ES8800897A1 - Un procedimiento para preparar el compuesto 3(s)-3-amino-2-oxo-4,4-dimetil-1-azetidinilsulfato - Google Patents

Un procedimiento para preparar el compuesto 3(s)-3-amino-2-oxo-4,4-dimetil-1-azetidinilsulfato

Info

Publication number
ES8800897A1
ES8800897A1 ES557056A ES557056A ES8800897A1 ES 8800897 A1 ES8800897 A1 ES 8800897A1 ES 557056 A ES557056 A ES 557056A ES 557056 A ES557056 A ES 557056A ES 8800897 A1 ES8800897 A1 ES 8800897A1
Authority
ES
Spain
Prior art keywords
amino
oxoethylidene
azetidinyl
thiazolyl
oxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557056A
Other languages
English (en)
Other versions
ES557056A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of ES8800897A1 publication Critical patent/ES8800897A1/es
Publication of ES557056A0 publication Critical patent/ES557056A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • C07D213/18—Salts thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS (3S)-3-AMINO-2-OXO-4,4-DIMETIL-1-AZETIDINILSULFATO, DE FORMULA GENERAL (I), Y SUS SALES BASICAS FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN SULFONAR UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE A ES UN GRUPO PROTECTOR DE AMINO QUE ES POSTERIORMENTE ELIMINADO. LA REACCION DE SULFONACION SE LLEVA A CABO PREFERENTEMENTE MEDIANTE EL EMPLEO, COMO AGENTE DE SULFONACION, UN COMPLEJO DE PIRIDINA-TIOXIDO DE AZUFRE DE PIRIDINA COMO DISOLVENTE. DE APLICACION COMO MEDICAMENTO PARA COMBATIR INFECCIONES POR BACTERIAS GRAM-NEGATIVAS EN ESPECIES MAMIFERAS, TALES COMO ANIMALES DOMESTICOS Y SERES HUMANOS.
ES557056A 1985-01-28 1986-09-09 Un procedimiento para preparar el compuesto 3(s)-3-amino-2-oxo-4,4-dimetil-1-azetidinilsulfato Expired ES8800897A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/695,775 US4638061A (en) 1985-01-28 1985-01-28 [3S(Z)]-2-[[[1-(2-amino-4-thiazolyl)-2-[[2,2-dimethyl-4-oxo-1-(sulfooxy)-3-azetidinyl]amino]-2-oxoethylidene]-amino]oxy] acetic acid and intermediate

Publications (2)

Publication Number Publication Date
ES8800897A1 true ES8800897A1 (es) 1987-12-01
ES557056A0 ES557056A0 (es) 1987-12-01

Family

ID=24794413

Family Applications (3)

Application Number Title Priority Date Filing Date
ES551252A Expired ES8706112A1 (es) 1985-01-28 1986-01-27 Un procedimiento para preparar derivados de 4 4-dialquil- -2-azetidinomas
ES557056A Expired ES8800897A1 (es) 1985-01-28 1986-09-09 Un procedimiento para preparar el compuesto 3(s)-3-amino-2-oxo-4,4-dimetil-1-azetidinilsulfato
ES557057A Expired ES8801917A1 (es) 1985-01-28 1986-09-09 Un procedimiento para preparar el compuesto acido (3s(z))7-2-(1-(2-amino-4-tiazolil)-2-(2,2-dimetil-4-oxo-1(sulfooxi)-3-azetidinil)amino)-2-oxoetiliden)amino)oxi)acetico

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES551252A Expired ES8706112A1 (es) 1985-01-28 1986-01-27 Un procedimiento para preparar derivados de 4 4-dialquil- -2-azetidinomas

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES557057A Expired ES8801917A1 (es) 1985-01-28 1986-09-09 Un procedimiento para preparar el compuesto acido (3s(z))7-2-(1-(2-amino-4-tiazolil)-2-(2,2-dimetil-4-oxo-1(sulfooxi)-3-azetidinil)amino)-2-oxoetiliden)amino)oxi)acetico

Country Status (35)

Country Link
US (1) US4638061A (es)
JP (2) JPH0780840B2 (es)
KR (1) KR900000675B1 (es)
CN (1) CN1014894B (es)
AR (1) AR242024A1 (es)
AT (1) AT389511B (es)
AU (1) AU588017B2 (es)
BE (1) BE904121A (es)
CA (2) CA1283924C (es)
CH (3) CH670825A5 (es)
CS (1) CS253740B2 (es)
DD (3) DD241600A5 (es)
DE (1) DE3602347A1 (es)
DK (1) DK39486A (es)
EG (1) EG17682A (es)
ES (3) ES8706112A1 (es)
FI (1) FI85022C (es)
FR (1) FR2576596B1 (es)
GB (2) GB2170201B (es)
GR (1) GR860239B (es)
HU (1) HU196367B (es)
IE (2) IE930750L (es)
IL (1) IL77661A (es)
IT (1) IT1190604B (es)
LU (1) LU86262A1 (es)
NL (1) NL8600136A (es)
NO (1) NO170014C (es)
NZ (1) NZ214836A (es)
PH (3) PH22425A (es)
PL (3) PL257668A1 (es)
PT (1) PT81914B (es)
RO (1) RO93483B (es)
SE (3) SE467824B (es)
YU (2) YU45760B (es)
ZA (1) ZA86302B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751220A (en) * 1986-12-19 1988-06-14 E. R. Squibb & Sons, Inc. Crystalline salts of [3S(Z)]-2[[[1-(2-amino-4-thiazolyl)-2-[[2,2-dimethyl-4-oxo-1-(sulfooxy)-3-azetidinyl]amino]-2-oxoethylidene]-amino]oxy]acetic acid
US5143913A (en) * 1988-04-04 1992-09-01 E. R. Squibb & Sons, Inc. [3S(Z)]-3-[[(2-amino-4-thiazolyl)[[2-(hydroxyamino)-2-oxoethoxy]imino]acetyl]amino]-2,2-dimethyl-4-oxo-1-azetidinyl sulfate
EP0336667A3 (en) * 1988-04-04 1991-04-10 E.R. Squibb & Sons, Inc. [3S(Z)]-3-[[(2-amino-4-thiazolyl)[[2-(hydroxyamino)-2-oxoethoxy]imino]acetyl]-amino]-2,2-dimethyl-4-oxo-1-azetidinyl sulfate
US4973747A (en) * 1989-08-15 1990-11-27 E. R. Squibb & Sons, Inc. Process for preparing 3-hydroxy 2-keto acids
EP2308874B1 (en) * 2005-12-07 2013-01-23 Basilea Pharmaceutica AG Bridged monobactams useful as beta-lactamase inhibitors
WO2017180794A1 (en) 2016-04-13 2017-10-19 Skyline Antiinfectives, Inc. Deuterated o-sulfated beta-lactam hydroxamic acids and deuterated n-sulfated beta-lactams

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4337197A (en) * 1980-10-31 1982-06-29 E. R. Squibb & Sons, Inc. O-sulfated β-lactam hydroxamic acids and intermediates
JPS58113174A (ja) * 1981-12-26 1983-07-05 Toyama Chem Co Ltd 新規なアゼチジン誘導体またはその塩類を含有する抗菌剤
JPS58194856A (ja) * 1982-05-10 1983-11-12 Yamanouchi Pharmaceut Co Ltd 新規２−アゼチジノン誘導体
JPS58206589A (ja) * 1982-05-26 1983-12-01 Yamanouchi Pharmaceut Co Ltd ２−アゼチジノン誘導体
US4565654A (en) * 1983-03-28 1986-01-21 University Of Notre Dame Du Lac N-Acyloxy monocyclic β-lactams

Also Published As

Publication number Publication date
AT389511B (de) 1989-12-27
PL262318A1 (en) 1987-09-07
FI85022C (fi) 1992-02-25
KR860005812A (ko) 1986-08-13
NO860273L (no) 1986-07-29
PH22425A (en) 1988-09-12
HU196367B (en) 1988-11-28
ES8706112A1 (es) 1987-06-01
CH670824A5 (es) 1989-07-14
SE9002337D0 (sv) 1990-07-03
US4638061A (en) 1987-01-20
CH670825A5 (es) 1989-07-14
AU588017B2 (en) 1989-09-07
PL257668A1 (en) 1987-03-09
HUT40407A (en) 1986-12-28
CS253740B2 (en) 1987-12-17
AU5246086A (en) 1986-07-31
FR2576596A1 (fr) 1986-08-01
JPS61176563A (ja) 1986-08-08
CN1014894B (zh) 1991-11-27
BE904121A (fr) 1986-05-15
YU45760B (sh) 1992-07-20
JPH0853404A (ja) 1996-02-27
PL149156B1 (en) 1990-01-31
ES551252A0 (es) 1987-06-01
AR242024A1 (es) 1993-02-26
DD248584A5 (de) 1987-08-12
SE502442C2 (sv) 1995-10-16
SE8600355L (sv) 1986-07-29
PH23093A (en) 1989-04-10
SE9002338D0 (sv) 1990-07-03
FI860247A0 (fi) 1986-01-20
CH667872A5 (fr) 1988-11-15
SE9002338L (sv) 1990-07-03
ES557056A0 (es) 1987-12-01
IE59629B1 (en) 1994-03-09
KR900000675B1 (ko) 1990-02-02
DE3602347A1 (de) 1986-07-31
GB2198133A (en) 1988-06-08
GB8800425D0 (en) 1988-02-10
PT81914A (en) 1986-02-01
YU167087A (en) 1988-04-30
LU86262A1 (fr) 1986-08-04
DD248592A5 (de) 1987-08-12
GB2198133B (en) 1989-01-11
FI860247A (fi) 1986-07-29
CA1283924C (en) 1991-05-07
SE8600355D0 (sv) 1986-01-27
GB2170201A (en) 1986-07-30
PL262317A1 (en) 1987-09-07
RO93483B (ro) 1988-01-01
EG17682A (en) 1990-10-30
SE9002337L (sv) 1990-07-03
ATA20386A (de) 1989-05-15
DK39486D0 (da) 1986-01-27
PH23084A (en) 1989-04-10
NO170014C (no) 1992-09-02
CA1279322C (en) 1991-01-22
NZ214836A (en) 1988-10-28
DK39486A (da) 1986-07-29
IT8619206A0 (it) 1986-01-28
FI85022B (fi) 1991-11-15
IE860205L (en) 1986-07-28
GR860239B (en) 1986-05-28
SE468896B (sv) 1993-04-05
IE930750L (en) 1986-07-28
IT1190604B (it) 1988-02-16
ES557057A0 (es) 1988-03-01
RO93483A (ro) 1987-12-31
JPH0780840B2 (ja) 1995-08-30
PT81914B (pt) 1987-11-30
IL77661A (en) 1989-06-30
CN86100736A (zh) 1986-10-22
YU5886A (en) 1988-02-29
GB2170201B (en) 1989-01-11
NL8600136A (nl) 1986-08-18
FR2576596B1 (fr) 1989-12-15
SE467824B (sv) 1992-09-21
ES8801917A1 (es) 1988-03-01
ZA86302B (en) 1986-08-27
DD241600A5 (de) 1986-12-17
NO170014B (no) 1992-05-25

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001102