FI113765B - Menetelmä uusien antiproliferatiivisten 5-substituoitujen kinatsoliiniyhdisteiden valmistamiseksi - Google Patents

Menetelmä uusien antiproliferatiivisten 5-substituoitujen kinatsoliiniyhdisteiden valmistamiseksi Download PDF

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Publication number
FI113765B
FI113765B FI944525A FI944525A FI113765B FI 113765 B FI113765 B FI 113765B FI 944525 A FI944525 A FI 944525A FI 944525 A FI944525 A FI 944525A FI 113765 B FI113765 B FI 113765B
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FI
Finland
Prior art keywords
compound
med
formula
steg
anhydrous anhydrous
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FI944525A
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English (en)
Finnish (fi)
Swedish (sv)
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FI944525A0 (fi
FI944525A (fi
Inventor
Stephen E Webber
Ted M Bleckman
John Attard
Terence R Jones
Michael D Varney
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Agouron Pharma
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/86Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88Oxygen atoms
    • C07D239/90Oxygen atoms with acyclic radicals attached in position 2 or 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/86Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/93Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/95Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI944525A 1992-03-31 1994-09-29 Menetelmä uusien antiproliferatiivisten 5-substituoitujen kinatsoliiniyhdisteiden valmistamiseksi FI113765B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US86103092 1992-03-31
US07/861,030 US5430148A (en) 1992-03-31 1992-03-31 Antiproliferative quinazolines
PCT/US1993/002636 WO1993020055A1 (en) 1992-03-31 1993-03-26 Antiproliferative quinazolines
US9302636 1993-03-26

Publications (3)

Publication Number Publication Date
FI944525A0 FI944525A0 (fi) 1994-09-29
FI944525A FI944525A (fi) 1994-09-29
FI113765B true FI113765B (fi) 2004-06-15

Family

ID=25334675

Family Applications (1)

Application Number Title Priority Date Filing Date
FI944525A FI113765B (fi) 1992-03-31 1994-09-29 Menetelmä uusien antiproliferatiivisten 5-substituoitujen kinatsoliiniyhdisteiden valmistamiseksi

Country Status (20)

Country Link
US (3) US5430148A (hu)
EP (1) EP0637300B1 (hu)
JP (1) JP3272357B2 (hu)
KR (1) KR100226114B1 (hu)
AT (1) ATE205197T1 (hu)
AU (1) AU681075B2 (hu)
CA (2) CA2132514C (hu)
DE (1) DE69330715T2 (hu)
DK (1) DK0637300T3 (hu)
ES (1) ES2162818T3 (hu)
FI (1) FI113765B (hu)
HU (1) HU222523B1 (hu)
MD (1) MD1638G2 (hu)
NO (1) NO307829B1 (hu)
NZ (1) NZ251804A (hu)
PT (1) PT637300E (hu)
RU (1) RU2135481C1 (hu)
SG (2) SG46672A1 (hu)
TJ (1) TJ272B (hu)
WO (1) WO1993020055A1 (hu)

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US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
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US7166595B2 (en) * 2002-05-09 2007-01-23 Cytokinetics, Inc. Compounds, methods and compositions
US7214800B2 (en) * 2002-05-09 2007-05-08 Cytokinetics, Inc. Compounds, compositions, and methods
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US20080125441A1 (en) * 2002-06-21 2008-05-29 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
US6906205B2 (en) * 2002-06-21 2005-06-14 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
US7371778B2 (en) * 2002-06-21 2008-05-13 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
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CN1303080C (zh) * 2005-07-18 2007-03-07 康辰医药发展有限公司 盐酸洛拉曲克的合成工艺
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Also Published As

Publication number Publication date
EP0637300A1 (en) 1995-02-08
SG93183A1 (en) 2002-12-17
SG46672A1 (en) 1998-02-20
FI944525A0 (fi) 1994-09-29
FI944525A (fi) 1994-09-29
ATE205197T1 (de) 2001-09-15
US5430148A (en) 1995-07-04
NO943629L (no) 1994-09-29
US5707992A (en) 1998-01-13
WO1993020055A1 (en) 1993-10-14
DE69330715D1 (de) 2001-10-11
US5885996A (en) 1999-03-23
AU681075B2 (en) 1997-08-21
DE69330715T2 (de) 2002-02-14
ES2162818T3 (es) 2002-01-16
CA2474211C (en) 2006-10-03
DK0637300T3 (da) 2001-12-10
HU9402799D0 (en) 1994-12-28
KR100226114B1 (ko) 1999-10-15
NZ251804A (en) 1997-06-24
JP3272357B2 (ja) 2002-04-08
CA2474211A1 (en) 1993-10-14
RU2135481C1 (ru) 1999-08-27
CA2132514C (en) 2004-10-26
HUT68580A (en) 1995-06-28
MD1638F2 (en) 2001-03-31
HU222523B1 (hu) 2003-08-28
AU3966493A (en) 1993-11-08
NO307829B1 (no) 2000-06-05
RU94045251A (ru) 1996-07-20
MD1638G2 (ro) 2001-09-30
NO943629D0 (no) 1994-09-29
JPH07505395A (ja) 1995-06-15
PT637300E (pt) 2002-01-30
TJ272B (en) 2000-10-05
CA2132514A1 (en) 1993-10-14
EP0637300B1 (en) 2001-09-05

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