DK148392D0 - Heterocykliske forbindelser - Google Patents

Heterocykliske forbindelser

Info

Publication number
DK148392D0
DK148392D0 DK921483A DK148392A DK148392D0 DK 148392 D0 DK148392 D0 DK 148392D0 DK 921483 A DK921483 A DK 921483A DK 148392 A DK148392 A DK 148392A DK 148392 D0 DK148392 D0 DK 148392D0
Authority
DK
Denmark
Prior art keywords
hydrogen
group
compounds
divalent
substituents
Prior art date
Application number
DK921483A
Other languages
Danish (da)
English (en)
Inventor
Ejner K Moltzen
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Priority to DK921483A priority Critical patent/DK148392D0/da
Publication of DK148392D0 publication Critical patent/DK148392D0/da
Priority to IL10792393A priority patent/IL107923A/en
Priority to KR1019950702356A priority patent/KR100299624B1/ko
Priority to PCT/DK1993/000414 priority patent/WO1994013659A1/en
Priority to AT94900793T priority patent/ATE176909T1/de
Priority to RU95117096A priority patent/RU2141959C1/ru
Priority to DK94900793T priority patent/DK0673375T3/da
Priority to HU9501668A priority patent/HUT73632A/hu
Priority to JP6513691A priority patent/JPH08504410A/ja
Priority to DE69323630T priority patent/DE69323630T2/de
Priority to SK761-95A priority patent/SK280779B6/sk
Priority to EP94900793A priority patent/EP0673375B1/en
Priority to AU55618/94A priority patent/AU675263B2/en
Priority to ZA939203A priority patent/ZA939203B/xx
Priority to CZ951517A priority patent/CZ283143B6/cs
Priority to NZ258117A priority patent/NZ258117A/en
Priority to SG1996008300A priority patent/SG52722A1/en
Priority to ES94900793T priority patent/ES2127912T3/es
Priority to CA002151378A priority patent/CA2151378A1/en
Priority to MX9307779A priority patent/MX9307779A/es
Priority to US08/504,846 priority patent/US5753661A/en
Priority to NO19952275A priority patent/NO311617B1/no
Priority to FI952824A priority patent/FI109697B/fi
Priority to US08/998,245 priority patent/US6140331A/en
Priority to GR990401285T priority patent/GR3030200T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C07D233/36—One oxygen atom with hydrocarbon radicals, substituted by nitrogen atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Lubricants (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK921483A 1992-12-09 1992-12-09 Heterocykliske forbindelser DK148392D0 (da)

Priority Applications (25)

Application Number Priority Date Filing Date Title
DK921483A DK148392D0 (da) 1992-12-09 1992-12-09 Heterocykliske forbindelser
IL10792393A IL107923A (en) 1992-12-09 1993-12-07 Fused benzo compounds and pharmaceutical compositions comprising them
CA002151378A CA2151378A1 (en) 1992-12-09 1993-12-08 1,4-disubstituted 4-fused phenyl piperidines and piperazines as high-affinity ligands for 5h-t1a receptor
SK761-95A SK280779B6 (sk) 1992-12-09 1993-12-08 Kondenzované benzozlúčeniny, farmaceutický príprav
ZA939203A ZA939203B (en) 1992-12-09 1993-12-08 Fused benzo compounds
AT94900793T ATE176909T1 (de) 1992-12-09 1993-12-08 Benzokondensierte verbindungen
RU95117096A RU2141959C1 (ru) 1992-12-09 1993-12-08 Конденсированное бензосоединение и фармацевтическая композиция
DK94900793T DK0673375T3 (da) 1992-12-09 1993-12-08 Kondenserede benzoforbindelser
HU9501668A HUT73632A (en) 1992-12-09 1993-12-08 Fused benzo compounds and pharmaceutical compositions containing them
JP6513691A JPH08504410A (ja) 1992-12-09 1993-12-08 融合されたベンゾ化合物
DE69323630T DE69323630T2 (de) 1992-12-09 1993-12-08 Benzokondensierte verbindungen
KR1019950702356A KR100299624B1 (ko) 1992-12-09 1993-12-08 축합벤조화합물
EP94900793A EP0673375B1 (en) 1992-12-09 1993-12-08 Fused benzo compounds
AU55618/94A AU675263B2 (en) 1992-12-09 1993-12-08 Fused benzo compounds
PCT/DK1993/000414 WO1994013659A1 (en) 1992-12-09 1993-12-08 Fused benzo compounds
CZ951517A CZ283143B6 (cs) 1992-12-09 1993-12-08 Kondenzované benzoderiváty, jejich použití a farmaceutické prostředky a jejich obsahem
NZ258117A NZ258117A (en) 1992-12-09 1993-12-08 4-benzofused carbo (and hetero) cyclic substituted piperidine and piperazine derivatives and medicaments
SG1996008300A SG52722A1 (en) 1992-12-09 1993-12-08 Fused benzo compounds
ES94900793T ES2127912T3 (es) 1992-12-09 1993-12-08 Benzoderivados condensados.
MX9307779A MX9307779A (es) 1992-12-09 1993-12-09 Compuestos benzoicos fundidos.
US08/504,846 US5753661A (en) 1992-12-09 1995-06-06 Fused benzo compounds containing a nitrogen heterocycle for the treatment of central nervous system disorders
NO19952275A NO311617B1 (no) 1992-12-09 1995-06-08 Kondenserte benzoforbindelser
FI952824A FI109697B (fi) 1992-12-09 1995-06-08 Menetelmä uusien terapeuttisesti käyttökelpoisten fuusioituneiden bentsojohdannaisten valmistamiseksi
US08/998,245 US6140331A (en) 1992-12-09 1997-12-24 Fused benzo compounds for the treatment of central nervous system disorders
GR990401285T GR3030200T3 (en) 1992-12-09 1999-05-13 Fused benzo compounds.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK921483A DK148392D0 (da) 1992-12-09 1992-12-09 Heterocykliske forbindelser

Publications (1)

Publication Number Publication Date
DK148392D0 true DK148392D0 (da) 1992-12-09

Family

ID=8105314

Family Applications (2)

Application Number Title Priority Date Filing Date
DK921483A DK148392D0 (da) 1992-12-09 1992-12-09 Heterocykliske forbindelser
DK94900793T DK0673375T3 (da) 1992-12-09 1993-12-08 Kondenserede benzoforbindelser

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK94900793T DK0673375T3 (da) 1992-12-09 1993-12-08 Kondenserede benzoforbindelser

Country Status (23)

Country Link
US (2) US5753661A (cs)
EP (1) EP0673375B1 (cs)
JP (1) JPH08504410A (cs)
KR (1) KR100299624B1 (cs)
AT (1) ATE176909T1 (cs)
AU (1) AU675263B2 (cs)
CA (1) CA2151378A1 (cs)
CZ (1) CZ283143B6 (cs)
DE (1) DE69323630T2 (cs)
DK (2) DK148392D0 (cs)
ES (1) ES2127912T3 (cs)
FI (1) FI109697B (cs)
GR (1) GR3030200T3 (cs)
HU (1) HUT73632A (cs)
IL (1) IL107923A (cs)
MX (1) MX9307779A (cs)
NO (1) NO311617B1 (cs)
NZ (1) NZ258117A (cs)
RU (1) RU2141959C1 (cs)
SG (1) SG52722A1 (cs)
SK (1) SK280779B6 (cs)
WO (1) WO1994013659A1 (cs)
ZA (1) ZA939203B (cs)

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FR2723091B1 (fr) * 1994-07-29 1996-11-08 Esteve Labor Dr Tetrahydropyridine-(6,4-hydroxypiperidine) alkylazoles
ES2117934B1 (es) * 1994-07-29 1999-04-01 Esteve Labor Dr Tetrahidropiridinas (0 4-hidroxipiperidinas) alquilazoles.
FR2735127B1 (fr) * 1995-06-09 1997-08-22 Pf Medicament Nouvelles piperazines heteroaromatiques utiles comme medicaments.
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ATE340173T1 (de) 1996-03-29 2006-10-15 Duphar Int Res Piperazin- und piperidin- derivate
FR2757161B1 (fr) * 1996-12-13 1999-03-12 Sanofi Sa Diphenylalkyl-tetrahydropyridines
GB9706222D0 (en) * 1997-03-26 1997-05-14 Zeneca Ltd Bicyclic amine derivatives
US6034256A (en) 1997-04-21 2000-03-07 G.D. Searle & Co. Substituted benzopyran derivatives for the treatment of inflammation
US6077850A (en) * 1997-04-21 2000-06-20 G.D. Searle & Co. Substituted benzopyran analogs for the treatment of inflammation
SE9900190D0 (sv) 1999-01-22 1999-01-22 Astra Ab New compounds
SE9702799D0 (sv) 1997-07-25 1997-07-25 Astra Ab New compounds
DE69819266T2 (de) 1997-09-02 2004-07-29 Duphar International Research B.V. Piperidin- und Piperazin Derivate als 5-HT1-Rezeptor-Agonisten
EP0900792B1 (en) * 1997-09-02 2003-10-29 Duphar International Research B.V Piperazine and piperidine derivatives as 5-HT1A and dopamine D2-receptor (ant)agonists
EP1146045A1 (en) * 1998-06-30 2001-10-17 Eli Lilly And Company Piperidine derivatives having effects on serotonin related systems
ES2181366T3 (es) * 1998-06-30 2003-02-16 Lilly Co Eli Derivados de piperidina que tienen efectos sobre sistemas relacionados con serotonina.
UA71590C2 (en) 1998-11-13 2004-12-15 Duphar Int Res Piperazine and piperidine derivatives
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WO2001000620A2 (en) * 1999-06-29 2001-01-04 Eli Lilly And Company Preparation of 7-substituted benzothiophenes
AR027134A1 (es) * 1999-12-30 2003-03-12 Lundbeck & Co As H Derivados de indol.
FR2803298A1 (fr) * 1999-12-30 2001-07-06 Adir Nouvelles urees lineaires ou cycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AR027133A1 (es) * 1999-12-30 2003-03-12 Lundbeck & Co As H Derivados de heteroarilo, su preparacion y uso.
FR2804429B1 (fr) * 2000-01-31 2003-05-09 Adir Nouveaux derives de 4-sulfonamides piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP2003532676A (ja) * 2000-05-12 2003-11-05 ソルベイ・フアーマシユーチカルズ・ベー・ブイ ＣＮＳ障害を治療するための組合せられたドーパミンＤ２、５−ＨＴ１Ａおよびαアドレノレセプターアゴニスト作用、を有する化合物の使用
DE10043659A1 (de) * 2000-09-05 2002-03-14 Merck Patent Gmbh Arylpiperazinderivate
US6743796B2 (en) 2001-05-07 2004-06-01 Wyeth Piperazinyl-isatins
EP1408976B3 (en) 2001-07-20 2010-08-25 Psychogenics Inc. Treatment for attention-deficit hyperactivity disorder
BR0313405A (pt) 2002-08-12 2005-07-12 Takeda Pharmaceutical Compostos, métodos para preparar um composto e para prevenir e/ou tratar câncer, prodroga, medicamento, modulador do receptor de androgênio, agente para prevenir e/ou tratar hipogonadismo ou pertubação climatérica masculina, osteoporose e câncer, e, uso de um composto
DE602004010791T2 (de) 2003-03-03 2008-12-04 F. Hoffmann-La Roche Ag 2,5-substituiertetetrahydroisochinoline zur verwendung als 5-ht6 modulatoren
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
US8389510B2 (en) * 2005-11-18 2013-03-05 Astrazeneca Ab Crystalline forms
US20100016284A1 (en) * 2006-12-20 2010-01-21 Astrazeneca Ab Compounds and uses thereof - 151
US8367676B2 (en) * 2009-06-30 2013-02-05 Astrazeneca Ab 2-carboxamide-7-piperazinyl-benzofuran derivatives 774
KR20120092175A (ko) 2009-12-04 2012-08-20 죤 이. 그랜트 카테콜-0-메틸-트랜스퍼라제 저해제를 사용한 충동 제어 장애의 치료
CN106065018B (zh) * 2015-04-23 2020-04-21 广东东阳光药业有限公司 取代的吲哚化合物及其使用方法和用途
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Also Published As

Publication number Publication date
NO952275L (no) 1995-08-03
US6140331A (en) 2000-10-31
AU5561894A (en) 1994-07-04
SK76195A3 (en) 1995-11-08
IL107923A0 (en) 1994-04-12
GR3030200T3 (en) 1999-08-31
RU95117096A (ru) 1997-06-10
KR950704294A (ko) 1995-11-17
FI952824A7 (fi) 1995-06-08
ES2127912T3 (es) 1999-05-01
HUT73632A (en) 1996-08-28
EP0673375B1 (en) 1999-02-24
NO311617B1 (no) 2001-12-17
SG52722A1 (en) 1998-09-28
DE69323630D1 (de) 1999-04-01
IL107923A (en) 1999-08-17
CA2151378A1 (en) 1994-06-23
JPH08504410A (ja) 1996-05-14
AU675263B2 (en) 1997-01-30
DE69323630T2 (de) 1999-10-14
CZ151795A3 (en) 1996-01-17
CZ283143B6 (cs) 1998-01-14
EP0673375A1 (en) 1995-09-27
ZA939203B (en) 1994-08-08
HU9501668D0 (en) 1995-08-28
KR100299624B1 (ko) 2001-11-05
SK280779B6 (sk) 2000-07-11
NZ258117A (en) 1996-08-27
MX9307779A (es) 1994-06-30
ATE176909T1 (de) 1999-03-15
US5753661A (en) 1998-05-19
FI109697B (fi) 2002-09-30
FI952824A0 (fi) 1995-06-08
WO1994013659A1 (en) 1994-06-23
RU2141959C1 (ru) 1999-11-27
NO952275D0 (no) 1995-06-08
DK0673375T3 (da) 1999-10-04

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