FI109697B - Menetelmä uusien terapeuttisesti käyttökelpoisten fuusioituneiden bentsojohdannaisten valmistamiseksi - Google Patents
Menetelmä uusien terapeuttisesti käyttökelpoisten fuusioituneiden bentsojohdannaisten valmistamiseksi Download PDFInfo
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- FI109697B FI109697B FI952824A FI952824A FI109697B FI 109697 B FI109697 B FI 109697B FI 952824 A FI952824 A FI 952824A FI 952824 A FI952824 A FI 952824A FI 109697 B FI109697 B FI 109697B
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- Finland
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- formula
- compound
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- phenyl
- halogen
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- 238000000034 method Methods 0.000 title claims description 43
- 230000008569 process Effects 0.000 title claims description 9
- 238000002360 preparation method Methods 0.000 title claims description 6
- 125000005605 benzo group Chemical group 0.000 title abstract description 6
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- 125000000217 alkyl group Chemical group 0.000 claims abstract description 32
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 19
- 239000001257 hydrogen Substances 0.000 claims abstract description 19
- 125000001424 substituent group Chemical group 0.000 claims abstract description 15
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- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 2
- -1 cycloalk (en) yl Chemical group 0.000 claims description 41
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 22
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- 150000002431 hydrogen Chemical class 0.000 claims description 7
- 125000002030 1,2-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([*:2])C([H])=C1[H] 0.000 claims description 6
- 125000004122 cyclic group Chemical group 0.000 claims description 6
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- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/36—One oxygen atom with hydrocarbon radicals, substituted by nitrogen atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Saccharide Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Lubricants (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK148392 | 1992-12-09 | ||
| DK921483A DK148392D0 (da) | 1992-12-09 | 1992-12-09 | Heterocykliske forbindelser |
| PCT/DK1993/000414 WO1994013659A1 (en) | 1992-12-09 | 1993-12-08 | Fused benzo compounds |
| DK9300414 | 1993-12-08 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI952824A7 FI952824A7 (fi) | 1995-06-08 |
| FI952824A0 FI952824A0 (fi) | 1995-06-08 |
| FI109697B true FI109697B (fi) | 2002-09-30 |
Family
ID=8105314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI952824A FI109697B (fi) | 1992-12-09 | 1995-06-08 | Menetelmä uusien terapeuttisesti käyttökelpoisten fuusioituneiden bentsojohdannaisten valmistamiseksi |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US5753661A (cs) |
| EP (1) | EP0673375B1 (cs) |
| JP (1) | JPH08504410A (cs) |
| KR (1) | KR100299624B1 (cs) |
| AT (1) | ATE176909T1 (cs) |
| AU (1) | AU675263B2 (cs) |
| CA (1) | CA2151378A1 (cs) |
| CZ (1) | CZ283143B6 (cs) |
| DE (1) | DE69323630T2 (cs) |
| DK (2) | DK148392D0 (cs) |
| ES (1) | ES2127912T3 (cs) |
| FI (1) | FI109697B (cs) |
| GR (1) | GR3030200T3 (cs) |
| HU (1) | HUT73632A (cs) |
| IL (1) | IL107923A (cs) |
| MX (1) | MX9307779A (cs) |
| NO (1) | NO311617B1 (cs) |
| NZ (1) | NZ258117A (cs) |
| RU (1) | RU2141959C1 (cs) |
| SG (1) | SG52722A1 (cs) |
| SK (1) | SK280779B6 (cs) |
| WO (1) | WO1994013659A1 (cs) |
| ZA (1) | ZA939203B (cs) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4333254A1 (de) * | 1993-09-30 | 1995-04-06 | Merck Patent Gmbh | Piperidine und Piperazine |
| FR2723091B1 (fr) * | 1994-07-29 | 1996-11-08 | Esteve Labor Dr | Tetrahydropyridine-(6,4-hydroxypiperidine) alkylazoles |
| ES2117934B1 (es) * | 1994-07-29 | 1999-04-01 | Esteve Labor Dr | Tetrahidropiridinas (0 4-hidroxipiperidinas) alquilazoles. |
| FR2735127B1 (fr) * | 1995-06-09 | 1997-08-22 | Pf Medicament | Nouvelles piperazines heteroaromatiques utiles comme medicaments. |
| SE9601110D0 (sv) * | 1996-03-22 | 1996-03-22 | Astra Ab | Substituted 1,2,3,4-tetrahydronaphthalene derivatives |
| WO1997036893A1 (en) * | 1996-03-29 | 1997-10-09 | Duphar International Research B.V. | Piperazine and piperidine compounds |
| FR2757161B1 (fr) * | 1996-12-13 | 1999-03-12 | Sanofi Sa | Diphenylalkyl-tetrahydropyridines |
| GB9706222D0 (en) * | 1997-03-26 | 1997-05-14 | Zeneca Ltd | Bicyclic amine derivatives |
| US6034256A (en) | 1997-04-21 | 2000-03-07 | G.D. Searle & Co. | Substituted benzopyran derivatives for the treatment of inflammation |
| US6077850A (en) * | 1997-04-21 | 2000-06-20 | G.D. Searle & Co. | Substituted benzopyran analogs for the treatment of inflammation |
| SE9900190D0 (sv) | 1999-01-22 | 1999-01-22 | Astra Ab | New compounds |
| SE9702799D0 (sv) | 1997-07-25 | 1997-07-25 | Astra Ab | New compounds |
| ATE253058T1 (de) | 1997-09-02 | 2003-11-15 | Duphar Int Res | Piperidin- und piperazin derivate als 5-ht1- rezeptor-agonisten |
| EP0900792B1 (en) * | 1997-09-02 | 2003-10-29 | Duphar International Research B.V | Piperazine and piperidine derivatives as 5-HT1A and dopamine D2-receptor (ant)agonists |
| AR019178A1 (es) | 1998-06-30 | 2001-12-26 | Lilly Co Eli | Compuestos de 7-(benzo(b)tiofeno, furan e indolpiridil o tetrahidropiridilo), efectivos sobre sistemas relacionados con la serotonina, composicionesfarmaceuticas formuladas con dichos compuestos; compuestos intermediarios utiles para preparar dichos compuestos de tiofeno, furan e indolpiridilo otetr |
| EP1146045A1 (en) * | 1998-06-30 | 2001-10-17 | Eli Lilly And Company | Piperidine derivatives having effects on serotonin related systems |
| UA71590C2 (en) | 1998-11-13 | 2004-12-15 | Duphar Int Res | Piperazine and piperidine derivatives |
| AR022303A1 (es) * | 1999-01-22 | 2002-09-04 | Lundbeck & Co As H | Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion |
| EP1196413A2 (en) * | 1999-06-29 | 2002-04-17 | Eli Lilly And Company | Preparation of 7-substituted benzothiophenes |
| AR027134A1 (es) * | 1999-12-30 | 2003-03-12 | Lundbeck & Co As H | Derivados de indol. |
| AR027133A1 (es) * | 1999-12-30 | 2003-03-12 | Lundbeck & Co As H | Derivados de heteroarilo, su preparacion y uso. |
| FR2803298A1 (fr) * | 1999-12-30 | 2001-07-06 | Adir | Nouvelles urees lineaires ou cycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2804429B1 (fr) * | 2000-01-31 | 2003-05-09 | Adir | Nouveaux derives de 4-sulfonamides piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CA2405758A1 (en) * | 2000-05-12 | 2001-11-15 | Solvay Pharmaceuticals B.V. | Use of compounds having combined dopamine d2, 5-ht1a and alpha adrenoreceptor agonistic action for treating cns disorders |
| DE10043659A1 (de) * | 2000-09-05 | 2002-03-14 | Merck Patent Gmbh | Arylpiperazinderivate |
| US6743796B2 (en) | 2001-05-07 | 2004-06-01 | Wyeth | Piperazinyl-isatins |
| ATE424825T1 (de) * | 2001-07-20 | 2009-03-15 | Psychogenics Inc | Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten |
| US7649001B2 (en) | 2002-08-12 | 2010-01-19 | Takeda Pharmaceutical Company Limited | Fused benzene derivative and use |
| JP2006515341A (ja) | 2003-03-03 | 2006-05-25 | エフ．ホフマン−ラ ロシュ アーゲー | ５−ｈｔ６調節物質として使用するための２，５−および２，６−置換テトラヒドロイソキノリン |
| TWI320783B (en) | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
| US8389510B2 (en) * | 2005-11-18 | 2013-03-05 | Astrazeneca Ab | Crystalline forms |
| US20100016284A1 (en) * | 2006-12-20 | 2010-01-21 | Astrazeneca Ab | Compounds and uses thereof - 151 |
| US8367676B2 (en) * | 2009-06-30 | 2013-02-05 | Astrazeneca Ab | 2-carboxamide-7-piperazinyl-benzofuran derivatives 774 |
| US8598235B2 (en) | 2009-12-04 | 2013-12-03 | Jon E. Grant | Treating impulse control disorders with catechol-O-methyl-transferase inhibitors |
| CN106065018B (zh) * | 2015-04-23 | 2020-04-21 | 广东东阳光药业有限公司 | 取代的吲哚化合物及其使用方法和用途 |
| EP3414234B1 (en) * | 2015-10-14 | 2022-06-29 | Zibo Biopolar Changsheng Pharmaceutical Co. Ltd. | Bruton's tyrosine kinase inhibitors |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH511235A (de) * | 1969-07-17 | 1971-08-15 | Ciba Geigy Ag | Verfahren zur Herstellung von 1-Alkyl-3-(2-halogen-äthyl)-2-imidazolidinonen |
| DE2263211A1 (de) * | 1972-12-23 | 1974-07-04 | Boehringer Sohn Ingelheim | Neue arylpiperazine und verfahren zu ihrer herstellung |
| DE2727469A1 (de) * | 1977-06-18 | 1978-12-21 | Hoechst Ag | Neue hexahydropyrimidine, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten |
| US4302592A (en) * | 1980-09-15 | 1981-11-24 | Shell Oil Company | Pesticidal 3-(2,3-dihydrobenzofuran-7-yl)-5-methoxy-1,3,4-oxadiazol-2(3H)-one |
| US4506078A (en) * | 1981-06-05 | 1985-03-19 | Hoffmann-La Roche Inc. | 7-Nitroindoles |
| AU577802B2 (en) * | 1983-10-17 | 1988-10-06 | Duphar International Research B.V. | Blood-pressure lowering piperazine derivatives |
| CA1297877C (en) * | 1983-12-22 | 1992-03-24 | Daniel Lednicer | Benzofurancarboxamides useful as antiemetic or antipsychotic agents |
| JPS6133183A (ja) * | 1984-07-25 | 1986-02-17 | Mitsubishi Chem Ind Ltd | ２，３−ジヒドロ−７−アミノベンゾフランの製造法 |
| EP0190472B1 (en) * | 1984-12-21 | 1989-07-12 | Duphar International Research B.V | New pharmaceutical compositions having anti-psychotic properties |
| ATE81975T1 (de) * | 1984-12-21 | 1992-11-15 | Duphar Int Res | Arzneimittel mit psychotroper wirkung. |
| MX173362B (es) * | 1987-03-02 | 1994-02-23 | Pfizer | Compuestos de piperazinil heterociclicos y procedimiento para su preparacion |
| US4831031A (en) * | 1988-01-22 | 1989-05-16 | Pfizer Inc. | Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity |
| FR2631625B1 (fr) * | 1988-05-17 | 1992-10-16 | Synthelabo | Derives de phenyl-6 piperazinylalkyl-3 1h,3h-pyrimidinedione-2,4, leur preparation et leur application en therapeutique |
| FR2637591B1 (fr) * | 1988-10-11 | 1992-10-23 | Synthelabo | Derives de quinoleinone, leur preparation et leur application en therapeutique |
| DK611489A (da) * | 1988-12-08 | 1990-06-09 | Duphar Int Res | Anxiolytisk aktive piperazinderivater og farmaceutiske praeparater med indhold af saadanne forbindelser |
| GB8830312D0 (en) * | 1988-12-28 | 1989-02-22 | Lundbeck & Co As H | Heterocyclic compounds |
| DK152090D0 (da) * | 1990-06-22 | 1990-06-22 | Lundbaek A S H | Piperidylsubstituerede indolderivater |
| FR2664592B1 (fr) * | 1990-07-10 | 1994-09-02 | Adir | Nouveaux derives de la piperidine, de la tetrahydropyridine et de la pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| DK203990D0 (da) * | 1990-08-24 | 1990-08-24 | Novo Nordisk As | Piperazinylderivater |
| FR2670491B1 (fr) * | 1990-12-14 | 1993-02-05 | Adir | Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
| IT1251144B (it) * | 1991-07-30 | 1995-05-04 | Boehringer Ingelheim Italia | Derivati del benzimidazolone |
-
1992
- 1992-12-09 DK DK921483A patent/DK148392D0/da not_active IP Right Cessation
-
1993
- 1993-12-07 IL IL10792393A patent/IL107923A/en not_active IP Right Cessation
- 1993-12-08 DK DK94900793T patent/DK0673375T3/da active
- 1993-12-08 NZ NZ258117A patent/NZ258117A/en unknown
- 1993-12-08 EP EP94900793A patent/EP0673375B1/en not_active Expired - Lifetime
- 1993-12-08 JP JP6513691A patent/JPH08504410A/ja not_active Withdrawn
- 1993-12-08 HU HU9501668A patent/HUT73632A/hu unknown
- 1993-12-08 SG SG1996008300A patent/SG52722A1/en unknown
- 1993-12-08 DE DE69323630T patent/DE69323630T2/de not_active Expired - Fee Related
- 1993-12-08 WO PCT/DK1993/000414 patent/WO1994013659A1/en active IP Right Grant
- 1993-12-08 AU AU55618/94A patent/AU675263B2/en not_active Ceased
- 1993-12-08 CZ CZ951517A patent/CZ283143B6/cs not_active IP Right Cessation
- 1993-12-08 AT AT94900793T patent/ATE176909T1/de not_active IP Right Cessation
- 1993-12-08 RU RU95117096A patent/RU2141959C1/ru not_active IP Right Cessation
- 1993-12-08 KR KR1019950702356A patent/KR100299624B1/ko not_active Expired - Fee Related
- 1993-12-08 CA CA002151378A patent/CA2151378A1/en not_active Abandoned
- 1993-12-08 SK SK761-95A patent/SK280779B6/sk unknown
- 1993-12-08 ES ES94900793T patent/ES2127912T3/es not_active Expired - Lifetime
- 1993-12-08 ZA ZA939203A patent/ZA939203B/xx unknown
- 1993-12-09 MX MX9307779A patent/MX9307779A/es not_active IP Right Cessation
-
1995
- 1995-06-06 US US08/504,846 patent/US5753661A/en not_active Expired - Fee Related
- 1995-06-08 NO NO19952275A patent/NO311617B1/no not_active IP Right Cessation
- 1995-06-08 FI FI952824A patent/FI109697B/fi not_active IP Right Cessation
-
1997
- 1997-12-24 US US08/998,245 patent/US6140331A/en not_active Expired - Fee Related
-
1999
- 1999-05-13 GR GR990401285T patent/GR3030200T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired |