FI119640B - Bisyklisiä N-substituoituja piperidinyylibentsoaattijohdannaisia - Google Patents
Bisyklisiä N-substituoituja piperidinyylibentsoaattijohdannaisia Download PDFInfo
- Publication number
- FI119640B FI119640B FI971274A FI971274A FI119640B FI 119640 B FI119640 B FI 119640B FI 971274 A FI971274 A FI 971274A FI 971274 A FI971274 A FI 971274A FI 119640 B FI119640 B FI 119640B
- Authority
- FI
- Finland
- Prior art keywords
- alkyl
- formula
- chloro
- dihydro
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP94202792 | 1994-09-27 | ||
EP94202792 | 1994-09-27 | ||
US45548695A | 1995-05-31 | 1995-05-31 | |
US45548695 | 1995-05-31 | ||
EP9503691 | 1995-09-19 | ||
PCT/EP1995/003691 WO1996010027A1 (en) | 1994-09-27 | 1995-09-19 | N-substituted piperidinyl bicyclic benzoate derivatives |
Publications (3)
Publication Number | Publication Date |
---|---|
FI971274A FI971274A (fi) | 1997-03-26 |
FI971274A0 FI971274A0 (fi) | 1997-03-26 |
FI119640B true FI119640B (fi) | 2009-01-30 |
Family
ID=26136613
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI971274A FI119640B (fi) | 1994-09-27 | 1997-03-26 | Bisyklisiä N-substituoituja piperidinyylibentsoaattijohdannaisia |
Country Status (23)
Country | Link |
---|---|
EP (1) | EP0784620B1 (da) |
JP (1) | JP3953097B2 (da) |
CN (1) | CN1068880C (da) |
AT (1) | ATE187453T1 (da) |
AU (1) | AU699152B2 (da) |
BR (1) | BR9509036A (da) |
CA (1) | CA2200578C (da) |
CZ (1) | CZ289031B6 (da) |
DE (1) | DE69513846T2 (da) |
DK (1) | DK0784620T3 (da) |
ES (1) | ES2141383T3 (da) |
FI (1) | FI119640B (da) |
GR (1) | GR3032646T3 (da) |
HU (1) | HU218698B (da) |
IL (1) | IL115413A (da) |
MY (1) | MY113202A (da) |
NO (1) | NO313238B1 (da) |
NZ (1) | NZ293605A (da) |
PL (1) | PL182502B1 (da) |
PT (1) | PT784620E (da) |
RU (1) | RU2154064C2 (da) |
WO (1) | WO1996010027A1 (da) |
ZA (1) | ZA958081B (da) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU753706B2 (en) * | 1998-05-14 | 2002-10-24 | Egis Gyogyszergyar Rt. | Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient |
RU2301806C2 (ru) * | 2002-01-16 | 2007-06-27 | Янссен Фармацевтика Н.В. | Прукалоприд-n-оксид |
WO2005061483A2 (en) * | 2003-12-23 | 2005-07-07 | Bio-Medisinsk Innovasjon As | Modulators of peripheral 5-ht receptors |
NZ551603A (en) | 2004-06-24 | 2010-11-26 | Incyte Corp | N-substituted piperidines and their use as pharmaceuticals |
CN102775396B (zh) | 2005-11-08 | 2014-10-08 | 沃泰克斯药物股份有限公司 | Atp-结合弹夹转运蛋白的杂环调控剂 |
AU2008251504B2 (en) | 2007-05-09 | 2013-07-18 | Vertex Pharmaceuticals Incorporated | Modulators of CFTR |
DK2639223T3 (da) | 2007-12-07 | 2017-06-19 | Vertex Pharma | Fremgangsmåde til fremstilling af cycloalkylcarboxiamido-pyridinbenzosyrer |
ES2790830T3 (es) | 2007-12-07 | 2020-10-29 | Vertex Pharma | Formas solidas de ácido 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-il)ciclopropanocarboxamido)-3-metilpiridin-2-il) benzoico |
NZ703814A (en) | 2008-02-28 | 2016-06-24 | Vertex Pharma | Heteroaryl derivatives as cftr modulators |
NZ708598A (en) | 2010-04-07 | 2017-05-26 | Vertex Pharma | Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d](1,3)dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid and administration thereof |
TWI549950B (zh) * | 2010-04-07 | 2016-09-21 | 維泰克斯製藥公司 | 3-(6-(1-(2,2-二氟苯并[d][1,3]二氧雜環戊烯-5-基)環丙烷甲醯胺基)-3-甲基吡啶-2-基)苯甲酸之固體形式 |
US10231932B2 (en) | 2013-11-12 | 2019-03-19 | Vertex Pharmaceuticals Incorporated | Process of preparing pharmaceutical compositions for the treatment of CFTR mediated diseases |
WO2016081556A1 (en) | 2014-11-18 | 2016-05-26 | Vertex Pharmaceuticals Incorporated | Process of conducting high throughput testing high performance liquid chromatography |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1317940C (en) * | 1987-09-25 | 1993-05-18 | Georges H. P. Van Daele | Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides |
DE3810552A1 (de) * | 1988-03-29 | 1989-10-19 | Sandoz Ag | Ester und amide von indol-, benzo(b)thiopen-, benzo(b)furancarbonsaeuren oder 4-amino-2-methoxy-benzolsaeuren mit n-heterocyclischen oder n-heterobicyclischen alkoholen oder aminen, verfahren zu deren herstellung sie enthaltende pharmazeutische zusammensetzungen sowie applikator zur verabreichung derselben |
US5374637A (en) * | 1989-03-22 | 1994-12-20 | Janssen Pharmaceutica N.V. | N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives |
GB9005014D0 (en) * | 1990-03-06 | 1990-05-02 | Janssen Pharmaceutica Nv | N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives |
WO1993003725A1 (en) * | 1991-08-20 | 1993-03-04 | Smithkline Beecham Plc | 5-ht4 receptor antagonists |
MX9306311A (es) * | 1992-10-13 | 1994-04-29 | Smithkline Beecham Plc | Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen |
-
1995
- 1995-09-19 BR BR9509036A patent/BR9509036A/pt not_active IP Right Cessation
- 1995-09-19 CZ CZ1997918A patent/CZ289031B6/cs not_active IP Right Cessation
- 1995-09-19 JP JP51133896A patent/JP3953097B2/ja not_active Expired - Fee Related
- 1995-09-19 PL PL95319997A patent/PL182502B1/pl not_active IP Right Cessation
- 1995-09-19 EP EP95933400A patent/EP0784620B1/en not_active Expired - Lifetime
- 1995-09-19 NZ NZ293605A patent/NZ293605A/en not_active IP Right Cessation
- 1995-09-19 RU RU97107464/04A patent/RU2154064C2/ru not_active IP Right Cessation
- 1995-09-19 DE DE69513846T patent/DE69513846T2/de not_active Expired - Lifetime
- 1995-09-19 CN CN95195300A patent/CN1068880C/zh not_active Expired - Fee Related
- 1995-09-19 AU AU36081/95A patent/AU699152B2/en not_active Ceased
- 1995-09-19 WO PCT/EP1995/003691 patent/WO1996010027A1/en active IP Right Grant
- 1995-09-19 HU HU9701944A patent/HU218698B/hu not_active IP Right Cessation
- 1995-09-19 AT AT95933400T patent/ATE187453T1/de not_active IP Right Cessation
- 1995-09-19 CA CA002200578A patent/CA2200578C/en not_active Expired - Lifetime
- 1995-09-19 ES ES95933400T patent/ES2141383T3/es not_active Expired - Lifetime
- 1995-09-19 PT PT95933400T patent/PT784620E/pt unknown
- 1995-09-19 DK DK95933400T patent/DK0784620T3/da active
- 1995-09-22 IL IL11541395A patent/IL115413A/xx not_active IP Right Cessation
- 1995-09-26 ZA ZA958081A patent/ZA958081B/xx unknown
- 1995-09-26 MY MYPI95002870A patent/MY113202A/en unknown
-
1997
- 1997-03-24 NO NO19971376A patent/NO313238B1/no not_active IP Right Cessation
- 1997-03-26 FI FI971274A patent/FI119640B/fi active
-
2000
- 2000-02-11 GR GR20000400344T patent/GR3032646T3/el not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI101624B (fi) | Menetelmä terapeuttisesti käyttökelpoisten N-(3-hydroksi-4-piperidinyy li)(dihydrobentsofuraani-, dihydro-2H-bentsopyraani- tai dihydrobentso dioksiini)karboksamidijohdannaisten valmistamiseksi ja välituote | |
KR100500372B1 (ko) | 위장운동 조절성 3- 또는 4-치환된4-(아미노메틸)-피페리딘 유도체의 비사이클릭 벤즈아미드 | |
FI119640B (fi) | Bisyklisiä N-substituoituja piperidinyylibentsoaattijohdannaisia | |
SK282406B6 (sk) | N-(4-Piperidinyl) (dihydrobenzofurán alebo dihydro-2H-benzopyrán) karboxamidové deriváty, spôsob a medziprodukty na ich výrobu a farmaceutické prípravky na ich báze | |
FI94129B (fi) | Menetelmä terapeuttisesti käyttökelpoisten N-(1-alkyyli-3-hydroksi-4-piperidinyyli)bentsamidien valmistamiseksi | |
US6544997B1 (en) | 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders | |
US5053411A (en) | N-aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides and pharmaceutical compositions and methods employing such compounds | |
AU718695B2 (en) | Esters of 3-hydroxy-piperidinemethanol derivatives | |
WO2005030722A1 (ja) | N-置換-n-(4-ピペリジニル)アミド誘導体 | |
USRE34201E (en) | N-aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides and pharmaceutical compositions and methods employing such compounds | |
JP3862750B2 (ja) | フェニル−オキソ−アルキル−(4−ピペリジニル)ベンゾエート誘導体 | |
HUT77311A (hu) | Fenil-oxo-alkil-(4-piperidinil)-benzoát-származékok, e vegyületeket tartalmazó gyógyszerkészítmények, eljárás előállításukra és alkalmazásuk | |
MXPA97002363A (es) | Derivados biciclicos de benzoato de piperidinilon-substituidos | |
MXPA01006409A (en) | 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders | |
MXPA97002356A (en) | Derivatives of phenyl-oxy-alkyl- (4-piperidinyl) benzo |