NO307829B1 - Antiproliferative quinazoliner, anvendelse, fremgangsmÕte for fremstilling derav samt farmasøytisk preparat - Google Patents

Antiproliferative quinazoliner, anvendelse, fremgangsmÕte for fremstilling derav samt farmasøytisk preparat

Info

Publication number
NO307829B1
NO307829B1 NO943629A NO943629A NO307829B1 NO 307829 B1 NO307829 B1 NO 307829B1 NO 943629 A NO943629 A NO 943629A NO 943629 A NO943629 A NO 943629A NO 307829 B1 NO307829 B1 NO 307829B1
Authority
NO
Norway
Prior art keywords
compounds
quinazolines
antiproliferative
preparation
pharmaceutical composition
Prior art date
Application number
NO943629A
Other languages
English (en)
Norwegian (no)
Other versions
NO943629L (no
NO943629D0 (no
Inventor
Stephen E Webber
Ted M Bleckman
John Attard
Terence R Jones
Michael D Varney
Original Assignee
Agouron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharma filed Critical Agouron Pharma
Publication of NO943629L publication Critical patent/NO943629L/no
Publication of NO943629D0 publication Critical patent/NO943629D0/no
Publication of NO307829B1 publication Critical patent/NO307829B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/93—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO943629A 1992-03-31 1994-09-29 Antiproliferative quinazoliner, anvendelse, fremgangsmÕte for fremstilling derav samt farmasøytisk preparat NO307829B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/861,030 US5430148A (en) 1992-03-31 1992-03-31 Antiproliferative quinazolines
PCT/US1993/002636 WO1993020055A1 (en) 1992-03-31 1993-03-26 Antiproliferative quinazolines

Publications (3)

Publication Number Publication Date
NO943629L NO943629L (no) 1994-09-29
NO943629D0 NO943629D0 (no) 1994-09-29
NO307829B1 true NO307829B1 (no) 2000-06-05

Family

ID=25334675

Family Applications (1)

Application Number Title Priority Date Filing Date
NO943629A NO307829B1 (no) 1992-03-31 1994-09-29 Antiproliferative quinazoliner, anvendelse, fremgangsmÕte for fremstilling derav samt farmasøytisk preparat

Country Status (20)

Country Link
US (3) US5430148A (hu)
EP (1) EP0637300B1 (hu)
JP (1) JP3272357B2 (hu)
KR (1) KR100226114B1 (hu)
AT (1) ATE205197T1 (hu)
AU (1) AU681075B2 (hu)
CA (2) CA2132514C (hu)
DE (1) DE69330715T2 (hu)
DK (1) DK0637300T3 (hu)
ES (1) ES2162818T3 (hu)
FI (1) FI113765B (hu)
HU (1) HU222523B1 (hu)
MD (1) MD1638G2 (hu)
NO (1) NO307829B1 (hu)
NZ (1) NZ251804A (hu)
PT (1) PT637300E (hu)
RU (1) RU2135481C1 (hu)
SG (2) SG46672A1 (hu)
TJ (1) TJ272B (hu)
WO (1) WO1993020055A1 (hu)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5480883A (en) * 1991-05-10 1996-01-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US5430148A (en) * 1992-03-31 1995-07-04 Agouron Pharmaceuticals, Inc. Antiproliferative quinazolines
US5756502A (en) * 1994-08-08 1998-05-26 Warner-Lambert Company Quinazolinone derivatives as cholyecystokinin (CCK) ligands
US5593999A (en) * 1995-06-07 1997-01-14 Nair; Madhavan G. Non-classical folate analogue inhibitors of glycinamide ribonucleotide formyltransferase (GARFT)
US5783577A (en) * 1995-09-15 1998-07-21 Trega Biosciences, Inc. Synthesis of quinazolinone libraries and derivatives thereof
WO1997042192A1 (de) * 1996-05-07 1997-11-13 Basf Aktiengesellschaft Imidazo-chinazoline, sie enthaltende mittel und deren verwendung zur bekämpfung von schadpilzen und tierischen schädlingen
AR012634A1 (es) * 1997-05-02 2000-11-08 Sugen Inc Compuesto basado en quinazolina, composicion famaceutica que lo comprende, metodo para sintetizarlo, su uso, metodos de modulacion de la funcion deserina/treonina proteinaquinasa con dicho compuesto y metodo in vitro para identificar compuestos que modulan dicha funcion
JP2001512830A (ja) * 1997-08-08 2001-08-28 ニューバイオティックス インコーポレイテッド 生物療法耐性および化学療法耐性を克服するための方法および組成物
US7462605B2 (en) * 1998-01-23 2008-12-09 Celmed Oncology (Usa), Inc. Phosphoramidate compounds and methods of use
ES2172303T3 (es) 1998-01-23 2002-09-16 Newbiotics Inc Agentes terapeuticos obtenidos por catalisis enzimatica.
US6706721B1 (en) * 1998-04-29 2004-03-16 Osi Pharmaceuticals, Inc. N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate
US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
US6683061B1 (en) 1999-07-22 2004-01-27 Newbiotics, Inc. Enzyme catalyzed therapeutic activation
WO2001007088A2 (en) 1999-07-22 2001-02-01 Newbiotics, Inc. Methods for treating therapy-resistant tumors
US7230000B1 (en) * 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
US6545004B1 (en) * 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
UA74803C2 (uk) 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
US7087613B2 (en) * 1999-11-11 2006-08-08 Osi Pharmaceuticals, Inc. Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
BR0114713A (pt) * 2000-10-16 2004-01-13 Neopharm Inc Formulação lipossÈmica de mitoxantrona
US6486199B1 (en) 2001-06-21 2002-11-26 Medicines For Malaria Venture Mmv International Centre Cointrin Spiro and dispiro 1,2,4-trioxolane antimalarials
WO2003043995A1 (en) * 2001-11-20 2003-05-30 Cytokinetics, Inc. Process for the racemization of chiral quinazolinones
CA2475879A1 (en) * 2002-02-15 2003-08-28 Cytokinetics, Inc. Synthesis of quinazolinones
US7166595B2 (en) * 2002-05-09 2007-01-23 Cytokinetics, Inc. Compounds, methods and compositions
US7214800B2 (en) * 2002-05-09 2007-05-08 Cytokinetics, Inc. Compounds, compositions, and methods
WO2003103575A2 (en) * 2002-05-23 2003-12-18 Cytokinetics, Inc. Compounds, compositions, and methods
WO2003106426A1 (en) * 2002-06-14 2003-12-24 Cytokinetics, Inc. Compounds, compositions, and methods
US20080125441A1 (en) * 2002-06-21 2008-05-29 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
US6906205B2 (en) * 2002-06-21 2005-06-14 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
US7371778B2 (en) * 2002-06-21 2008-05-13 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
EP1537089A4 (en) * 2002-07-23 2008-04-16 Cytokinetics Inc CONNECTIONS, COMPOSITIONS AND PROCEDURES
US20040048853A1 (en) * 2002-08-21 2004-03-11 Gustave Bergnes Compounds, compositions, and methods
WO2004034972A2 (en) * 2002-09-30 2004-04-29 Cytokinetics, Inc. Compounds, compositions, and methods
WO2005032481A2 (en) * 2003-09-30 2005-04-14 Scios Inc. Quinazoline derivatives as medicaments
EP1682534A2 (en) * 2003-11-03 2006-07-26 Cytokinetics, Inc. Pyrimidin-4-one compounds, compositions, and methods
EP1680420A4 (en) * 2003-11-07 2008-09-24 Cytokinetics Inc COMPOUNDS, COMPOSITIONS AND METHODS
EP1692112A4 (en) * 2003-12-08 2008-09-24 Cytokinetics Inc COMPOUNDS, COMPOSITIONS, AND METHODS
DE602006010979D1 (de) * 2005-01-19 2010-01-21 Rigel Pharmaceuticals Inc Prodrugs aus 2,4-pyrimidindiamin-verbindungen und ihre verwendungen
US8067620B2 (en) * 2005-05-04 2011-11-29 Medicines For Malaria Venture Mmv Dispiro 1,2,4-trioxolane antimalarials
CN1303080C (zh) * 2005-07-18 2007-03-07 康辰医药发展有限公司 盐酸洛拉曲克的合成工艺
JO2985B1 (ar) 2006-12-20 2016-09-05 Takeda Pharmaceuticals Co مثبطات كينازmapk/erk
CN101353343B (zh) * 2007-07-27 2012-07-04 上海医药工业研究院 高纯度盐酸诺拉曲塞二水合物的制备方法
US8426430B2 (en) * 2008-06-30 2013-04-23 Hutchison Medipharma Enterprises Limited Quinazoline derivatives
CA2778931A1 (en) 2009-06-12 2010-12-16 Marianne Allard Guanine riboswitch binding compounds and their use as antibiotics
EP2513115B1 (en) 2009-12-18 2013-10-09 Basilea Pharmaceutica AG Tricyclic antibiotics
CN103635474B (zh) 2011-06-17 2016-04-27 巴斯利尔药物股份公司 三环抗生素
RU2507198C1 (ru) * 2012-09-10 2014-02-20 Владимир Иванович Петров Производные хиназолина, обладающие ноотропной и антигипоксической активностью
RU2507199C1 (ru) * 2012-09-10 2014-02-20 Владимир Иванович Петров Производные хиназолина, обладающие антидепрессивной, анксиолитической и ноотропной активностью
RU2622638C1 (ru) * 2016-07-14 2017-06-19 Владимир Иванович Петров Производные хиназолин-4(3н)-она, обладающие нейро- и кардиопротекторной активностью
EP3923988A1 (en) 2019-02-14 2021-12-22 Som Innovation Biotech, S.A. Triamterene or nolatrexed for use in the treatment of phenylketonuria

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1817982A (en) * 1931-08-11 Winfrid hentrich and max habdtmann
CA793845A (en) * 1968-09-03 Davoll John Amine compounds and production thereof
GB206565A (en) * 1922-08-03 1923-11-05 Walter Wood Tullis Improvements in or relating to the concentration and preparation for smelting of iron ores
GB1045180A (en) * 1963-09-20 1966-10-12 Parke Davis & Co Quinazoline derivatives
GB1212613A (en) * 1967-02-28 1970-11-18 Chinoin Gyogyszer Es Vegyeszet 4-quinazolone derivatives and process for the preparation thereof
GB1161644A (en) * 1967-09-11 1969-08-13 Parke Davis & Co Quinazoline Compounds and process means for producing the same
US4048312A (en) * 1973-10-30 1977-09-13 Eli Lilly And Company 2,4-Diaminoquinazolines as antithrombotic agents
IT1050750B (it) * 1975-12-05 1981-03-20 Erba Carlo Spa Derivati della 3.4 di idro chinazolina
US4223143A (en) * 1978-12-11 1980-09-16 Siegfried Aktiengesellschaft Quinazoline derivatives
US4391809A (en) * 1979-10-15 1983-07-05 Warner-Lambert Company Methods for treating psoriasis
EP0031237B1 (en) * 1979-12-19 1984-10-17 National Research Development Corporation Quinazoline derivatives, processes for their preparation, compositions containing them and their use as anti-cancer agents
US4853221A (en) * 1980-11-13 1989-08-01 Warner-Lambert Company Method for treating non-small cell lung cancer, head and neck cancers and breast cancer
JPS57156467A (en) * 1981-03-20 1982-09-27 Asahi Chem Ind Co Ltd 2,4-disubstituted-6-quinazolinesulfonamide derivative
JPS6136273A (ja) * 1984-07-26 1986-02-20 Mitsubishi Yuka Yakuhin Kk ２−フエニルアルキル−４（３ｈ）−キナゾリノン誘導体
US4749698A (en) * 1985-07-08 1988-06-07 Rorer Pharmaceutical Corporation Antihypertensive derivatives
GB8513754D0 (en) * 1985-05-31 1985-07-03 Jones T R Anti-cancer quinazoline derivatives
GB8707053D0 (en) * 1987-03-25 1987-04-29 Ici Plc Anti-tumour agents
US4857530A (en) * 1987-11-03 1989-08-15 Warner-Lambert Company Substituted quinazolinones as anticancer agents
GB8809978D0 (en) * 1988-04-27 1988-06-02 Ici Plc Anti-tumour agents
EP0365763A1 (en) * 1988-09-30 1990-05-02 Agouron Pharmaceuticals, Inc. Antiproliferative cyclic compounds
GB8829296D0 (en) * 1988-12-15 1989-01-25 Ici Plc Anti-tumour compounds
NO171069C (no) * 1990-05-29 1993-01-20 Protan Biopolymer As Kovalent tverrbundne, sterkt svellende alkalimetall- og ammonium-alginatgeler, samt fremgangsmaate for fremstilling derav
IL98167A0 (en) * 1990-05-30 1992-06-21 Ici Plc Anti-tumour quinazoline derivatives,processes for their preparation and pharmaceutical compositions comprising them
US5430148A (en) * 1992-03-31 1995-07-04 Agouron Pharmaceuticals, Inc. Antiproliferative quinazolines

Also Published As

Publication number Publication date
EP0637300A1 (en) 1995-02-08
SG93183A1 (en) 2002-12-17
SG46672A1 (en) 1998-02-20
FI944525A0 (fi) 1994-09-29
FI944525A (fi) 1994-09-29
ATE205197T1 (de) 2001-09-15
US5430148A (en) 1995-07-04
NO943629L (no) 1994-09-29
US5707992A (en) 1998-01-13
WO1993020055A1 (en) 1993-10-14
DE69330715D1 (de) 2001-10-11
US5885996A (en) 1999-03-23
AU681075B2 (en) 1997-08-21
DE69330715T2 (de) 2002-02-14
ES2162818T3 (es) 2002-01-16
CA2474211C (en) 2006-10-03
DK0637300T3 (da) 2001-12-10
HU9402799D0 (en) 1994-12-28
KR100226114B1 (ko) 1999-10-15
NZ251804A (en) 1997-06-24
JP3272357B2 (ja) 2002-04-08
CA2474211A1 (en) 1993-10-14
RU2135481C1 (ru) 1999-08-27
CA2132514C (en) 2004-10-26
HUT68580A (en) 1995-06-28
MD1638F2 (en) 2001-03-31
FI113765B (fi) 2004-06-15
HU222523B1 (hu) 2003-08-28
AU3966493A (en) 1993-11-08
RU94045251A (ru) 1996-07-20
MD1638G2 (ro) 2001-09-30
NO943629D0 (no) 1994-09-29
JPH07505395A (ja) 1995-06-15
PT637300E (pt) 2002-01-30
TJ272B (en) 2000-10-05
CA2132514A1 (en) 1993-10-14
EP0637300B1 (en) 2001-09-05

Similar Documents

Publication Publication Date Title
NO307829B1 (no) Antiproliferative quinazoliner, anvendelse, fremgangsmÕte for fremstilling derav samt farmasøytisk preparat
CA2236160A1 (en) Method and composition for inhibiting growth of microorganisms including peracetic acid and a non-oxidizing biocide
CA2129489A1 (en) Method and Composition for Inhibiting Growth of Microorganisms Including Peracetic Acid and a Non-Oxidizing Biocide
MY145332A (en) Trisubstituted 4-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
MXPA06001134A (es) Inhibidores de la actividad de la proteina cinasa b.
WO2000034265A3 (en) Quinoline-indole antimicrobial agents
PL316033A1 (en) Acidified nitrite as an agent against micro-organisms
HU9501146D0 (en) 2-amino-4-phenyl-4-oxo-butyric acid derivatives with kynureninase and/or kynurenine-3-hydroxylase inhibiting activity
WO2000024773A3 (en) Inhibition of transglutaminase-mediated microbial infection of a mammalian host
AU3589895A (en) Synthetic antibiotics
AU2289400A (en) 6-arylphenanthridines with pde-iv inhibiting activity
WO1999067238A3 (en) Tetrahydroquinoline-indole derivatives antimicrobial agents, their uses and compositions containing them
AU2267899A (en) Fungi of the genus piriformospora
EP0333000A3 (en) Peptides with inhibitory activity of enzymatic systems, process for their preparation and pharmaceutical compositions containing them
MX9407877A (es) Sustrato de cultivo solido que incluye cebada.
AU2003287138A1 (en) On-growth inhibiting compounds
GB9615498D0 (en) Kinase
CA2335397A1 (en) A method for screening compounds for their potential to inhibit neoplasia and pharmaceutical compositions containing such compounds
WO2024077078A3 (en) Sterylglucosidase inhibiting compositions and method of using
ATE53922T1 (de) Synergistische, antimikrobische beimischungen, enthaltend 2-bromo-2-bromomethylglutaronitril, verfahren zur hemmung mikrobischen wachstums und gegen mikrobisches wachstum geschuetzte substrate.
WO1987001279A3 (en) Antitumor chamigrene derivatives and their methods of use
RU93005169A (ru) Производные замещенного нафталина, способ их получения, фармацевтическая композиция и способ лечения
MX9603754A (es) Compuestos, de amplio espectro, activos contra microbios.
NZ500671A (en) Stable crystalline hydrochloride and hydrobromide salts of swainsonine and use in the treatment of fungal, bacterial and viral diseases