IL115413A - N-substituted piperidinyl bicyclic benzoate derivatives their preparation and pharmaceutical compositions containing them - Google Patents

N-substituted piperidinyl bicyclic benzoate derivatives their preparation and pharmaceutical compositions containing them

Info

Publication number
IL115413A
IL115413A IL11541395A IL11541395A IL115413A IL 115413 A IL115413 A IL 115413A IL 11541395 A IL11541395 A IL 11541395A IL 11541395 A IL11541395 A IL 11541395A IL 115413 A IL115413 A IL 115413A
Authority
IL
Israel
Prior art keywords
6alkyl
substituted
halo
hydrogen
alk
Prior art date
Application number
IL11541395A
Other languages
English (en)
Other versions
IL115413A0 (en
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of IL115413A0 publication Critical patent/IL115413A0/xx
Publication of IL115413A publication Critical patent/IL115413A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL11541395A 1994-09-27 1995-09-22 N-substituted piperidinyl bicyclic benzoate derivatives their preparation and pharmaceutical compositions containing them IL115413A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94202792 1994-09-27
US45548695A 1995-05-31 1995-05-31

Publications (2)

Publication Number Publication Date
IL115413A0 IL115413A0 (en) 1995-12-31
IL115413A true IL115413A (en) 2000-02-17

Family

ID=26136613

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11541395A IL115413A (en) 1994-09-27 1995-09-22 N-substituted piperidinyl bicyclic benzoate derivatives their preparation and pharmaceutical compositions containing them

Country Status (23)

Country Link
EP (1) EP0784620B1 (xx)
JP (1) JP3953097B2 (xx)
CN (1) CN1068880C (xx)
AT (1) ATE187453T1 (xx)
AU (1) AU699152B2 (xx)
BR (1) BR9509036A (xx)
CA (1) CA2200578C (xx)
CZ (1) CZ289031B6 (xx)
DE (1) DE69513846T2 (xx)
DK (1) DK0784620T3 (xx)
ES (1) ES2141383T3 (xx)
FI (1) FI119640B (xx)
GR (1) GR3032646T3 (xx)
HU (1) HU218698B (xx)
IL (1) IL115413A (xx)
MY (1) MY113202A (xx)
NO (1) NO313238B1 (xx)
NZ (1) NZ293605A (xx)
PL (1) PL182502B1 (xx)
PT (1) PT784620E (xx)
RU (1) RU2154064C2 (xx)
WO (1) WO1996010027A1 (xx)
ZA (1) ZA958081B (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2332275A1 (en) * 1998-05-14 1999-11-18 Zoltan Tamas Nagy Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient
AU2003206722B2 (en) * 2002-01-16 2008-01-24 Mercury Pharma Group Limited Prucalopride-N-oxide
ATE457309T1 (de) * 2003-12-23 2010-02-15 Serodus As Modulatoren von peripheren 5-ht-rezeptoren
EA200700117A1 (ru) 2004-06-24 2007-06-29 Инсайт Корпорейшн N-замещенные пиперидины и их применение в качестве фармацевтических препаратов
SI1945632T1 (sl) 2005-11-08 2014-03-31 Vertex Pharmaceuticals Incorporated Heterocikliäśni modulatorji za prenaĺ alce z atp-vezavno kaseto
JP5497633B2 (ja) 2007-05-09 2014-05-21 バーテックス ファーマシューティカルズ インコーポレイテッド Ｃｆｔｒのモジュレーター
WO2009073757A1 (en) 2007-12-07 2009-06-11 Vertex Pharmaceuticals Incorporated Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3] dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid
WO2009076142A2 (en) 2007-12-07 2009-06-18 Vertex Pharmaceuticals Incorporated Processes for producing cycloalkylcarboxiamido-pyridine benzoic acids
CA3039943C (en) 2008-02-28 2021-07-13 Vertex Pharmaceuticals Incorporated Heteroaryl derivatives as cftr modulators
CA2795748C (en) * 2010-04-07 2020-12-08 Vertex Pharmaceuticals Incorporated Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
CA2795804C (en) 2010-04-07 2021-10-26 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyriodin-2-yl)benzoic acid and administration thereof
CA2930199C (en) 2013-11-12 2022-10-25 Vertex Pharmaceuticals Incorporated Process of preparing pharmaceutical compositions for the treatment of cftr mediated diseases
PT3221692T (pt) 2014-11-18 2021-09-10 Vertex Pharma Processo de realização de testagem de alta produtividade por cromatografia líquida de alta eficiência

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1317940C (en) * 1987-09-25 1993-05-18 Georges H. P. Van Daele Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
DE3810552A1 (de) * 1988-03-29 1989-10-19 Sandoz Ag Ester und amide von indol-, benzo(b)thiopen-, benzo(b)furancarbonsaeuren oder 4-amino-2-methoxy-benzolsaeuren mit n-heterocyclischen oder n-heterobicyclischen alkoholen oder aminen, verfahren zu deren herstellung sie enthaltende pharmazeutische zusammensetzungen sowie applikator zur verabreichung derselben
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
GB9005014D0 (en) * 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
CA2116024A1 (en) * 1991-08-20 1993-03-04 Francis David King 5-ht4 receptor antagonists
MX9306311A (es) * 1992-10-13 1994-04-29 Smithkline Beecham Plc Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen

Also Published As

Publication number Publication date
MX9702363A (es) 1997-10-31
CN1068880C (zh) 2001-07-25
NO971376D0 (no) 1997-03-24
NZ293605A (en) 1998-07-28
FI971274A0 (fi) 1997-03-26
DE69513846D1 (de) 2000-01-13
JP3953097B2 (ja) 2007-08-01
DE69513846T2 (de) 2000-07-06
MY113202A (en) 2001-12-31
PT784620E (pt) 2000-05-31
ATE187453T1 (de) 1999-12-15
CA2200578A1 (en) 1996-04-04
DK0784620T3 (da) 2000-05-22
HUT77173A (hu) 1998-03-02
GR3032646T3 (en) 2000-06-30
AU3608195A (en) 1996-04-19
AU699152B2 (en) 1998-11-26
FI971274A (fi) 1997-03-26
NO971376L (no) 1997-05-05
EP0784620A1 (en) 1997-07-23
EP0784620B1 (en) 1999-12-08
BR9509036A (pt) 1997-10-14
RU2154064C2 (ru) 2000-08-10
JPH10506118A (ja) 1998-06-16
CZ289031B6 (cs) 2001-10-17
CN1166171A (zh) 1997-11-26
NO313238B1 (no) 2002-09-02
FI119640B (fi) 2009-01-30
PL182502B1 (pl) 2002-01-31
CA2200578C (en) 2006-11-07
PL319997A1 (en) 1997-09-01
CZ91897A3 (en) 1997-12-17
WO1996010027A1 (en) 1996-04-04
HU218698B (hu) 2000-11-28
IL115413A0 (en) 1995-12-31
ZA958081B (en) 1997-03-26
ES2141383T3 (es) 2000-03-16

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees