MD1638G2 - Chinazoline, procedeu de obţinere a lor, compoziţie farmaceutică şi metodă terapeutică de inhibare a creşterii şi proliferare a celulelor organismelor superioare şi microorganismelor - Google Patents
Chinazoline, procedeu de obţinere a lor, compoziţie farmaceutică şi metodă terapeutică de inhibare a creşterii şi proliferare a celulelor organismelor superioare şi microorganismelorInfo
- Publication number
- MD1638G2 MD1638G2 MD96-0277A MD960277A MD1638G2 MD 1638 G2 MD1638 G2 MD 1638G2 MD 960277 A MD960277 A MD 960277A MD 1638 G2 MD1638 G2 MD 1638G2
- Authority
- MD
- Moldova
- Prior art keywords
- proliferation
- growth inhibition
- quinazolines
- obtaining
- higher organisms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/93—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Invenţia se referă la compuşi ai chinazolinei, care manifestă o activitate antiproliferativă, cum ar fi activitatea antitumorală, la procedeele de preparare a acestor compuşi, la compoziţiile farmaceutice ce conţin aceşti compuşi şi la utilizarea lor pentru inhibarea creşterii şi proliferării celulelor organismelor superioare şi microorganismelor, cum sunt bacteriile, drojdiile şi fungii. Compuşii preferenţiali ai acestei invenţii sunt capabili să inhibe enzima timidilatsintază.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/861,030 US5430148A (en) | 1992-03-31 | 1992-03-31 | Antiproliferative quinazolines |
PCT/US1993/002636 WO1993020055A1 (en) | 1992-03-31 | 1993-03-26 | Antiproliferative quinazolines |
Publications (2)
Publication Number | Publication Date |
---|---|
MD1638F2 MD1638F2 (ro) | 2001-03-31 |
MD1638G2 true MD1638G2 (ro) | 2001-09-30 |
Family
ID=25334675
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MD96-0277A MD1638G2 (ro) | 1992-03-31 | 1993-03-26 | Chinazoline, procedeu de obţinere a lor, compoziţie farmaceutică şi metodă terapeutică de inhibare a creşterii şi proliferare a celulelor organismelor superioare şi microorganismelor |
Country Status (20)
Country | Link |
---|---|
US (3) | US5430148A (ro) |
EP (1) | EP0637300B1 (ro) |
JP (1) | JP3272357B2 (ro) |
KR (1) | KR100226114B1 (ro) |
AT (1) | ATE205197T1 (ro) |
AU (1) | AU681075B2 (ro) |
CA (2) | CA2132514C (ro) |
DE (1) | DE69330715T2 (ro) |
DK (1) | DK0637300T3 (ro) |
ES (1) | ES2162818T3 (ro) |
FI (1) | FI113765B (ro) |
HU (1) | HU222523B1 (ro) |
MD (1) | MD1638G2 (ro) |
NO (1) | NO307829B1 (ro) |
NZ (1) | NZ251804A (ro) |
PT (1) | PT637300E (ro) |
RU (1) | RU2135481C1 (ro) |
SG (2) | SG46672A1 (ro) |
TJ (1) | TJ272B (ro) |
WO (1) | WO1993020055A1 (ro) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5480883A (en) * | 1991-05-10 | 1996-01-02 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
US5430148A (en) * | 1992-03-31 | 1995-07-04 | Agouron Pharmaceuticals, Inc. | Antiproliferative quinazolines |
US5756502A (en) * | 1994-08-08 | 1998-05-26 | Warner-Lambert Company | Quinazolinone derivatives as cholyecystokinin (CCK) ligands |
US5593999A (en) * | 1995-06-07 | 1997-01-14 | Nair; Madhavan G. | Non-classical folate analogue inhibitors of glycinamide ribonucleotide formyltransferase (GARFT) |
US5783577A (en) * | 1995-09-15 | 1998-07-21 | Trega Biosciences, Inc. | Synthesis of quinazolinone libraries and derivatives thereof |
WO1997042192A1 (de) * | 1996-05-07 | 1997-11-13 | Basf Aktiengesellschaft | Imidazo-chinazoline, sie enthaltende mittel und deren verwendung zur bekämpfung von schadpilzen und tierischen schädlingen |
AR012634A1 (es) * | 1997-05-02 | 2000-11-08 | Sugen Inc | Compuesto basado en quinazolina, composicion famaceutica que lo comprende, metodo para sintetizarlo, su uso, metodos de modulacion de la funcion deserina/treonina proteinaquinasa con dicho compuesto y metodo in vitro para identificar compuestos que modulan dicha funcion |
ATE413881T1 (de) * | 1997-08-08 | 2008-11-15 | Celmed Oncology Usa Inc | Verfahren und zubereitungen um resistenz gegen biologische oder chemische therapien zu überwinden |
US7462605B2 (en) * | 1998-01-23 | 2008-12-09 | Celmed Oncology (Usa), Inc. | Phosphoramidate compounds and methods of use |
CA2317505C (en) | 1998-01-23 | 2011-01-04 | Newbiotics, Inc. | Enzyme catalyzed therapeutic agents |
US6706721B1 (en) | 1998-04-29 | 2004-03-16 | Osi Pharmaceuticals, Inc. | N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate |
US6184226B1 (en) * | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
US6683061B1 (en) * | 1999-07-22 | 2004-01-27 | Newbiotics, Inc. | Enzyme catalyzed therapeutic activation |
MXPA02000762A (es) | 1999-07-22 | 2002-08-20 | Newbiotics Inc | Metodos para tratar tumores resistentes a terapia. |
US7230000B1 (en) | 1999-10-27 | 2007-06-12 | Cytokinetics, Incorporated | Methods and compositions utilizing quinazolinones |
US6545004B1 (en) | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
UA74803C2 (uk) | 1999-11-11 | 2006-02-15 | Осі Фармасьютікалз, Інк. | Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування |
US7087613B2 (en) * | 1999-11-11 | 2006-08-08 | Osi Pharmaceuticals, Inc. | Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride |
WO2002032400A1 (en) * | 2000-10-16 | 2002-04-25 | Neopharm, Inc. | Liposomal formulation of mitoxantrone |
US6486199B1 (en) | 2001-06-21 | 2002-11-26 | Medicines For Malaria Venture Mmv International Centre Cointrin | Spiro and dispiro 1,2,4-trioxolane antimalarials |
AU2002346471A1 (en) * | 2001-11-20 | 2003-06-10 | Cytokinetics, Inc. | Process for the racemization of chiral quinazolinones |
WO2003070701A2 (en) * | 2002-02-15 | 2003-08-28 | Cytokinetics, Inc. | Syntheses of quinazolinones |
CN100491358C (zh) * | 2002-05-09 | 2009-05-27 | 赛特凯恩蒂克公司 | 嘧啶酮类化合物、组合物及方法 |
WO2003097053A1 (en) | 2002-05-09 | 2003-11-27 | Cytokinetics, Inc. | Compounds, compositions, and methods |
US7038048B2 (en) * | 2002-05-23 | 2006-05-02 | Cytokinetics, Inc. | 3H-pyridopyrimidin-4-one compounds, compositions, and methods of their use |
WO2003106426A1 (en) * | 2002-06-14 | 2003-12-24 | Cytokinetics, Inc. | Compounds, compositions, and methods |
US6906205B2 (en) * | 2002-06-21 | 2005-06-14 | Medicines For Malaria Venture Mmv | Spiro and dispiro 1,2,4-trioxolane antimalarials |
US7371778B2 (en) * | 2002-06-21 | 2008-05-13 | Medicines For Malaria Venture Mmv | Spiro and dispiro 1,2,4-trioxolane antimalarials |
US20080125441A1 (en) * | 2002-06-21 | 2008-05-29 | Medicines For Malaria Venture Mmv | Spiro and dispiro 1,2,4-trioxolane antimalarials |
JP2006501201A (ja) * | 2002-07-23 | 2006-01-12 | サイトキネティクス・インコーポレーテッド | 化合物、組成物および方法 |
US20040048853A1 (en) * | 2002-08-21 | 2004-03-11 | Gustave Bergnes | Compounds, compositions, and methods |
WO2004034972A2 (en) * | 2002-09-30 | 2004-04-29 | Cytokinetics, Inc. | Compounds, compositions, and methods |
US7232824B2 (en) * | 2003-09-30 | 2007-06-19 | Scios, Inc. | Quinazoline derivatives as medicaments |
EP1682534A2 (en) * | 2003-11-03 | 2006-07-26 | Cytokinetics, Inc. | Pyrimidin-4-one compounds, compositions, and methods |
WO2005046588A2 (en) * | 2003-11-07 | 2005-05-26 | Cytokinetics, Inc. | Compounds, compositions, and methods |
WO2005061460A1 (en) * | 2003-12-08 | 2005-07-07 | Cytokinetics, Inc. | Compounds, compositions, and methods |
BRPI0606318B8 (pt) * | 2005-01-19 | 2021-05-25 | Rigel Pharmaceuticals Inc | composto, composição, e, uso de um composto |
US8067620B2 (en) * | 2005-05-04 | 2011-11-29 | Medicines For Malaria Venture Mmv | Dispiro 1,2,4-trioxolane antimalarials |
CN1303080C (zh) * | 2005-07-18 | 2007-03-07 | 康辰医药发展有限公司 | 盐酸洛拉曲克的合成工艺 |
JO2985B1 (ar) | 2006-12-20 | 2016-09-05 | Takeda Pharmaceuticals Co | مثبطات كينازmapk/erk |
CN101353343B (zh) * | 2007-07-27 | 2012-07-04 | 上海医药工业研究院 | 高纯度盐酸诺拉曲塞二水合物的制备方法 |
US8426430B2 (en) * | 2008-06-30 | 2013-04-23 | Hutchison Medipharma Enterprises Limited | Quinazoline derivatives |
EP2440533B1 (en) * | 2009-06-12 | 2015-09-23 | Socpra-Sciences Et Génie S.E.C. | Guanine riboswitch binding compounds and their use as antibiotics |
MX2012006094A (es) | 2009-12-18 | 2012-06-19 | Basilea Pharmaceutica Ag | Antibioticos triciclicos. |
WO2012171860A1 (en) | 2011-06-17 | 2012-12-20 | Basilea Pharmaceutica Ag | Tricyclic antibiotics |
RU2507199C1 (ru) * | 2012-09-10 | 2014-02-20 | Владимир Иванович Петров | Производные хиназолина, обладающие антидепрессивной, анксиолитической и ноотропной активностью |
RU2507198C1 (ru) * | 2012-09-10 | 2014-02-20 | Владимир Иванович Петров | Производные хиназолина, обладающие ноотропной и антигипоксической активностью |
RU2622638C1 (ru) * | 2016-07-14 | 2017-06-19 | Владимир Иванович Петров | Производные хиназолин-4(3н)-она, обладающие нейро- и кардиопротекторной активностью |
US20220133726A1 (en) | 2019-02-14 | 2022-05-05 | Som Innovation Biotech, S.A. | Triamterene or nolatrexed for use in the treatment of phenylketonuria |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4857530A (en) * | 1987-11-03 | 1989-08-15 | Warner-Lambert Company | Substituted quinazolinones as anticancer agents |
EP0459730A2 (en) * | 1990-05-30 | 1991-12-04 | Zeneca Limited | Anti-tumour compounds |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
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US1817982A (en) * | 1931-08-11 | Winfrid hentrich and max habdtmann | ||
CA793845A (en) * | 1968-09-03 | Davoll John | Amine compounds and production thereof | |
GB206565A (en) * | 1922-08-03 | 1923-11-05 | Walter Wood Tullis | Improvements in or relating to the concentration and preparation for smelting of iron ores |
GB1045180A (en) * | 1963-09-20 | 1966-10-12 | Parke Davis & Co | Quinazoline derivatives |
GB1212613A (en) * | 1967-02-28 | 1970-11-18 | Chinoin Gyogyszer Es Vegyeszet | 4-quinazolone derivatives and process for the preparation thereof |
GB1161644A (en) * | 1967-09-11 | 1969-08-13 | Parke Davis & Co | Quinazoline Compounds and process means for producing the same |
US4048312A (en) * | 1973-10-30 | 1977-09-13 | Eli Lilly And Company | 2,4-Diaminoquinazolines as antithrombotic agents |
IT1050750B (it) * | 1975-12-05 | 1981-03-20 | Erba Carlo Spa | Derivati della 3.4 di idro chinazolina |
US4223143A (en) * | 1978-12-11 | 1980-09-16 | Siegfried Aktiengesellschaft | Quinazoline derivatives |
US4391809A (en) * | 1979-10-15 | 1983-07-05 | Warner-Lambert Company | Methods for treating psoriasis |
EP0031237B1 (en) * | 1979-12-19 | 1984-10-17 | National Research Development Corporation | Quinazoline derivatives, processes for their preparation, compositions containing them and their use as anti-cancer agents |
US4853221A (en) * | 1980-11-13 | 1989-08-01 | Warner-Lambert Company | Method for treating non-small cell lung cancer, head and neck cancers and breast cancer |
JPS57156467A (en) * | 1981-03-20 | 1982-09-27 | Asahi Chem Ind Co Ltd | 2,4-disubstituted-6-quinazolinesulfonamide derivative |
JPS6136273A (ja) * | 1984-07-26 | 1986-02-20 | Mitsubishi Yuka Yakuhin Kk | 2−フエニルアルキル−4(3h)−キナゾリノン誘導体 |
US4749698A (en) * | 1985-07-08 | 1988-06-07 | Rorer Pharmaceutical Corporation | Antihypertensive derivatives |
GB8513754D0 (en) * | 1985-05-31 | 1985-07-03 | Jones T R | Anti-cancer quinazoline derivatives |
GB8707053D0 (en) * | 1987-03-25 | 1987-04-29 | Ici Plc | Anti-tumour agents |
GB8809978D0 (en) * | 1988-04-27 | 1988-06-02 | Ici Plc | Anti-tumour agents |
EP0365763A1 (en) * | 1988-09-30 | 1990-05-02 | Agouron Pharmaceuticals, Inc. | Antiproliferative cyclic compounds |
GB8829296D0 (en) * | 1988-12-15 | 1989-01-25 | Ici Plc | Anti-tumour compounds |
NO171069C (no) * | 1990-05-29 | 1993-01-20 | Protan Biopolymer As | Kovalent tverrbundne, sterkt svellende alkalimetall- og ammonium-alginatgeler, samt fremgangsmaate for fremstilling derav |
US5430148A (en) * | 1992-03-31 | 1995-07-04 | Agouron Pharmaceuticals, Inc. | Antiproliferative quinazolines |
-
1992
- 1992-03-31 US US07/861,030 patent/US5430148A/en not_active Expired - Lifetime
-
1993
- 1993-03-26 EP EP93909143A patent/EP0637300B1/en not_active Expired - Lifetime
- 1993-03-26 AT AT93909143T patent/ATE205197T1/de not_active IP Right Cessation
- 1993-03-26 AU AU39664/93A patent/AU681075B2/en not_active Ceased
- 1993-03-26 MD MD96-0277A patent/MD1638G2/ro not_active IP Right Cessation
- 1993-03-26 SG SG1996008023A patent/SG46672A1/en unknown
- 1993-03-26 PT PT93909143T patent/PT637300E/pt unknown
- 1993-03-26 RU RU94045251A patent/RU2135481C1/ru not_active IP Right Cessation
- 1993-03-26 CA CA002132514A patent/CA2132514C/en not_active Expired - Fee Related
- 1993-03-26 KR KR1019940703402A patent/KR100226114B1/ko not_active IP Right Cessation
- 1993-03-26 DK DK93909143T patent/DK0637300T3/da active
- 1993-03-26 TJ TJ96000367A patent/TJ272B/xx unknown
- 1993-03-26 HU HU9402799A patent/HU222523B1/hu not_active IP Right Cessation
- 1993-03-26 WO PCT/US1993/002636 patent/WO1993020055A1/en active IP Right Grant
- 1993-03-26 JP JP51751493A patent/JP3272357B2/ja not_active Expired - Fee Related
- 1993-03-26 NZ NZ251804A patent/NZ251804A/en not_active IP Right Cessation
- 1993-03-26 DE DE69330715T patent/DE69330715T2/de not_active Expired - Fee Related
- 1993-03-26 ES ES93909143T patent/ES2162818T3/es not_active Expired - Lifetime
- 1993-03-26 CA CA002474211A patent/CA2474211C/en not_active Expired - Fee Related
-
1994
- 1994-09-29 FI FI944525A patent/FI113765B/fi active
- 1994-09-29 NO NO943629A patent/NO307829B1/no unknown
-
1995
- 1995-04-07 US US08/418,415 patent/US5707992A/en not_active Expired - Fee Related
-
1996
- 1996-02-22 SG SG9800739A patent/SG93183A1/en unknown
-
1997
- 1997-09-04 US US08/923,117 patent/US5885996A/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4857530A (en) * | 1987-11-03 | 1989-08-15 | Warner-Lambert Company | Substituted quinazolinones as anticancer agents |
EP0459730A2 (en) * | 1990-05-30 | 1991-12-04 | Zeneca Limited | Anti-tumour compounds |
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