DE69513846T2 - N-substituierte piperidinyl bicyclische benzoatderivate - Google Patents

N-substituierte piperidinyl bicyclische benzoatderivate

Info

Publication number
DE69513846T2
DE69513846T2 DE69513846T DE69513846T DE69513846T2 DE 69513846 T2 DE69513846 T2 DE 69513846T2 DE 69513846 T DE69513846 T DE 69513846T DE 69513846 T DE69513846 T DE 69513846T DE 69513846 T2 DE69513846 T2 DE 69513846T2
Authority
DE
Germany
Prior art keywords
6alkyl
substituted
halo
hydrogen
alk
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69513846T
Other languages
English (en)
Other versions
DE69513846D1 (de
Inventor
Daele Georges Van
Jean-Paul Bosmans
Den Keybus Frans Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of DE69513846D1 publication Critical patent/DE69513846D1/de
Publication of DE69513846T2 publication Critical patent/DE69513846T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69513846T 1994-09-27 1995-09-19 N-substituierte piperidinyl bicyclische benzoatderivate Expired - Lifetime DE69513846T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP94202792 1994-09-27
US45548695A 1995-05-31 1995-05-31
PCT/EP1995/003691 WO1996010027A1 (en) 1994-09-27 1995-09-19 N-substituted piperidinyl bicyclic benzoate derivatives

Publications (2)

Publication Number Publication Date
DE69513846D1 DE69513846D1 (de) 2000-01-13
DE69513846T2 true DE69513846T2 (de) 2000-07-06

Family

ID=26136613

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69513846T Expired - Lifetime DE69513846T2 (de) 1994-09-27 1995-09-19 N-substituierte piperidinyl bicyclische benzoatderivate

Country Status (23)

Country Link
EP (1) EP0784620B1 (de)
JP (1) JP3953097B2 (de)
CN (1) CN1068880C (de)
AT (1) ATE187453T1 (de)
AU (1) AU699152B2 (de)
BR (1) BR9509036A (de)
CA (1) CA2200578C (de)
CZ (1) CZ289031B6 (de)
DE (1) DE69513846T2 (de)
DK (1) DK0784620T3 (de)
ES (1) ES2141383T3 (de)
FI (1) FI119640B (de)
GR (1) GR3032646T3 (de)
HU (1) HU218698B (de)
IL (1) IL115413A (de)
MY (1) MY113202A (de)
NO (1) NO313238B1 (de)
NZ (1) NZ293605A (de)
PL (1) PL182502B1 (de)
PT (1) PT784620E (de)
RU (1) RU2154064C2 (de)
WO (1) WO1996010027A1 (de)
ZA (1) ZA958081B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002514643A (ja) * 1998-05-14 2002-05-21 エギシュ ヂョヂセルヂャール エルテー ベンゾフラン誘導体、それを含有する製薬学的な組成物及びその活性成分の製造方法。
NZ533041A (en) * 2002-01-16 2006-04-28 Janssen Pharmaceutica Nv Prucalopride-N-oxide
CA2551171C (en) 2003-12-23 2012-07-10 Bio-Medisinsk Innovasjon As Modulators of peripheral 5-ht receptors
NZ551603A (en) 2004-06-24 2010-11-26 Incyte Corp N-substituted piperidines and their use as pharmaceuticals
EP3208272B1 (de) 2005-11-08 2020-01-08 Vertex Pharmaceuticals Incorporated Heterocyclische modulatoren von atp-bindenden kassettentransportern
EP2164840A2 (de) 2007-05-09 2010-03-24 Vertex Pharmaceuticals Incorporated Modulatoren von cftr
RS55559B1 (sr) 2007-12-07 2017-05-31 Vertex Pharma Čvrste forme 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il)ciklopropankarboksamido)-3-metilpiridin-2-il) benzoeve kiseline
EA201070700A1 (ru) 2007-12-07 2011-06-30 Вертекс Фармасьютикалз Инкорпорейтед Способы получения циклоалкилкарбоксамидопиридинбензойных кислот
JP5523352B2 (ja) 2008-02-28 2014-06-18 バーテックス ファーマシューティカルズ インコーポレイテッド Ｃｆｔｒ修飾因子としてのへテロアリール誘導体
NZ602838A (en) 2010-04-07 2015-06-26 Vertex Pharma Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid and administration thereof
CN102933206A (zh) * 2010-04-07 2013-02-13 弗特克斯药品有限公司 3-(6-(1-(2，2-二氟苯并[d][1，3]二氧杂环戊烯-5-基)环丙烷甲酰胺基)-3-甲基吡啶-2-基)苯甲酸的固体形式
JP6963896B2 (ja) 2013-11-12 2021-11-10 バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated Ｃｆｔｒ媒介性疾患の処置のための医薬組成物を調製する方法
RU2691136C2 (ru) 2014-11-18 2019-06-11 Вертекс Фармасьютикалз Инкорпорейтед Способ проведения высокопроизводительной тестовой высокоэффективной жидкостной хроматографии

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1317940C (en) * 1987-09-25 1993-05-18 Georges H. P. Van Daele Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
DE3810552A1 (de) * 1988-03-29 1989-10-19 Sandoz Ag Ester und amide von indol-, benzo(b)thiopen-, benzo(b)furancarbonsaeuren oder 4-amino-2-methoxy-benzolsaeuren mit n-heterocyclischen oder n-heterobicyclischen alkoholen oder aminen, verfahren zu deren herstellung sie enthaltende pharmazeutische zusammensetzungen sowie applikator zur verabreichung derselben
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
GB9005014D0 (en) * 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
AU2435092A (en) * 1991-08-20 1993-03-16 Smithkline Beecham Plc 5-ht4 receptor antagonists
MX9306311A (es) * 1992-10-13 1994-04-29 Smithkline Beecham Plc Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen

Also Published As

Publication number Publication date
EP0784620A1 (de) 1997-07-23
IL115413A0 (en) 1995-12-31
NZ293605A (en) 1998-07-28
HU218698B (hu) 2000-11-28
AU699152B2 (en) 1998-11-26
PL182502B1 (pl) 2002-01-31
FI119640B (fi) 2009-01-30
CA2200578C (en) 2006-11-07
ATE187453T1 (de) 1999-12-15
CN1166171A (zh) 1997-11-26
FI971274A0 (fi) 1997-03-26
NO971376L (no) 1997-05-05
GR3032646T3 (en) 2000-06-30
DK0784620T3 (da) 2000-05-22
WO1996010027A1 (en) 1996-04-04
MX9702363A (es) 1997-10-31
BR9509036A (pt) 1997-10-14
CZ91897A3 (en) 1997-12-17
IL115413A (en) 2000-02-17
JPH10506118A (ja) 1998-06-16
NO971376D0 (no) 1997-03-24
FI971274A (fi) 1997-03-26
HUT77173A (hu) 1998-03-02
AU3608195A (en) 1996-04-19
MY113202A (en) 2001-12-31
JP3953097B2 (ja) 2007-08-01
NO313238B1 (no) 2002-09-02
CN1068880C (zh) 2001-07-25
PL319997A1 (en) 1997-09-01
ZA958081B (en) 1997-03-26
PT784620E (pt) 2000-05-31
EP0784620B1 (de) 1999-12-08
CA2200578A1 (en) 1996-04-04
DE69513846D1 (de) 2000-01-13
RU2154064C2 (ru) 2000-08-10
CZ289031B6 (cs) 2001-10-17
ES2141383T3 (es) 2000-03-16

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