ES2089255T3 - N-(ariloxialquil)heteroaril-8-azabiciclo(3.2.1)octanos, compuestos intermedios y un procedimiento para su preparacion y su uso como medicamentos. - Google Patents
N-(ariloxialquil)heteroaril-8-azabiciclo(3.2.1)octanos, compuestos intermedios y un procedimiento para su preparacion y su uso como medicamentos.Info
- Publication number
- ES2089255T3 ES2089255T3 ES92101706T ES92101706T ES2089255T3 ES 2089255 T3 ES2089255 T3 ES 2089255T3 ES 92101706 T ES92101706 T ES 92101706T ES 92101706 T ES92101706 T ES 92101706T ES 2089255 T3 ES2089255 T3 ES 2089255T3
- Authority
- ES
- Spain
- Prior art keywords
- loweralkoxy
- chem
- halogen
- aryloxialkyl
- azabiciclo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
Abstract
ESTA INVENCION SE REFIERE A LOS COMPUESTOS DE FORMULA (I): EN LA QUE X ES -O-, -SCOXI INFERIOR; P ES 1 O 2; N ES 2, 3 O 4; R ES HIDROGENO, ALQUILO INFERIOR, ALCOXI INFERIOR, HIDROXI, HALOGENO, AMINO, ALQUILAMINO INFERIOR, NITRO, ALQUILTIO INFERIOR, TRIFLUOROMETOXI, CIANO, TRIFLUOROMETIL, DONDE ARILO ES; R SUB 1 ES HIDROGENO ALQUILO INFERIOR, ALCOXI INFERIOR, HALOGENO, HIDROXI , CARBOXILO, ALQUILAMINO INFERIOR, NITRO, ALQUILTIO INFERIOR, CIANO Y TRIFLUOROMETILO; M ES 1 O 2; UNA SAL DE ADICION DE ACIDO DE ESTOS FARMACEUTICAMENTE ACEPTABLE, DONDE SE PUEDE APLICAR LOS ISOMEROS OPTICOS Y GEOMETRICOS Y LAS MEZCLAS RACEMICAS DE ESTOS. LOS COMPUESTOS Y LAS COMPOSICIONES DE ESTA INVENCION SON UTILES COMO AGENTES ANTISICOTICOS Y COMO INHIBIDORES DE LA RESUBIDA DE SEROTONINA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65014491A | 1991-02-04 | 1991-02-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2089255T3 true ES2089255T3 (es) | 1996-10-01 |
Family
ID=24607667
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92101706T Expired - Lifetime ES2089255T3 (es) | 1991-02-04 | 1992-02-03 | N-(ariloxialquil)heteroaril-8-azabiciclo(3.2.1)octanos, compuestos intermedios y un procedimiento para su preparacion y su uso como medicamentos. |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0498331B1 (es) |
JP (1) | JPH089613B2 (es) |
KR (1) | KR100222774B1 (es) |
AT (1) | ATE138377T1 (es) |
AU (1) | AU641842B2 (es) |
CA (1) | CA2060573C (es) |
CZ (1) | CZ284754B6 (es) |
DE (1) | DE69210849T2 (es) |
DK (1) | DK0498331T3 (es) |
ES (1) | ES2089255T3 (es) |
FI (1) | FI111367B (es) |
GR (1) | GR3020094T3 (es) |
HU (2) | HU207863B (es) |
IE (1) | IE74905B1 (es) |
IL (1) | IL100861A (es) |
MX (1) | MX9200471A (es) |
NO (1) | NO300040B1 (es) |
NZ (1) | NZ241481A (es) |
PL (1) | PL169092B1 (es) |
RU (1) | RU2075479C1 (es) |
ZA (1) | ZA92753B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9510459D0 (en) | 1995-05-24 | 1995-07-19 | Zeneca Ltd | Bicyclic amines |
IL123583A (en) * | 1995-10-13 | 2003-07-31 | Neurosearch As | 3-substituted -8-azabicyclo [3,2,1] oct-2-ene derivatives, their preparation and pharmaceutical compositions containing them |
EP0901490B1 (en) * | 1996-05-13 | 2004-04-07 | Syngenta Limited | Bicyclic amines as insecticides |
GB9623944D0 (en) * | 1996-11-15 | 1997-01-08 | Zeneca Ltd | Bicyclic amine derivatives |
GB9624114D0 (en) * | 1996-11-20 | 1997-01-08 | Zeneca Ltd | Pesticidal bicyclic amine derivatives |
SK69299A3 (en) | 1996-11-26 | 2000-01-18 | Zeneca Ltd | 8-azabicyclo[3.2.1]octane-, 8-azabicyclo[3.2.1]oct-6-ene-, 9-azabicyclo[3.3.1]nonane-, 9-aza-3-oxabicyclo[3.3.1]nonane- and 9-aza-3-thiabicyclo[3.3.1]nonane derivatives, their preparation and their use as insecticides |
GB9624611D0 (en) * | 1996-11-26 | 1997-01-15 | Zeneca Ltd | Bicyclic amine compounds |
ATE267199T1 (de) | 1997-05-30 | 2004-06-15 | Neurosearch As | 8-azabicyclo(3,2,1)oct-2-en- und octanderivate als liganden der nicotinergen ach rezeptoren |
US6251893B1 (en) * | 1998-06-15 | 2001-06-26 | Nps Allelix Corp. | Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity |
AU2049501A (en) | 1999-12-20 | 2001-07-03 | Eli Lilly And Company | Benzofuran derivatives |
EP1242419A1 (en) * | 1999-12-20 | 2002-09-25 | Eli Lilly And Company | Azabicyclo 3.2.1]octane derivatives |
JP4497815B2 (ja) * | 2001-02-16 | 2010-07-07 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | 新規な複素環式アミド誘導体およびドーパミンd3受容体リガンドとしてのその使用 |
DE602004024033D1 (de) * | 2003-02-12 | 2009-12-24 | Neurosearch As | 8-azabicycloä3.2.1üoctanderivate und ihre verwendung als monoamine-neurotransmitter-reuptake inhibitoren |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2548666A1 (fr) * | 1983-07-08 | 1985-01-11 | Delalande Sa | Nouveaux derives du nor-tropane et du granatane, leur procede de preparation et leur application en therapeutique |
ATE108791T1 (de) * | 1987-11-04 | 1994-08-15 | Beecham Group Plc | Neue 4-oxobenzotriazine und 4-oxochinazoline. |
-
1992
- 1992-01-31 NZ NZ241481A patent/NZ241481A/en unknown
- 1992-01-31 FI FI920435A patent/FI111367B/fi active
- 1992-02-01 KR KR1019920001588A patent/KR100222774B1/ko not_active IP Right Cessation
- 1992-02-03 RU SU925010691A patent/RU2075479C1/ru active
- 1992-02-03 HU HU9200321A patent/HU207863B/hu not_active IP Right Cessation
- 1992-02-03 JP JP4017668A patent/JPH089613B2/ja not_active Expired - Fee Related
- 1992-02-03 IE IE920349A patent/IE74905B1/en not_active IP Right Cessation
- 1992-02-03 HU HU9203977A patent/HU217616B/hu not_active IP Right Cessation
- 1992-02-03 CZ CS92297A patent/CZ284754B6/cs not_active IP Right Cessation
- 1992-02-03 CA CA002060573A patent/CA2060573C/en not_active Expired - Fee Related
- 1992-02-03 AT AT92101706T patent/ATE138377T1/de not_active IP Right Cessation
- 1992-02-03 IL IL10086192A patent/IL100861A/xx not_active IP Right Cessation
- 1992-02-03 EP EP92101706A patent/EP0498331B1/en not_active Expired - Lifetime
- 1992-02-03 MX MX9200471A patent/MX9200471A/es not_active IP Right Cessation
- 1992-02-03 ES ES92101706T patent/ES2089255T3/es not_active Expired - Lifetime
- 1992-02-03 AU AU10605/92A patent/AU641842B2/en not_active Ceased
- 1992-02-03 DK DK92101706.7T patent/DK0498331T3/da active
- 1992-02-03 DE DE69210849T patent/DE69210849T2/de not_active Expired - Fee Related
- 1992-02-03 NO NO920438A patent/NO300040B1/no unknown
- 1992-02-03 PL PL92293363A patent/PL169092B1/pl unknown
- 1992-02-03 ZA ZA92753A patent/ZA92753B/xx unknown
-
1996
- 1996-05-30 GR GR960401453T patent/GR3020094T3/el unknown
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Legal Events
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