FI111367B - Förfarande för framställning av terapeutiskt användbara N-(aryloxialkyl)heteroaryl-8-azabicyklo[3.2.1]oktanderivat och mellanprodukter som används vid förfarandet - Google Patents
Förfarande för framställning av terapeutiskt användbara N-(aryloxialkyl)heteroaryl-8-azabicyklo[3.2.1]oktanderivat och mellanprodukter som används vid förfarandet Download PDFInfo
- Publication number
- FI111367B FI111367B FI920435A FI920435A FI111367B FI 111367 B FI111367 B FI 111367B FI 920435 A FI920435 A FI 920435A FI 920435 A FI920435 A FI 920435A FI 111367 B FI111367 B FI 111367B
- Authority
- FI
- Finland
- Prior art keywords
- azabicyclo
- formula
- octan
- methoxyphenyl
- ethanone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
Claims (7)
1. Förfarande för framställning av nya terapeutiskt användbara N-(aryloxialkyl)-heteroaryl-8-5 azabicyklo[3.2.1]oktanderivat med formeln I och farma- ceutiskt godtagbara syraadditionssalt och geometriska och optiska isomerer och racemiska blandningar därav, R
10 A~\ /H-ICH^O-/ Λ (I) 15 i vilken formel X är 0, S eller NH; Y är väte eller halogen; n är 2, 3 eller 4; och 20. och R' betecknar oberoende av varandra lägre alkoxi eller lägre alkanoyl, kännetecknat av att en förening med formeln NH där X och Y betecknar samma som ovan bringas att reagera 30 med en förening med formeln R pjL-R·· <XII> Z- (CH~) — 35. n 42 111367 där Z är klor eller brom och n, R och R' betecknar sairatia som ovan.
2. Förfarande enligt patentkrav 1, känne- tecknat av att man framställer en förening med formeln
3. Förfarande enligt patentkrav 1, känne- tecknat av att man framställer en förening med formeln I, där X är 0 och R är OCH3 eller 0 II
10 -C-CH3.
4. Förfarande enligt patentkrav 1, kanne - tecknat av att man framställer [4-[2-[3-[1,2-bens-isoxazol-3-yl]-8-azabicyklo[3.2.1]oktan-8-yl]etoxi]-3-metoxifenyl]etanon eller ett farmaceutiskt godtagbart 15 syraadditionssalt därav.
5. Förfarande enligt patentkrav 1, kanne - tecknat av att man framställer [4-[4-[3-[lH-indazol-3-yl]-8-azabicyklo[3.2.1]oktan-8-yl]butoxi]-3-metoxifenyl]-etanon eller ett farmaceutiskt godtagbart syraaddi- 20 tionssalt därav.
5 I, där X är O eller S, n är 3 och Y är väte eller fluor.
6. Förfarande enligt patentkrav 1, känne- tecknat av att man framställer [4-[4-[3-[6-fluor-lH-indazol-3-yl]-8-azabicyklo[3.2.1]oktan-8-yl]butoxi]-3-metoxifenyl]etanon eller ett farmaceutiskt godtagbart 25 syraadditionssalt därav.
7. Heteroaryl-8-azabicyklo[3.2.1]oktanderivat med formeln .N H där X är O, S eller NH; och 35 Y är väte eller halogen.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65014491A | 1991-02-04 | 1991-02-04 | |
| US65014491 | 1991-02-04 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI920435A0 FI920435A0 (fi) | 1992-01-31 |
| FI920435A FI920435A (fi) | 1992-08-05 |
| FI111367B true FI111367B (sv) | 2003-07-15 |
Family
ID=24607667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI920435A FI111367B (sv) | 1991-02-04 | 1992-01-31 | Förfarande för framställning av terapeutiskt användbara N-(aryloxialkyl)heteroaryl-8-azabicyklo[3.2.1]oktanderivat och mellanprodukter som används vid förfarandet |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0498331B1 (sv) |
| JP (1) | JPH089613B2 (sv) |
| KR (1) | KR100222774B1 (sv) |
| AT (1) | ATE138377T1 (sv) |
| AU (1) | AU641842B2 (sv) |
| CA (1) | CA2060573C (sv) |
| CZ (1) | CZ284754B6 (sv) |
| DE (1) | DE69210849T2 (sv) |
| DK (1) | DK0498331T3 (sv) |
| ES (1) | ES2089255T3 (sv) |
| FI (1) | FI111367B (sv) |
| GR (1) | GR3020094T3 (sv) |
| HU (2) | HU217616B (sv) |
| IE (1) | IE74905B1 (sv) |
| IL (1) | IL100861A (sv) |
| MX (1) | MX9200471A (sv) |
| NO (1) | NO300040B1 (sv) |
| NZ (1) | NZ241481A (sv) |
| PL (1) | PL169092B1 (sv) |
| RU (1) | RU2075479C1 (sv) |
| ZA (1) | ZA92753B (sv) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9510459D0 (en) | 1995-05-24 | 1995-07-19 | Zeneca Ltd | Bicyclic amines |
| HUP9802433A3 (en) * | 1995-10-13 | 2000-03-28 | Neurosearch As | 8-azabicyclo[3.2.1]oct-2-ene derivatives, their preparation and use |
| ES2218676T3 (es) * | 1996-05-13 | 2004-11-16 | Syngenta Limited | Aminas biciclicas como insecticidas. |
| GB9623944D0 (en) * | 1996-11-15 | 1997-01-08 | Zeneca Ltd | Bicyclic amine derivatives |
| GB9624114D0 (en) * | 1996-11-20 | 1997-01-08 | Zeneca Ltd | Pesticidal bicyclic amine derivatives |
| GB9624611D0 (en) * | 1996-11-26 | 1997-01-15 | Zeneca Ltd | Bicyclic amine compounds |
| WO1998025924A1 (en) | 1996-11-26 | 1998-06-18 | Zeneca Limited | 8-azabicyclo[3.2.1]octane-, 8-azabicyclo[3.2.1]oct-6-ene-, 9-azabicyclo[3.3.1]nonane-, 9-aza-3-oxabicyclo[3.3.1]nonane- and 9-aza-3-thiabicyclo[3.3.1]nonane derivatives, their preparation and their use as insecticides |
| BR9809697A (pt) | 1997-05-30 | 2000-07-11 | Neurosearch As | Composto, uso, e processo para a preparação do mesmo, composição farmacêutica, e, processo para tratar uma doença de um corpo de animal vivo, incluindo um humano |
| US6251893B1 (en) * | 1998-06-15 | 2001-06-26 | Nps Allelix Corp. | Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity |
| EP1248786A1 (en) | 1999-12-20 | 2002-10-16 | Eli Lilly And Company | Benzofuran derivatives |
| WO2001046187A1 (en) * | 1999-12-20 | 2001-06-28 | Eli Lilly And Company | Azabicyclo[3.2.1]octane derivatives |
| EP1361875A2 (en) * | 2001-02-16 | 2003-11-19 | Aventis Pharmaceuticals Inc. | Novel heterocyclic amide derivatives and their use as dopamine d3 receptor ligands |
| US7247643B2 (en) * | 2003-02-12 | 2007-07-24 | Neurosearch A/S | 8-aza-bicyclo (3.2.1) octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2548666A1 (fr) * | 1983-07-08 | 1985-01-11 | Delalande Sa | Nouveaux derives du nor-tropane et du granatane, leur procede de preparation et leur application en therapeutique |
| EP0315390B1 (en) * | 1987-11-04 | 1994-07-20 | Beecham Group Plc | Novel 4-oxobenzotriazines and 4-oxoquinazolines |
-
1992
- 1992-01-31 NZ NZ241481A patent/NZ241481A/en unknown
- 1992-01-31 FI FI920435A patent/FI111367B/sv active
- 1992-02-01 KR KR1019920001588A patent/KR100222774B1/ko not_active IP Right Cessation
- 1992-02-03 RU SU925010691A patent/RU2075479C1/ru active
- 1992-02-03 ZA ZA92753A patent/ZA92753B/xx unknown
- 1992-02-03 ES ES92101706T patent/ES2089255T3/es not_active Expired - Lifetime
- 1992-02-03 MX MX9200471A patent/MX9200471A/es not_active IP Right Cessation
- 1992-02-03 JP JP4017668A patent/JPH089613B2/ja not_active Expired - Fee Related
- 1992-02-03 CZ CS92297A patent/CZ284754B6/cs not_active IP Right Cessation
- 1992-02-03 EP EP92101706A patent/EP0498331B1/en not_active Expired - Lifetime
- 1992-02-03 DK DK92101706.7T patent/DK0498331T3/da active
- 1992-02-03 PL PL92293363A patent/PL169092B1/pl unknown
- 1992-02-03 HU HU9203977A patent/HU217616B/hu not_active IP Right Cessation
- 1992-02-03 HU HU9200321A patent/HU207863B/hu not_active IP Right Cessation
- 1992-02-03 AT AT92101706T patent/ATE138377T1/de not_active IP Right Cessation
- 1992-02-03 IL IL10086192A patent/IL100861A/xx not_active IP Right Cessation
- 1992-02-03 AU AU10605/92A patent/AU641842B2/en not_active Ceased
- 1992-02-03 CA CA002060573A patent/CA2060573C/en not_active Expired - Fee Related
- 1992-02-03 DE DE69210849T patent/DE69210849T2/de not_active Expired - Fee Related
- 1992-02-03 IE IE920349A patent/IE74905B1/en not_active IP Right Cessation
- 1992-02-03 NO NO920438A patent/NO300040B1/no unknown
-
1996
- 1996-05-30 GR GR960401453T patent/GR3020094T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or assigment of application |
Owner name: HOECHST MARION ROUSSEL, INC. |