DK0498331T3 - N-(Aryloxyalkyl)-heteroaryl-8-azabicyclo(3.2.1)octaner, mellemprodukter og en fremgangsmåde til fremstilling deraf samt deres anvendelse som lægemidler - Google Patents

N-(Aryloxyalkyl)-heteroaryl-8-azabicyclo(3.2.1)octaner, mellemprodukter og en fremgangsmåde til fremstilling deraf samt deres anvendelse som lægemidler

Info

Publication number
DK0498331T3
DK0498331T3 DK92101706.7T DK92101706T DK0498331T3 DK 0498331 T3 DK0498331 T3 DK 0498331T3 DK 92101706 T DK92101706 T DK 92101706T DK 0498331 T3 DK0498331 T3 DK 0498331T3
Authority
DK
Denmark
Prior art keywords
loweralkoxy
chem
halogen
hydrogen
octanes
Prior art date
Application number
DK92101706.7T
Other languages
English (en)
Inventor
Edward J Glamkowski
Barbara E Kurys
David M Fink
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Application granted granted Critical
Publication of DK0498331T3 publication Critical patent/DK0498331T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
DK92101706.7T 1991-02-04 1992-02-03 N-(Aryloxyalkyl)-heteroaryl-8-azabicyclo(3.2.1)octaner, mellemprodukter og en fremgangsmåde til fremstilling deraf samt deres anvendelse som lægemidler DK0498331T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65014491A 1991-02-04 1991-02-04

Publications (1)

Publication Number Publication Date
DK0498331T3 true DK0498331T3 (da) 1996-09-09

Family

ID=24607667

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92101706.7T DK0498331T3 (da) 1991-02-04 1992-02-03 N-(Aryloxyalkyl)-heteroaryl-8-azabicyclo(3.2.1)octaner, mellemprodukter og en fremgangsmåde til fremstilling deraf samt deres anvendelse som lægemidler

Country Status (21)

Country Link
EP (1) EP0498331B1 (da)
JP (1) JPH089613B2 (da)
KR (1) KR100222774B1 (da)
AT (1) ATE138377T1 (da)
AU (1) AU641842B2 (da)
CA (1) CA2060573C (da)
CZ (1) CZ284754B6 (da)
DE (1) DE69210849T2 (da)
DK (1) DK0498331T3 (da)
ES (1) ES2089255T3 (da)
FI (1) FI111367B (da)
GR (1) GR3020094T3 (da)
HU (2) HU217616B (da)
IE (1) IE74905B1 (da)
IL (1) IL100861A (da)
MX (1) MX9200471A (da)
NO (1) NO300040B1 (da)
NZ (1) NZ241481A (da)
PL (1) PL169092B1 (da)
RU (1) RU2075479C1 (da)
ZA (1) ZA92753B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9510459D0 (en) 1995-05-24 1995-07-19 Zeneca Ltd Bicyclic amines
HUP9802433A3 (en) * 1995-10-13 2000-03-28 Neurosearch As 8-azabicyclo[3.2.1]oct-2-ene derivatives, their preparation and use
ES2218676T3 (es) * 1996-05-13 2004-11-16 Syngenta Limited Aminas biciclicas como insecticidas.
GB9623944D0 (en) * 1996-11-15 1997-01-08 Zeneca Ltd Bicyclic amine derivatives
GB9624114D0 (en) * 1996-11-20 1997-01-08 Zeneca Ltd Pesticidal bicyclic amine derivatives
GB9624611D0 (en) * 1996-11-26 1997-01-15 Zeneca Ltd Bicyclic amine compounds
WO1998025924A1 (en) 1996-11-26 1998-06-18 Zeneca Limited 8-azabicyclo[3.2.1]octane-, 8-azabicyclo[3.2.1]oct-6-ene-, 9-azabicyclo[3.3.1]nonane-, 9-aza-3-oxabicyclo[3.3.1]nonane- and 9-aza-3-thiabicyclo[3.3.1]nonane derivatives, their preparation and their use as insecticides
BR9809697A (pt) 1997-05-30 2000-07-11 Neurosearch As Composto, uso, e processo para a preparação do mesmo, composição farmacêutica, e, processo para tratar uma doença de um corpo de animal vivo, incluindo um humano
US6251893B1 (en) * 1998-06-15 2001-06-26 Nps Allelix Corp. Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity
EP1248786A1 (en) 1999-12-20 2002-10-16 Eli Lilly And Company Benzofuran derivatives
WO2001046187A1 (en) * 1999-12-20 2001-06-28 Eli Lilly And Company Azabicyclo[3.2.1]octane derivatives
EP1361875A2 (en) * 2001-02-16 2003-11-19 Aventis Pharmaceuticals Inc. Novel heterocyclic amide derivatives and their use as dopamine d3 receptor ligands
US7247643B2 (en) * 2003-02-12 2007-07-24 Neurosearch A/S 8-aza-bicyclo (3.2.1) octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2548666A1 (fr) * 1983-07-08 1985-01-11 Delalande Sa Nouveaux derives du nor-tropane et du granatane, leur procede de preparation et leur application en therapeutique
EP0315390B1 (en) * 1987-11-04 1994-07-20 Beecham Group Plc Novel 4-oxobenzotriazines and 4-oxoquinazolines

Also Published As

Publication number Publication date
NZ241481A (en) 1994-06-27
CA2060573C (en) 2002-08-13
KR100222774B1 (ko) 1999-10-01
FI111367B (fi) 2003-07-15
EP0498331A1 (en) 1992-08-12
JPH0559049A (ja) 1993-03-09
NO300040B1 (no) 1997-03-24
IE74905B1 (en) 1997-08-13
PL293363A1 (en) 1993-03-08
MX9200471A (es) 1992-08-01
EP0498331B1 (en) 1996-05-22
ES2089255T3 (es) 1996-10-01
FI920435A0 (fi) 1992-01-31
CZ284754B6 (cs) 1999-02-17
IE920349A1 (en) 1992-08-12
HUT60494A (en) 1992-09-28
HU217616B (hu) 2000-03-28
NO920438L (no) 1992-08-05
DE69210849T2 (de) 1996-12-05
HU207863B (en) 1993-06-28
HU9203977D0 (en) 1993-04-28
GR3020094T3 (en) 1996-08-31
HU9200321D0 (en) 1992-04-28
PL169092B1 (pl) 1996-05-31
ATE138377T1 (de) 1996-06-15
RU2075479C1 (ru) 1997-03-20
ZA92753B (en) 1992-10-28
DE69210849D1 (de) 1996-06-27
HUT62295A (en) 1993-04-28
FI920435A (fi) 1992-08-05
CS29792A3 (en) 1992-08-12
AU641842B2 (en) 1993-09-30
AU1060592A (en) 1992-08-06
IL100861A (en) 1997-02-18
NO920438D0 (no) 1992-02-03
KR920016452A (ko) 1992-09-24
IL100861A0 (en) 1992-11-15
CA2060573A1 (en) 1992-08-05
JPH089613B2 (ja) 1996-01-31

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