DE69513846D1 - N-substituierte piperidinyl bicyclische benzoatderivate - Google Patents

N-substituierte piperidinyl bicyclische benzoatderivate

Info

Publication number
DE69513846D1
DE69513846D1 DE69513846T DE69513846T DE69513846D1 DE 69513846 D1 DE69513846 D1 DE 69513846D1 DE 69513846 T DE69513846 T DE 69513846T DE 69513846 T DE69513846 T DE 69513846T DE 69513846 D1 DE69513846 D1 DE 69513846D1
Authority
DE
Germany
Prior art keywords
6alkyl
substituted
halo
hydrogen
alk
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69513846T
Other languages
English (en)
Other versions
DE69513846T2 (de
Inventor
Daele Georges Van
Jean-Paul Bosmans
Den Keybus Frans Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of DE69513846D1 publication Critical patent/DE69513846D1/de
Application granted granted Critical
Publication of DE69513846T2 publication Critical patent/DE69513846T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69513846T 1994-09-27 1995-09-19 N-substituierte piperidinyl bicyclische benzoatderivate Expired - Lifetime DE69513846T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP94202792 1994-09-27
US45548695A 1995-05-31 1995-05-31
PCT/EP1995/003691 WO1996010027A1 (en) 1994-09-27 1995-09-19 N-substituted piperidinyl bicyclic benzoate derivatives

Publications (2)

Publication Number Publication Date
DE69513846D1 true DE69513846D1 (de) 2000-01-13
DE69513846T2 DE69513846T2 (de) 2000-07-06

Family

ID=26136613

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69513846T Expired - Lifetime DE69513846T2 (de) 1994-09-27 1995-09-19 N-substituierte piperidinyl bicyclische benzoatderivate

Country Status (23)

Country Link
EP (1) EP0784620B1 (de)
JP (1) JP3953097B2 (de)
CN (1) CN1068880C (de)
AT (1) ATE187453T1 (de)
AU (1) AU699152B2 (de)
BR (1) BR9509036A (de)
CA (1) CA2200578C (de)
CZ (1) CZ289031B6 (de)
DE (1) DE69513846T2 (de)
DK (1) DK0784620T3 (de)
ES (1) ES2141383T3 (de)
FI (1) FI119640B (de)
GR (1) GR3032646T3 (de)
HU (1) HU218698B (de)
IL (1) IL115413A (de)
MY (1) MY113202A (de)
NO (1) NO313238B1 (de)
NZ (1) NZ293605A (de)
PL (1) PL182502B1 (de)
PT (1) PT784620E (de)
RU (1) RU2154064C2 (de)
WO (1) WO1996010027A1 (de)
ZA (1) ZA958081B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2332275A1 (en) * 1998-05-14 1999-11-18 Zoltan Tamas Nagy Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient
AU2003206722B2 (en) * 2002-01-16 2008-01-24 Mercury Pharma Group Limited Prucalopride-N-oxide
ATE457309T1 (de) * 2003-12-23 2010-02-15 Serodus As Modulatoren von peripheren 5-ht-rezeptoren
EA200700117A1 (ru) 2004-06-24 2007-06-29 Инсайт Корпорейшн N-замещенные пиперидины и их применение в качестве фармацевтических препаратов
SI1945632T1 (sl) 2005-11-08 2014-03-31 Vertex Pharmaceuticals Incorporated Heterocikliäśni modulatorji za prenaĺ alce z atp-vezavno kaseto
JP5497633B2 (ja) 2007-05-09 2014-05-21 バーテックス ファーマシューティカルズ インコーポレイテッド Ｃｆｔｒのモジュレーター
WO2009073757A1 (en) 2007-12-07 2009-06-11 Vertex Pharmaceuticals Incorporated Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3] dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid
WO2009076142A2 (en) 2007-12-07 2009-06-18 Vertex Pharmaceuticals Incorporated Processes for producing cycloalkylcarboxiamido-pyridine benzoic acids
CA3039943C (en) 2008-02-28 2021-07-13 Vertex Pharmaceuticals Incorporated Heteroaryl derivatives as cftr modulators
CA2795748C (en) * 2010-04-07 2020-12-08 Vertex Pharmaceuticals Incorporated Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
CA2795804C (en) 2010-04-07 2021-10-26 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyriodin-2-yl)benzoic acid and administration thereof
CA2930199C (en) 2013-11-12 2022-10-25 Vertex Pharmaceuticals Incorporated Process of preparing pharmaceutical compositions for the treatment of cftr mediated diseases
PT3221692T (pt) 2014-11-18 2021-09-10 Vertex Pharma Processo de realização de testagem de alta produtividade por cromatografia líquida de alta eficiência

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1317940C (en) * 1987-09-25 1993-05-18 Georges H. P. Van Daele Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
DE3810552A1 (de) * 1988-03-29 1989-10-19 Sandoz Ag Ester und amide von indol-, benzo(b)thiopen-, benzo(b)furancarbonsaeuren oder 4-amino-2-methoxy-benzolsaeuren mit n-heterocyclischen oder n-heterobicyclischen alkoholen oder aminen, verfahren zu deren herstellung sie enthaltende pharmazeutische zusammensetzungen sowie applikator zur verabreichung derselben
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
GB9005014D0 (en) * 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
CA2116024A1 (en) * 1991-08-20 1993-03-04 Francis David King 5-ht4 receptor antagonists
MX9306311A (es) * 1992-10-13 1994-04-29 Smithkline Beecham Plc Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen

Also Published As

Publication number Publication date
MX9702363A (es) 1997-10-31
CN1068880C (zh) 2001-07-25
NO971376D0 (no) 1997-03-24
NZ293605A (en) 1998-07-28
FI971274A0 (fi) 1997-03-26
JP3953097B2 (ja) 2007-08-01
DE69513846T2 (de) 2000-07-06
MY113202A (en) 2001-12-31
PT784620E (pt) 2000-05-31
ATE187453T1 (de) 1999-12-15
CA2200578A1 (en) 1996-04-04
DK0784620T3 (da) 2000-05-22
HUT77173A (hu) 1998-03-02
GR3032646T3 (en) 2000-06-30
AU3608195A (en) 1996-04-19
AU699152B2 (en) 1998-11-26
FI971274A (fi) 1997-03-26
NO971376L (no) 1997-05-05
EP0784620A1 (de) 1997-07-23
EP0784620B1 (de) 1999-12-08
BR9509036A (pt) 1997-10-14
RU2154064C2 (ru) 2000-08-10
JPH10506118A (ja) 1998-06-16
CZ289031B6 (cs) 2001-10-17
CN1166171A (zh) 1997-11-26
NO313238B1 (no) 2002-09-02
FI119640B (fi) 2009-01-30
PL182502B1 (pl) 2002-01-31
CA2200578C (en) 2006-11-07
IL115413A (en) 2000-02-17
PL319997A1 (en) 1997-09-01
CZ91897A3 (en) 1997-12-17
WO1996010027A1 (en) 1996-04-04
HU218698B (hu) 2000-11-28
IL115413A0 (en) 1995-12-31
ZA958081B (en) 1997-03-26
ES2141383T3 (es) 2000-03-16

Similar Documents

Publication Publication Date Title
ATE187453T1 (de) N-substituierte piperidinyl bicyclische benzoatderivate
ES449191A1 (es) Un procedimiento de preparacion de derivados de 4,5,6,7-te- trahidro-tieno-(2,3-c)-piridina.
TW369526B (en) Diazabicyclic neurokinin antagonists
DE69633607D1 (de) Piperidinderivate mit tachykinin-antagonistischer wirkung
CA2036876A1 (fr) Derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EA200100710A1 (ru) 4-(аминометил)пиперидинбензамиды для лечения желудочно-кишечных расстройств
ATE171943T1 (de) Piperidin-verbindungen, ihre darstellung und ihre verwendung
BG104717A (en) Water soluble azoles as broad-spectrum antifungals
PL322872A1 (en) Novel triazolones - inhibitors of b apolipoprotein synthesis
TW360653B (en) A oxadiazole compound having colon motility stimulating properties, its preparation process and its pharmaceutical composition
ATE178064T1 (de) Phenyl-oxo-alkyl-(4-piperidinyl) benzoatderivate
JO1648B1 (en) Nitrogen compounds
JO1697B1 (en) Pyridine derivatives
NO932513L (no) N-alkyl-kinuklidinium-salter

Legal Events

Date Code Title Description
8364 No opposition during term of opposition