ATE187453T1 - N-substituierte piperidinyl bicyclische benzoatderivate - Google Patents

N-substituierte piperidinyl bicyclische benzoatderivate

Info

Publication number
ATE187453T1
ATE187453T1 AT95933400T AT95933400T ATE187453T1 AT E187453 T1 ATE187453 T1 AT E187453T1 AT 95933400 T AT95933400 T AT 95933400T AT 95933400 T AT95933400 T AT 95933400T AT E187453 T1 ATE187453 T1 AT E187453T1
Authority
AT
Austria
Prior art keywords
6alkyl
substituted
halo
hydrogen
alk
Prior art date
Application number
AT95933400T
Other languages
English (en)
Inventor
Daele Georges Henri Paul Van
Jean-Paul Rene Marie A Bosmans
Den Keybus Frans Maria Alf Van
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE187453T1 publication Critical patent/ATE187453T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
AT95933400T 1994-09-27 1995-09-19 N-substituierte piperidinyl bicyclische benzoatderivate ATE187453T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94202792 1994-09-27
US45548695A 1995-05-31 1995-05-31

Publications (1)

Publication Number Publication Date
ATE187453T1 true ATE187453T1 (de) 1999-12-15

Family

ID=26136613

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95933400T ATE187453T1 (de) 1994-09-27 1995-09-19 N-substituierte piperidinyl bicyclische benzoatderivate

Country Status (23)

Country Link
EP (1) EP0784620B1 (de)
JP (1) JP3953097B2 (de)
CN (1) CN1068880C (de)
AT (1) ATE187453T1 (de)
AU (1) AU699152B2 (de)
BR (1) BR9509036A (de)
CA (1) CA2200578C (de)
CZ (1) CZ289031B6 (de)
DE (1) DE69513846T2 (de)
DK (1) DK0784620T3 (de)
ES (1) ES2141383T3 (de)
FI (1) FI119640B (de)
GR (1) GR3032646T3 (de)
HU (1) HU218698B (de)
IL (1) IL115413A (de)
MY (1) MY113202A (de)
NO (1) NO313238B1 (de)
NZ (1) NZ293605A (de)
PL (1) PL182502B1 (de)
PT (1) PT784620E (de)
RU (1) RU2154064C2 (de)
WO (1) WO1996010027A1 (de)
ZA (1) ZA958081B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999058527A2 (en) * 1998-05-14 1999-11-18 EGIS Gyógyszergyár Rt. Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient
CA2471729C (en) * 2002-01-16 2010-03-23 Janssen Pharmaceutica N.V. Prucalopride-n-oxide
EP1701951B1 (de) 2003-12-23 2010-02-10 Serodus AS Modulatoren von peripheren 5-ht-rezeptoren
NZ551603A (en) 2004-06-24 2010-11-26 Incyte Corp N-substituted piperidines and their use as pharmaceuticals
HUE032640T2 (en) 2005-11-08 2017-10-30 Vertex Pharma Heterocyclic modulator of ATP-binding cassette transcripts
US8969386B2 (en) 2007-05-09 2015-03-03 Vertex Pharmaceuticals Incorporated Modulators of CFTR
CN101910134B (zh) 2007-12-07 2014-03-19 沃泰克斯药物股份有限公司 环烷基甲酰氨基-吡啶苯甲酸类的生产方法
US8507534B2 (en) 2007-12-07 2013-08-13 Vertex Pharmaceuticals Incorporated Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
CN103382201B (zh) 2008-02-28 2016-12-28 沃泰克斯药物股份有限公司 作为cftr调节剂的杂芳基衍生物
JP2013523833A (ja) 2010-04-07 2013-06-17 バーテックス ファーマシューティカルズ インコーポレイテッド ３−（６−（１−（２，２−ジフルオロベンゾ［ｄ］［１，３］ジオキソール−５−イル）シクロプロパンカルボキサミド）−３−メチルピリジン−２−イル）安息香酸の医薬組成物およびその投与
AR081069A1 (es) * 2010-04-07 2012-06-06 Vertex Pharma Formas solidas del acido 3-(6-(1-(2,2-difluorbenzo[d][1,3]dioxol-5-il)ciclopropancarboxamido)-3-metilpiridin-2-il)benzoico
WO2015073231A1 (en) 2013-11-12 2015-05-21 Vertex Pharmaceuticals Incorporated Process of preparing pharmaceutical compositions for the treatment of cftr mediated diseases
SI3221692T1 (sl) 2014-11-18 2021-11-30 Vertex Pharmaceuticals Inc. Postopek za izvajanje testov visoke prepustnosti z visoko zmogljivostno tekočinsko kromatografijo

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1317940C (en) * 1987-09-25 1993-05-18 Georges H. P. Van Daele Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
DE3810552A1 (de) * 1988-03-29 1989-10-19 Sandoz Ag Ester und amide von indol-, benzo(b)thiopen-, benzo(b)furancarbonsaeuren oder 4-amino-2-methoxy-benzolsaeuren mit n-heterocyclischen oder n-heterobicyclischen alkoholen oder aminen, verfahren zu deren herstellung sie enthaltende pharmazeutische zusammensetzungen sowie applikator zur verabreichung derselben
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
GB9005014D0 (en) * 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
JPH06510283A (ja) * 1991-08-20 1994-11-17 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５−ｈｔ４レセプター拮抗薬
MX9306311A (es) * 1992-10-13 1994-04-29 Smithkline Beecham Plc Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen

Also Published As

Publication number Publication date
CN1068880C (zh) 2001-07-25
FI971274A0 (fi) 1997-03-26
NO313238B1 (no) 2002-09-02
RU2154064C2 (ru) 2000-08-10
FI971274A (fi) 1997-03-26
PT784620E (pt) 2000-05-31
IL115413A0 (en) 1995-12-31
NZ293605A (en) 1998-07-28
HUT77173A (hu) 1998-03-02
NO971376D0 (no) 1997-03-24
JPH10506118A (ja) 1998-06-16
ZA958081B (en) 1997-03-26
PL182502B1 (pl) 2002-01-31
DE69513846T2 (de) 2000-07-06
DK0784620T3 (da) 2000-05-22
IL115413A (en) 2000-02-17
AU3608195A (en) 1996-04-19
CZ91897A3 (en) 1997-12-17
PL319997A1 (en) 1997-09-01
AU699152B2 (en) 1998-11-26
BR9509036A (pt) 1997-10-14
JP3953097B2 (ja) 2007-08-01
MX9702363A (es) 1997-10-31
CA2200578A1 (en) 1996-04-04
CN1166171A (zh) 1997-11-26
DE69513846D1 (de) 2000-01-13
FI119640B (fi) 2009-01-30
CZ289031B6 (cs) 2001-10-17
HU218698B (hu) 2000-11-28
CA2200578C (en) 2006-11-07
GR3032646T3 (en) 2000-06-30
EP0784620B1 (de) 1999-12-08
NO971376L (no) 1997-05-05
WO1996010027A1 (en) 1996-04-04
EP0784620A1 (de) 1997-07-23
ES2141383T3 (es) 2000-03-16
MY113202A (en) 2001-12-31

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee