FI111641B - Menetelmä aryylipiperatsinyyli-heterosyklisten yhdisteiden valmistamiseksi - Google Patents

Menetelmä aryylipiperatsinyyli-heterosyklisten yhdisteiden valmistamiseksi Download PDF

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Publication number
FI111641B
FI111641B FI932012A FI932012A FI111641B FI 111641 B FI111641 B FI 111641B FI 932012 A FI932012 A FI 932012A FI 932012 A FI932012 A FI 932012A FI 111641 B FI111641 B FI 111641B
Authority
FI
Finland
Prior art keywords
neutralizing agent
piperazine
formula
water
compound
Prior art date
Application number
FI932012A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI932012A0 (fi
FI932012L (fi
Inventor
Frank R Busch
Dennis M Godek
Douglas J M Allen
Sabeto A Diroma
Paul Bowles
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25468285&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI111641(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of FI932012A0 publication Critical patent/FI932012A0/fi
Publication of FI932012L publication Critical patent/FI932012L/fi
Application granted granted Critical
Publication of FI111641B publication Critical patent/FI111641B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Eye Examination Apparatus (AREA)
  • Lubricants (AREA)
FI932012A 1992-08-26 1993-05-04 Menetelmä aryylipiperatsinyyli-heterosyklisten yhdisteiden valmistamiseksi FI111641B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/936,179 US5206366A (en) 1992-08-26 1992-08-26 Process for preparing aryl piperazinyl-heterocyclic compounds
US93617992 1992-08-26

Publications (3)

Publication Number Publication Date
FI932012A0 FI932012A0 (fi) 1993-05-04
FI932012L FI932012L (fi) 1994-02-27
FI111641B true FI111641B (fi) 2003-08-29

Family

ID=25468285

Family Applications (1)

Application Number Title Priority Date Filing Date
FI932012A FI111641B (fi) 1992-08-26 1993-05-04 Menetelmä aryylipiperatsinyyli-heterosyklisten yhdisteiden valmistamiseksi

Country Status (27)

Country Link
US (1) US5206366A (cs)
EP (2) EP1029861B1 (cs)
JP (1) JP2742370B2 (cs)
KR (1) KR0123441B1 (cs)
CN (1) CN1033089C (cs)
AT (2) ATE206422T1 (cs)
AU (1) AU642836B1 (cs)
BR (1) BR9302065A (cs)
CZ (1) CZ281893B6 (cs)
DE (2) DE69330853T2 (cs)
DK (2) DK1029861T3 (cs)
EG (1) EG20214A (cs)
ES (2) ES2161703T3 (cs)
FI (1) FI111641B (cs)
HU (1) HU223312B1 (cs)
IL (1) IL105622A (cs)
MX (1) MX9302813A (cs)
MY (1) MY109731A (cs)
NO (1) NO300685B1 (cs)
NZ (1) NZ247539A (cs)
PL (1) PL173840B1 (cs)
PT (2) PT584903E (cs)
RU (1) RU2061695C1 (cs)
SI (1) SI9300287A (cs)
SK (1) SK280584B6 (cs)
YU (1) YU48964B (cs)
ZA (1) ZA936225B (cs)

Families Citing this family (47)

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US5206366A (en) * 1992-08-26 1993-04-27 Pfizer Inc. Process for preparing aryl piperazinyl-heterocyclic compounds
US5338846A (en) * 1992-08-26 1994-08-16 Pfizer Inc. Process for preparing aryl piperazinyl-heterocyclic compounds with a piperazine salt
US5359068A (en) * 1993-06-28 1994-10-25 Pfizer Inc. Processes and intermediates for the preparation of 5-[2-(4-(benzoisothiazol-3-yl)-piperazin-1-yl)ethyl]-6-chloro-1,3-dihydro-indol-2-one
AU697953B2 (en) * 1995-06-06 1998-10-22 Hoechst Marion Roussel, Inc. Benzisoxazole and indazole derivatives as antipsychotic agents
KR100333214B1 (ko) * 1996-05-07 2002-06-20 디. 제이. 우드, 스피겔 알렌 제이 5-(2-(4-(1,2-벤즈이소티아졸-3-일)-1-피페라지닐)에틸)-6-클로로-1,3-디하이드로-2(1에이치)인돌-2-온(지프라시돈)의메실레이트트리하이드레이트염,이의제조방법및도파민디2길항물질로서의이의용도
TW491847B (en) * 1996-05-07 2002-06-21 Pfizer Mesylate dihydrate salts of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2h-indol-2-one
TWI242011B (en) * 1997-03-31 2005-10-21 Eisai Co Ltd 1,4-substituted cyclic amine derivatives
US5945421A (en) * 1997-08-11 1999-08-31 Warner-Lambert Company Dopamine D4 receptor antagonists
US6040448A (en) * 1997-10-24 2000-03-21 Neurogen Corporation Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands
IL127497A (en) * 1997-12-18 2002-07-25 Pfizer Prod Inc Medicinal products containing piperazinyl-heterocyclic compounds for the treatment of psychiatric disorders
AU735381B2 (en) * 1998-03-06 2001-07-05 Astrazeneca Ab New use
US6150366A (en) * 1998-06-15 2000-11-21 Pfizer Inc. Ziprasidone formulations
US6660858B2 (en) 2001-03-28 2003-12-09 Lion Bioscience Ag 2-aminobenzoxazole derivatives and combinatorial libraries thereof
US20040048876A1 (en) * 2002-02-20 2004-03-11 Pfizer Inc. Ziprasidone composition and synthetic controls
UY27668A1 (es) 2002-02-20 2003-10-31 Pfizer Prod Inc Composición de ziprasidona y controles sintéticos
BR0314393A (pt) * 2002-09-17 2005-07-19 Warner Lambert Co Piperazinas heterocìclicas substituìdas para o tratamento de esquizofrenia
AU2003269331B2 (en) * 2002-10-24 2010-02-18 Pfizer Products Inc. acyl derivatives of 5-(2-(4-(1,2 benzisothiazole-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one having neuroleptic activity
MXPA05004273A (es) * 2002-11-08 2005-10-18 Warner Lambert Co Derivados de fenilalquil y piridilalquil piperazina.
WO2004050655A1 (en) * 2002-12-04 2004-06-17 Dr. Reddy's Laboratories Limited Polymorphic forms of ziprasidone and its hydrochloride
US7488729B2 (en) 2002-12-04 2009-02-10 Dr. Reddy's Laboratories Limited Polymorphic forms of ziprasidone and its hydrochloride salt and process for preparation thereof
CN1255105C (zh) * 2002-12-17 2006-05-10 上海医药工业研究院 齐拉西酮及其盐的水溶性包合物及其制备方法
AU2003245027A1 (en) * 2003-04-11 2004-11-01 Hetero Drugs Limited Novel crystalline forms of ziprasidone hydrochloride
WO2005016325A2 (en) * 2003-06-03 2005-02-24 Teva Pharmaceutical Industries Ltd. CRISTALLINE ZIPRASIDONE HCl AND PROCESSES FOR PREPARATION THEREOF
US20050049295A1 (en) * 2003-06-12 2005-03-03 Dr. Reddy's Laboratories Limited Process for the preparation of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1piperazinyl) ethyl)-6-chloro-1, 3-dihydro-2h-indol-2-one hydrochloride (ziprasidone hydrochloride) and its intermediate
US7160888B2 (en) * 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
EP1628973A2 (en) 2003-10-24 2006-03-01 Teva Pharmaceutical Industries Ltd. Processes for preparation of ziprasidone
WO2005061493A2 (en) * 2003-12-18 2005-07-07 Teva Pharmaceutical Industries Ltd. Polymorphic form b2 of ziprasidone base
US20080312254A1 (en) * 2004-02-27 2008-12-18 Ranbaxy Laboratories Limited Process for the Preparation of Ziprasidone
ITMI20040944A1 (it) * 2004-05-11 2004-08-11 Dinamite Dipharma S P A In For Polimorfo di ziprasidone cloridrato e procedimento per la sua preparazione
CA2467538C (en) * 2004-05-14 2010-08-24 Apotex Pharmachem Inc. New amorphous ziprasidone hydrochloride (5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride) and processes to produce the same
CA2471219A1 (en) * 2004-06-14 2005-12-14 Apotex Pharmachem Inc. Improved preparation of an anhydrate form of 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride (ziprasidone hydrochloride)
WO2006011157A2 (en) * 2004-06-18 2006-02-02 Lupin Limited Methods for the preparation of aryl piperazinyl-heterocyclic compounds
US9044503B2 (en) * 2004-08-27 2015-06-02 University Of Kentucky Research Foundation Amyloid peptide inactivating enzyme to treat alzheimer's disease peripherally
ES2250000B1 (es) * 2004-09-29 2007-06-01 Medichem, S.A. Procedimiento para la preparacion de ziprasidona.
ES2250001B1 (es) * 2004-09-29 2007-06-01 Medichem, S.A. Proceso para la purificacion de ziprasidona.
US7777037B2 (en) * 2004-10-27 2010-08-17 Dr. Reddy's Laboratories Limited Ziprasidone process
WO2006086779A1 (en) * 2005-02-11 2006-08-17 Teva Pharmaceutical Industries Ltd. Amorphous ziprasidone mesylate
WO2006099452A1 (en) * 2005-03-14 2006-09-21 Teva Pharmaceutical Industries Ltd. Anhydrous ziprasidone mesylate and a process for its preparation
WO2006098834A2 (en) * 2005-03-14 2006-09-21 Teva Pharmaceutical Industries Ltd. Crystalline forms of ziprasidone mesylate
KR20070112228A (ko) * 2005-04-01 2007-11-22 워너-램버트 캄파니 엘엘씨 정신분열증을 치료하기 위한테트라하이드로-피리도아제핀-8-온 및 관련 화합물
HU230479B1 (hu) * 2006-05-02 2016-07-28 Richter Gedeon Nyrt. Eljárás 5-{2-[4-(1,2-benzizotiazol-3-il)-1-piperazinil]-etil}-6-klór-1,3-dihidro-2H-indol-2-on (Ziprasidon) előállítására
HUP0600868A3 (en) * 2006-11-24 2009-03-30 Richter Gedeon Nyrt 5-{2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl}-6-chloro-1,3-dihydro-2h-indol-2-one hydrogen bromide polimorphs and process for their preparation
US8410268B2 (en) * 2008-03-11 2013-04-02 Alkem Laboratories Limited Process for the preparation of ziprasidone
CN102958927A (zh) 2010-05-12 2013-03-06 Abbvie公司 激酶的吲唑抑制剂
PL391810A1 (pl) 2010-07-14 2012-01-16 Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna Nowe sole ziprasidonu oraz sposoby ich otrzymywania
WO2012020424A1 (en) 2010-08-12 2012-02-16 Arch Pharmalabs Limited A short process for the preparation of ziprasidone and intermediates thereof
SI23610A (sl) 2011-01-13 2012-07-31 Diagen@d@o@o Nove adicijske soli ziprasidona postopek za njihovo pripravo in njihova uporaba v terapiji

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Also Published As

Publication number Publication date
KR940003952A (ko) 1994-03-14
FI932012A0 (fi) 1993-05-04
NZ247539A (en) 1995-09-26
HUT65750A (en) 1994-07-28
NO931656D0 (no) 1993-05-06
EG20214A (en) 1997-11-30
NO300685B1 (no) 1997-07-07
DK1029861T3 (da) 2004-11-15
US5206366A (en) 1993-04-27
DE69330853T2 (de) 2002-05-02
ES2161703T3 (es) 2001-12-16
PL299002A1 (en) 1994-03-21
ZA936225B (en) 1995-02-27
RU2061695C1 (ru) 1996-06-10
SK280584B6 (sk) 2000-04-10
HU223312B1 (hu) 2004-05-28
YU48964B (sh) 2003-01-31
DK0584903T3 (da) 2001-12-03
EP1029861B1 (en) 2004-08-18
FI932012L (fi) 1994-02-27
MY109731A (en) 1997-05-31
EP0584903B1 (en) 2001-10-04
PL173840B1 (pl) 1998-05-29
IL105622A0 (en) 1993-09-22
CZ87793A3 (en) 1994-04-13
SK48593A3 (en) 1994-04-06
PT1029861E (pt) 2004-11-30
IL105622A (en) 1998-06-15
MX9302813A (es) 1994-02-28
AU642836B1 (en) 1993-10-28
JP2742370B2 (ja) 1998-04-22
ATE273976T1 (de) 2004-09-15
BR9302065A (pt) 1994-07-26
ATE206422T1 (de) 2001-10-15
DE69333597D1 (de) 2004-09-23
EP1029861A1 (en) 2000-08-23
KR0123441B1 (ko) 1997-11-24
YU56593A (sh) 1996-07-24
NO931656L (no) 1994-02-28
CN1083061A (zh) 1994-03-02
DE69330853D1 (de) 2001-11-08
EP0584903A1 (en) 1994-03-02
JPH06184143A (ja) 1994-07-05
ES2225015T3 (es) 2005-03-16
PT584903E (pt) 2002-02-28
SI9300287A (en) 1994-03-31
HU9301291D0 (en) 1993-07-28
CN1033089C (zh) 1996-10-23
CZ281893B6 (cs) 1997-03-12
DE69333597T2 (de) 2005-09-15

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