NO941516L - 3-kinolylsubstituerte dihydropyridiner, fremgangsmåter for deres fremstilling og deres anvendelse - Google Patents
3-kinolylsubstituerte dihydropyridiner, fremgangsmåter for deres fremstilling og deres anvendelseInfo
- Publication number
- NO941516L NO941516L NO941516A NO941516A NO941516L NO 941516 L NO941516 L NO 941516L NO 941516 A NO941516 A NO 941516A NO 941516 A NO941516 A NO 941516A NO 941516 L NO941516 L NO 941516L
- Authority
- NO
- Norway
- Prior art keywords
- substituted
- carbon atoms
- cyano
- branched
- quinolyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Det er beskrevet nye 3-kinolylsubstituerte dihydropyri- diner med generell formel (I) N (I), hvori R1 og R4 er like eller forskjellige og kan ha flere betydninger, blant annet stå for hydrogen, amlno, cyano, formyl, trlfluormetyl eller for rettkjedet eller forgrenet alkyl med Inntil 8 karbonatomer som eventuelt er substituert, R2 står for en gruppe med formelen -CO- NRUR12 eller -CO-A-R13, hvori R11 og R12 er like eller forskjellige og kan ha flere betydninger, olant annet stå for hydrogen, en rettkjedet, forgrenet eller cykllsk, mettet eller umettet hydrokarbonrest med Inntil 8 karbonatomer som eventuelt er substituert, f.eks. med halogen, hydroksy, cyano eller med aryl eller aryloksy, R3 står for cyano, formyl eller nltro eller R3 og R4 danner sammen en rest med formelen O hvori E betyr et oksygen- eller svovelatom eller -CH2- gruppen, og R5 kan ha flere betydninger og blant annet bety en cykllsk, rettkjedet eller forgrenet, mettet eller umettet hydrokarbonrest med Inntil 12 kar- bonatomer, som eventuelt er avbrutt med oksygen eller svovel og som eventuelt kan være substituert, under den forutsetningen at R5 Ikke kan stå for eventuelt halogensubstituert pyrldyl eller tlenyl. Det er videre angitt fremgangsmåter for fremstilling av forbindelsene og deres anvendelse i legemidler er beskrevet, spesielt l midler for behandling av hjerte-kretsløpssykdommer.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4313692A DE4313692A1 (de) | 1993-04-27 | 1993-04-27 | 3-Chinolyl substituierte Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln |
Publications (2)
Publication Number | Publication Date |
---|---|
NO941516D0 NO941516D0 (no) | 1994-04-26 |
NO941516L true NO941516L (no) | 1994-10-28 |
Family
ID=6486451
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO941516A NO941516L (no) | 1993-04-27 | 1994-04-26 | 3-kinolylsubstituerte dihydropyridiner, fremgangsmåter for deres fremstilling og deres anvendelse |
Country Status (15)
Country | Link |
---|---|
US (3) | US5504210A (no) |
EP (1) | EP0627427A1 (no) |
JP (1) | JPH06329667A (no) |
CN (1) | CN1100419A (no) |
AU (1) | AU675693B2 (no) |
CA (1) | CA2121971A1 (no) |
CZ (1) | CZ99994A3 (no) |
DE (1) | DE4313692A1 (no) |
FI (1) | FI941912A (no) |
HU (1) | HUT70486A (no) |
IL (1) | IL109438A0 (no) |
NO (1) | NO941516L (no) |
NZ (1) | NZ260384A (no) |
RU (1) | RU94014631A (no) |
SK (1) | SK47694A3 (no) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4313697A1 (de) * | 1993-04-27 | 1994-11-03 | Bayer Ag | Chinolyl-dihydropyridinester, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln |
WO1996014846A1 (en) * | 1994-11-16 | 1996-05-23 | Synaptic Pharmaceutical Corporation | Dihydropyrimidines and uses thereof |
US6268369B1 (en) | 1994-11-16 | 2001-07-31 | Synaptic Pharmaceutical Corporation | 5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines |
US6228861B1 (en) | 1995-11-16 | 2001-05-08 | Synaptic Pharmaceutical Corporation | Dihydropyrimidines and uses thereof |
US6172066B1 (en) | 1996-05-16 | 2001-01-09 | Synaptic Pharmaceutical Corporation | Dihydropyrimidines and uses thereof |
US6245773B1 (en) | 1996-05-16 | 2001-06-12 | Synaptic Pharmaceutical Corporation | 5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines |
US6680323B2 (en) | 1998-12-23 | 2004-01-20 | Synaptic Pharmaceutical Corporation | Dihydropyrimidines and uses thereof |
US6274585B1 (en) | 1998-12-23 | 2001-08-14 | Synaptic Pharmaceutical Corporation | Dihydropyrimidines and uses thereof |
US6720324B2 (en) | 2000-07-05 | 2004-04-13 | Synaptic Pharmaceutical Corporation | Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof |
WO2005025507A2 (en) * | 2003-09-10 | 2005-03-24 | Synta Phamaceuticals Corp. | Dihydropyridine compounds for treating or preventing metabolic disorders |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1552911A (en) * | 1975-07-02 | 1979-09-19 | Fujisawa Pharmaceutical Co | 1,4 dihydropyridine derivatives and the preparation thereof |
DE2752820A1 (de) * | 1977-11-26 | 1979-05-31 | Bayer Ag | Neue nitrosubstituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
NZ201395A (en) * | 1981-07-30 | 1987-02-20 | Bayer Ag | Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines |
DE4011105A1 (de) * | 1990-04-06 | 1991-10-10 | Bayer Ag | Neue 4-chinolyl-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
US5204472A (en) * | 1990-04-06 | 1993-04-20 | Bayer Aktiengesellschaft | Quinoline and isoquinoline intermediates |
DE4011695A1 (de) * | 1990-04-11 | 1991-10-17 | Bayer Ag | Verwendung von n-alkylierten 1,4-dihydropyridindicarbonsaeureestern als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung |
DE4117750A1 (de) * | 1991-05-30 | 1992-12-24 | Bayer Ag | Neue 2-amino-5-cyano-1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
DE4118707A1 (de) * | 1991-06-07 | 1992-12-10 | Bayer Ag | Pharmazeutische verwendung von 3-formyl-1,4-dihydropyridinen, neue verbindungen und verfahren zu ihrer herstellung |
DE4134760A1 (de) * | 1991-10-22 | 1993-07-08 | Bayer Ag | Aryl-chinolyl-substituierte 1,4-dihydropyridin-dicarbonsaeurederivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
-
1993
- 1993-04-27 DE DE4313692A patent/DE4313692A1/de not_active Withdrawn
-
1994
- 1994-03-31 AU AU59220/94A patent/AU675693B2/en not_active Ceased
- 1994-04-14 EP EP94105773A patent/EP0627427A1/de not_active Withdrawn
- 1994-04-20 US US08/230,286 patent/US5504210A/en not_active Expired - Fee Related
- 1994-04-22 NZ NZ260384A patent/NZ260384A/en unknown
- 1994-04-22 CA CA002121971A patent/CA2121971A1/en not_active Abandoned
- 1994-04-25 FI FI941912A patent/FI941912A/fi unknown
- 1994-04-26 NO NO941516A patent/NO941516L/no unknown
- 1994-04-26 JP JP6110546A patent/JPH06329667A/ja active Pending
- 1994-04-26 CZ CZ94999A patent/CZ99994A3/cs unknown
- 1994-04-26 RU RU94014631/04A patent/RU94014631A/ru unknown
- 1994-04-26 HU HU9401188A patent/HUT70486A/hu unknown
- 1994-04-26 IL IL10943894A patent/IL109438A0/xx unknown
- 1994-04-26 SK SK476-94A patent/SK47694A3/sk unknown
- 1994-04-27 CN CN94104689A patent/CN1100419A/zh active Pending
-
1995
- 1995-05-25 US US08/448,930 patent/US5629320A/en not_active Expired - Fee Related
- 1995-05-25 US US08/450,461 patent/US5550245A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
FI941912A (fi) | 1994-10-28 |
CZ99994A3 (en) | 1994-11-16 |
HU9401188D0 (en) | 1994-07-28 |
NZ260384A (en) | 1996-03-26 |
NO941516D0 (no) | 1994-04-26 |
CN1100419A (zh) | 1995-03-22 |
RU94014631A (ru) | 1997-02-20 |
US5550245A (en) | 1996-08-27 |
EP0627427A1 (de) | 1994-12-07 |
FI941912A0 (fi) | 1994-04-25 |
DE4313692A1 (de) | 1994-11-03 |
CA2121971A1 (en) | 1994-10-28 |
HUT70486A (en) | 1995-10-30 |
US5629320A (en) | 1997-05-13 |
IL109438A0 (en) | 1994-07-31 |
SK47694A3 (en) | 1995-02-08 |
AU5922094A (en) | 1994-11-03 |
US5504210A (en) | 1996-04-02 |
JPH06329667A (ja) | 1994-11-29 |
AU675693B2 (en) | 1997-02-13 |
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