FI119640B - Bisyklisiä N-substituoituja piperidinyylibentsoaattijohdannaisia - Google Patents

Bisyklisiä N-substituoituja piperidinyylibentsoaattijohdannaisia Download PDF

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Publication number
FI119640B
FI119640B FI971274A FI971274A FI119640B FI 119640 B FI119640 B FI 119640B FI 971274 A FI971274 A FI 971274A FI 971274 A FI971274 A FI 971274A FI 119640 B FI119640 B FI 119640B
Authority
FI
Finland
Prior art keywords
alkyl
formula
chloro
dihydro
amino
Prior art date
Application number
FI971274A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI971274A (fi
FI971274A0 (fi
Inventor
Daele Georges Henri Paul Van
Den Keybus Frans Maria Alf Van
Jean-Paul Rene Marie A Bosmans
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of FI971274A publication Critical patent/FI971274A/fi
Publication of FI971274A0 publication Critical patent/FI971274A0/fi
Application granted granted Critical
Publication of FI119640B publication Critical patent/FI119640B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI971274A 1994-09-27 1997-03-26 Bisyklisiä N-substituoituja piperidinyylibentsoaattijohdannaisia FI119640B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP94202792 1994-09-27
EP94202792 1994-09-27
US45548695A 1995-05-31 1995-05-31
US45548695 1995-05-31
EP9503691 1995-09-19
PCT/EP1995/003691 WO1996010027A1 (en) 1994-09-27 1995-09-19 N-substituted piperidinyl bicyclic benzoate derivatives

Publications (3)

Publication Number Publication Date
FI971274A FI971274A (fi) 1997-03-26
FI971274A0 FI971274A0 (fi) 1997-03-26
FI119640B true FI119640B (fi) 2009-01-30

Family

ID=26136613

Family Applications (1)

Application Number Title Priority Date Filing Date
FI971274A FI119640B (fi) 1994-09-27 1997-03-26 Bisyklisiä N-substituoituja piperidinyylibentsoaattijohdannaisia

Country Status (23)

Country Link
EP (1) EP0784620B1 (da)
JP (1) JP3953097B2 (da)
CN (1) CN1068880C (da)
AT (1) ATE187453T1 (da)
AU (1) AU699152B2 (da)
BR (1) BR9509036A (da)
CA (1) CA2200578C (da)
CZ (1) CZ289031B6 (da)
DE (1) DE69513846T2 (da)
DK (1) DK0784620T3 (da)
ES (1) ES2141383T3 (da)
FI (1) FI119640B (da)
GR (1) GR3032646T3 (da)
HU (1) HU218698B (da)
IL (1) IL115413A (da)
MY (1) MY113202A (da)
NO (1) NO313238B1 (da)
NZ (1) NZ293605A (da)
PL (1) PL182502B1 (da)
PT (1) PT784620E (da)
RU (1) RU2154064C2 (da)
WO (1) WO1996010027A1 (da)
ZA (1) ZA958081B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU753706B2 (en) * 1998-05-14 2002-10-24 Egis Gyogyszergyar Rt. Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient
RU2301806C2 (ru) * 2002-01-16 2007-06-27 Янссен Фармацевтика Н.В. Прукалоприд-n-оксид
WO2005061483A2 (en) * 2003-12-23 2005-07-07 Bio-Medisinsk Innovasjon As Modulators of peripheral 5-ht receptors
NZ551603A (en) 2004-06-24 2010-11-26 Incyte Corp N-substituted piperidines and their use as pharmaceuticals
CN102775396B (zh) 2005-11-08 2014-10-08 沃泰克斯药物股份有限公司 Atp-结合弹夹转运蛋白的杂环调控剂
AU2008251504B2 (en) 2007-05-09 2013-07-18 Vertex Pharmaceuticals Incorporated Modulators of CFTR
DK2639223T3 (da) 2007-12-07 2017-06-19 Vertex Pharma Fremgangsmåde til fremstilling af cycloalkylcarboxiamido-pyridinbenzosyrer
ES2790830T3 (es) 2007-12-07 2020-10-29 Vertex Pharma Formas solidas de ácido 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-il)ciclopropanocarboxamido)-3-metilpiridin-2-il) benzoico
NZ703814A (en) 2008-02-28 2016-06-24 Vertex Pharma Heteroaryl derivatives as cftr modulators
NZ708598A (en) 2010-04-07 2017-05-26 Vertex Pharma Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d](1,3)dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid and administration thereof
TWI549950B (zh) * 2010-04-07 2016-09-21 維泰克斯製藥公司 ３－（６－（１－（２，２－二氟苯并［ｄ］［１，３］二氧雜環戊烯－５－基）環丙烷甲醯胺基）－３－甲基吡啶－２－基）苯甲酸之固體形式
US10231932B2 (en) 2013-11-12 2019-03-19 Vertex Pharmaceuticals Incorporated Process of preparing pharmaceutical compositions for the treatment of CFTR mediated diseases
WO2016081556A1 (en) 2014-11-18 2016-05-26 Vertex Pharmaceuticals Incorporated Process of conducting high throughput testing high performance liquid chromatography

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1317940C (en) * 1987-09-25 1993-05-18 Georges H. P. Van Daele Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
DE3810552A1 (de) * 1988-03-29 1989-10-19 Sandoz Ag Ester und amide von indol-, benzo(b)thiopen-, benzo(b)furancarbonsaeuren oder 4-amino-2-methoxy-benzolsaeuren mit n-heterocyclischen oder n-heterobicyclischen alkoholen oder aminen, verfahren zu deren herstellung sie enthaltende pharmazeutische zusammensetzungen sowie applikator zur verabreichung derselben
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
GB9005014D0 (en) * 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
WO1993003725A1 (en) * 1991-08-20 1993-03-04 Smithkline Beecham Plc 5-ht4 receptor antagonists
MX9306311A (es) * 1992-10-13 1994-04-29 Smithkline Beecham Plc Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen

Also Published As

Publication number Publication date
GR3032646T3 (en) 2000-06-30
WO1996010027A1 (en) 1996-04-04
FI971274A (fi) 1997-03-26
AU3608195A (en) 1996-04-19
FI971274A0 (fi) 1997-03-26
EP0784620A1 (en) 1997-07-23
NZ293605A (en) 1998-07-28
MY113202A (en) 2001-12-31
ZA958081B (en) 1997-03-26
HUT77173A (hu) 1998-03-02
DE69513846D1 (de) 2000-01-13
NO971376D0 (no) 1997-03-24
CZ91897A3 (en) 1997-12-17
NO971376L (no) 1997-05-05
JP3953097B2 (ja) 2007-08-01
ES2141383T3 (es) 2000-03-16
CZ289031B6 (cs) 2001-10-17
ATE187453T1 (de) 1999-12-15
CN1166171A (zh) 1997-11-26
EP0784620B1 (en) 1999-12-08
PL182502B1 (pl) 2002-01-31
JPH10506118A (ja) 1998-06-16
DK0784620T3 (da) 2000-05-22
CA2200578A1 (en) 1996-04-04
IL115413A0 (en) 1995-12-31
AU699152B2 (en) 1998-11-26
MX9702363A (es) 1997-10-31
BR9509036A (pt) 1997-10-14
PT784620E (pt) 2000-05-31
IL115413A (en) 2000-02-17
CN1068880C (zh) 2001-07-25
PL319997A1 (en) 1997-09-01
CA2200578C (en) 2006-11-07
RU2154064C2 (ru) 2000-08-10
HU218698B (hu) 2000-11-28
NO313238B1 (no) 2002-09-02
DE69513846T2 (de) 2000-07-06

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