ATE441421T1 - Zusammensetzungen und verfahren zur behandlung von amyloidosis mit sulphonatderivaten - Google Patents
Zusammensetzungen und verfahren zur behandlung von amyloidosis mit sulphonatderivatenInfo
- Publication number
- ATE441421T1 ATE441421T1 AT00922395T AT00922395T ATE441421T1 AT E441421 T1 ATE441421 T1 AT E441421T1 AT 00922395 T AT00922395 T AT 00922395T AT 00922395 T AT00922395 T AT 00922395T AT E441421 T1 ATE441421 T1 AT E441421T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- hydrogen atom
- independently
- methods
- therapeutic compound
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 206010002022 amyloidosis Diseases 0.000 title 1
- JXLHNMVSKXFWAO-UHFFFAOYSA-N azane;7-fluoro-2,1,3-benzoxadiazole-4-sulfonic acid Chemical class N.OS(=O)(=O)C1=CC=C(F)C2=NON=C12 JXLHNMVSKXFWAO-UHFFFAOYSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 230000001225 therapeutic effect Effects 0.000 abstract 4
- 230000006933 amyloid-beta aggregation Effects 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000000129 anionic group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
- 150000003462 sulfoxides Chemical class 0.000 abstract 1
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 abstract 1
Classifications
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- A61K31/16—Amides, e.g. hydroxamic acids
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- A61K31/33—Heterocyclic compounds
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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US13146499P | 1999-04-28 | 1999-04-28 | |
US13554599P | 1999-05-24 | 1999-05-24 | |
US14312399P | 1999-07-09 | 1999-07-09 | |
PCT/CA2000/000494 WO2000064420A2 (en) | 1999-04-28 | 2000-04-28 | Compositions and methods for treating amyloidosis using sulphonate derivatives |
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ATE441421T1 true ATE441421T1 (de) | 2009-09-15 |
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AT00922395T ATE441421T1 (de) | 1999-04-28 | 2000-04-28 | Zusammensetzungen und verfahren zur behandlung von amyloidosis mit sulphonatderivaten |
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US (3) | US20040198832A1 (de) |
EP (1) | EP1276483B1 (de) |
JP (1) | JP4726304B2 (de) |
KR (2) | KR20070094996A (de) |
CN (1) | CN100482233C (de) |
AT (1) | ATE441421T1 (de) |
AU (1) | AU4282400A (de) |
BR (1) | BR0010099A (de) |
CA (1) | CA2369997C (de) |
DE (1) | DE60042896D1 (de) |
DK (1) | DK1276483T3 (de) |
ES (1) | ES2331905T3 (de) |
HK (1) | HK1054862A1 (de) |
IL (1) | IL146143A0 (de) |
MX (1) | MXPA01010835A (de) |
NZ (1) | NZ543319A (de) |
WO (1) | WO2000064420A2 (de) |
Families Citing this family (26)
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US7311893B2 (en) | 2000-07-25 | 2007-12-25 | Neurochem (International) Limited | Amyloid targeting imaging agents and uses thereof |
US6716589B2 (en) * | 2000-11-20 | 2004-04-06 | Alphabeta Ab | Discordant helix stabilization for prevention of amyloid formation |
US20070129438A1 (en) * | 2002-07-11 | 2007-06-07 | Yuuichi Murayama | Method for suppressing proliferation of abnormal prion protein |
JP2006512417A (ja) * | 2002-12-24 | 2006-04-13 | ニューロケム (インターナショナル) リミテッド | β−アミロイド関連疾患の治療のための治療用製剤 |
JP2007516938A (ja) * | 2003-06-23 | 2007-06-28 | ニューロケム (インターナショナル) リミテッド | アミロイド関連疾患を治療するための方法および組成物 |
US7244764B2 (en) * | 2003-06-23 | 2007-07-17 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
US20050142191A1 (en) * | 2003-06-23 | 2005-06-30 | Neurochem (International) Limited | Pharmaceutical formulations of amyloid inhibiting compounds |
AU2011250847B2 (en) * | 2003-06-23 | 2013-06-20 | Bhi Limited Partnership | Methods and compositions for treating amyloid-related diseases |
US7253306B2 (en) | 2003-06-23 | 2007-08-07 | Neurochem (International) Limited | Pharmaceutical drug candidates and methods for preparation thereof |
JP2007516940A (ja) * | 2003-06-23 | 2007-06-28 | ニューロケム (インターナショナル) リミテッド | 改善された薬剤候補およびその調製法 |
BRPI0517790A (pt) * | 2004-11-12 | 2008-10-21 | Neurochem Int Ltd | métodos e composições fluoradas para tratar doenças relacionadas à amilóide |
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US7253306B2 (en) * | 2003-06-23 | 2007-08-07 | Neurochem (International) Limited | Pharmaceutical drug candidates and methods for preparation thereof |
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- 2000-04-28 WO PCT/CA2000/000494 patent/WO2000064420A2/en active Application Filing
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- 2000-04-28 JP JP2000613411A patent/JP4726304B2/ja not_active Expired - Fee Related
- 2000-04-28 DK DK00922395T patent/DK1276483T3/da active
- 2000-04-28 CA CA002369997A patent/CA2369997C/en not_active Expired - Fee Related
- 2000-04-28 CN CNB008094152A patent/CN100482233C/zh not_active Expired - Fee Related
- 2000-04-28 DE DE60042896T patent/DE60042896D1/de not_active Expired - Lifetime
- 2000-04-28 ES ES00922395T patent/ES2331905T3/es not_active Expired - Lifetime
- 2000-04-28 EP EP00922395A patent/EP1276483B1/de not_active Expired - Lifetime
- 2000-04-28 AU AU42824/00A patent/AU4282400A/en not_active Abandoned
- 2000-04-28 KR KR1020017013824A patent/KR100822525B1/ko not_active IP Right Cessation
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2003
- 2003-07-22 HK HK03105281.4A patent/HK1054862A1/xx not_active IP Right Cessation
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Also Published As
Publication number | Publication date |
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CA2369997C (en) | 2009-11-17 |
CN100482233C (zh) | 2009-04-29 |
WO2000064420A2 (en) | 2000-11-02 |
JP4726304B2 (ja) | 2011-07-20 |
KR20020010138A (ko) | 2002-02-02 |
KR20070094996A (ko) | 2007-09-27 |
DE60042896D1 (de) | 2009-10-15 |
DK1276483T3 (da) | 2009-12-14 |
NZ543319A (en) | 2007-06-29 |
ES2331905T3 (es) | 2010-01-20 |
HK1054862A1 (en) | 2003-12-19 |
IL146143A0 (en) | 2002-07-25 |
WO2000064420A3 (en) | 2002-11-07 |
JP2003517458A (ja) | 2003-05-27 |
KR100822525B1 (ko) | 2008-04-16 |
US20110281951A1 (en) | 2011-11-17 |
CA2369997A1 (en) | 2000-11-02 |
CN1523992A (zh) | 2004-08-25 |
MXPA01010835A (es) | 2003-07-14 |
EP1276483A2 (de) | 2003-01-22 |
AU4282400A (en) | 2000-11-10 |
BR0010099A (pt) | 2002-06-04 |
US20090099100A1 (en) | 2009-04-16 |
US20040198832A1 (en) | 2004-10-07 |
EP1276483B1 (de) | 2009-09-02 |
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