-19
CA2169219A1 (en) 1996-08-11
GR3034886T3 (en) 2001-02-28
MY114693A (en) 2002-12-31
FI960587A (fi) 1996-08-11
AR001082A1 (es) 1997-09-24
AU4442996A (en) 1996-08-22
CN1137519A (zh) 1996-12-11
FI960587A0 (fi) 1996-02-08
IL117078A0 (en) 1996-06-18
PT726250E (pt) 2001-03-30
IL117078A (en) 2001-01-11
HUT73975A (en) 1996-10-28
US5607976A (en) 1997-03-04
DE19504379A1 (de) 1996-08-14
TW419457B (en) 2001-01-21
JP3774773B2 (ja) 2006-05-17
ZA961050B (en) 1996-08-29
SI9600040B (en) 2001-12-31
HU224211B1 (hu) 2005-06-28
AU700883B2 (en) 1999-01-14
CA2169219C (en) 2009-01-06
TR199600747A2 (tr) 1996-08-21
EP0726250A1 (de) 1996-08-14
ATE197291T1 (de) 2000-11-15

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