HUP0100760A2 - 2-Aril-etil-(piperidin-4-il-metil)-amin-származékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyászati készítmények - Google Patents

2-Aril-etil-(piperidin-4-il-metil)-amin-származékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyászati készítmények

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Publication number
HUP0100760A2
HUP0100760A2 HU0100760A HUP0100760A HUP0100760A2 HU P0100760 A2 HUP0100760 A2 HU P0100760A2 HU 0100760 A HU0100760 A HU 0100760A HU P0100760 A HUP0100760 A HU P0100760A HU P0100760 A2 HUP0100760 A2 HU P0100760A2
Authority
HU
Hungary
Prior art keywords
group
alkyl
arylethyl
piperidin
ylmethyl
Prior art date
Application number
HU0100760A
Other languages
English (en)
Inventor
Joan Marie Caroon
Robin Douglas Clark
Michael Patrick Dillon
Ralph New Harris III.
Sharathchandra Surendra Hegde
Clara Jeou Jen Lin
Hans Maag
David Bruce Repke
Original Assignee
F.Hoffmann-La Roche Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag. filed Critical F.Hoffmann-La Roche Ag.
Publication of HUP0100760A2 publication Critical patent/HUP0100760A2/hu
Publication of HUP0100760A3 publication Critical patent/HUP0100760A3/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/08—Mydriatics or cycloplegics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

Az (I) általános képletű vegyületek (mely képletben R1 jelentésehidrogénatom, alkil-, alkoxicsoport, halogénatom, halogén-alkil- vagyaminocsoport; R2 jelentése alkilcsoport; alkoxicsoport; halogénatom;halogén-alkil-csoport; nitrocsoport; adott esetben oxocsoporttalhelyettesített heterociklikus csoport; -O (CH2)PX, -NR7R8, -NR6COR9, -NR6CONR7R8, -NR6CSR9, -NR6CSNR7R8, -NR6SO2R9, -NR6SO2NR7R8, -SR9, -SOR9, -SO2R9, -SO2NR7R8; vagy R1 és R2 a gyűrűvel együtt, amelyhezkapcsolódnak, 5- vagy 6-tagú monociklikus telített vagy telítetlengyűrűt képeznek, amely adott esetben 0, 1 vagy 2 nitrogén-, oxigén-és/vagy kénatomot tartalmazhat; R3 és R4 jelentése egymástólfüggetlenül kis szénatomszámú alkil-, alkenil- vagy cikloalkilcsoport;R5 jelentése hidrogénatom, COR9, -COOR7, -CONR7R8, -CO ( CH2 ) nCOR9,-CO ( CH2 ) nSO2R9, -CO (CH2) nCONR7R8, -CO (CH2) nSO2NR7R8, -CO ( CH2) nNR6COR9, -CO ( CH2 ) nNR6SO2R9, -CO ( CH2 ) nNR6CONR7R8, -CO (CH2)nNR6SO2NR7R8, -CSR9, -CSNR7R8, -SO2R9, -SO2NR7R8, -SO2 ( CH2 ) nNR6SO2R9, vagy -SO2NR6 ( CH2 ) nCOOR7 és gyógyászatilag alkalmas sóik a gyógyászatbana muszkarin receptorral kapcsolatos betegségek kezelésérealkalmazhatók. Ó
HU0100760A 1998-02-27 1999-02-19 2-arylethyl-(piperidin-4-ylmethyl)amine derivatives, process for producing them and pharmaceutical compositions containing them HUP0100760A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7611398P 1998-02-27 1998-02-27
US10909798P 1998-11-19 1998-11-19
PCT/EP1999/001102 WO1999043657A1 (en) 1998-02-27 1999-02-19 2-arylethyl-(piperidin-4-ylmethyl)amine derivatives as muscarinic receptor antagonists

Publications (2)

Publication Number Publication Date
HUP0100760A2 true HUP0100760A2 (hu) 2001-08-28
HUP0100760A3 HUP0100760A3 (en) 2002-12-28

Family

ID=26757679

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0100760A HUP0100760A3 (en) 1998-02-27 1999-02-19 2-arylethyl-(piperidin-4-ylmethyl)amine derivatives, process for producing them and pharmaceutical compositions containing them

Country Status (27)

Country Link
US (1) US6319920B1 (hu)
EP (1) EP1058680B1 (hu)
JP (1) JP3523198B2 (hu)
KR (1) KR100384906B1 (hu)
CN (1) CN1143848C (hu)
AR (1) AR015523A1 (hu)
AT (1) ATE400554T1 (hu)
AU (1) AU753255B2 (hu)
BR (1) BR9909253A (hu)
CA (1) CA2321198C (hu)
CO (1) CO4990939A1 (hu)
DE (1) DE69939053D1 (hu)
ES (1) ES2310032T3 (hu)
HK (1) HK1036623A1 (hu)
HR (1) HRP20000544A2 (hu)
HU (1) HUP0100760A3 (hu)
IL (1) IL137936A0 (hu)
MA (1) MA26610A1 (hu)
MY (1) MY133445A (hu)
NO (1) NO317106B1 (hu)
NZ (1) NZ506317A (hu)
PE (1) PE20000325A1 (hu)
PL (1) PL194037B1 (hu)
RU (1) RU2220138C2 (hu)
TR (1) TR200002481T2 (hu)
WO (1) WO1999043657A1 (hu)
YU (1) YU53100A (hu)

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Publication number Priority date Publication date Assignee Title
AU7687998A (en) * 1997-05-19 1998-12-11 Sugen, Inc. Heteroarylcarboxamide compounds active against protein tyrosine kinase related disorders
ATE280162T1 (de) 2000-05-25 2004-11-15 Hoffmann La Roche Substituierte 1-aminoalkyl-lactame und ihre verwendung als muscarinrezeptor antagonisten
HUP0302010A2 (hu) 2000-05-25 2003-09-29 F.Hoffmann-La Roche Ag. Helyettesített 1-aminoalkil-laktámok, és felhasználásuk mint muszkarin receptor antagonisták, a vegyületek elżállítása és az ezeket tartalmazó gyógyszerkészítmények
CA2469055C (en) * 2001-12-03 2011-03-29 F. Hoffmann-La Roche Ag Aminotetralin derivatives as muscarinic receptor antagonists
PL370765A1 (en) 2001-12-03 2005-05-30 F.Hoffmann-La Roche Ag 4-piperidinyl alkylamine derivatives as muscarinic receptor antagonists
RU2004135563A (ru) * 2002-06-07 2005-06-10 Яманоути Фармасьютикал Ко.,Лтд. (Jp) Лекарственное средство для лечения повышенной активности мочевого пузыря
WO2004004629A2 (en) 2002-07-08 2004-01-15 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
TWI295669B (en) * 2002-10-30 2008-04-11 Theravance Inc Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds
CN100364990C (zh) * 2002-10-30 2008-01-30 施万制药 取代的4-氨基-1-(吡啶甲基)哌啶和相关化合物
EP1424079A1 (en) * 2002-11-27 2004-06-02 Boehringer Ingelheim International GmbH Combination of a beta-3-receptor agonist and of a reuptake inhibitor of serotonin and/or norepinephrine
WO2004058168A2 (en) * 2002-12-20 2004-07-15 Dynogen Pharmaceuticals, Inc. METHODS OF TREATING NON-PAINFUL BLADDER DISORDERS USING α2δ SUBUNIT CALCIUM CHANNEL MODULATORS
BRPI0408608A (pt) * 2003-03-21 2006-03-07 Dynogen Pharmaceuticals Inc uso de moduladores da subunidade (alfa)2(delta) de canal de cálcio e moduladores de músculo liso para tratamento de sintoma de um distúrbio do trato urinário inferior
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US7368463B2 (en) * 2003-07-11 2008-05-06 Theravance, Inc. Substituted 4-amino-1-benzylpiperidine compounds
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DE102007020492A1 (de) * 2007-04-30 2008-11-06 Grünenthal GmbH Substituierte Sulfonamid-Derivate
EP3170807B1 (en) * 2015-11-23 2019-12-11 Frau Pharma S.r.l. New method for synthesis of fenfluramine
SI25272A (sl) 2016-09-23 2018-03-30 Univerza V Ljubljani Disubstituirani azetidini, pirolidini, piperidini in azepani kot zaviralci monoamin oksidaze B za zdravljenje nevrodegenerativnih bolezni
CN112824378A (zh) * 2019-11-20 2021-05-21 珠海润都制药股份有限公司 一种盐酸坦索罗辛的制备方法

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Also Published As

Publication number Publication date
NO317106B1 (no) 2004-08-09
CA2321198C (en) 2009-11-17
EP1058680A1 (en) 2000-12-13
YU53100A (sh) 2003-04-30
CA2321198A1 (en) 1999-09-02
NO20004261D0 (no) 2000-08-25
AU2835399A (en) 1999-09-15
CN1143848C (zh) 2004-03-31
MA26610A1 (fr) 2004-12-20
NZ506317A (en) 2003-08-29
NO20004261L (no) 2000-08-25
US6319920B1 (en) 2001-11-20
IL137936A0 (en) 2001-10-31
TR200002481T2 (tr) 2000-11-21
MY133445A (en) 2007-11-30
BR9909253A (pt) 2000-11-28
ATE400554T1 (de) 2008-07-15
CN1295563A (zh) 2001-05-16
PL194037B1 (pl) 2007-04-30
ES2310032T3 (es) 2008-12-16
CO4990939A1 (es) 2000-12-26
AR015523A1 (es) 2001-05-02
EP1058680B1 (en) 2008-07-09
HRP20000544A2 (en) 2001-02-28
HUP0100760A3 (en) 2002-12-28
WO1999043657A1 (en) 1999-09-02
RU2220138C2 (ru) 2003-12-27
HK1036623A1 (en) 2002-01-11
KR100384906B1 (ko) 2003-05-23
JP2002504543A (ja) 2002-02-12
KR20010041321A (ko) 2001-05-15
JP3523198B2 (ja) 2004-04-26
PL342692A1 (en) 2001-07-02
AU753255B2 (en) 2002-10-10
DE69939053D1 (de) 2008-08-21
PE20000325A1 (es) 2000-05-08

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