ATE192736T1 - (2,4-disulfophenyl) n-tertiär butyl nitron, seine salze und ihre verwendung als pharmazeutische radikalfänger - Google Patents

(2,4-disulfophenyl) n-tertiär butyl nitron, seine salze und ihre verwendung als pharmazeutische radikalfänger

Info

Publication number
ATE192736T1
ATE192736T1 AT95907224T AT95907224T ATE192736T1 AT E192736 T1 ATE192736 T1 AT E192736T1 AT 95907224 T AT95907224 T AT 95907224T AT 95907224 T AT95907224 T AT 95907224T AT E192736 T1 ATE192736 T1 AT E192736T1
Authority
AT
Austria
Prior art keywords
pharmaceutical
salts
disulfophenyl
tertiary butyl
butyl nitrone
Prior art date
Application number
AT95907224T
Other languages
English (en)
Inventor
John M Carney
Original Assignee
Oklahoma Med Res Found
Univ Kentucky Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oklahoma Med Res Found, Univ Kentucky Res Found filed Critical Oklahoma Med Res Found
Application granted granted Critical
Publication of ATE192736T1 publication Critical patent/ATE192736T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/46—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton having the sulfo groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT95907224T 1993-12-23 1994-12-22 (2,4-disulfophenyl) n-tertiär butyl nitron, seine salze und ihre verwendung als pharmazeutische radikalfänger ATE192736T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/173,579 US5488145A (en) 1993-12-23 1993-12-23 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps
PCT/US1994/014545 WO1995017876A2 (en) 1993-12-23 1994-12-22 2,4-disulphophenyl butylnitrone, its salts, and their use as pharmaceutical spintraps

Publications (1)

Publication Number Publication Date
ATE192736T1 true ATE192736T1 (de) 2000-05-15

Family

ID=22632663

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95907224T ATE192736T1 (de) 1993-12-23 1994-12-22 (2,4-disulfophenyl) n-tertiär butyl nitron, seine salze und ihre verwendung als pharmazeutische radikalfänger

Country Status (28)

Country Link
US (4) US5488145A (de)
EP (1) EP0736004B1 (de)
JP (3) JP3412821B2 (de)
KR (1) KR100370522B1 (de)
CN (1) CN1070176C (de)
AT (1) ATE192736T1 (de)
AU (1) AU679835B2 (de)
BR (2) BR9408378A (de)
CA (1) CA2179521C (de)
CZ (1) CZ289629B6 (de)
DE (1) DE69424441T2 (de)
DK (1) DK0736004T3 (de)
ES (1) ES2145264T3 (de)
FI (1) FI111718B (de)
GR (1) GR3034134T3 (de)
HR (1) HRP950358B1 (de)
HU (1) HU221167B1 (de)
MY (1) MY114178A (de)
NO (1) NO306457B1 (de)
NZ (1) NZ279025A (de)
PL (1) PL185189B1 (de)
PT (1) PT736004E (de)
RU (1) RU2159231C2 (de)
SG (1) SG64903A1 (de)
SK (1) SK282403B6 (de)
TW (1) TW299315B (de)
UA (1) UA45964C2 (de)
WO (1) WO1995017876A2 (de)

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US6002001A (en) * 1991-06-18 1999-12-14 Oklahoma Medical Research Foundation Spin trapping pharmaceutical compositions and methods for use thereof
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TW429241B (en) * 1996-09-26 2001-04-11 Sumitomo Pharma Nitrone derivatives
MA26553A1 (fr) * 1997-10-17 2004-12-20 Centaur Pharmaceuticals Inc Alpha-aryl-n-alkylnitrones et compositions pharmaceutiques contenant ceux-la
NZ505757A (en) * 1998-01-16 2002-09-27 Centaur Pharmaceuticals Inc Thioether furan nitrone compounds and pharmaceuticals thereof; useful for the treatment or prophylaxis of neurodegenerative, autoimmune and inflammatory conditions
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US6255353B1 (en) * 1998-03-13 2001-07-03 Centaur Pharmaceuticals, Inc. Inhibition of angiogenesis
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US6730700B2 (en) * 1998-12-02 2004-05-04 Renovis, Inc. 3,4,5,-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same
UA66401C2 (en) 1998-12-02 2004-05-17 Sentor Pharmaceuticals Inc 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical composition containing the same
EP1155019B1 (de) 1999-01-25 2005-12-07 National Jewish Medical and Research Center Substituierte porphyrine und deren therapeutische verwendungen
NZ543319A (en) * 1999-04-28 2007-06-29 Neurochem Int Ltd Compositions and methods for treating amyloidosis using sulphonate derivatives
BR9904931A (pt) * 1999-10-18 2001-06-12 Sergio Teixeira Ferreira Inibição de amiloidoses
US6815425B1 (en) 1999-10-22 2004-11-09 The United States Of America As Represented By The Secretary Of The Army Pharmaceutical composition containing pGLU-GLU-PRO-NH2 and method for treating diseases and injuries to the brain, spinal cord and retina using same
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SE0000056D0 (sv) 2000-01-10 2000-01-10 Astrazeneca Ab Novel process
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WO2003010154A1 (en) * 2001-07-26 2003-02-06 Samsung Electronics Co. Ltd. Seleno compounds containing nitrone moiety, their preparation and their therapeutic uses
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WO2006085149A2 (en) 2004-12-22 2006-08-17 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
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Also Published As

Publication number Publication date
US5780510A (en) 1998-07-14
BR1100626A (pt) 1999-11-23
FI111718B (fi) 2003-09-15
WO1995017876A3 (en) 1995-08-10
RU2159231C2 (ru) 2000-11-20
KR100370522B1 (ko) 2003-05-16
CN1070176C (zh) 2001-08-29
JPH09507232A (ja) 1997-07-22
HUT76788A (en) 1997-11-28
WO1995017876A2 (en) 1995-07-06
NO306457B1 (no) 1999-11-08
GR3034134T3 (en) 2000-11-30
CA2179521C (en) 2002-03-19
ES2145264T3 (es) 2000-07-01
JP2004075696A (ja) 2004-03-11
NO962637L (no) 1996-08-13
HRP950358B1 (en) 2001-04-30
DK0736004T3 (da) 2000-10-09
NZ279025A (en) 1998-02-26
US5488145A (en) 1996-01-30
HRP950358A2 (en) 1997-08-31
JP3412821B2 (ja) 2003-06-03
CZ177596A3 (en) 1996-12-11
HU9601739D0 (en) 1996-08-28
PL315154A1 (en) 1996-10-14
SK78896A3 (en) 1997-09-10
SK282403B6 (sk) 2002-01-07
UA45964C2 (uk) 2002-05-15
JP2001010953A (ja) 2001-01-16
PL185189B1 (pl) 2003-03-31
US5475032A (en) 1995-12-12
AU679835B2 (en) 1997-07-10
CZ289629B6 (cs) 2002-03-13
DE69424441T2 (de) 2000-10-12
BR9408378A (pt) 1997-08-19
FI962589L (fi) 1996-08-20
SG64903A1 (en) 1999-05-25
TW299315B (de) 1997-03-01
HK1008294A1 (en) 1999-05-07
AU1552795A (en) 1995-07-17
FI962589A0 (fi) 1996-06-20
NO962637D0 (no) 1996-06-20
DE69424441D1 (de) 2000-06-15
HK1001768A1 (en) 1998-07-10
EP0736004A1 (de) 1996-10-09
EP0736004B1 (de) 2000-05-10
CN1156447A (zh) 1997-08-06
PT736004E (pt) 2000-09-29
CA2179521A1 (en) 1995-07-06
MY114178A (en) 2002-08-30
US5508305A (en) 1996-04-16
HU221167B1 (en) 2002-08-28

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