ATE255165T1 - Rekombinantes mersacidin und verfahren zu seiner herstellung - Google Patents
Rekombinantes mersacidin und verfahren zu seiner herstellungInfo
- Publication number
- ATE255165T1 ATE255165T1 AT94114298T AT94114298T ATE255165T1 AT E255165 T1 ATE255165 T1 AT E255165T1 AT 94114298 T AT94114298 T AT 94114298T AT 94114298 T AT94114298 T AT 94114298T AT E255165 T1 ATE255165 T1 AT E255165T1
- Authority
- AT
- Austria
- Prior art keywords
- mersacidine
- recombinant
- production
- amino acid
- premersacidin
- Prior art date
Links
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 108010062877 Bacteriocins Proteins 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 108010067215 mersacidin Proteins 0.000 abstract 1
- JSWKNDSDVHJUKY-CYGWNLPQSA-N mersacidin Chemical compound C([C@@H](C(=O)N[C@@H]1[C@H](C)SC[C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC1=O)C(=O)N[C@@H]1[C@H](C)SC[C@H]2C(=O)N[C@H](C(N/C=C/S[C@@H](C)C(NC(=O)[C@H](CC(C)C)NC1=O)C(=O)NC(=C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)[C@H](C)CC)NC(=O)[C@H]1[C@@H](SC[C@H](N)C(=O)N1)C)C1=CC=CC=C1 JSWKNDSDVHJUKY-CYGWNLPQSA-N 0.000 abstract 1
- 239000003910 polypeptide antibiotic agent Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000012163 sequencing technique Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Plant Pathology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP94114298A EP0700998B1 (de) | 1994-09-12 | 1994-09-12 | Rekombinantes Mersacidin und Verfahren zu seiner Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE255165T1 true ATE255165T1 (de) | 2003-12-15 |
Family
ID=8216276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94114298T ATE255165T1 (de) | 1994-09-12 | 1994-09-12 | Rekombinantes mersacidin und verfahren zu seiner herstellung |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5667991A (de) |
| EP (1) | EP0700998B1 (de) |
| JP (1) | JPH0898695A (de) |
| KR (1) | KR100394289B1 (de) |
| CN (1) | CN1149287C (de) |
| AT (1) | ATE255165T1 (de) |
| AU (1) | AU696450B2 (de) |
| CA (1) | CA2157975C (de) |
| CZ (1) | CZ285741B6 (de) |
| DE (1) | DE69433357T2 (de) |
| DK (1) | DK0700998T3 (de) |
| ES (1) | ES2207636T3 (de) |
| FI (1) | FI120100B (de) |
| HU (1) | HU216619B (de) |
| IL (1) | IL115242A0 (de) |
| NZ (1) | NZ272960A (de) |
| PT (1) | PT700998E (de) |
| RU (1) | RU2198924C2 (de) |
| SI (1) | SI9500270B (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6567473B1 (en) * | 1999-03-12 | 2003-05-20 | Aware, Inc. | Method for seamlessly changing power modes in a ADSL system |
| US6775320B1 (en) | 1999-03-12 | 2004-08-10 | Aware, Inc. | Method and a multi-carrier transceiver supporting dynamic switching between active application sets |
| US6861236B2 (en) | 2002-05-24 | 2005-03-01 | Applied Nanosystems B.V. | Export and modification of (poly)peptides in the lantibiotic way |
| US7592308B2 (en) | 2004-03-26 | 2009-09-22 | Novacta Biosystems Limited | F3W variants of the lantibiotic mersacidin and its use |
| GB0406870D0 (en) * | 2004-03-26 | 2004-04-28 | Novacta Biosystems Ltd | Improvements relating to the production of lantibiotics |
| EP1928900A1 (de) * | 2005-09-27 | 2008-06-11 | Novacta Biosystems Limited | Varianten des lantibiotikums mersacidin und deren verwendung |
| GB0600928D0 (en) | 2006-01-17 | 2006-02-22 | Novacta Biosystems Ltd | Improvements relating to lantibiotics |
| GB0714030D0 (en) | 2007-07-18 | 2007-08-29 | Novacta Biosystems Ltd | The use of type-B lantibiotic-based compounds having antimicrobial activity |
| GB0714029D0 (en) | 2007-07-18 | 2007-08-29 | Novacta Biosystems Ltd | Lantibiotic-based compounds having antimicrobial activity |
| RU2441915C9 (ru) * | 2007-08-03 | 2012-06-20 | Сентинелла Фармасьютикалс, Инк. | Гены и белки для биосинтеза лантибиотика 107891 |
| CN102046652B (zh) * | 2008-04-02 | 2014-11-05 | 赛诺菲-安万特 | 来自Actinomadura namibiensis的高度桥联的肽 |
| AU2008364202A1 (en) * | 2008-11-24 | 2011-07-07 | Sentinella Pharmaceuticals, Inc. ("Sentinella") | Lantibiotic carboxyamide derivatives with enhanced antibacterial activity |
| DK2387580T3 (da) | 2009-01-14 | 2014-10-13 | Novacta Biosystems Ltd | Deoxyactagardinderivater |
| EA020733B1 (ru) | 2009-02-04 | 2015-01-30 | Новакта Биосистемс Лимитед | Производные актагардина |
| GB201001688D0 (en) | 2010-02-02 | 2010-03-17 | Novacta Biosystems Ltd | Compounds |
| GB201013513D0 (en) | 2010-08-11 | 2010-09-22 | Novacta Biosystems Ltd | Formulations |
| CN106188253B (zh) * | 2016-08-26 | 2020-08-18 | 上海交通大学 | 抗菌肽Lexapeptide及其制备方法和用途 |
| US12427174B2 (en) | 2019-02-05 | 2025-09-30 | Biomedit, Inc. | Probiotic compositions comprising lactobacillus reuteri strains and methods of use |
| CN111235119B (zh) * | 2020-03-05 | 2021-11-23 | 苏州十一方生物科技有限公司 | 一种融合抗菌蛋白的制备及应用 |
| CN114457102B (zh) * | 2022-02-24 | 2023-12-26 | 重庆市畜牧科学院 | 用于编码分泌型Mersacidin的基因表达盒及其制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5218101A (en) * | 1988-07-05 | 1993-06-08 | The University Of Maryland | Leader sequence inducing a post-translational modification of polypeptides in bacteria, and gene therefor |
| IN167138B (de) * | 1988-08-17 | 1990-09-01 | Hoechst India |
-
1994
- 1994-09-12 AT AT94114298T patent/ATE255165T1/de active
- 1994-09-12 PT PT94114298T patent/PT700998E/pt unknown
- 1994-09-12 ES ES94114298T patent/ES2207636T3/es not_active Expired - Lifetime
- 1994-09-12 DK DK94114298T patent/DK0700998T3/da active
- 1994-09-12 EP EP94114298A patent/EP0700998B1/de not_active Expired - Lifetime
- 1994-09-12 DE DE69433357T patent/DE69433357T2/de not_active Expired - Lifetime
-
1995
- 1995-09-01 SI SI9500270A patent/SI9500270B/sl not_active IP Right Cessation
- 1995-09-08 NZ NZ272960A patent/NZ272960A/en not_active IP Right Cessation
- 1995-09-08 CZ CZ952318A patent/CZ285741B6/cs not_active IP Right Cessation
- 1995-09-08 FI FI954220A patent/FI120100B/fi not_active IP Right Cessation
- 1995-09-08 US US08/524,677 patent/US5667991A/en not_active Expired - Lifetime
- 1995-09-08 AU AU30554/95A patent/AU696450B2/en not_active Ceased
- 1995-09-08 CN CNB951162330A patent/CN1149287C/zh not_active Expired - Fee Related
- 1995-09-11 CA CA002157975A patent/CA2157975C/en not_active Expired - Fee Related
- 1995-09-11 IL IL11524295A patent/IL115242A0/xx not_active IP Right Cessation
- 1995-09-11 RU RU95115686/13A patent/RU2198924C2/ru not_active IP Right Cessation
- 1995-09-11 HU HU9502643A patent/HU216619B/hu not_active IP Right Cessation
- 1995-09-11 JP JP7232356A patent/JPH0898695A/ja active Pending
- 1995-09-12 KR KR1019950029599A patent/KR100394289B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR100394289B1 (ko) | 2003-10-22 |
| DE69433357D1 (de) | 2004-01-08 |
| CZ231895A3 (en) | 1996-03-13 |
| CN1149287C (zh) | 2004-05-12 |
| HUT73800A (en) | 1996-09-30 |
| RU2198924C2 (ru) | 2003-02-20 |
| EP0700998A1 (de) | 1996-03-13 |
| NZ272960A (en) | 1996-05-28 |
| ES2207636T3 (es) | 2004-06-01 |
| JPH0898695A (ja) | 1996-04-16 |
| FI954220A0 (fi) | 1995-09-08 |
| CZ285741B6 (cs) | 1999-10-13 |
| KR960010863A (ko) | 1996-04-20 |
| CN1131192A (zh) | 1996-09-18 |
| FI120100B (fi) | 2009-06-30 |
| FI954220L (fi) | 1996-03-13 |
| CA2157975C (en) | 2008-11-18 |
| CA2157975A1 (en) | 1996-03-13 |
| DE69433357T2 (de) | 2004-09-09 |
| SI9500270B (sl) | 2002-02-28 |
| PT700998E (pt) | 2004-03-31 |
| HU216619B (hu) | 1999-07-28 |
| SI9500270A (en) | 1996-04-30 |
| HU9502643D0 (en) | 1995-11-28 |
| EP0700998B1 (de) | 2003-11-26 |
| DK0700998T3 (da) | 2004-03-29 |
| US5667991A (en) | 1997-09-16 |
| AU3055495A (en) | 1996-03-28 |
| AU696450B2 (en) | 1998-09-10 |
| IL115242A0 (en) | 1995-12-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69433357D1 (de) | Rekombinantes Mersacidin und Verfahren zu seiner Herstellung | |
| PT699076E (pt) | Vacina contra a otite media | |
| DE69422909D1 (de) | Material und Verfahren zur stark vermehrter Sekretion von Aminosäuren | |
| DE69231939D1 (de) | Hybrid-Plasmid-Vektoren, die für Nitril-abbauende Enzyme kodierende Gene enthalten und Verfahren zur Herstellung von Amiden und Säuren | |
| HU9200548D0 (en) | Improved activity process of recombined proteins | |
| DE69530306D1 (de) | Verfahren zur herstellung von l-lysin und l-glutaminsäure durch fermentation | |
| ATE97421T1 (de) | Gentechnologisch hergestellter pankreatischer sekretorischer trypsininhibitor und seine varianten. | |
| DE59601822D1 (de) | Verfahren zur herstellung von weizenproteinhydrolysaten | |
| DE69334152D1 (de) | Verknüpftes D-Protein und Verfahren zur Identifizierung von Rezeptor Aktivität modulierenden Verbindungen | |
| PT920501E (pt) | Neuritina um neurogene | |
| ATE165363T1 (de) | Verfahren und mittel zur sortierung und bestimmung biologischer informationen | |
| ATE264913T1 (de) | Protease-resistente analoge des thrombomodulin | |
| DE69430975D1 (de) | Verfahren zur Herstellung von Proteinen | |
| ATE154609T1 (de) | Nicht-lineare peptide, die hydropatisch komplementär zu bekannten aminosäuresequenzen sind, verfahren zur herstellung und verwendung davon | |
| PL320084A1 (en) | Nucleic acids of amino acid type | |
| ATE281523T1 (de) | Acarbose-biosynthesegene aus actinoplanes sp., verfahren zu ihrer isolierung sowie ihrer verwendung | |
| DE69315730D1 (de) | Verfahren zur Herstellung von Peptiden und neue Zwischenverbindungen dazu | |
| DE59604613D1 (de) | Verfahren zur herstellung von optisch aktiven alpha-aminosäuren und alpha-aminosäure-derivaten | |
| DE69208652D1 (de) | Verbessertes verfahren zur herstellung von chloressigsäure phenylester | |
| DE69526462D1 (de) | Verfahren zur Herstellung von Peptiden aus N-Carboxyanhydridaminosäuren | |
| DE3865389D1 (de) | Verfahren zur herstellung von l,l oder d,d oder racemat n6 benzyloxycarbonyl 2,6 diaminopimelinsaeuremonoamid. | |
| IL98170A0 (en) | Method for amino acid sequencing in internal regions of proteins |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0700998 Country of ref document: EP |