NO962637L - 2,4-disulfonylfenylbutylnitron, salter derav og anveldelse som farmasöytiske midler - Google Patents
2,4-disulfonylfenylbutylnitron, salter derav og anveldelse som farmasöytiske midlerInfo
- Publication number
- NO962637L NO962637L NO962637A NO962637A NO962637L NO 962637 L NO962637 L NO 962637L NO 962637 A NO962637 A NO 962637A NO 962637 A NO962637 A NO 962637A NO 962637 L NO962637 L NO 962637L
- Authority
- NO
- Norway
- Prior art keywords
- nervous system
- central nervous
- pharmaceutical agents
- salts
- disulfonylphenylbutylnitrone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
- C07C309/46—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton having the sulfo groups bound to carbon atoms of non-condensed six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/173,579 US5488145A (en) | 1993-12-23 | 1993-12-23 | 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps |
PCT/US1994/014545 WO1995017876A2 (en) | 1993-12-23 | 1994-12-22 | 2,4-disulphophenyl butylnitrone, its salts, and their use as pharmaceutical spintraps |
Publications (3)
Publication Number | Publication Date |
---|---|
NO962637D0 NO962637D0 (no) | 1996-06-20 |
NO962637L true NO962637L (no) | 1996-08-13 |
NO306457B1 NO306457B1 (no) | 1999-11-08 |
Family
ID=22632663
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO962637A NO306457B1 (no) | 1993-12-23 | 1996-06-20 | 2,4-disulfonylfenylbutylnitron, salter derav, farmasöytisk sammensetning, samt anvendelse av denne forbindelse til fremstilling av et medikament |
Country Status (29)
Country | Link |
---|---|
US (4) | US5488145A (no) |
EP (1) | EP0736004B1 (no) |
JP (3) | JP3412821B2 (no) |
KR (1) | KR100370522B1 (no) |
CN (1) | CN1070176C (no) |
AT (1) | ATE192736T1 (no) |
AU (1) | AU679835B2 (no) |
BR (2) | BR9408378A (no) |
CA (1) | CA2179521C (no) |
CZ (1) | CZ289629B6 (no) |
DE (1) | DE69424441T2 (no) |
DK (1) | DK0736004T3 (no) |
ES (1) | ES2145264T3 (no) |
FI (1) | FI111718B (no) |
GR (1) | GR3034134T3 (no) |
HK (2) | HK1001768A1 (no) |
HR (1) | HRP950358B1 (no) |
HU (1) | HU221167B1 (no) |
MY (1) | MY114178A (no) |
NO (1) | NO306457B1 (no) |
NZ (1) | NZ279025A (no) |
PL (1) | PL185189B1 (no) |
PT (1) | PT736004E (no) |
RU (1) | RU2159231C2 (no) |
SG (1) | SG64903A1 (no) |
SK (1) | SK282403B6 (no) |
TW (1) | TW299315B (no) |
UA (1) | UA45964C2 (no) |
WO (1) | WO1995017876A2 (no) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
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US5723502A (en) * | 1985-07-18 | 1998-03-03 | Proctor; Peter H. | Topical spin trap composition and method |
EP0496796B1 (en) * | 1989-10-17 | 1994-08-31 | Oklahoma Medical Research Foundation | Method and compositions for inhibition of disorders associated with oxidative damage |
US5622994A (en) * | 1989-10-17 | 1997-04-22 | Oklahoma Medical Research Foundation | Spin trapping pharmaceutical compositions and methods for use thereof |
US6002001A (en) * | 1991-06-18 | 1999-12-14 | Oklahoma Medical Research Foundation | Spin trapping pharmaceutical compositions and methods for use thereof |
US20050107366A1 (en) * | 1991-06-18 | 2005-05-19 | Carney John M. | Spin trapping pharmaceutical compositions and methods for use thereof |
US20040208875A1 (en) * | 1995-03-15 | 2004-10-21 | Queen's University At Kingston | Method for treating amyloidosis |
US5488145A (en) * | 1993-12-23 | 1996-01-30 | Oklahoma Medical Research Foundation | 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps |
DE69625701T2 (de) * | 1995-09-11 | 2003-10-02 | Aventis Pharma Inc | Cyclische nitrone und pharmazeutische zusammensetzungen die sie enthalten |
EP0888290B1 (en) | 1995-11-17 | 2006-12-27 | Florida International University | Azulenyl nitrone spin trapping agents, methods of making and using same |
NZ332315A (en) * | 1996-04-17 | 2000-03-27 | Centaur Pharmaceuticals Inc | Nitrone free radical trapping compounds and their use in the treatment of dementia associated with aids virus (HIV-1) infection |
EP1021430A1 (en) * | 1996-07-19 | 2000-07-26 | Centaur Pharmaceuticals, Inc. | Furan nitrone compounds |
TW429241B (en) * | 1996-09-26 | 2001-04-11 | Sumitomo Pharma | Nitrone derivatives |
MA26553A1 (fr) | 1997-10-17 | 2004-12-20 | Centaur Pharmaceuticals Inc | Alpha-aryl-n-alkylnitrones et compositions pharmaceutiques contenant ceux-la |
DE69904018D1 (en) * | 1998-01-16 | 2003-01-02 | Centaur Pharmaceuticals Inc | Thiophennitronderivate |
ZA99252B (en) * | 1998-01-16 | 1999-07-14 | Centaur Pharmaceuticals Inc | Thioether furan nitrone compounds. |
WO1999045909A2 (en) * | 1998-03-13 | 1999-09-16 | Centaur Pharmaceuticals | Use of nitrone compounds for the inhibition of angiogenesis |
CA2333190A1 (en) * | 1998-05-19 | 1999-11-25 | Beverly Greenwood-Van Meerveld | Furan nitrone therapeutics for the treatment of inflammatory bowel disease |
US6083989A (en) * | 1999-05-18 | 2000-07-04 | Centaur Pharmaceuticals, Inc. | Aryl nitrone therapeutics for the treatment of inflammatory bowel disease |
UA66401C2 (en) | 1998-12-02 | 2004-05-17 | Sentor Pharmaceuticals Inc | 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical composition containing the same |
US6730700B2 (en) | 1998-12-02 | 2004-05-04 | Renovis, Inc. | 3,4,5,-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same |
JP4501128B2 (ja) | 1999-01-25 | 2010-07-14 | ナショナル ジュウィッシュ ヘルス | 置換ポルフィリン |
WO2000064420A2 (en) * | 1999-04-28 | 2000-11-02 | Queen's University At Kingston | Compositions and methods for treating amyloidosis using sulphonate derivatives |
BR9904931A (pt) * | 1999-10-18 | 2001-06-12 | Sergio Teixeira Ferreira | Inibição de amiloidoses |
US6815425B1 (en) | 1999-10-22 | 2004-11-09 | The United States Of America As Represented By The Secretary Of The Army | Pharmaceutical composition containing pGLU-GLU-PRO-NH2 and method for treating diseases and injuries to the brain, spinal cord and retina using same |
AU1574701A (en) * | 1999-10-22 | 2001-04-30 | Wrair Walter Reed Army Institute Of Research | A pharmaceutical composition containing pglu-glu-pro-nh2 and method for treating diseases and injuries to the brain, spinal cord and retina using same |
SE0000056D0 (sv) * | 2000-01-10 | 2000-01-10 | Astrazeneca Ab | Novel process |
SE0000055D0 (sv) | 2000-01-10 | 2000-01-10 | Centaur Pharmaceuticals Inc | Novel process |
AU2001236442A1 (en) * | 2000-01-10 | 2001-07-24 | Centaur Phamaceuticals, Inc. | Method for the purification of aryl sulfonic acids and salts |
SE0001916D0 (sv) * | 2000-05-23 | 2000-05-23 | Astrazeneca Ab | Novel formulation |
US6664297B1 (en) | 2000-10-18 | 2003-12-16 | Universidade Federal Do Rio De Janeiro | Methods for inhibition and dissolution of amyloidoses by administration of compositions comprising 2,4-dinitrophenol |
AU2002253857A1 (en) | 2001-01-08 | 2002-09-04 | Centaur Pharmaceuticals, Inc. | Use of aryl nitrone compounds in methods for treating neuropathic pain |
WO2003010154A1 (en) * | 2001-07-26 | 2003-02-06 | Samsung Electronics Co. Ltd. | Seleno compounds containing nitrone moiety, their preparation and their therapeutic uses |
US20030045461A1 (en) * | 2001-09-06 | 2003-03-06 | Jen-Chang Hsia | Composition and methods of esterified nitroxides gated with carboxylic acids |
FR2846968B1 (fr) * | 2002-11-08 | 2005-02-04 | Salles Jean Pierre | Nouveaux derives amphiphiles de l'alpha-c-phenyl-n-tert- butyl nitrone |
US7414076B2 (en) * | 2003-06-23 | 2008-08-19 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
US7244764B2 (en) * | 2003-06-23 | 2007-07-17 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
US20070010573A1 (en) * | 2003-06-23 | 2007-01-11 | Xianqi Kong | Methods and compositions for treating amyloid-related diseases |
US20050059638A1 (en) * | 2003-08-04 | 2005-03-17 | Kelly Michael G. | Aryl, heteroaromatic and bicyclic aryl nitrone compounds, prodrugs and pharmaceutical compositions of the same to treat human disorders |
US20050182060A1 (en) * | 2004-02-13 | 2005-08-18 | Kelly Michael G. | 2-Substituted and 4-substituted aryl nitrone compounds |
WO2006059252A2 (en) * | 2004-11-12 | 2006-06-08 | Neurochem (International) Limited | Methods and fluorinated compositions for treating amyloid-related diseases |
JP2008520647A (ja) * | 2004-11-16 | 2008-06-19 | ニューロケム (インターナショナル) リミテッド | Cnsおよびアミロイド関連疾患治療のための化合物 |
CA2900876A1 (en) | 2004-12-22 | 2006-08-17 | Bhi Limited Partnership | Methods and compositions for treating amyloid-related diseases |
US20060235370A1 (en) * | 2005-04-04 | 2006-10-19 | Oblong John E | Method of regulating mammalian keratinous tissue |
TW200716088A (en) * | 2005-04-15 | 2007-05-01 | Neurochem Int Ltd | Formulations and methods for treating amyloidosis |
WO2007013843A1 (en) * | 2005-07-26 | 2007-02-01 | Astrazeneca Ab | Use of 4-[(tert-butylimino)methyl]benzene-1,3-disulfonate n-oxide against myocardial ischaemia |
WO2007013841A1 (en) * | 2005-07-26 | 2007-02-01 | Astrazeneca Ab | Use of 4-((tert-butylimine)methyl) benzene-1,3-disulfonate n-oxide against cerebral oedema |
WO2007013842A1 (en) * | 2005-07-26 | 2007-02-01 | Astrazeneca Ab | Use of 4-((tert-butylimino)methyl) benzene-1,3-disulfonate n-oxide against maemorrhagic changes in the brain |
WO2007013844A1 (en) * | 2005-07-26 | 2007-02-01 | Astrazeneca Ab | Use of 4-[(tert-butylimino)benzene-1,3-disulfonate n-oxide against nausea |
AU2006342958A1 (en) * | 2005-12-22 | 2007-11-08 | Bellus Health (International) Limited | Treatment of renal disorders, diabetic nephropathy and dyslipidemias |
WO2008013866A2 (en) * | 2006-07-25 | 2008-01-31 | Hough Ear Institute | Methods for treating acute acoustic trauma |
WO2009019534A2 (en) | 2006-10-12 | 2009-02-12 | Bellus Health (International) Limited | Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid |
EP2120905A1 (en) * | 2006-12-22 | 2009-11-25 | BELLUS Health (International) Limited | Methods, compounds, and compositions for treating metabolic disorders and diabetes |
US20090082454A1 (en) * | 2007-09-25 | 2009-03-26 | Protia, Llc | Deuterium-enriched disufenton |
EP3028670B1 (en) | 2007-09-26 | 2023-12-20 | St. Jude Medical, LLC | Collapsible prosthetic heart valves |
US8227517B2 (en) * | 2008-02-12 | 2012-07-24 | Tosk, Incorporated | Doxorubicin adjuvants to reduce toxicity and methods for using the same |
EP2300003B1 (en) * | 2008-05-23 | 2014-03-05 | National Jewish Health | Compounds for use in treating injury associated with exposure to an alkylating species |
WO2010028058A1 (en) * | 2008-09-02 | 2010-03-11 | Oklahoma Medical Research Foundation | 2, 4-disulfonyl pheny tert-butyl nitrone for the treatment of gliomas |
JP5762414B2 (ja) * | 2009-08-24 | 2015-08-12 | ハフ イヤ インスティテュート | 急性音響外傷の治療方法 |
EP2670403B1 (en) | 2011-02-04 | 2021-08-18 | Hough Ear Institute | Methods for treating brain injury |
CN110248650A (zh) | 2016-10-31 | 2019-09-17 | 霍夫耳科研究所 | 用于增强突触发生和神经突发生的方法 |
US11020354B2 (en) | 2017-01-19 | 2021-06-01 | Otologic Pharmaceuticals, Inc. | Formulations of n-acetylcysteine and uses thereof |
KR20200055722A (ko) * | 2017-09-20 | 2020-05-21 | 오클라호마 메디컬 리써치 화운데이션 | 약물 내성 신경아교종의 치료 |
US10829441B2 (en) | 2017-11-14 | 2020-11-10 | The University Of Toledo | Reactive oxygen species-sensitive nitric oxide synthase inhibitors for the treatment of ischemic stroke |
JP2021523126A (ja) | 2018-05-03 | 2021-09-02 | ハフ イアー インスティテュート | 蓄積した病理学的Tauタンパク質を低減する方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5036097A (en) * | 1989-10-17 | 1991-07-30 | Oklahoma Medical Research Foundation | Phenylbutyl nitrone compositions and methods for prevention of gastric ulceration |
US5025032A (en) * | 1989-10-17 | 1991-06-18 | Oklahoma Medical Research Foundation | Phenyl butyl nitrone compositions and methods for treatment of oxidative tissue damage |
EP0496796B1 (en) * | 1989-10-17 | 1994-08-31 | Oklahoma Medical Research Foundation | Method and compositions for inhibition of disorders associated with oxidative damage |
ATE209908T1 (de) * | 1991-06-18 | 2001-12-15 | Oklahoma Med Res Found | RADIKALFÄNGER (ßSPIN TRAPSß) ZUR BEHANDLUNG VON MIT OXIDATION VON LIPIDEN UND PROTEINEN VERBUNDENEN ERKRANKUNGEN |
US5488145A (en) * | 1993-12-23 | 1996-01-30 | Oklahoma Medical Research Foundation | 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps |
-
1993
- 1993-12-23 US US08/173,579 patent/US5488145A/en not_active Expired - Lifetime
-
1994
- 1994-12-22 US US08/663,316 patent/US5780510A/en not_active Expired - Fee Related
- 1994-12-22 RU RU96115200/04A patent/RU2159231C2/ru not_active IP Right Cessation
- 1994-12-22 SG SG1996007103A patent/SG64903A1/en unknown
- 1994-12-22 JP JP51809895A patent/JP3412821B2/ja not_active Expired - Lifetime
- 1994-12-22 DK DK95907224T patent/DK0736004T3/da active
- 1994-12-22 ES ES95907224T patent/ES2145264T3/es not_active Expired - Lifetime
- 1994-12-22 CN CN94194993A patent/CN1070176C/zh not_active Expired - Fee Related
- 1994-12-22 KR KR1019960703367A patent/KR100370522B1/ko not_active IP Right Cessation
- 1994-12-22 HU HU9601739A patent/HU221167B1/hu not_active IP Right Cessation
- 1994-12-22 UA UA96072885A patent/UA45964C2/uk unknown
- 1994-12-22 AU AU15527/95A patent/AU679835B2/en not_active Ceased
- 1994-12-22 AT AT95907224T patent/ATE192736T1/de not_active IP Right Cessation
- 1994-12-22 PT PT95907224T patent/PT736004E/pt unknown
- 1994-12-22 CZ CZ19961775A patent/CZ289629B6/cs not_active IP Right Cessation
- 1994-12-22 SK SK788-96A patent/SK282403B6/sk unknown
- 1994-12-22 NZ NZ279025A patent/NZ279025A/en unknown
- 1994-12-22 WO PCT/US1994/014545 patent/WO1995017876A2/en active IP Right Grant
- 1994-12-22 EP EP95907224A patent/EP0736004B1/en not_active Expired - Lifetime
- 1994-12-22 CA CA002179521A patent/CA2179521C/en not_active Expired - Lifetime
- 1994-12-22 PL PL94315154A patent/PL185189B1/pl not_active IP Right Cessation
- 1994-12-22 BR BR9408378A patent/BR9408378A/pt not_active Application Discontinuation
- 1994-12-22 DE DE69424441T patent/DE69424441T2/de not_active Expired - Fee Related
-
1995
- 1995-01-27 TW TW084100747A patent/TW299315B/zh active
- 1995-04-24 US US08/426,961 patent/US5475032A/en not_active Expired - Lifetime
- 1995-06-06 US US08/468,564 patent/US5508305A/en not_active Expired - Lifetime
- 1995-06-20 MY MYPI95001668A patent/MY114178A/en unknown
- 1995-06-23 HR HR950358A patent/HRP950358B1/xx not_active IP Right Cessation
-
1996
- 1996-06-20 FI FI962589A patent/FI111718B/fi not_active IP Right Cessation
- 1996-06-20 NO NO962637A patent/NO306457B1/no unknown
-
1997
- 1997-05-13 BR BR1100626-9A patent/BR1100626A/pt active IP Right Grant
-
1998
- 1998-02-04 HK HK98100831A patent/HK1001768A1/xx not_active IP Right Cessation
- 1998-07-11 HK HK98109078A patent/HK1008294A1/xx not_active IP Right Cessation
-
2000
- 2000-05-22 JP JP2000150128A patent/JP2001010953A/ja not_active Withdrawn
- 2000-08-07 GR GR20000401829T patent/GR3034134T3/el not_active IP Right Cessation
-
2003
- 2003-12-02 JP JP2003403744A patent/JP2004075696A/ja not_active Withdrawn
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