FI120100B - Yhdistelmä-mersasidiini ja sen valmistusmenetelmä - Google Patents

Yhdistelmä-mersasidiini ja sen valmistusmenetelmä Download PDF

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Publication number
FI120100B
FI120100B FI954220A FI954220A FI120100B FI 120100 B FI120100 B FI 120100B FI 954220 A FI954220 A FI 954220A FI 954220 A FI954220 A FI 954220A FI 120100 B FI120100 B FI 120100B
Authority
FI
Finland
Prior art keywords
sequence
dna
amino acid
lantibiotics
mersacidin
Prior art date
Application number
FI954220A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI954220A (fi
FI954220A0 (fi
Inventor
Klaus-Peter Koller
Hans Georg Sahl
Gabriele Bierbaum
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI954220A0 publication Critical patent/FI954220A0/fi
Publication of FI954220A publication Critical patent/FI954220A/fi
Application granted granted Critical
Publication of FI120100B publication Critical patent/FI120100B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
FI954220A 1994-09-12 1995-09-08 Yhdistelmä-mersasidiini ja sen valmistusmenetelmä FI120100B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94114298A EP0700998B1 (en) 1994-09-12 1994-09-12 Recombinant mersacidin and a method for production
EP94114298 1994-09-12

Publications (3)

Publication Number Publication Date
FI954220A0 FI954220A0 (fi) 1995-09-08
FI954220A FI954220A (fi) 1996-03-13
FI120100B true FI120100B (fi) 2009-06-30

Family

ID=8216276

Family Applications (1)

Application Number Title Priority Date Filing Date
FI954220A FI120100B (fi) 1994-09-12 1995-09-08 Yhdistelmä-mersasidiini ja sen valmistusmenetelmä

Country Status (19)

Country Link
US (1) US5667991A (ru)
EP (1) EP0700998B1 (ru)
JP (1) JPH0898695A (ru)
KR (1) KR100394289B1 (ru)
CN (1) CN1149287C (ru)
AT (1) ATE255165T1 (ru)
AU (1) AU696450B2 (ru)
CA (1) CA2157975C (ru)
CZ (1) CZ285741B6 (ru)
DE (1) DE69433357T2 (ru)
DK (1) DK0700998T3 (ru)
ES (1) ES2207636T3 (ru)
FI (1) FI120100B (ru)
HU (1) HU216619B (ru)
IL (1) IL115242A0 (ru)
NZ (1) NZ272960A (ru)
PT (1) PT700998E (ru)
RU (1) RU2198924C2 (ru)
SI (1) SI9500270B (ru)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1956785B1 (en) * 1999-03-12 2012-12-26 Daphimo Co. B.V., LLC Multicarrier modulation system and method
US6775320B1 (en) * 1999-03-12 2004-08-10 Aware, Inc. Method and a multi-carrier transceiver supporting dynamic switching between active application sets
US6861236B2 (en) 2002-05-24 2005-03-01 Applied Nanosystems B.V. Export and modification of (poly)peptides in the lantibiotic way
GB0406870D0 (en) * 2004-03-26 2004-04-28 Novacta Biosystems Ltd Improvements relating to the production of lantibiotics
US7592308B2 (en) 2004-03-26 2009-09-22 Novacta Biosystems Limited F3W variants of the lantibiotic mersacidin and its use
JP2009509519A (ja) * 2005-09-27 2009-03-12 ノヴァクタ バイオシステムズ リミティッド ランチビオティックメルサシジンの変種およびそれらの使用
GB0600928D0 (en) 2006-01-17 2006-02-22 Novacta Biosystems Ltd Improvements relating to lantibiotics
GB0714029D0 (en) 2007-07-18 2007-08-29 Novacta Biosystems Ltd Lantibiotic-based compounds having antimicrobial activity
GB0714030D0 (en) 2007-07-18 2007-08-29 Novacta Biosystems Ltd The use of type-B lantibiotic-based compounds having antimicrobial activity
EP2271665B1 (en) * 2008-04-02 2012-01-18 Sanofi Highly bridged peptides from actinomadura namibiensis
CA2742753A1 (en) * 2008-11-24 2010-05-27 Sentinella Pharmaceuticals, Inc. ("Sentinella") Lantibiotic carboxyamide derivatives with enhanced antibacterial activity
MX2011007313A (es) 2009-01-14 2011-08-04 Novacta Biosystems Ltd Derivados de desoxiactagardina.
SG173504A1 (en) 2009-02-04 2011-09-29 Novacta Biosystems Ltd Actagardine derivatives
GB201001688D0 (en) 2010-02-02 2010-03-17 Novacta Biosystems Ltd Compounds
GB201013513D0 (en) 2010-08-11 2010-09-22 Novacta Biosystems Ltd Formulations
CN106188253B (zh) * 2016-08-26 2020-08-18 上海交通大学 抗菌肽Lexapeptide及其制备方法和用途
CA3127806A1 (en) 2019-02-05 2020-08-13 Elanco Us Inc. Probiotic compositions comprising lactobacillus reuteri strains and methods of use
CN111235119B (zh) * 2020-03-05 2021-11-23 苏州十一方生物科技有限公司 一种融合抗菌蛋白的制备及应用
CN114457102B (zh) * 2022-02-24 2023-12-26 重庆市畜牧科学院 用于编码分泌型Mersacidin的基因表达盒及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5218101A (en) * 1988-07-05 1993-06-08 The University Of Maryland Leader sequence inducing a post-translational modification of polypeptides in bacteria, and gene therefor
IN167138B (ru) * 1988-08-17 1990-09-01 Hoechst India

Also Published As

Publication number Publication date
KR960010863A (ko) 1996-04-20
CZ231895A3 (en) 1996-03-13
CN1131192A (zh) 1996-09-18
NZ272960A (en) 1996-05-28
SI9500270B (sl) 2002-02-28
EP0700998B1 (en) 2003-11-26
DE69433357D1 (de) 2004-01-08
AU3055495A (en) 1996-03-28
ATE255165T1 (de) 2003-12-15
EP0700998A1 (en) 1996-03-13
DK0700998T3 (da) 2004-03-29
PT700998E (pt) 2004-03-31
HUT73800A (en) 1996-09-30
FI954220A (fi) 1996-03-13
CZ285741B6 (cs) 1999-10-13
HU9502643D0 (en) 1995-11-28
CA2157975C (en) 2008-11-18
IL115242A0 (en) 1995-12-31
KR100394289B1 (ko) 2003-10-22
JPH0898695A (ja) 1996-04-16
ES2207636T3 (es) 2004-06-01
SI9500270A (en) 1996-04-30
US5667991A (en) 1997-09-16
HU216619B (hu) 1999-07-28
FI954220A0 (fi) 1995-09-08
CA2157975A1 (en) 1996-03-13
CN1149287C (zh) 2004-05-12
DE69433357T2 (de) 2004-09-09
RU2198924C2 (ru) 2003-02-20
AU696450B2 (en) 1998-09-10

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FI120100B (fi) Yhdistelmä-mersasidiini ja sen valmistusmenetelmä
Bierbaum et al. Cloning, sequencing and production of the lantibiotic mersacidin
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