MD1638F2 - Chinazoline, procedeu de obtinere a lor, compozitie farmaceutica si metoda terapeutica de inhibare a cresterii si proliferare a celulelor organismelor superioare si microorganismelor - Google Patents

Chinazoline, procedeu de obtinere a lor, compozitie farmaceutica si metoda terapeutica de inhibare a cresterii si proliferare a celulelor organismelor superioare si microorganismelor

Info

Publication number
MD1638F2
MD1638F2 MD96-0277A MD960277A MD1638F2 MD 1638 F2 MD1638 F2 MD 1638F2 MD 960277 A MD960277 A MD 960277A MD 1638 F2 MD1638 F2 MD 1638F2
Authority
MD
Moldova
Prior art keywords
proliferation
growth inhibition
quinazolines
obtaining
higher organisms
Prior art date
Application number
MD96-0277A
Other languages
English (en)
Other versions
MD1638G2 (ro
Inventor
Stephen E Webber
Ted M Bleckman
John Attard
Terence R Jones
Michael D Varney
Original Assignee
Agouron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharma filed Critical Agouron Pharma
Publication of MD1638F2 publication Critical patent/MD1638F2/ro
Publication of MD1638G2 publication Critical patent/MD1638G2/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/93—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
MD96-0277A 1992-03-31 1993-03-26 Chinazoline, procedeu de obţinere a lor, compoziţie farmaceutică şi metodă terapeutică de inhibare a creşterii şi proliferare a celulelor organismelor superioare şi microorganismelor MD1638G2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/861,030 US5430148A (en) 1992-03-31 1992-03-31 Antiproliferative quinazolines
PCT/US1993/002636 WO1993020055A1 (en) 1992-03-31 1993-03-26 Antiproliferative quinazolines

Publications (2)

Publication Number Publication Date
MD1638F2 true MD1638F2 (ro) 2001-03-31
MD1638G2 MD1638G2 (ro) 2001-09-30

Family

ID=25334675

Family Applications (1)

Application Number Title Priority Date Filing Date
MD96-0277A MD1638G2 (ro) 1992-03-31 1993-03-26 Chinazoline, procedeu de obţinere a lor, compoziţie farmaceutică şi metodă terapeutică de inhibare a creşterii şi proliferare a celulelor organismelor superioare şi microorganismelor

Country Status (20)

Country Link
US (3) US5430148A (ro)
EP (1) EP0637300B1 (ro)
JP (1) JP3272357B2 (ro)
KR (1) KR100226114B1 (ro)
AT (1) ATE205197T1 (ro)
AU (1) AU681075B2 (ro)
CA (2) CA2132514C (ro)
DE (1) DE69330715T2 (ro)
DK (1) DK0637300T3 (ro)
ES (1) ES2162818T3 (ro)
FI (1) FI113765B (ro)
HU (1) HU222523B1 (ro)
MD (1) MD1638G2 (ro)
NO (1) NO307829B1 (ro)
NZ (1) NZ251804A (ro)
PT (1) PT637300E (ro)
RU (1) RU2135481C1 (ro)
SG (2) SG46672A1 (ro)
TJ (1) TJ272B (ro)
WO (1) WO1993020055A1 (ro)

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US7371778B2 (en) * 2002-06-21 2008-05-13 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
US20080125441A1 (en) * 2002-06-21 2008-05-29 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
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JO2985B1 (ar) 2006-12-20 2016-09-05 Takeda Pharmaceuticals Co مثبطات كينازmapk/erk
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JP5756096B2 (ja) 2009-06-12 2015-07-29 ソックプラ−シアンセ エ ジェニー エス．ウ．セ． グアニンリボスイッチ結合化合物及び抗生物質としてのその使用
HRP20140005T1 (hr) 2009-12-18 2014-01-31 Basilea Pharmaceutica Ag Tricikliäśki antibiotici
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RU2622638C1 (ru) * 2016-07-14 2017-06-19 Владимир Иванович Петров Производные хиназолин-4(3н)-она, обладающие нейро- и кардиопротекторной активностью
IL285265B2 (en) 2019-02-14 2024-12-01 Som Innovation Biotech S A Triamterene or nolatrexed for use in the treatment of phenylketonuria
TW202517614A (zh) 2023-07-12 2025-05-01 瑞士商先正達農作物保護股份公司 ２－（三氟甲基）吡啶－４－胺的合成

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Also Published As

Publication number Publication date
DE69330715T2 (de) 2002-02-14
TJ272B (en) 2000-10-05
RU2135481C1 (ru) 1999-08-27
KR100226114B1 (ko) 1999-10-15
NZ251804A (en) 1997-06-24
FI944525A0 (fi) 1994-09-29
AU3966493A (en) 1993-11-08
US5707992A (en) 1998-01-13
JPH07505395A (ja) 1995-06-15
FI944525L (fi) 1994-09-29
EP0637300A1 (en) 1995-02-08
HU222523B1 (hu) 2003-08-28
US5430148A (en) 1995-07-04
NO307829B1 (no) 2000-06-05
MD1638G2 (ro) 2001-09-30
DK0637300T3 (da) 2001-12-10
ES2162818T3 (es) 2002-01-16
US5885996A (en) 1999-03-23
CA2132514A1 (en) 1993-10-14
RU94045251A (ru) 1996-07-20
JP3272357B2 (ja) 2002-04-08
HUT68580A (en) 1995-06-28
SG93183A1 (en) 2002-12-17
NO943629L (no) 1994-09-29
WO1993020055A1 (en) 1993-10-14
HU9402799D0 (en) 1994-12-28
CA2474211C (en) 2006-10-03
ATE205197T1 (de) 2001-09-15
AU681075B2 (en) 1997-08-21
NO943629D0 (no) 1994-09-29
CA2132514C (en) 2004-10-26
DE69330715D1 (de) 2001-10-11
PT637300E (pt) 2002-01-30
CA2474211A1 (en) 1993-10-14
SG46672A1 (en) 1998-02-20
EP0637300B1 (en) 2001-09-05
FI113765B (fi) 2004-06-15

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Legal Events

Date Code Title Description
PD99 Pending application
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees