FI113765B - Menetelmä uusien antiproliferatiivisten 5-substituoitujen kinatsoliiniyhdisteiden valmistamiseksi - Google Patents

Menetelmä uusien antiproliferatiivisten 5-substituoitujen kinatsoliiniyhdisteiden valmistamiseksi Download PDF

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Publication number
FI113765B
FI113765B FI944525A FI944525A FI113765B FI 113765 B FI113765 B FI 113765B FI 944525 A FI944525 A FI 944525A FI 944525 A FI944525 A FI 944525A FI 113765 B FI113765 B FI 113765B
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FI
Finland
Prior art keywords
compound
med
formula
steg
anhydrous anhydrous
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FI944525A
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English (en)
Finnish (fi)
Swedish (sv)
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FI944525A0 (fi
FI944525A (fi
Inventor
Stephen E Webber
Ted M Bleckman
John Attard
Terence R Jones
Michael D Varney
Original Assignee
Agouron Pharma
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Publication of FI944525A0 publication Critical patent/FI944525A0/fi
Publication of FI944525A publication Critical patent/FI944525A/fi
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Publication of FI113765B publication Critical patent/FI113765B/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/93—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI944525A 1992-03-31 1994-09-29 Menetelmä uusien antiproliferatiivisten 5-substituoitujen kinatsoliiniyhdisteiden valmistamiseksi FI113765B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US86103092 1992-03-31
US07/861,030 US5430148A (en) 1992-03-31 1992-03-31 Antiproliferative quinazolines
PCT/US1993/002636 WO1993020055A1 (en) 1992-03-31 1993-03-26 Antiproliferative quinazolines
US9302636 1993-03-26

Publications (3)

Publication Number Publication Date
FI944525A0 FI944525A0 (fi) 1994-09-29
FI944525A FI944525A (fi) 1994-09-29
FI113765B true FI113765B (fi) 2004-06-15

Family

ID=25334675

Family Applications (1)

Application Number Title Priority Date Filing Date
FI944525A FI113765B (fi) 1992-03-31 1994-09-29 Menetelmä uusien antiproliferatiivisten 5-substituoitujen kinatsoliiniyhdisteiden valmistamiseksi

Country Status (20)

Country Link
US (3) US5430148A (hu)
EP (1) EP0637300B1 (hu)
JP (1) JP3272357B2 (hu)
KR (1) KR100226114B1 (hu)
AT (1) ATE205197T1 (hu)
AU (1) AU681075B2 (hu)
CA (2) CA2132514C (hu)
DE (1) DE69330715T2 (hu)
DK (1) DK0637300T3 (hu)
ES (1) ES2162818T3 (hu)
FI (1) FI113765B (hu)
HU (1) HU222523B1 (hu)
MD (1) MD1638G2 (hu)
NO (1) NO307829B1 (hu)
NZ (1) NZ251804A (hu)
PT (1) PT637300E (hu)
RU (1) RU2135481C1 (hu)
SG (2) SG46672A1 (hu)
TJ (1) TJ272B (hu)
WO (1) WO1993020055A1 (hu)

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JP2001512830A (ja) * 1997-08-08 2001-08-28 ニューバイオティックス インコーポレイテッド 生物療法耐性および化学療法耐性を克服するための方法および組成物
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US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
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UA74803C2 (uk) 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
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US7166595B2 (en) * 2002-05-09 2007-01-23 Cytokinetics, Inc. Compounds, methods and compositions
US7214800B2 (en) * 2002-05-09 2007-05-08 Cytokinetics, Inc. Compounds, compositions, and methods
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US20080125441A1 (en) * 2002-06-21 2008-05-29 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
US6906205B2 (en) * 2002-06-21 2005-06-14 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
US7371778B2 (en) * 2002-06-21 2008-05-13 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
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Also Published As

Publication number Publication date
EP0637300A1 (en) 1995-02-08
SG93183A1 (en) 2002-12-17
SG46672A1 (en) 1998-02-20
FI944525A0 (fi) 1994-09-29
FI944525A (fi) 1994-09-29
ATE205197T1 (de) 2001-09-15
US5430148A (en) 1995-07-04
NO943629L (no) 1994-09-29
US5707992A (en) 1998-01-13
WO1993020055A1 (en) 1993-10-14
DE69330715D1 (de) 2001-10-11
US5885996A (en) 1999-03-23
AU681075B2 (en) 1997-08-21
DE69330715T2 (de) 2002-02-14
ES2162818T3 (es) 2002-01-16
CA2474211C (en) 2006-10-03
DK0637300T3 (da) 2001-12-10
HU9402799D0 (en) 1994-12-28
KR100226114B1 (ko) 1999-10-15
NZ251804A (en) 1997-06-24
JP3272357B2 (ja) 2002-04-08
CA2474211A1 (en) 1993-10-14
RU2135481C1 (ru) 1999-08-27
CA2132514C (en) 2004-10-26
HUT68580A (en) 1995-06-28
MD1638F2 (en) 2001-03-31
HU222523B1 (hu) 2003-08-28
AU3966493A (en) 1993-11-08
NO307829B1 (no) 2000-06-05
RU94045251A (ru) 1996-07-20
MD1638G2 (ro) 2001-09-30
NO943629D0 (no) 1994-09-29
JPH07505395A (ja) 1995-06-15
PT637300E (pt) 2002-01-30
TJ272B (en) 2000-10-05
CA2132514A1 (en) 1993-10-14
EP0637300B1 (en) 2001-09-05

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