FI117900B - Menetelmä solun valmistamiseksi, joka ilmentää soluvälitteisen immuuniteetin uudelleensuuntaavia reseptorikimeeroja, ja niitä koodaava DNA ja vektori - Google Patents
Menetelmä solun valmistamiseksi, joka ilmentää soluvälitteisen immuuniteetin uudelleensuuntaavia reseptorikimeeroja, ja niitä koodaava DNA ja vektori Download PDFInfo
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N9/10—Transferases (2.)
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- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
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- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
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- C—CHEMISTRY; METALLURGY
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- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/033—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the internal surface of the plasma membrane, e.g. containing a myristoylation motif
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- C—CHEMISTRY; METALLURGY
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- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
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- Biomedical Technology (AREA)
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- Microbiology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Gynecology & Obstetrics (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66596191A | 1991-03-07 | 1991-03-07 | |
| US66596191 | 1991-03-07 | ||
| US9201785 | 1992-03-06 | ||
| PCT/US1992/001785 WO1992015322A1 (en) | 1991-03-07 | 1992-03-06 | Redirection of cellular immunity by receptor chimeras |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI933882A0 FI933882A0 (fi) | 1993-09-06 |
| FI933882A FI933882A (fi) | 1993-09-06 |
| FI117900B true FI117900B (fi) | 2007-04-13 |
Family
ID=24672250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI933882A FI117900B (fi) | 1991-03-07 | 1993-09-06 | Menetelmä solun valmistamiseksi, joka ilmentää soluvälitteisen immuuniteetin uudelleensuuntaavia reseptorikimeeroja, ja niitä koodaava DNA ja vektori |
Country Status (24)
| Country | Link |
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| EP (1) | EP0574512B1 (hu) |
| JP (1) | JP3696232B2 (hu) |
| KR (1) | KR100257780B1 (hu) |
| AT (1) | ATE232107T1 (hu) |
| AU (2) | AU662136B2 (hu) |
| BR (1) | BR9205736A (hu) |
| CA (1) | CA2104957C (hu) |
| CZ (1) | CZ281881B6 (hu) |
| DE (1) | DE69232921T2 (hu) |
| DK (1) | DK0574512T3 (hu) |
| ES (1) | ES2191006T3 (hu) |
| FI (1) | FI117900B (hu) |
| HK (1) | HK1011935A1 (hu) |
| HU (1) | HU218732B (hu) |
| IE (1) | IE920716A1 (hu) |
| IL (1) | IL101147A (hu) |
| MX (1) | MX9201002A (hu) |
| NO (1) | NO317202B1 (hu) |
| NZ (1) | NZ241855A (hu) |
| PT (1) | PT100207B (hu) |
| RU (1) | RU2161044C2 (hu) |
| SK (1) | SK283643B6 (hu) |
| UA (1) | UA41870C2 (hu) |
| WO (1) | WO1992015322A1 (hu) |
Families Citing this family (145)
| Publication number | Priority date | Publication date | Assignee | Title |
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| ES2096749T3 (es) * | 1990-12-14 | 1997-03-16 | Cell Genesys Inc | Cadenas quimericas para vias de transduccion de señal asociada a un receptor. |
| US6407221B1 (en) | 1990-12-14 | 2002-06-18 | Cell Genesys, Inc. | Chimeric chains for receptor-associated signal transduction pathways |
| US6319494B1 (en) | 1990-12-14 | 2001-11-20 | Cell Genesys, Inc. | Chimeric chains for receptor-associated signal transduction pathways |
| US5851828A (en) * | 1991-03-07 | 1998-12-22 | The General Hospital Corporation | Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells |
| US7049136B2 (en) | 1991-03-07 | 2006-05-23 | The General Hospital Corporation | Redirection of cellular immunity by receptor chimeras |
| US5843728A (en) * | 1991-03-07 | 1998-12-01 | The General Hospital Corporation | Redirection of cellular immunity by receptor chimeras |
| US5912170A (en) | 1991-03-07 | 1999-06-15 | The General Hospital Corporation | Redirection of cellular immunity by protein-tyrosine kinase chimeras |
| US6753162B1 (en) | 1991-03-07 | 2004-06-22 | The General Hospital Corporation | Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells |
| US6004811A (en) * | 1991-03-07 | 1999-12-21 | The Massachussetts General Hospital | Redirection of cellular immunity by protein tyrosine kinase chimeras |
| IL104570A0 (en) | 1992-03-18 | 1993-05-13 | Yeda Res & Dev | Chimeric genes and cells transformed therewith |
| US8211422B2 (en) | 1992-03-18 | 2012-07-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric receptor genes and cells transformed therewith |
| CA2166102C (en) * | 1993-07-16 | 2008-03-18 | Brian Seed | Redirection of cellular immunity by receptor chimeras |
| WO1995026985A1 (en) * | 1994-04-05 | 1995-10-12 | Board Of Regents, The University Of Texas System | Modified receptors that continuously signal |
| WO1995030014A1 (en) | 1994-05-02 | 1995-11-09 | Ciba-Geigy Ag | Bifunctional protein, preparation and use |
| US5798100A (en) * | 1994-07-06 | 1998-08-25 | Immunomedics, Inc. | Multi-stage cascade boosting vaccine |
| US7354587B1 (en) | 1994-07-06 | 2008-04-08 | Immunomedics, Inc. | Use of immunoconjugates to enhance the efficacy of multi-stage cascade boosting vaccines |
| WO1996003883A1 (en) * | 1994-08-02 | 1996-02-15 | The General Hospital Corporation | Cells bearing cd4 decoy receptors and related molecules and methods |
| US5837544A (en) * | 1995-02-02 | 1998-11-17 | Cell Genesys, Inc. | Method of inducing a cell to proliferate using a chimeric receptor comprising janus kinase |
| US6103521A (en) * | 1995-02-06 | 2000-08-15 | Cell Genesys, Inc. | Multispecific chimeric receptors |
| JP4170390B2 (ja) * | 1995-02-24 | 2008-10-22 | ザ ジェネラル ホスピタル コーポレーション | 受容体キメラによる細胞性免疫の再指示 |
| US5916771A (en) * | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
| US6420140B1 (en) | 1996-10-11 | 2002-07-16 | Abgenix, Inc. | Production of multimeric protein by cell fusion method |
| KR100620481B1 (ko) * | 1996-10-23 | 2006-09-06 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 개선된 백신 |
| WO1999028349A2 (en) | 1997-12-02 | 1999-06-10 | Medarex, Inc. | CELLS EXPRESSING ANTI-Fc RECEPTOR BINDING COMPONENTS |
| GB9809658D0 (en) * | 1998-05-06 | 1998-07-01 | Celltech Therapeutics Ltd | Biological products |
| US7723111B2 (en) | 2001-03-09 | 2010-05-25 | The United States Of America As Represented By The Department Of Health And Human Services | Activated dual specificity lymphocytes and their methods of use |
| US8562988B2 (en) | 2005-10-19 | 2013-10-22 | Ibc Pharmaceuticals, Inc. | Strategies for improved cancer vaccines |
| US9481878B2 (en) | 2004-02-13 | 2016-11-01 | Immunomedics, Inc. | Compositions and methods of use of immunotoxins comprising ranpirnase (Rap) show potent cytotoxic activity |
| US8551480B2 (en) | 2004-02-13 | 2013-10-08 | Immunomedics, Inc. | Compositions and methods of use of immunotoxins comprising ranpirnase (Rap) show potent cytotoxic activity |
| US8435539B2 (en) | 2004-02-13 | 2013-05-07 | Immunomedics, Inc. | Delivery system for cytotoxic drugs by bispecific antibody pretargeting |
| US8652484B2 (en) | 2004-02-13 | 2014-02-18 | Immunomedics, Inc. | Delivery system for cytotoxic drugs by bispecific antibody pretargeting |
| WO2006036445A2 (en) | 2004-09-24 | 2006-04-06 | Trustees Of Dartmouth College | Chimeric nk receptor and methods for treating cancer |
| AU2006304392B2 (en) | 2005-10-18 | 2014-05-01 | National Jewish Health | Conditionally immortalized long-term stem cells and methods of making and using such cells |
| EA021131B1 (ru) | 2008-05-16 | 2015-04-30 | Тэйга Байотекнолоджис, Инк. | Антитела и способы их получения |
| CN102186499B (zh) | 2008-08-20 | 2015-05-20 | Ibc医药公司 | 用于癌症治疗的对接和锁定(dnl)疫苗 |
| CA2735522C (en) | 2008-08-28 | 2017-04-18 | Taiga Biotechnologies, Inc. | Modulators of myc, methods of using the same, and methods of identifying agents that modulate myc |
| US9273283B2 (en) | 2009-10-29 | 2016-03-01 | The Trustees Of Dartmouth College | Method of producing T cell receptor-deficient T cells expressing a chimeric receptor |
| WO2011059836A2 (en) | 2009-10-29 | 2011-05-19 | Trustees Of Dartmouth College | T cell receptor-deficient t cell compositions |
| AR083495A1 (es) | 2010-10-22 | 2013-02-27 | Esbatech Alcon Biomed Res Unit | Anticuerpos estables y solubles |
| KR102243575B1 (ko) | 2010-12-09 | 2021-04-22 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 암을 치료하기 위한 키메릭 항원 수용체 변형 t 세포의 용도 |
| WO2013033626A2 (en) | 2011-08-31 | 2013-03-07 | Trustees Of Dartmouth College | Nkp30 receptor targeted therapeutics |
| ES2719495T3 (es) | 2012-05-07 | 2019-07-10 | Dartmouth College | Anticuerpo dirigido contra b7-h6, proteínas de fusión, y métodos de uso de los mismos |
| EP3868387A1 (en) | 2012-07-20 | 2021-08-25 | Taiga Biotechnologies, Inc. | Enhanced reconstitution and autoreconstitution of the hematopoietic compartment |
| RS61345B1 (sr) | 2012-08-20 | 2021-02-26 | Hutchinson Fred Cancer Res | Postupak i kompozicije za ćelijsku imunoterapiju |
| EP3744736A1 (en) | 2013-02-20 | 2020-12-02 | Novartis AG | Effective targeting of primary human leukemia using anti-cd123 chimeric antigen receptor engineered t cells |
| KR102313997B1 (ko) | 2013-02-20 | 2021-10-20 | 노파르티스 아게 | 인간화 항-EGFRvIII 키메라 항원 수용체를 사용한 암의 치료 |
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| IL162181A (en) * | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
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