FI111718B - Menetelmä 2,4-disulfonyylifenyylibutyylinitronin tai sen suolan valmistamiseksi - Google Patents

Menetelmä 2,4-disulfonyylifenyylibutyylinitronin tai sen suolan valmistamiseksi Download PDF

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Publication number
FI111718B
FI111718B FI962589A FI962589A FI111718B FI 111718 B FI111718 B FI 111718B FI 962589 A FI962589 A FI 962589A FI 962589 A FI962589 A FI 962589A FI 111718 B FI111718 B FI 111718B
Authority
FI
Finland
Prior art keywords
compound
pbn
dose
disulfonyl
phenyl
Prior art date
Application number
FI962589A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI962589A0 (fi
FI962589A (fi
Inventor
John M Carney
Original Assignee
Univ Kentucky Res Found
Oklahoma Med Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Kentucky Res Found, Oklahoma Med Res Found filed Critical Univ Kentucky Res Found
Publication of FI962589A0 publication Critical patent/FI962589A0/fi
Publication of FI962589A publication Critical patent/FI962589A/fi
Application granted granted Critical
Publication of FI111718B publication Critical patent/FI111718B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/46—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton having the sulfo groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI962589A 1993-12-23 1996-06-20 Menetelmä 2,4-disulfonyylifenyylibutyylinitronin tai sen suolan valmistamiseksi FI111718B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US17357993 1993-12-23
US08/173,579 US5488145A (en) 1993-12-23 1993-12-23 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps
US9414545 1994-12-22
PCT/US1994/014545 WO1995017876A2 (en) 1993-12-23 1994-12-22 2,4-disulphophenyl butylnitrone, its salts, and their use as pharmaceutical spintraps

Publications (3)

Publication Number Publication Date
FI962589A0 FI962589A0 (fi) 1996-06-20
FI962589A FI962589A (fi) 1996-08-20
FI111718B true FI111718B (fi) 2003-09-15

Family

ID=22632663

Family Applications (1)

Application Number Title Priority Date Filing Date
FI962589A FI111718B (fi) 1993-12-23 1996-06-20 Menetelmä 2,4-disulfonyylifenyylibutyylinitronin tai sen suolan valmistamiseksi

Country Status (29)

Country Link
US (4) US5488145A (no)
EP (1) EP0736004B1 (no)
JP (3) JP3412821B2 (no)
KR (1) KR100370522B1 (no)
CN (1) CN1070176C (no)
AT (1) ATE192736T1 (no)
AU (1) AU679835B2 (no)
BR (2) BR9408378A (no)
CA (1) CA2179521C (no)
CZ (1) CZ289629B6 (no)
DE (1) DE69424441T2 (no)
DK (1) DK0736004T3 (no)
ES (1) ES2145264T3 (no)
FI (1) FI111718B (no)
GR (1) GR3034134T3 (no)
HK (2) HK1001768A1 (no)
HR (1) HRP950358B1 (no)
HU (1) HU221167B1 (no)
MY (1) MY114178A (no)
NO (1) NO306457B1 (no)
NZ (1) NZ279025A (no)
PL (1) PL185189B1 (no)
PT (1) PT736004E (no)
RU (1) RU2159231C2 (no)
SG (1) SG64903A1 (no)
SK (1) SK282403B6 (no)
TW (1) TW299315B (no)
UA (1) UA45964C2 (no)
WO (1) WO1995017876A2 (no)

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US5622994A (en) * 1989-10-17 1997-04-22 Oklahoma Medical Research Foundation Spin trapping pharmaceutical compositions and methods for use thereof
ATE110565T1 (de) * 1989-10-17 1994-09-15 Oklahoma Med Res Found Verfahren und zubereitungen zur hemmung von mit oxidativer schädigung assoziierten krankheiten.
US20050107366A1 (en) * 1991-06-18 2005-05-19 Carney John M. Spin trapping pharmaceutical compositions and methods for use thereof
US6002001A (en) * 1991-06-18 1999-12-14 Oklahoma Medical Research Foundation Spin trapping pharmaceutical compositions and methods for use thereof
US20040208875A1 (en) * 1995-03-15 2004-10-21 Queen's University At Kingston Method for treating amyloidosis
US5488145A (en) * 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps
IL123345A (en) * 1995-09-11 2003-07-31 Aventis Pharma Inc Cyclic nitrones and pharmaceutical compositions containing them
EP0888290B1 (en) 1995-11-17 2006-12-27 Florida International University Azulenyl nitrone spin trapping agents, methods of making and using same
WO1997038683A1 (en) * 1996-04-17 1997-10-23 Oklahoma Medical Research Foundation Nitrone free radical trap treatment of dementia associated with aids virus (hiv-1) infection
IL128070A0 (en) * 1996-07-19 1999-11-30 Centaur Pharmaceuticals Inc Furan nitrone compounds
TW429241B (en) * 1996-09-26 2001-04-11 Sumitomo Pharma Nitrone derivatives
US6046232A (en) 1997-10-17 2000-04-04 Centaur Pharmaceuticals, Inc. α-aryl-N-alkylnitrones and pharmaceutical compositions containing the same
CN1291980A (zh) * 1998-01-16 2001-04-18 桑道药品有限公司 硫醚呋喃硝酮化合物
JP2002509147A (ja) * 1998-01-16 2002-03-26 センター ファーマシューティカルズ， インコーポレイテッド チオフェンニトロン化合物
US6255353B1 (en) * 1998-03-13 2001-07-03 Centaur Pharmaceuticals, Inc. Inhibition of angiogenesis
AU3985799A (en) * 1998-05-19 1999-12-06 Centaur Pharmaceuticals, Inc. Furan nitrone therapeutics for the treatment of inflammatory bowel disease
US6083989A (en) * 1999-05-18 2000-07-04 Centaur Pharmaceuticals, Inc. Aryl nitrone therapeutics for the treatment of inflammatory bowel disease
UA66401C2 (en) 1998-12-02 2004-05-17 Sentor Pharmaceuticals Inc 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical composition containing the same
US6730700B2 (en) 1998-12-02 2004-05-04 Renovis, Inc. 3,4,5,-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same
CN1156478C (zh) 1999-01-25 2004-07-07 国家犹太医疗及研究中心 取代的卟啉
ATE441421T1 (de) * 1999-04-28 2009-09-15 Bellus Health Int Ltd Zusammensetzungen und verfahren zur behandlung von amyloidosis mit sulphonatderivaten
BR9904931A (pt) * 1999-10-18 2001-06-12 Sergio Teixeira Ferreira Inibição de amiloidoses
US6815425B1 (en) 1999-10-22 2004-11-09 The United States Of America As Represented By The Secretary Of The Army Pharmaceutical composition containing pGLU-GLU-PRO-NH2 and method for treating diseases and injuries to the brain, spinal cord and retina using same
WO2001028578A2 (en) * 1999-10-22 2001-04-26 Wrair A PHARMACEUTICAL COMPOSITION CONTAINING pGLU-GLU-PRO-NH2 AND METHOD FOR TREATING DISEASES AND INJURIES TO THE BRAIN, SPINAL CORD AND RETINA USING SAME
SE0000056D0 (sv) * 2000-01-10 2000-01-10 Astrazeneca Ab Novel process
AU2001236442A1 (en) * 2000-01-10 2001-07-24 Centaur Phamaceuticals, Inc. Method for the purification of aryl sulfonic acids and salts
SE0000055D0 (sv) * 2000-01-10 2000-01-10 Centaur Pharmaceuticals Inc Novel process
SE0001916D0 (sv) * 2000-05-23 2000-05-23 Astrazeneca Ab Novel formulation
US6664297B1 (en) 2000-10-18 2003-12-16 Universidade Federal Do Rio De Janeiro Methods for inhibition and dissolution of amyloidoses by administration of compositions comprising 2,4-dinitrophenol
AU2002253857A1 (en) 2001-01-08 2002-09-04 Centaur Pharmaceuticals, Inc. Use of aryl nitrone compounds in methods for treating neuropathic pain
WO2003010154A1 (en) * 2001-07-26 2003-02-06 Samsung Electronics Co. Ltd. Seleno compounds containing nitrone moiety, their preparation and their therapeutic uses
US20030045461A1 (en) * 2001-09-06 2003-03-06 Jen-Chang Hsia Composition and methods of esterified nitroxides gated with carboxylic acids
FR2846968B1 (fr) * 2002-11-08 2005-02-04 Salles Jean Pierre Nouveaux derives amphiphiles de l'alpha-c-phenyl-n-tert- butyl nitrone
US7414076B2 (en) * 2003-06-23 2008-08-19 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US7244764B2 (en) * 2003-06-23 2007-07-17 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US20070010573A1 (en) * 2003-06-23 2007-01-11 Xianqi Kong Methods and compositions for treating amyloid-related diseases
US20050059638A1 (en) * 2003-08-04 2005-03-17 Kelly Michael G. Aryl, heteroaromatic and bicyclic aryl nitrone compounds, prodrugs and pharmaceutical compositions of the same to treat human disorders
US20050182060A1 (en) * 2004-02-13 2005-08-18 Kelly Michael G. 2-Substituted and 4-substituted aryl nitrone compounds
US20060183800A1 (en) * 2004-11-12 2006-08-17 Xianqi Kong Methods and fluorinated compositions for treating amyloid-related diseases
CN101103018A (zh) * 2004-11-16 2008-01-09 神经化学（国际）有限公司 治疗cns和淀粉样蛋白-相关疾病的化合物
CA2592320C (en) 2004-12-22 2015-11-24 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US20060235370A1 (en) * 2005-04-04 2006-10-19 Oblong John E Method of regulating mammalian keratinous tissue
TW200716088A (en) * 2005-04-15 2007-05-01 Neurochem Int Ltd Formulations and methods for treating amyloidosis
WO2007013842A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-((tert-butylimino)methyl) benzene-1,3-disulfonate n-oxide against maemorrhagic changes in the brain
WO2007013844A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-[(tert-butylimino)benzene-1,3-disulfonate n-oxide against nausea
WO2007013843A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-[(tert-butylimino)methyl]benzene-1,3-disulfonate n-oxide against myocardial ischaemia
WO2007013841A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-((tert-butylimine)methyl) benzene-1,3-disulfonate n-oxide against cerebral oedema
MX2008008213A (es) * 2005-12-22 2008-09-03 Neurochem Int Ltd Tratamiento de trastornos renales, nefropatia diabetica y dislipidemias.
US8420595B2 (en) * 2006-07-25 2013-04-16 Oklahoma Medical Research Foundation Methods for treating acute acoustic trauma
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JP2010529947A (ja) * 2006-12-22 2010-09-02 ベラス ヘルス（インターナショナル）リミテッド 代謝性疾患および糖尿病を治療するための方法、化合物、および組成物
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US10829441B2 (en) 2017-11-14 2020-11-10 The University Of Toledo Reactive oxygen species-sensitive nitric oxide synthase inhibitors for the treatment of ischemic stroke
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US5036097A (en) * 1989-10-17 1991-07-30 Oklahoma Medical Research Foundation Phenylbutyl nitrone compositions and methods for prevention of gastric ulceration
ATE110565T1 (de) * 1989-10-17 1994-09-15 Oklahoma Med Res Found Verfahren und zubereitungen zur hemmung von mit oxidativer schädigung assoziierten krankheiten.
US5025032A (en) * 1989-10-17 1991-06-18 Oklahoma Medical Research Foundation Phenyl butyl nitrone compositions and methods for treatment of oxidative tissue damage
ATE209908T1 (de) * 1991-06-18 2001-12-15 Oklahoma Med Res Found RADIKALFÄNGER (ßSPIN TRAPSß) ZUR BEHANDLUNG VON MIT OXIDATION VON LIPIDEN UND PROTEINEN VERBUNDENEN ERKRANKUNGEN
US5488145A (en) * 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps

Also Published As

Publication number Publication date
SK78896A3 (en) 1997-09-10
CZ289629B6 (cs) 2002-03-13
EP0736004A1 (en) 1996-10-09
ATE192736T1 (de) 2000-05-15
FI962589A0 (fi) 1996-06-20
JPH09507232A (ja) 1997-07-22
JP2001010953A (ja) 2001-01-16
CA2179521A1 (en) 1995-07-06
CN1070176C (zh) 2001-08-29
US5475032A (en) 1995-12-12
HK1001768A1 (en) 1998-07-10
HU9601739D0 (en) 1996-08-28
DE69424441T2 (de) 2000-10-12
PT736004E (pt) 2000-09-29
NO962637L (no) 1996-08-13
WO1995017876A2 (en) 1995-07-06
BR9408378A (pt) 1997-08-19
PL185189B1 (pl) 2003-03-31
WO1995017876A3 (en) 1995-08-10
PL315154A1 (en) 1996-10-14
CN1156447A (zh) 1997-08-06
JP2004075696A (ja) 2004-03-11
BR1100626A (pt) 1999-11-23
MY114178A (en) 2002-08-30
AU1552795A (en) 1995-07-17
SK282403B6 (sk) 2002-01-07
CA2179521C (en) 2002-03-19
CZ177596A3 (en) 1996-12-11
NO962637D0 (no) 1996-06-20
HRP950358B1 (en) 2001-04-30
RU2159231C2 (ru) 2000-11-20
KR100370522B1 (ko) 2003-05-16
HRP950358A2 (en) 1997-08-31
ES2145264T3 (es) 2000-07-01
US5780510A (en) 1998-07-14
TW299315B (no) 1997-03-01
UA45964C2 (uk) 2002-05-15
US5488145A (en) 1996-01-30
NO306457B1 (no) 1999-11-08
EP0736004B1 (en) 2000-05-10
NZ279025A (en) 1998-02-26
HUT76788A (en) 1997-11-28
DK0736004T3 (da) 2000-10-09
HK1008294A1 (en) 1999-05-07
GR3034134T3 (en) 2000-11-30
HU221167B1 (en) 2002-08-28
US5508305A (en) 1996-04-16
FI962589A (fi) 1996-08-20
SG64903A1 (en) 1999-05-25
JP3412821B2 (ja) 2003-06-03
AU679835B2 (en) 1997-07-10
DE69424441D1 (de) 2000-06-15

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