FI118792B - Användningar av inducering T-celltorerans med hänsyn till vävnads- eller organtransplantat - Google Patents
Användningar av inducering T-celltorerans med hänsyn till vävnads- eller organtransplantat Download PDFInfo
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- FI118792B FI118792B FI964272A FI964272A FI118792B FI 118792 B FI118792 B FI 118792B FI 964272 A FI964272 A FI 964272A FI 964272 A FI964272 A FI 964272A FI 118792 B FI118792 B FI 118792B
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Claims (28)
1. Användning av a) en allogen eller xenogen cell, som uttrycker minst en donators antigen och pä vars yta 5 förekommer en ligand, som deltar i växelverkan med gp39, som förekommer pä ytan av en mottagares T-cell och b) en antagonist till gp39 för framställning av ett kombinerat preparat för samtidig, separat eller pä varandra följande användning 10 för inducering av T-celltolerans som riktar sig mot en donators vävnad eller organ hos mottagaren av derma vävnad eller detta organ under förutsättning att dä den allogena eller xenogena cellen är en allogen cell, omfattar dona-torns vävnad eller organ bukspottkörtelns cellöar, lever, 15 njurar, hjärta, lunga, hud, muskel, nervvävnad, magsäck eller tarm.
2. Användning av a) en allogen eller xenogen cell, som uttrycker minst en donators antigen och pä vars yta förekommer en ligand, som deltar i växelverkan med gp39, 20 som förekommer pä ytan av en mottagares T-cell och b) en antagonist till gp39, och « · :.**J c) cellöar frän en donators bukspottkörtel ·« ! *.. för framställning av ett kombinerat preparat för i\; samtidig, separat eller pä varandra följande användning * · 25 för behandling av diabetes.
··<· , 3. Användning enligt patentkrav 1 eller 2, kän- *·* * #···φ netecknad av att antagonisten är en mot gp39 riktad an- • · * tikropp.
,, 4. Användning av a) en allogen donatorcell, som • · « *·]·* 30 uttrycker minst en donators antigen och pä vars yta före- *·..* kommer en ligand, som deltar i växelverkan med gp39, som ····· förekommer pä ytan av en mottagares T-cell och .··*. b) en mot gp39 riktad antikropp / . vid framställning av ett kombinerat preparat för • t · *· *· 35 samtidig, separat eller pä varandra följande användning *. *: för inducering av T-celltolerans som riktar sig mot en do- 118792 45 nators vävnad eller organ hos mottagaren av denna vävnad eller detta organ, varvid den allogena donatorcellen och den mot gp39 riktade antikroppen ges till mottagaren före transplantation av vävnad eller organ, varvid donatorns 5 vävnad eller organ omfattar bukspottkörtelns cellöar, lever, njurar, hjärta, lunga, hud, muskel, nervvävnad, mag-säck eller tarm.
5. Användning enligt nägot av patentkraven 1-4, kännetecknad av att den allogena eller xenogena cellen 10 är en lymfoidcell.
6. Användning enligt patentkrav 5, kännetecknad av att lymfoidcellen är en B-cell.
7. Användning enligt patentkrav 6, kännetecknad av att B-cellen är en B-cell i vilofas.
8. Användning enligt nägot av patentkraven 1 eller 5 - 7, kännetecknad av att den allogena eller xenogena cellen och antagonisten ges tili mottagaren före transplantation av vävnad eller organ.
9. Användning enligt nägot av patentkraven 1 eller 20 4 - 8, kännetecknad av att vävnaden eller organet om- fattar bukspottkörtelns cellöar. • ·
10. Användning enligt nägot av patentkraven 1 el- ler 4 - 8, kännetecknad av att vävnaden eller organet :*·.· har valts bland lever, njurar, hjärta, lunga, hud, muskel, • · ·*. 25 nervvävnad, magsäck och tarm.
···· . ,·, 11. Användning enligt nägot av patentkraven 3 - 10, • · · t···' kännetecknad av att den mot gp39 riktade antikroppen • · · är en monoklonal antikropp.
. , 12. Användning enligt patentkrav 11, känneteck- • « « *·]** 30 nad av att den monoklonala antikroppen kan erhällas frän • *· *·.·* hybridomcellinjen MRl, som är deponerad med deponerings- ·;··: nummer ATCC HB11048.
.***. 13. Användning enligt patentkrav 11, känneteck- / nad av att den monoklonala antikroppen är en chimär mo- • · *· " 35 noklonal antikropp. • · • · * • ·· • · 118792 46
14. Användning enligt patentkrav 11, känneteck-nad av att den monoklonala antikroppen är en humaniserad monoklonal antikropp.
15. Användning enligt nägot av patentkraven 3-14, 5 kännetecknad av att den mot gp39 riktade antikroppen är en mot humant gp39 riktad antikropp.
16. Användning enligt patentkrav 1 eller 2, kännetecknad av att antagonisten tili gp39 är en löslig form av en gp39 ligand.
17. Användning enligt patentkrav 16, känneteck nad av att den lösliga formen av gp39 liganden är ett CD40 fusionsprotein.
18. Användning av en antagonist till gp39 för framställning av ett sädant preparat som är avsett för in-15 ducering av T-celltolerans som riktar sig mot en donators vävnad eller organ hos mottagaren, som kommer att utsättas för allogena eller xenogena celler som uttrycker minst en donators antigen och pä vars yta förekommer en ligand, som deltar i växelverkan med gp39, som förekommer pä ytan av 20 mottagarens T-cell under förutsättning att dä de allogena eller xenogena cellerna är allogena celler, omfattar dona- • · torns vävnad eller organ bukspottkörtelns cellöar, lever, ϊ *.. njurar, hjärta, lunga, hud, muskel, nervvävnad, magsäck eller tarm. • · ··· 25
19. Användning enligt patentkrav 18, känneteck- • · · · . nad av att de allogena eller xenogena cellerna som ut- • · · trycker minst en donators antigen omfattar lymfoidceller • · · eller celler som representerar antigenen.
.. 20. Användning enligt patentkrav 19, känneteck- • * * *·[;* 30 nad av att lymfoidcellen är en B-lymfocyt.
• · *···* 21. Användning enligt patentkrav 19, känneteck- ·:··· nad av att cellen som representerar antigenen har valts bland monocyter, dendritceller, Langerhans celler, keroti- • · · .· , nocyter, endotelceller, astrocyter, fibroblaster och oli- • · · 35 godendrocyter. • · · • · · • · 47 1 1 8792
22. Användning enligt patentkrav 19, känneteck-nad av att cellen som representerar antigenen är en B-cell.
23. Användning enligt patentkrav 18, känneteck-5 nad av att donatorns vävnad eller organ omfattar buk- spottkörtelns cellöar, lever, njurar, hjärta, lunga, hud, muskel, nervvävnad, magsäck eller tarm.
24. Användning av en antagonist till gp39 för framställning av ett sädant läkemedel som är avsett för 10 behandling av diabetes hos en patient, som kommer att ut-sättas för celler av bukspottkörtelns cellöar frän en donator och allogena och xenogena celler som uttrycker minst en donators antigen och pä vars yta förekommer en ligand, som deltar i växelverkan med gp39, som förekommer pä ytan 15 av mottagarens T-cell.
25. Användning enligt patentkrav 24, känneteck-nad av att tili allogena och xenogena celler som uttrycker minst en donators antigen hör dendritceller, monocyter, Langerhans celler samt lymfoidceller säsom B-lymfocyter.
26. Användning enligt nägot av patentkraven 18-25, kännetecknad av att antagonisten tili gp39 är en mot • φ ·.1·· gp39 riktad antikropp eller ett lösligt CD40 fusionsprote- ·· : ·.· in. :1·.·
27. Användning enligt patentkrav 26, känneteck- * · ··· 25 nad av att antikroppen är en mot gp39 riktad monoklonal ···· . antikropp. 9
28. Användning enligt patentkrav 27, känneteck- • · · nad av att den monoklonala antikroppen är en chimär anti- .. kropp eller humaniserad monoklonal antikropp. • ♦ · « · • · ··· • · • · ·♦» • · ··· • · • · ··· • · • · · • ·· • · · • · · ♦ ·1 • ·
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23498794 | 1994-04-25 | ||
| US08/234,987 US5683693A (en) | 1994-04-25 | 1994-04-25 | Method for inducing T cell unresponsiveness to a tissue or organ graft with anti-CD40 ligand antibody or soluble CD40 |
| US9504832 | 1995-04-25 | ||
| PCT/US1995/004832 WO1995028957A2 (en) | 1994-04-25 | 1995-04-25 | Methods for inducing t cell tolerance to a tissue or organ graft |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI964272A0 FI964272A0 (sv) | 1996-10-23 |
| FI964272A FI964272A (sv) | 1996-12-19 |
| FI118792B true FI118792B (sv) | 2008-03-31 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI964272A FI118792B (sv) | 1994-04-25 | 1996-10-23 | Användningar av inducering T-celltorerans med hänsyn till vävnads- eller organtransplantat |
Country Status (34)
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|---|---|
| US (4) | US5683693A (sv) |
| EP (2) | EP1530973A3 (sv) |
| JP (1) | JP2974415B2 (sv) |
| KR (1) | KR100468330B1 (sv) |
| CN (1) | CN1134266C (sv) |
| AP (1) | AP764A (sv) |
| AT (1) | ATE288281T1 (sv) |
| AU (1) | AU710925B2 (sv) |
| BG (1) | BG62121B1 (sv) |
| BR (1) | BR9507509A (sv) |
| CA (1) | CA2188672A1 (sv) |
| CZ (1) | CZ291266B6 (sv) |
| DE (1) | DE69533984T2 (sv) |
| DK (1) | DK0757557T3 (sv) |
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| ES (1) | ES2237757T3 (sv) |
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| HU (1) | HU221752B1 (sv) |
| IS (1) | IS2118B (sv) |
| LT (1) | LT4309B (sv) |
| LV (1) | LV11785B (sv) |
| MD (1) | MD1444B2 (sv) |
| NO (2) | NO319787B1 (sv) |
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| OA (1) | OA10591A (sv) |
| PL (1) | PL180031B1 (sv) |
| PT (1) | PT757557E (sv) |
| RO (1) | RO114743B1 (sv) |
| RU (1) | RU2169009C2 (sv) |
| SI (1) | SI9520057A (sv) |
| SK (1) | SK136996A3 (sv) |
| UA (1) | UA44892C2 (sv) |
| WO (1) | WO1995028957A2 (sv) |
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| US7070777B1 (en) | 1991-11-15 | 2006-07-04 | The Trustees Of Columbia University In The City Of New York | Method for inhibiting inflammation with an antibody that binds the 5C8 protein |
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| ZA946765B (en) * | 1993-09-02 | 1996-02-15 | Dartmouth College | Methods of prolonged suppression of humoral immunity |
| US5683693A (en) * | 1994-04-25 | 1997-11-04 | Trustees Of Dartmouth College | Method for inducing T cell unresponsiveness to a tissue or organ graft with anti-CD40 ligand antibody or soluble CD40 |
| US5876950A (en) * | 1995-01-26 | 1999-03-02 | Bristol-Myers Squibb Company | Monoclonal antibodies specific for different epitopes of human GP39 and methods for their use in diagnosis and therapy |
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| US6440418B1 (en) * | 1995-11-07 | 2002-08-27 | Idec Pharmaceuticals Corporation | Methods of treating autoimmune diseases with gp39-specific antibodies |
| US6340459B1 (en) | 1995-12-01 | 2002-01-22 | The Trustees Of Columbia University In The City Of New York | Therapeutic applications for the anti-T-BAM (CD40-L) monoclonal antibody 5C8 in the treatment of reperfusion injury in non-transplant recipients |
| WO1997034633A1 (en) * | 1996-03-20 | 1997-09-25 | Bristol-Myers Squibb Company | Methods for inhibiting an immune response by blocking the gp39/cd40 and ctla4/cd28/b7 pathways and compositions for use therewith |
| CZ244399A3 (cs) * | 1997-01-10 | 1999-10-13 | Biogen, Inc. | Použití sloučeniny anti-CD40L pro výrobu léku pro léčení imunologických onemocnění |
| NZ502052A (en) * | 1997-06-20 | 2001-01-26 | Biogen Inc | CD154 blockade therapy for pancreatic islet tissue transplantation |
| EP1754490A3 (en) * | 1997-06-20 | 2010-01-20 | Biogen Idec MA Inc. | CD 154 blockage therapy for pancreatic islet tissue transplantation in primates |
| US20050031611A1 (en) * | 1998-05-08 | 2005-02-10 | Beth Israel Deaconess Medical Center | Transplant tolerance by costimulation blockade and T-cell activation-induced apoptosis |
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| RU2162297C1 (ru) * | 1999-11-25 | 2001-01-27 | Камакин Владислав Владимирович | Способ индивидуального подбора оптимального питания человека |
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| RU2270691C2 (ru) | 2000-05-12 | 2006-02-27 | Бет Израел Диконесс Медикал Сентер, Инк. | Композиции и способы достижения иммунной супрессии |
| CA2410786A1 (en) * | 2000-06-02 | 2001-12-13 | Regents Of The University Of Minnesota | Immunotherapeutic method to prevent islet cell rejection |
| CA2410188A1 (en) * | 2000-06-06 | 2001-12-13 | Idec Pharmaceutical Corporation | Non-agonistic antibodies to human gp39, compositions containing, and therapeutic use thereof |
| TWI311564B (en) | 2000-07-03 | 2009-07-01 | Bristol Myers Squibb Compan | Methods for treating rheumatic diseases using a soluble ctla4 molecule |
| US20040022787A1 (en) | 2000-07-03 | 2004-02-05 | Robert Cohen | Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID |
| CA2364983A1 (en) * | 2000-12-13 | 2002-06-13 | John R. Coleman | Nucleic acid molecules and polypeptides for catabolism of abscisic acid |
| WO2002078743A1 (en) * | 2001-02-16 | 2002-10-10 | University Of Rochester | Compositions and methods for reducing tranfusion reactions |
| US7597895B2 (en) * | 2001-02-20 | 2009-10-06 | The Governing Council Of The University Of Toronto | Signal peptides, nucleic acid molecules and methods for treatment of caries |
| US7556807B2 (en) | 2001-02-20 | 2009-07-07 | Kane Biotech, Inc. | Signal peptides, nucleic acid molecules and methods for treatment of caries |
| DK1397153T3 (da) | 2001-05-23 | 2008-05-26 | Bristol Myers Squibb Co | Fremgangsmåde til beskyttelse af allogent ö-celle-transplantat ved anvendelse af oplöselige CTLA4-mutantmolekyler |
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| US7563443B2 (en) * | 2004-09-17 | 2009-07-21 | Domantis Limited | Monovalent anti-CD40L antibody polypeptides and compositions thereof |
| EP1795587A1 (en) * | 2005-12-07 | 2007-06-13 | Schuler, Gerold, Prof. Dr. | Method for the direct culture of dendritic cells without a preceding centrifugation step |
| MX2008011054A (es) * | 2006-03-02 | 2009-03-03 | Alexion Pharma Inc | Prolongacion de supervivencia de un aloinjerto, mediante la inhibicion de actividad de complemento. |
| FR2934140B1 (fr) * | 2008-07-25 | 2010-09-03 | Seb Sa | Couvercle d'appareil electromenager de cuisson comportant un sous-ensemble de filtration |
| CA2766272C (en) | 2009-06-26 | 2021-02-09 | Soricimed Biopharma Inc. | Soricidin derived peptides and methods for the detection of trpv-6 cancers and drug delivery |
| WO2013013708A1 (en) | 2011-07-26 | 2013-01-31 | Fundació Institut D'investigació Biomèdica De Bellvitge | Treatment of acute rejection in renal transplant |
| WO2016094679A1 (en) | 2014-12-10 | 2016-06-16 | Regents Of The University Of Minnesota | Genetically modified cells, tissues, and organs for treating disease |
| RU2580640C1 (ru) * | 2014-12-25 | 2016-04-10 | Федеральное государственное бюджетное учреждение "Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации | Способ профилактики гуморального отторжения при аво-несовместимой трансплантации печени детям раннего возраста |
| RU2688172C1 (ru) * | 2018-04-05 | 2019-05-20 | Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) | Способ профилактики отторжения трансплантата трупной почки |
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| EP0408859B1 (en) * | 1989-05-23 | 1995-08-09 | Otsuka Pharmaceutical Co., Ltd. | Monoclonal antibodies to activated endothelial cells |
| US5690933A (en) | 1989-05-31 | 1997-11-25 | Glaxo Wellcome Inc. | Monoclonal antibodies for inducing tolerance |
| DE69233402T3 (de) * | 1991-10-25 | 2009-06-25 | Immunex Corp., Seattle | Neue cytokine |
| US5474771A (en) * | 1991-11-15 | 1995-12-12 | The Trustees Of Columbia University In The City Of New York | Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same |
| CA2089229C (en) * | 1992-02-14 | 2010-04-13 | Alejandro A. Aruffo | Cd40cr receptor and ligands therefor |
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| MX9306682A (es) * | 1992-10-30 | 1994-04-29 | Bristol Myers Squibb Co | Ligandos del receptor de la matriz extracelular, que modulan la funcion de los leucocitos. |
| ZA946765B (en) * | 1993-09-02 | 1996-02-15 | Dartmouth College | Methods of prolonged suppression of humoral immunity |
| JP2991499B2 (ja) * | 1993-09-02 | 1999-12-20 | トラスティーズ・オブ・ダートマス・カレッジ | 抗ｇｐ３９抗体およびその用途 |
| US5869049A (en) * | 1993-09-02 | 1999-02-09 | Trustees Of Dartmouth College | Methods of inducing T cell unresponsiveness to bone marrow with gp39 antagonists |
| US5683693A (en) * | 1994-04-25 | 1997-11-04 | Trustees Of Dartmouth College | Method for inducing T cell unresponsiveness to a tissue or organ graft with anti-CD40 ligand antibody or soluble CD40 |
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1994
- 1994-04-25 US US08/234,987 patent/US5683693A/en not_active Expired - Lifetime
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1995
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- 1995-04-25 DK DK95917593T patent/DK0757557T3/da active
- 1995-04-25 CZ CZ19963125A patent/CZ291266B6/cs unknown
- 1995-04-25 HU HU9602924A patent/HU221752B1/hu not_active IP Right Cessation
- 1995-04-25 CA CA002188672A patent/CA2188672A1/en not_active Abandoned
- 1995-04-25 SI SI9520057A patent/SI9520057A/sl unknown
- 1995-04-25 AU AU23585/95A patent/AU710925B2/en not_active Ceased
- 1995-04-25 EP EP05075209A patent/EP1530973A3/en not_active Withdrawn
- 1995-04-25 KR KR1019960705968A patent/KR100468330B1/ko not_active IP Right Cessation
- 1995-04-25 RU RU96122475/14A patent/RU2169009C2/ru not_active IP Right Cessation
- 1995-04-25 DE DE69533984T patent/DE69533984T2/de not_active Expired - Fee Related
- 1995-04-25 PT PT95917593T patent/PT757557E/pt unknown
- 1995-04-25 PL PL95317022A patent/PL180031B1/pl unknown
- 1995-04-25 JP JP7527745A patent/JP2974415B2/ja not_active Expired - Fee Related
- 1995-04-25 ES ES95917593T patent/ES2237757T3/es not_active Expired - Lifetime
- 1995-04-25 GE GEAP19953439A patent/GEP20022648B/en unknown
- 1995-04-25 AT AT95917593T patent/ATE288281T1/de not_active IP Right Cessation
- 1995-04-25 SK SK1369-96A patent/SK136996A3/sk unknown
- 1995-04-25 EE EE9600162A patent/EE03516B1/xx not_active IP Right Cessation
- 1995-04-25 EP EP95917593A patent/EP0757557B1/en not_active Expired - Lifetime
- 1995-04-25 CN CNB951935623A patent/CN1134266C/zh not_active Expired - Fee Related
- 1995-04-25 MD MD97-0009A patent/MD1444B2/ro unknown
- 1995-04-25 WO PCT/US1995/004832 patent/WO1995028957A2/en active IP Right Grant
- 1995-04-25 AP APAP/P/1996/000906A patent/AP764A/en active
- 1995-04-25 UA UA96114392A patent/UA44892C2/uk unknown
- 1995-04-25 BR BR9507509A patent/BR9507509A/pt not_active Application Discontinuation
- 1995-04-25 RO RO96-02051A patent/RO114743B1/ro unknown
-
1996
- 1996-10-18 NO NO19964440A patent/NO319787B1/no unknown
- 1996-10-22 IS IS4378A patent/IS2118B/is unknown
- 1996-10-23 FI FI964272A patent/FI118792B/sv active
- 1996-10-24 OA OA60909A patent/OA10591A/en unknown
- 1996-11-19 BG BG100991A patent/BG62121B1/bg unknown
- 1996-11-25 LT LT96-165A patent/LT4309B/lt not_active IP Right Cessation
- 1996-11-25 LV LVP-96-440A patent/LV11785B/en unknown
-
1997
- 1997-08-05 US US08/906,332 patent/US5902585A/en not_active Expired - Lifetime
-
1999
- 1999-01-05 US US09/227,081 patent/US6375950B1/en not_active Expired - Lifetime
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2004
- 2004-10-07 US US10/962,033 patent/US7501124B2/en not_active Expired - Fee Related
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2005
- 2005-03-04 NO NO20051182A patent/NO20051182L/no not_active Application Discontinuation
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