WO2024077078A3 - Sterylglucosidase inhibiting compositions and method of using - Google Patents

Sterylglucosidase inhibiting compositions and method of using Download PDF

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Publication number
WO2024077078A3
WO2024077078A3 PCT/US2023/075977 US2023075977W WO2024077078A3 WO 2024077078 A3 WO2024077078 A3 WO 2024077078A3 US 2023075977 W US2023075977 W US 2023075977W WO 2024077078 A3 WO2024077078 A3 WO 2024077078A3
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WO
WIPO (PCT)
Prior art keywords
sterylglucosidase
inhibiting compositions
fungus
inhibiting
compositions
Prior art date
Application number
PCT/US2023/075977
Other languages
French (fr)
Other versions
WO2024077078A2 (en
Inventor
Iwao Ojima
Maurizio Del Poeta
Michael AIROLA
Nivea PEREIRA DE SA
Seung Youn SHIN
Kalani JAYANETTI
Dominick RENDINA
Ananya SHIBANA THENNARASU
Original Assignee
The Research Foundation For The State University Of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Research Foundation For The State University Of New York filed Critical The Research Foundation For The State University Of New York
Publication of WO2024077078A2 publication Critical patent/WO2024077078A2/en
Publication of WO2024077078A3 publication Critical patent/WO2024077078A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides a method of inhibiting growth of a fungus in a subject, comprising reducing the activity of sterylglucosidase I (SigIl) and/or sterylglucosidase A (SglA) in the fungus.
PCT/US2023/075977 2022-10-05 2023-10-04 Sterylglucosidase inhibiting compositions and method of using WO2024077078A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202263378403P 2022-10-05 2022-10-05
US63/378,403 2022-10-05

Publications (2)

Publication Number Publication Date
WO2024077078A2 WO2024077078A2 (en) 2024-04-11
WO2024077078A3 true WO2024077078A3 (en) 2024-05-30

Family

ID=90609049

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2023/075977 WO2024077078A2 (en) 2022-10-05 2023-10-04 Sterylglucosidase inhibiting compositions and method of using

Country Status (1)

Country Link
WO (1) WO2024077078A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143935A (en) * 1990-10-16 1992-09-01 Teikoku Chemical Industry Co., Ltd. Benzamide derivatives
US9067955B2 (en) * 2001-04-24 2015-06-30 Massachusetts Institute Of Technology Copper-catalyzed formation of carbon-heteroatom and carbon—carbon bonds
US20180085442A1 (en) * 2016-08-10 2018-03-29 The Research Foundation For The State University Of New York Vaccine compositions against pathogenic fungi and methods for use thereof
US10287521B2 (en) * 2012-03-16 2019-05-14 Keclon S.A. Enzymatic removal of steryl glycosides

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143935A (en) * 1990-10-16 1992-09-01 Teikoku Chemical Industry Co., Ltd. Benzamide derivatives
US9067955B2 (en) * 2001-04-24 2015-06-30 Massachusetts Institute Of Technology Copper-catalyzed formation of carbon-heteroatom and carbon—carbon bonds
US10287521B2 (en) * 2012-03-16 2019-05-14 Keclon S.A. Enzymatic removal of steryl glycosides
US20180085442A1 (en) * 2016-08-10 2018-03-29 The Research Foundation For The State University Of New York Vaccine compositions against pathogenic fungi and methods for use thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PEREIRA DE SA, TAOUIL ADAM, KIM JINWOO, CLEMENT TIMOTHY, HOFFMANN REECE M., BURKE JOHN E., RIZZO ROBERT C., OJIMA IWAO, DEL POETA : "Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents", NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, UK, vol. 12, no. 1, UK, XP093177512, ISSN: 2041-1723, DOI: 10.1038/s41467-021-26163-5 *

Also Published As

Publication number Publication date
WO2024077078A2 (en) 2024-04-11

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