FI119413B - Proteiinien ja peptidien aerosoliformuloinnit - Google Patents
Proteiinien ja peptidien aerosoliformuloinnit Download PDFInfo
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- FI119413B FI119413B FI972657A FI972657A FI119413B FI 119413 B FI119413 B FI 119413B FI 972657 A FI972657 A FI 972657A FI 972657 A FI972657 A FI 972657A FI 119413 B FI119413 B FI 119413B
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- Prior art keywords
- aerosol formulation
- formulation according
- pharmaceutical aerosol
- polypeptide
- surfactant
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P39/00—General protective or antinoxious agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9404467A SE9404467D0 (sv) | 1994-12-22 | 1994-12-22 | Drug formulations |
| SE9404467 | 1994-12-22 | ||
| SE9502453A SE9502453D0 (sv) | 1995-07-06 | 1995-07-06 | Drug formulations |
| SE9502453 | 1995-07-06 | ||
| PCT/SE1995/001540 WO1996019197A1 (en) | 1994-12-22 | 1995-12-19 | Aerosol formulations of peptides and proteins |
| SE9501540 | 1995-12-19 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI972657A0 FI972657A0 (fi) | 1997-06-19 |
| FI972657L FI972657L (fi) | 1997-06-19 |
| FI119413B true FI119413B (fi) | 2008-11-14 |
Family
ID=26662195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI972657A FI119413B (fi) | 1994-12-22 | 1997-06-19 | Proteiinien ja peptidien aerosoliformuloinnit |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6524557B1 (ru) |
| EP (2) | EP1180365A3 (ru) |
| JP (2) | JP3862178B2 (ru) |
| KR (1) | KR100428281B1 (ru) |
| CN (1) | CN1088581C (ru) |
| AR (1) | AR002013A1 (ru) |
| AT (1) | ATE217787T1 (ru) |
| AU (1) | AU702879B2 (ru) |
| BR (1) | BR9510501A (ru) |
| CA (1) | CA2206736C (ru) |
| CZ (1) | CZ288145B6 (ru) |
| DE (1) | DE69526801T2 (ru) |
| DK (1) | DK0797431T3 (ru) |
| EE (1) | EE03590B1 (ru) |
| ES (1) | ES2176355T3 (ru) |
| FI (1) | FI119413B (ru) |
| HU (1) | HU227790B1 (ru) |
| IL (1) | IL116458A (ru) |
| IS (1) | IS1810B (ru) |
| MX (1) | MX9704545A (ru) |
| MY (1) | MY120664A (ru) |
| NO (1) | NO316105B1 (ru) |
| NZ (1) | NZ298167A (ru) |
| PL (1) | PL182560B1 (ru) |
| PT (1) | PT797431E (ru) |
| RU (1) | RU2175866C2 (ru) |
| SA (1) | SA95160483B1 (ru) |
| SK (1) | SK284346B6 (ru) |
| TR (1) | TR199501669A1 (ru) |
| TW (1) | TW398978B (ru) |
| UA (1) | UA42047C2 (ru) |
| WO (1) | WO1996019197A1 (ru) |
Families Citing this family (105)
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| US6794357B1 (en) * | 1993-06-24 | 2004-09-21 | Astrazeneca Ab | Compositions for inhalation |
| US6632456B1 (en) * | 1993-06-24 | 2003-10-14 | Astrazeneca Ab | Compositions for inhalation |
| WO1996019198A1 (en) * | 1994-12-22 | 1996-06-27 | Astra Aktiebolag | Aerosol drug formulations |
| US5874481A (en) * | 1995-06-07 | 1999-02-23 | Alliance Pharmaceutical Corp. | Fluorochemical solutions for the delivery of lipophilic pharmaceutical agents |
| US20020052310A1 (en) | 1997-09-15 | 2002-05-02 | Massachusetts Institute Of Technology The Penn State Research Foundation | Particles for inhalation having sustained release properties |
| US6433040B1 (en) | 1997-09-29 | 2002-08-13 | Inhale Therapeutic Systems, Inc. | Stabilized bioactive preparations and methods of use |
| US6946117B1 (en) | 1997-09-29 | 2005-09-20 | Nektar Therapeutics | Stabilized preparations for use in nebulizers |
| NZ503464A (en) * | 1997-09-29 | 2002-05-31 | Inhale Therapeutic Syst | Perforated microparticles containing a bioactive agent for pulmonary delivery |
| US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| US6309623B1 (en) | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| US6086376A (en) * | 1998-01-30 | 2000-07-11 | Rtp Pharma Inc. | Dry aerosol suspension of phospholipid-stabilized drug microparticles in a hydrofluoroalkane propellant |
| US6221378B1 (en) * | 1998-02-10 | 2001-04-24 | Generex Pharmaceuticals Incorporated | Mixed micellar delivery system and method of preparation |
| US7070799B1 (en) | 1998-02-10 | 2006-07-04 | Generex Pharmaceuticals, Inc. | Method for administering insulin to the buccal region |
| US6017545A (en) * | 1998-02-10 | 2000-01-25 | Modi; Pankaj | Mixed micellar delivery system and method of preparation |
| US6180142B1 (en) * | 1998-08-21 | 2001-01-30 | The Regents Of The University Of California | Reduction of surfactant inactivation in pulmonary surfactant therapy |
| MA25590A1 (fr) * | 1998-09-14 | 2002-12-31 | Inhale Therapeutic Syst | Agent actif de delivraison de poudre seche |
| US7087215B2 (en) * | 1998-12-21 | 2006-08-08 | Generex Pharmaceuticals Incorporated | Methods of administering and enhancing absorption of pharmaceutical agents |
| US7658938B2 (en) | 1999-02-22 | 2010-02-09 | Merrion Reasearch III Limited | Solid oral dosage form containing an enhancer |
| CA2369262A1 (en) | 1999-04-13 | 2000-10-19 | Sudha Nagarajan | Pulmonary administration of dry powder formulations for treating infertility |
| EP1064934A1 (en) | 1999-06-30 | 2001-01-03 | Applied Research Systems ARS Holding N.V. | GRF-containing lyophilized pharmaceutical composition |
| AU1189301A (en) * | 1999-10-29 | 2001-05-14 | Eli Lilly And Company | A pharmaceutical composition having high cell membrane permeability |
| AU3668501A (en) * | 2000-02-04 | 2001-08-14 | Seo Hong Yoo | Preparation of aqueous clear solution dosage forms with bile acids |
| AU4445201A (en) * | 2000-03-30 | 2001-10-08 | Generex Pharmaceuticals Inc. | Method for administering insulin to the buccal region |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| EP1280520B2 (en) | 2000-05-10 | 2018-03-21 | Novartis AG | Phospholipid-based powders for drug delivery |
| JP4147234B2 (ja) * | 2004-09-27 | 2008-09-10 | キヤノン株式会社 | 吐出用液体、吐出方法、カートリッジ及び吐出装置 |
| EP1309312A2 (en) | 2000-08-07 | 2003-05-14 | Inhale Therapeutic Systems, Inc. | Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation |
| US7374782B2 (en) | 2000-10-27 | 2008-05-20 | Baxter International Inc. | Production of microspheres |
| AU2002220857A1 (en) | 2000-11-30 | 2002-06-11 | Vectura Limited | Particles for use in a pharmaceutical composition |
| WO2002043702A2 (en) * | 2000-11-30 | 2002-06-06 | Vectura Limited | Pharmaceutical compositions for inhalation |
| EP2283817B1 (en) | 2000-11-30 | 2016-05-18 | Vectura Limited | Method of making particles for use in a pharmaceutical composition |
| US7891578B2 (en) | 2001-03-22 | 2011-02-22 | Battelle Memorial Institute | Liquid formations for electrohydrodymanic spraying containing polymer and suspended particles |
| EP1372608B1 (de) * | 2001-03-30 | 2007-10-10 | Jagotec Ag | Medizinische aerosolformulierungen |
| WO2002087542A1 (en) * | 2001-04-26 | 2002-11-07 | Inhale Therapeutic Systems, Inc. | Novel methods and compositions for delivering macromolecules to or via the respiratory tract |
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| US5506203C1 (en) | 1993-06-24 | 2001-02-06 | Astra Ab | Systemic administration of a therapeutic preparation |
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-
1994
- 1994-12-19 US US08/624,504 patent/US6524557B1/en not_active Expired - Fee Related
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1995
- 1995-12-19 DE DE69526801T patent/DE69526801T2/de not_active Expired - Lifetime
- 1995-12-19 MY MYPI95003943A patent/MY120664A/en unknown
- 1995-12-19 UA UA97073877A patent/UA42047C2/ru unknown
- 1995-12-19 PL PL95320824A patent/PL182560B1/pl not_active IP Right Cessation
- 1995-12-19 CN CN95196977A patent/CN1088581C/zh not_active Expired - Fee Related
- 1995-12-19 KR KR1019970704193A patent/KR100428281B1/ko not_active Expired - Fee Related
- 1995-12-19 BR BR9510501A patent/BR9510501A/pt not_active Application Discontinuation
- 1995-12-19 RU RU97112497/14A patent/RU2175866C2/ru not_active IP Right Cessation
- 1995-12-19 HU HU9800560A patent/HU227790B1/hu not_active IP Right Cessation
- 1995-12-19 ES ES95942341T patent/ES2176355T3/es not_active Expired - Lifetime
- 1995-12-19 DK DK95942341T patent/DK0797431T3/da active
- 1995-12-19 SK SK813-97A patent/SK284346B6/sk not_active IP Right Cessation
- 1995-12-19 IL IL11645895A patent/IL116458A/en not_active IP Right Cessation
- 1995-12-19 CZ CZ19971945A patent/CZ288145B6/cs not_active IP Right Cessation
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- 1995-12-19 TW TW084113556A patent/TW398978B/zh not_active IP Right Cessation
- 1995-12-19 PT PT95942341T patent/PT797431E/pt unknown
- 1995-12-19 EP EP01127823A patent/EP1180365A3/en not_active Withdrawn
- 1995-12-19 MX MX9704545A patent/MX9704545A/es not_active IP Right Cessation
- 1995-12-19 NZ NZ298167A patent/NZ298167A/xx not_active IP Right Cessation
- 1995-12-19 WO PCT/SE1995/001540 patent/WO1996019197A1/en not_active Ceased
- 1995-12-19 AT AT95942341T patent/ATE217787T1/de active
- 1995-12-19 JP JP51973096A patent/JP3862178B2/ja not_active Expired - Lifetime
- 1995-12-19 EP EP95942341A patent/EP0797431B1/en not_active Expired - Lifetime
- 1995-12-19 EE EE9700137A patent/EE03590B1/xx not_active IP Right Cessation
- 1995-12-19 AU AU43591/96A patent/AU702879B2/en not_active Ceased
- 1995-12-21 AR ARP950100705A patent/AR002013A1/es active IP Right Grant
- 1995-12-22 TR TR95/01669A patent/TR199501669A1/xx unknown
- 1995-12-30 SA SA95160483A patent/SA95160483B1/ar unknown
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1997
- 1997-06-04 IS IS4496A patent/IS1810B/is unknown
- 1997-06-16 NO NO19972781A patent/NO316105B1/no not_active IP Right Cessation
- 1997-06-19 FI FI972657A patent/FI119413B/fi not_active IP Right Cessation
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2006
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